{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:34:10Z","timestamp":1760150050627,"version":"build-2065373602"},"reference-count":32,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","doi-asserted-by":"publisher","award":["UIDB\/04585\/2020"],"award-info":[{"award-number":["UIDB\/04585\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Obstructive sleep apnea is a sleep disorder with a high prevalence in the world population. The mandibular advancement device is one of the options for treating obstructive sleep apnea. Neck computed tomography and drug-induced sleep endoscopy are complementary diagnostic tests that may help predict the effectiveness of mandibular advancement devices. This study aims to analyze the best method for predicting the effectiveness of mandibular advancement devices in the therapeutic approach to obstructive sleep apnea. PubMed, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), and Web of Science Core Collection databases will be comprehensively searched. We will include randomized clinical trials, non-randomized prospective or retrospective clinical studies, case controls, cohort studies, and case series. Two authors will independently conduct data extraction and assess the literature quality of the studies. The analysis of the included literature will be conducted by Revman 5.3 software. The outcomes that will be analyzed are craniofacial characteristics, cephalometric assessments, site and type of obstruction of the upper airway, mean values of the apnea\u2013hypopnea index, and SaO2 verified in the initial and follow-up polysomnography. This study will provide reliable, evidence-based support for the clinical application of mandibular advancement devices for obstructive sleep apnea.<\/jats:p>","DOI":"10.3390\/jcm12196328","type":"journal-article","created":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T04:39:30Z","timestamp":1696221570000},"page":"6328","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Computed Tomography versus Sleep Endoscopy (DISE) to Predict the Effectiveness of Mandibular Advancement Devices in Adult Patients with Obstructive Sleep Apnea: A Protocol for Systematic Review"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6271-8884","authenticated-orcid":false,"given":"Pedro","family":"Cebola","sequence":"first","affiliation":[{"name":"Egas Moniz Center for Interdisciplinary Research (CiiEM), Egas Moniz School of Health & Science, 2829-511 Almada, Portugal"},{"name":"CUF Tejo Hospital, 1300-352 Lisboa, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8096-8895","authenticated-orcid":false,"given":"Cristina","family":"Caro\u00e7a","sequence":"additional","affiliation":[{"name":"CUF Tejo Hospital, 1300-352 Lisboa, Portugal"},{"name":"CHRC, NOVA Medical School, Universidade Nova de Lisboa (NMS\/UNL), 1169-056 Lisboa, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1905-1268","authenticated-orcid":false,"given":"Helena","family":"Donato","sequence":"additional","affiliation":[{"name":"Documentation and Scientific Information Service, Centro Hospitalar e Universit\u00e1rio de Coimbra, 3000-075 Coimbra, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Campos","sequence":"additional","affiliation":[{"name":"CUF Tejo Hospital, 1300-352 Lisboa, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara Sim\u00f5es","family":"Dias","sequence":"additional","affiliation":[{"name":"EpiDoC Unit, Centro de Estudos de Doen\u00e7as Cr\u00f3nicas (CEDOC) da NOVA Medical School, Universidade Nova de Lisboa (NMS\/UNL), CEDOC\u2014Campus Sant\u2019Ana, P\u00f3lo de Investiga\u00e7\u00e3o, NMS, UNL, Edif\u00edcio Amarelo, Rua do Instituto Bacteriol\u00f3gico no. 5, 1150-082 Lisboa, Portugal"},{"name":"EpiSa\u00fade Sociedade Cient\u00edfica, 7005-837 \u00c9vora, Portugal"},{"name":"Escola Superior de Sa\u00fade do Instituto Polit\u00e9cnico de Leiria, Unidade de Investiga\u00e7\u00e3o em Sa\u00fade (UI), 2411-901 Leiria, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o","family":"Pa\u00e7o","sequence":"additional","affiliation":[{"name":"CUF Tejo Hospital, 1300-352 Lisboa, Portugal"},{"name":"CHRC, NOVA Medical School, Universidade Nova de Lisboa (NMS\/UNL), 1169-056 Lisboa, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Manso","sequence":"additional","affiliation":[{"name":"Egas Moniz Center for Interdisciplinary Research (CiiEM), Egas Moniz School of Health & Science, 2829-511 Almada, Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,1]]},"reference":[{"key":"ref_1","first-page":"468","article-title":"Efficacy and adherence of auto-CPAP therapy in patients with obstructive sleep apnea: A prospective study","volume":"15","year":"2020","journal-title":"Multidiscip. 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