{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:50:40Z","timestamp":1787028640428,"version":"build-2736575974"},"reference-count":111,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T00:00:00Z","timestamp":1696291200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Context: Implementation of pre-conception care units is still very limited in Italy. Nowadays, the population\u2019s awareness of the reproductive risks that can be reduced or prevented is very low. Purpose and main findings: We presented a new personalized multidisciplinary model of preconception care aimed at identifying and possibly reducing adverse reproductive events. We analyzed three cohorts of population: couples from the general population, infertile or subfertile couples, and couples with a previous history of adverse reproductive events. The proposal involves a deep investigation regarding family history, the personal histories of both partners, and reproductive history. Principal conclusions: Preconception care is still neglected in Italy and under-evaluated by clinicians involved in natural or in vitro reproduction. Adequate preconception counseling will improve maternal and fetal obstetrical outcomes.<\/jats:p>","DOI":"10.3390\/jcm12196352","type":"journal-article","created":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T09:43:01Z","timestamp":1696326181000},"page":"6352","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Before Is Better: Innovative Multidisciplinary Preconception Care in Different Clinical Contexts"],"prefix":"10.3390","volume":"12","author":[{"given":"Martina","family":"Cristodoro","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, 20072 Pieve Emanuele, Italy"},{"name":"IRCCS Humanitas Research Hospital, Via Manzoni 56, 20089 Milan, Italy"},{"name":"Division of Obstetrics and Gynecology, Humanitas San Pio X Hospital, 20159 Milan, Italy"},{"name":"Diabetes Center, Humanitas Gavazzeni Institute, Via M. Gavazzeni 21, 24100 Bergamo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marinella","family":"Dell\u2019Avanzo","sequence":"additional","affiliation":[{"name":"Division of Obstetrics and Gynecology, Humanitas San Pio X Hospital, 20159 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matilda","family":"Ghio","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, 20072 Pieve Emanuele, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faustina","family":"Lalatta","sequence":"additional","affiliation":[{"name":"Division of Obstetrics and Gynecology, Humanitas San Pio X Hospital, 20159 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Vena","sequence":"additional","affiliation":[{"name":"Diabetes Center, Humanitas Gavazzeni Institute, Via M. Gavazzeni 21, 24100 Bergamo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Lania","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, 20072 Pieve Emanuele, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Sacchi","sequence":"additional","affiliation":[{"name":"IRCCS Humanitas Research Hospital, Via Manzoni 56, 20089 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Bravo","sequence":"additional","affiliation":[{"name":"Division of Obstetrics and Gynecology, Humanitas San Pio X Hospital, 20159 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Bulfoni","sequence":"additional","affiliation":[{"name":"Division of Obstetrics and Gynecology, Humanitas San Pio X Hospital, 20159 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicoletta","family":"Di Simone","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, 20072 Pieve Emanuele, Italy"},{"name":"IRCCS Humanitas Research Hospital, Via Manzoni 56, 20089 Milan, Italy"},{"name":"Division of Obstetrics and Gynecology, Humanitas San Pio X Hospital, 20159 Milan, Italy"},{"name":"Diabetes Center, Humanitas Gavazzeni Institute, Via M. 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