{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T08:30:56Z","timestamp":1761294656754,"version":"build-2065373602"},"reference-count":27,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2023,10,8]],"date-time":"2023-10-08T00:00:00Z","timestamp":1696723200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"CNPq (National Council for Scientific and Technological Development)","award":["309023\/2015-7","316802\/2021-2","88882.181746\/2011-01","2021-0269"],"award-info":[{"award-number":["309023\/2015-7","316802\/2021-2","88882.181746\/2011-01","2021-0269"]}]},{"name":"CAPES (Coordination for the Improvement of Higher Education Personnel)","award":["309023\/2015-7","316802\/2021-2","88882.181746\/2011-01","2021-0269"],"award-info":[{"award-number":["309023\/2015-7","316802\/2021-2","88882.181746\/2011-01","2021-0269"]}]},{"name":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Cardiologia","award":["309023\/2015-7","316802\/2021-2","88882.181746\/2011-01","2021-0269"],"award-info":[{"award-number":["309023\/2015-7","316802\/2021-2","88882.181746\/2011-01","2021-0269"]}]},{"name":"Financiamento e Incentivo \u00e0 Pesquisa (FIPE\/HCPA)","award":["309023\/2015-7","316802\/2021-2","88882.181746\/2011-01","2021-0269"],"award-info":[{"award-number":["309023\/2015-7","316802\/2021-2","88882.181746\/2011-01","2021-0269"]}]},{"name":"Hospital de Clinicas de Porto Alegre","award":["309023\/2015-7","316802\/2021-2","88882.181746\/2011-01","2021-0269"],"award-info":[{"award-number":["309023\/2015-7","316802\/2021-2","88882.181746\/2011-01","2021-0269"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Myocardial injury (MI) is frequent in critically ill patients with COVID-19, but its pathogenesis remains unclear. We hypothesized that MI is not solely due to viral infection by SARS-CoV-2 but rather due to the common pathophysiological mechanisms associated with severe pulmonary infections and respiratory failure. This contemporary cohort study was designed to compare the incidence of MI in patients with acute respiratory failure caused by COVID-19 to patients with other pulmonary infections. In addition, we aimed to investigate whether MI was a distinct risk factor for in-hospital mortality in patients with COVID-19 compared to those with non-COVID-19 infections. This study included 1444 patients with COVID-19 (55.5% men; age 58 (46;68) years) and 182 patients with other pulmonary infections (46.9% men; age 62 (44;73) years). The incidence of MI at ICU admission was lower in COVID-19 patients (36.4%) compared to non-COVID-19 patients (56%), and this difference persisted after adjusting for age, sex, coronary artery disease, heart failure, SOFA score, lactate, and C-reactive protein (RR 0.84 (95% CI, 0.71\u20130.99)). MI at ICU admission was associated with a 59% increase in mortality (RR 1.59 (1.36\u20131.86); p &lt; 0.001), and there was no significant difference in the mortality between patients with COVID-19 and those with other pulmonary infections (p = 0.271). We concluded that MI is less frequent in patients with critical COVID-19 pneumonia and respiratory failure compared to those with other types of pneumonia. The occurrence of MI is a significant risk factor for in-hospital mortality, regardless of the etiology of the pulmonary infection.<\/jats:p>","DOI":"10.3390\/jcm12196403","type":"journal-article","created":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T04:56:43Z","timestamp":1696827403000},"page":"6403","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparison of Incidence and Prognosis of Myocardial Injury in Patients with COVID-19-Related Respiratory Failure and Other Pulmonary Infections: A Contemporary Cohort Study"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0261-9993","authenticated-orcid":false,"given":"Manoela Astolfi","family":"Vivan","sequence":"first","affiliation":[{"name":"Graduate Program in Cardiology, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre 90035-003, RS, Brazil"},{"name":"Divison of Intensive Care Medicine, Hospital de Cl\u00ednicas de Porto Alegre (HCPA), Porto Alegre 90035-903, RS, Brazil"},{"name":"School of Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre 90035-003, RS, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vania Naomi","family":"Hirakata","sequence":"additional","affiliation":[{"name":"Graduate Program in Cardiology, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre 90035-003, RS, Brazil"},{"name":"INCT PREVER, Hospital de Cl\u00ednicas de Porto Alegre (HCPA), Porto Alegre 90035-903, RS, Brazil"},{"name":"Research Board, Diretoria de Pesquisa, Hospital de Cl\u00ednicas de Porto Alegre (HCPA), Porto Alegre 90035-903, RS, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2366-1656","authenticated-orcid":false,"given":"Maria Ant\u00f4nia Torres","family":"Arteche","sequence":"additional","affiliation":[{"name":"School of Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre 90035-003, RS, Brazil"},{"name":"INCT PREVER, Hospital de Cl\u00ednicas de Porto Alegre (HCPA), Porto Alegre 90035-903, RS, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D\u00e9bora Marques","family":"de Araujo","sequence":"additional","affiliation":[{"name":"School of Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre 90035-003, RS, Brazil"},{"name":"INCT PREVER, Hospital de Cl\u00ednicas de Porto Alegre (HCPA), Porto Alegre 90035-903, RS, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6351-9588","authenticated-orcid":false,"given":"Sandra C.","family":"Fuchs","sequence":"additional","affiliation":[{"name":"Graduate Program in Cardiology, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre 90035-003, RS, Brazil"},{"name":"School of Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre 90035-003, RS, Brazil"},{"name":"INCT PREVER, Hospital de Cl\u00ednicas de Porto Alegre (HCPA), Porto Alegre 90035-903, RS, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1191-0523","authenticated-orcid":false,"given":"Fl\u00e1vio D.","family":"Fuchs","sequence":"additional","affiliation":[{"name":"Graduate Program in Cardiology, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre 90035-003, RS, Brazil"},{"name":"School of Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre 90035-003, RS, Brazil"},{"name":"INCT PREVER, Hospital de Cl\u00ednicas de Porto Alegre (HCPA), Porto Alegre 90035-903, RS, Brazil"},{"name":"Division of Cardiology, Hospital de Cl\u00ednicas de Porto Alegre (HCPA), Porto Alegre 90035-903, RS, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e618","DOI":"10.1161\/CIR.0000000000000617","article-title":"Fourth Universal Definition of Myocardial Infarction (2018)","volume":"138","author":"Thygesen","year":"2018","journal-title":"Circulation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"850447","DOI":"10.3389\/fcvm.2022.850447","article-title":"Myocardial Injury Predicts Risk of Short-Term All-Cause Mortality in Patients with COVID-19: A Dose-Response Meta-Analysis","volume":"9","author":"Li","year":"2022","journal-title":"Front. 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