{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T08:23:42Z","timestamp":1791015822615,"version":"4.1.0"},"reference-count":73,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T00:00:00Z","timestamp":1697241600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Gastric cancer (GCa) is an aggressive malignancy, representing the third leading cause of cancer mortality worldwide. The poor prognosis of GCa can be associated with the prevalence of peritoneal metastasis (PM). Current international and national GCa treatment guidelines only recommend palliative treatment options for patients with PM. Since the 1980s there have been multiple single arm trials, randomized controlled trials, and metanalysis investigating the use of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) in patients with advanced GCa, with or without PM. Results from these studies have been encouraging, with some large-volume centers even incorporating HIPEC into their treatment algorithms for patients with advanced GCa. Additionally, there are several ongoing trials that, when completed, will increase our understanding of the efficacy of CRS &amp; HIPEC in patients with GCa metastatic to the peritoneum. Herein we review the current evidence, ongoing trials, consensus guidelines, and future considerations regarding the use of CRS &amp; HIPEC in patients suffering from GCa with PM.<\/jats:p>","DOI":"10.3390\/jcm12206527","type":"journal-article","created":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T14:59:59Z","timestamp":1697295599000},"page":"6527","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Current Evidence for the Use of HIPEC and Cytoreductive Surgery in Gastric Cancer Metastatic to the Peritoneum"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8695-3969","authenticated-orcid":false,"given":"Anish J.","family":"Jain","sequence":"first","affiliation":[{"name":"Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9915-8355","authenticated-orcid":false,"given":"Brian D.","family":"Badgwell","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Manzanedo, I., Pereira, F., P\u00e9rez-Viejo, E., and Serrano, \u00c1. (2023). Gastric Cancer with Peritoneal Metastases: Current Status and Prospects for Treatment. Cancers, 15.","DOI":"10.3390\/cancers15061777"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1159\/000522604","article-title":"Indication of Hyperthermic Intraperitoneal Chemotherapy in Gastric Cancer (Gastripec, Gastrichip)","volume":"38","author":"Rau","year":"2022","journal-title":"Visc. Med."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Gamboa, A.C., and Winer, J.H. (2019). Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Gastric Cancer. Cancers, 11.","DOI":"10.3390\/cancers11111662"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1245\/s10434-021-11316-z","article-title":"Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Combined with Surgery: A 12-Year Meta-Analysis of this Promising Treatment Strategy for Advanced Gastric Cancer at Different Stages","volume":"29","author":"Zhang","year":"2022","journal-title":"Ann. Surg. Oncol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"7528","DOI":"10.1245\/s10434-022-12312-7","article-title":"Impact of Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy in the Treatment of Gastric Cancer with Peritoneal Carcinomatosis: A Systematic Review and Meta-analysis","volume":"29","author":"Martins","year":"2022","journal-title":"Ann. Surg. Oncol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1245\/s10434-019-07450-4","article-title":"Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) for Gastric Cancer with Peritoneal Carcinomatosis: Multicenter Study of Spanish Group of Peritoneal Oncologic Surgery (GECOP)","volume":"26","author":"Manzanedo","year":"2019","journal-title":"Ann. Surg. Oncol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"4332","DOI":"10.1245\/s10434-016-5409-7","article-title":"Yield of Staging Laparoscopy and Lavage Cytology for Radiologically Occult Peritoneal Carcinomatosis of Gastric Cancer","volume":"23","author":"Ikoma","year":"2016","journal-title":"Ann. Surg. Oncol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/jso.25094","article-title":"Repeat staging laparoscopy for gastric cancer after preoperative therapy","volume":"118","author":"Thiels","year":"2018","journal-title":"J. Surg. Oncol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2679","DOI":"10.1245\/s10434-017-5838-y","article-title":"Patterns of Initial Recurrence in Gastric Adenocarcinoma in the Era of Preoperative Therapy","volume":"24","author":"Ikoma","year":"2017","journal-title":"Ann. Surg. Oncol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1002\/jso.26718","article-title":"Regional therapy trials in peritoneal metastases: The path to standardization of care for gastric cancer","volume":"125","author":"Badgwell","year":"2022","journal-title":"J. Surg. Oncol."},{"key":"ref_12","unstructured":"Network, N.C.C. (2023, July 01). Gastric Cancer Version 1. Available online: https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/gastric.pdf."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.dld.2018.04.025","article-title":"Gastric cancer: French intergroup clinical practice guidelines for diagnosis, treatments and follow-up (SNFGE, FFCD, GERCOR, UNICANCER, SFCD, SFED, SFRO)","volume":"50","author":"Zaanan","year":"2018","journal-title":"Dig. Liver. Dis."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"v38","DOI":"10.1093\/annonc\/mdw350","article-title":"Gastric cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up","volume":"27","author":"Smyth","year":"2016","journal-title":"Ann. Oncol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1093\/annonc\/mdl428","article-title":"A systematic review on the efficacy of cytoreductive surgery combined with perioperative intraperitoneal chemotherapy for diffuse malignancy peritoneal mesothelioma","volume":"18","author":"Yan","year":"2007","journal-title":"Ann. Oncol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S1470-2045(05)70539-8","article-title":"New standard of care for appendiceal epithelial neoplasms and pseudomyxoma peritonei syndrome?","volume":"7","author":"Sugarbaker","year":"2006","journal-title":"Lancet Oncol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e186847","DOI":"10.1001\/jamanetworkopen.2018.6847","article-title":"Morbidity and Mortality Rates Following Cytoreductive Surgery Combined With Hyperthermic Intraperitoneal Chemotherapy Compared With Other High-Risk Surgical Oncology Procedures","volume":"2","author":"Foster","year":"2019","journal-title":"JAMA Netw. Open"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1245\/s10434-014-3978-x","article-title":"Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for malignant peritoneal mesothelioma: A systematic review and meta-analysis","volume":"22","author":"Helm","year":"2015","journal-title":"Ann. Surg. Oncol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1245\/s10434-014-4157-9","article-title":"Cytoreductive surgery and HIPEC in recurrent epithelial ovarian cancer: A prospective randomized phase III study","volume":"22","author":"Spiliotis","year":"2015","journal-title":"Ann. Surg. Oncol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1056\/NEJMoa1708618","article-title":"Hyperthermic Intraperitoneal Chemotherapy in Ovarian Cancer","volume":"378","author":"Koole","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"49","DOI":"10.4240\/wjgs.v10.i5.49","article-title":"Approach to pseudomyxoma peritonei","volume":"10","author":"Rizvi","year":"2018","journal-title":"World J. Gastrointest. Surg."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1002\/ijc.28373","article-title":"Peritoneal carcinomatosis of gastric origin: A population-based study on incidence, survival and risk factors","volume":"134","author":"Thomassen","year":"2014","journal-title":"Int. J. Cancer"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1007\/s10120-021-01160-1","article-title":"Synchronous peritoneal metastases of gastric cancer origin: Incidence, treatment and survival of a nationwide Dutch cohort","volume":"24","author":"Koemans","year":"2021","journal-title":"Gastric Cancer"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s101200100013","article-title":"A controlled clinical study of serosa-invasive gastric carcinoma patients who underwent surgery plus intraperitoneal hyperthermo-chemo-perfusion (IHCP)","volume":"4","author":"Kim","year":"2001","journal-title":"Gastric Cancer"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Sun, J., Song, Y., Wang, Z., Gao, P., Chen, X., Xu, Y., Liang, J., and Xu, H. (2012). Benefits of hyperthermic intraperitoneal chemotherapy for patients with serosal invasion in gastric cancer: A meta-analysis of the randomized controlled trials. BMC Cancer, 12.","DOI":"10.1186\/1471-2407-12-526"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejca.2017.03.030","article-title":"The 30-year experience-A meta-analysis of randomised and high-quality non-randomised studies of hyperthermic intraperitoneal chemotherapy in the treatment of gastric cancer","volume":"79","author":"Desiderio","year":"2017","journal-title":"Eur. J. Cancer"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1002\/1097-0142(19880115)61:2<232::AID-CNCR2820610205>3.0.CO;2-U","article-title":"Prophylactic therapy for peritoneal recurrence of gastric cancer by continuous hyperthermic peritoneal perfusion with mitomycin C","volume":"61","author":"Koga","year":"1988","journal-title":"Cancer"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1002\/1097-0142(19940415)73:8<2048::AID-CNCR2820730806>3.0.CO;2-Q","article-title":"Intraperitoneal thermochemotherapy for prevention of peritoneal recurrence of gastric cancer. Final results of a randomized controlled study","volume":"73","author":"Hamazoe","year":"1994","journal-title":"Cancer"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1007\/BF00348209","article-title":"Continuous hyperthermic peritoneal perfusion for the prevention of peritoneal recurrence of gastric cancer: Randomized controlled study","volume":"18","author":"Fujimura","year":"1994","journal-title":"World J. Surg."},{"key":"ref_30","first-page":"581","article-title":"Effects of continuous hyperthermic peritoneal perfusion on prognosis of gastric cancer with serosal invasion","volume":"161","author":"Ikeguchi","year":"1995","journal-title":"Eur. J. Surg."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1002\/(SICI)1097-0142(19990201)85:3<529::AID-CNCR3>3.0.CO;2-9","article-title":"Successful intraperitoneal hyperthermic chemoperfusion for the prevention of postoperative peritoneal recurrence in patients with advanced gastric carcinoma","volume":"85","author":"Fujimoto","year":"1999","journal-title":"Cancer"},{"key":"ref_32","first-page":"1776","article-title":"Intraoperative chemohyperthermic peritoneal perfusion as an adjuvant to gastric cancer: Final results of a randomized controlled study","volume":"48","author":"Yonemura","year":"2001","journal-title":"Hepatogastroenterology"},{"key":"ref_33","first-page":"247","article-title":"Postoperative intraperitioneal hyperthermic chemoperfusion combined with intravenous chemotherapy for 82 advanced gastric cancer patients","volume":"26","author":"Zuo","year":"2004","journal-title":"Zhonghua Zhong Liu Za Zhi"},{"key":"ref_34","first-page":"478","article-title":"Efficacy of intraoperative hypotonic peritoneal chemo-hyperthermia combined with early postoperative intraperitoneal chemotherapy on gastric cancer","volume":"24","author":"Wei","year":"2005","journal-title":"Ai Zheng"},{"key":"ref_35","first-page":"362","article-title":"Application of hyperthermic intraoperative intraperitoneal chemotherapy in patients with gastric cancer","volume":"10","author":"Zhang","year":"2007","journal-title":"Zhonghua Wei Chang Wai Ke Za Zhi"},{"key":"ref_36","first-page":"295","article-title":"Clinical application of perioperative continuous hyperthermic peritoneal perfusion chemotherapy for gastric cancer","volume":"29","author":"Deng","year":"2009","journal-title":"Nan Fang Yi Ke Da Xue Xue Bao"},{"key":"ref_37","first-page":"75","article-title":"Hyperthermic peritoneal perfusion combined with anticancer chemotherapy as prophylactic treatment of peritoneal recurrence of gastric cancer","volume":"36","author":"Kaibara","year":"1989","journal-title":"Hepatogastroenterology"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.3892\/etm.2014.1599","article-title":"Effect of neoadjuvant chemotherapy combined with hyperthermic intraperitoneal perfusion chemotherapy on advanced gastric cancer","volume":"7","author":"Cui","year":"2014","journal-title":"Exp. Ther. Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1007\/s12013-014-0326-5","article-title":"Fibrin-Sealant-Delivered Cisplatin Chemotherapy Versus Cisplatin Hyperthermic Intraperitoneal Perfusion Chemotherapy for Locally Advanced Gastric Cancer Without Peritoneal Metastases: A Randomized Phase-II Clinical Trial with a 40-Month Follow-up","volume":"71","author":"Huang","year":"2015","journal-title":"Cell Biochem. Biophys."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1002\/jso.23633","article-title":"Impact of maximal cytoreductive surgery plus regional heated intraperitoneal chemotherapy (HIPEC) on outcome of patients with peritoneal carcinomatosis of gastric origin: Results of the GYMSSA trial","volume":"110","author":"Rudloff","year":"2014","journal-title":"J. Surg. Oncol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1245\/s10434-011-1631-5","article-title":"Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy Improves Survival of Patients with Peritoneal Carcinomatosis from Gastric Cancer: Final Results of a Phase III Randomized Clinical Trial","volume":"18","author":"Yang","year":"2011","journal-title":"Ann. Surg. Oncol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1007\/BF00299188","article-title":"Prophylaxis with intraoperative chemohyperthermia against peritoneal recurrence of serosal invasion-positive gastric cancer","volume":"19","author":"Yonemura","year":"1995","journal-title":"World J. Surg."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.jcma.2013.04.004","article-title":"Intraoperative hyperthermic intraperitoneal chemotherapy as adjuvant chemotherapy for advanced gastric cancer patients with serosal invasion","volume":"76","author":"Kang","year":"2013","journal-title":"J. Chin. Med. Assoc."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1159\/000012016","article-title":"Efficacy of continuous hyperthermic peritoneal perfusion for the prophylaxis and treatment of peritoneal metastasis of advanced gastric cancer: Evaluation by multivariate regression analysis","volume":"57","author":"Hirose","year":"1999","journal-title":"Oncology"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"159","DOI":"10.3109\/02656736.2014.893451","article-title":"Hyperthermic intraperitoneal chemoperfusion in combined treatment of locally advanced and disseminated gastric cancer: Results of a single-centre retrospective study","volume":"30","author":"Yarema","year":"2014","journal-title":"Int. J. Hyperth."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1067\/msy.2002.123769","article-title":"Lack of efficacy of prophylactic continuous hyperthermic peritoneal perfusion on subsequent peritoneal recurrence and survival in patients with advanced gastric cancer","volume":"131","author":"Kunisaki","year":"2002","journal-title":"Surgery"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1159\/000093778","article-title":"Efficacy and Safety of Intraoperative Peritoneal Hyperthermic Chemotherapy for Advanced Gastric Cancer Patients with Serosal Invasion: A Long-Term Follow-Up Study","volume":"23","author":"Zhu","year":"2006","journal-title":"Dig. Surg."},{"key":"ref_48","first-page":"2079","article-title":"Continuous hyperthermic peritoneal perfusion for peritoneal dissemination of gastric cancer","volume":"45","author":"Akiyama","year":"1998","journal-title":"Hepato-Gastroenterol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1097\/00000658-199011000-00005","article-title":"Positive results of combined therapy of surgery and intraperitoneal hyperthermic perfusion for far-advanced gastric cancer","volume":"212","author":"Fujimoto","year":"1990","journal-title":"Ann. Surg."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"112","DOI":"10.3109\/0284186X.2011.594809","article-title":"Costs and clinical outcome of neoadjuvant systemic chemotherapy followed by cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in peritoneal carcinomatosis from gastric cancer","volume":"51","author":"Hultman","year":"2012","journal-title":"Acta Oncol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1002\/(SICI)1097-0142(19970301)79:5<884::AID-CNCR3>3.0.CO;2-C","article-title":"Improved mortality rate of gastric carcinoma patients with peritoneal carcinomatosis treated with intraperitoneal hyperthermic chemoperfusion combined with surgery","volume":"79","author":"Fujimoto","year":"1997","journal-title":"Cancer"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.amjsurg.2013.04.010","article-title":"Peritoneal carcinomatosis in patients with gastric cancer, and the role for surgical resection, cytoreductive surgery, and hyperthermic intraperitoneal chemotherapy","volume":"207","author":"Kim","year":"2014","journal-title":"Am. J. Surg."},{"key":"ref_53","first-page":"473","article-title":"Therapeutic outcomes of continuous hyperthermic peritoneal perfusion against advanced gastric cancer with peritoneal carcinomatosis","volume":"53","author":"Kunisaki","year":"2006","journal-title":"Hepato-Gastroenterol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/jso.21628","article-title":"Surgical resection with hyperthermic intraperitoneal chemotherapy for gastric cancer patients with peritoneal dissemination","volume":"102","author":"Li","year":"2010","journal-title":"J. Surg. Oncol."},{"key":"ref_55","first-page":"989","article-title":"Clinical study of cisplatin hyperthermic intraperitoneal perfusion chemotherapy in combination with docetaxel, 5-flourouracil and leucovorin intravenous chemotherapy for the treatment of advanced-stage gastric carcinoma","volume":"60","author":"Zhibing","year":"2013","journal-title":"Hepato-Gastroenterol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1093\/bjs\/znab200","article-title":"Prognosis of poorly cohesive gastric cancer after complete cytoreductive surgery with or without hyperthermic intraperitoneal chemotherapy (CYTO-CHIP study)","volume":"108","author":"Bonnot","year":"2021","journal-title":"Br. J. Surg."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"3338","DOI":"10.1245\/s10434-017-6047-4","article-title":"Phase II Trial of Laparoscopic Hyperthermic Intraperitoneal Chemoperfusion for Peritoneal Carcinomatosis or Positive Peritoneal Cytology in Patients with Gastric Adenocarcinoma","volume":"24","author":"Badgwell","year":"2017","journal-title":"Ann. Surg. Oncol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"2806","DOI":"10.1245\/s10434-020-08226-x","article-title":"Phase I Trial of Hyperthermic Intraperitoneal Chemoperfusion (HIPEC) with Cisplatin, Mitomycin, and Paclitaxel in Patients with Gastric Adenocarcinoma and Associated Carcinomatosis or Positive Cytology","volume":"27","author":"Ikoma","year":"2020","journal-title":"Ann. Surg. Oncol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"S1040","DOI":"10.1016\/j.annonc.2021.08.1485","article-title":"1376O The effect of hyperthermic intraperitoneal chemotherapy (HIPEC) upon cytoreductive surgery (CRS) in gastric cancer (GC) with synchronous peritoneal metastasis (PM): A randomized multicentre phase III trial (GASTRIPEC-I-trial)","volume":"32","author":"Rau","year":"2021","journal-title":"Ann. Oncol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1245\/s10434-020-08739-5","article-title":"A Phase II Trial of Cytoreduction, Gastrectomy, and Hyperthermic Intraperitoneal Perfusion with Chemotherapy for Patients with Gastric Cancer and Carcinomatosis or Positive Cytology","volume":"28","author":"Badgwell","year":"2021","journal-title":"Ann. Surg. Oncol."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Glehen, O., Passot, G., Villeneuve, L., Vaudoyer, D., Bin-Dorel, S., Boschetti, G., Piaton, E., and Garofalo, A. (2014). GASTRICHIP: D2 resection and hyperthermic intraperitoneal chemotherapy in locally advanced gastric carcinoma: A randomized and multicenter phase III study. BMC Cancer, 14.","DOI":"10.1186\/1471-2407-14-183"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1002\/bjs.11588","article-title":"Treatment of PERItoneal disease in Stomach Cancer with cytOreductive surgery and hyperthermic intraPEritoneal chemotherapy: PERISCOPE I initial results","volume":"107","author":"Wassenaar","year":"2020","journal-title":"Br. J. Surg."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Koemans, W.J., van der Kaaij, R.T., Boot, H., Buffart, T., Veenhof, A.A.F.A., Hartemink, K.J., Grootscholten, C., Snaebjornsson, P., Retel, V.P., and van Tinteren, H. (2019). Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy versus palliative systemic chemotherapy in stomach cancer patients with peritoneal dissemination, the study protocol of a multicentre randomised controlled trial (PERISCOPE II). BMC Cancer, 19.","DOI":"10.1186\/s12885-019-5640-2"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"(2020). The Chicago Consensus on peritoneal surface malignancies: Management of gastric metastases. Cancer, 126, 2541\u20132546.","DOI":"10.1002\/cncr.32868"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1245\/s10434-018-07140-7","article-title":"Laparoscopic Hyperthermic Intraperitoneal Chemotherapy is Safe for Patients with Peritoneal Metastases from Gastric Cancer and May Lead to Gastrectomy","volume":"26","author":"Newhook","year":"2019","journal-title":"Ann. Surg. Oncol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"7244","DOI":"10.1245\/s10434-022-12383-6","article-title":"Don\u2032t Call It a Comeback-HIPEC for Gastric Cancer","volume":"29","author":"Badgwell","year":"2022","journal-title":"Ann. Surg. Oncol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1007\/s00464-012-2148-0","article-title":"Description of a novel approach for intraperitoneal drug delivery and the related device","volume":"26","author":"Hetzel","year":"2012","journal-title":"Surg. Endosc."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1097\/01.sla.0000218089.61635.5f","article-title":"High intra-abdominal pressure enhances the penetration and antitumor effect of intraperitoneal cisplatin on experimental peritoneal carcinomatosis","volume":"244","author":"Esquis","year":"2006","journal-title":"Ann. Surg."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1001\/archsurg.1997.01430280012001","article-title":"Basic Principles in Surgical Oncology","volume":"132","author":"Cady","year":"1997","journal-title":"Arch. Surg."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"S59","DOI":"10.21037\/jgo-20-284","article-title":"A narrative review of intraperitoneal chemotherapy and cytoreductive surgery (CRS) for peritoneal metastases in gastric cancer","volume":"12","author":"Boerner","year":"2021","journal-title":"J. Gastrointest. Oncol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1136\/gutjnl-2019-319748","article-title":"YAP1 mediates gastric adenocarcinoma peritoneal metastases that are attenuated by YAP1 inhibition","volume":"70","author":"Ajani","year":"2021","journal-title":"Gut"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1002\/jso.26894","article-title":"Current role for cytoreduction and HIPEC for gastric cancer with peritoneal disease","volume":"125","author":"Khan","year":"2022","journal-title":"J. Surg. Oncol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"2400","DOI":"10.1245\/s10434-018-6561-z","article-title":"Preoperative Circulating Tumor DNA in Patients with Peritoneal Carcinomatosis is an Independent Predictor of Progression-Free Survival","volume":"25","author":"Baumgartner","year":"2018","journal-title":"Ann. Surg. Oncol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/20\/6527\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:06:58Z","timestamp":1760130418000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/20\/6527"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,14]]},"references-count":73,"journal-issue":{"issue":"20","published-online":{"date-parts":[[2023,10]]}},"alternative-id":["jcm12206527"],"URL":"https:\/\/doi.org\/10.3390\/jcm12206527","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,14]]}}}