{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T15:25:26Z","timestamp":1792855526707,"version":"4.5.0"},"reference-count":77,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T00:00:00Z","timestamp":1697846400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Borderline personality disorder (BPD) has long suffered from overshadowing in adolescents and hopelessness from the psychiatrists themselves. Comprehensive guidelines for this age group are lacking. Aims: This narrative review aims to describe current recommendations for BPD and recent empirical evidence on effective treatments (both pharmacological and non-pharmacological) and preventive approaches. Innovative approaches, based on recent and original research on BPD adolescents, are also discussed. Results: Very low-certainty evidence has supported that medication has a positive effect on core BPD symptoms in adolescents. Medication prescribed for suicidal crises or associated disorders should be included in a global therapeutic plan, including efficacy reassessment, treatment duration, and a security plan. The overall benefit of structured psychotherapy for adolescents with BPD (cognitive behavioral therapy, mentalization-based therapy, dialectic behavioral therapy, and group therapy) is more important for self-harm behaviors than other BPD symptoms. Their specific efficacy, although difficult to distinguish from the overall non-specific effect of integrative care. Conclusions: structured care of young BPD individuals should be based on the following principles: (1) setting the frame of care, including recognition of the diagnosis, and sharing information with patients and families about symptoms, prognosis, and putative psychological mechanisms involved; and (2) promoting comprehensive approaches, including both specific and non specific therapy, ecological interventions, community care, and preventive interventions in at-risk groups.<\/jats:p>","DOI":"10.3390\/jcm12206668","type":"journal-article","created":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T12:59:48Z","timestamp":1697893188000},"page":"6668","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Therapeutic and Preventive Interventions in Adolescents with Borderline Personality Disorder: Recent Findings, Current Challenges, and Future Directions"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3226-7829","authenticated-orcid":false,"given":"Nad\u00e8ge","family":"Bourvis","sequence":"first","affiliation":[{"name":"Centre Hospitalier Intercommunal Toulon la Seyne (CHITS), 83000 Toulon, France"},{"name":"Maison des Adolescents du Var, 83000 Toulon, France"},{"name":"Service Universitaire de Psychiatrie Infanto Juvenile, Aix-Marseille Universit\u00e9, 13009 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Cohen","sequence":"additional","affiliation":[{"name":"Institut des Syst\u00e8mes Intelligents et Robotique, APHP-Sorbonne Universit\u00e9, 75651 Paris, France"},{"name":"GH Piti\u00e9-Salp\u00eatri\u00e8re, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Benarous","sequence":"additional","affiliation":[{"name":"Institut des Syst\u00e8mes Intelligents et Robotique, APHP-Sorbonne Universit\u00e9, 75651 Paris, France"},{"name":"GH Piti\u00e9-Salp\u00eatri\u00e8re, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S0140-6736(04)16770-6","article-title":"Borderline Personality Disorder","volume":"364","author":"Lieb","year":"2004","journal-title":"Lancet"},{"key":"ref_2","first-page":"199","article-title":"Borderline Personality Disorder in Adolescents: Prevalence, Diagnosis, and Treatment Strategies","volume":"9","author":"Boissel","year":"2018","journal-title":"Adolesc. Health Med. Ther."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1542\/peds.2013-3677","article-title":"Borderline Personality Disorder in Adolescence","volume":"134","author":"Kaess","year":"2014","journal-title":"Pediatrics"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.comppsych.2011.12.003","article-title":"Borderline Personality Disorder in Adolescents: Evidence in Support of the Childhood Interview for DSM-IV Borderline Personality Disorder in a Sample of Adolescent Inpatients","volume":"53","author":"Sharp","year":"2012","journal-title":"Compr. Psychiatry"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s00787-020-01683-5","article-title":"Welfare Consequences of Early-Onset Borderline Personality Disorder: A Nationwide Register-Based Case-Control Study","volume":"31","author":"Hastrup","year":"2022","journal-title":"Eur. Child Adolesc. Psychiatry"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Aouidad, A., Cohen, D., Mirkovic, B., Pellerin, H., Garny de La Rivi\u00e8re, S., Consoli, A., G\u00e9rardin, P., and Guil\u00e9, J.-M. (2020). Borderline Personality Disorder and Prior Suicide Attempts Define a Severity Gradient among Hospitalized Adolescent Suicide Attempters. BMC Psychiatry, 20.","DOI":"10.1186\/s12888-020-02930-4"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s00787-014-0589-9","article-title":"Correlates, Stability and Predictors of Borderline Personality Disorder among Previously Suicidal Youth","volume":"24","author":"Greenfield","year":"2015","journal-title":"Eur. Child Adolesc. Psychiatry"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1177\/070674371305800907","article-title":"Changes in Treated Incidence of Borderline Personality Disorder in Denmark: 1970\u20132009","volume":"58","author":"Zanarini","year":"2013","journal-title":"Can. J. Psychiatry Rev. Can. Psychiatr."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1521\/pedi.2013.27.2.252","article-title":"Borderline Personality Disorder and Mental Healthcare Service Use Among Adolescents","volume":"27","author":"Cailhol","year":"2013","journal-title":"J. Personal. Disord."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"49","DOI":"10.18773\/austprescr.2016.019","article-title":"Prescribing and Borderline Personality Disorder","volume":"39","author":"Chanen","year":"2016","journal-title":"Aust. Prescr."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1007\/s40263-021-00855-4","article-title":"Pharmacological Treatments for Borderline Personality Disorder: A Systematic Review and Meta-Analysis","volume":"35","author":"Gartlehner","year":"2021","journal-title":"CNS Drugs"},{"key":"ref_12","first-page":"CD012956","article-title":"Pharmacological Interventions for People with Borderline Personality Disorder","volume":"11","author":"Kongerslev","year":"2022","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1177\/070674371305800705","article-title":"Omega-3 Fatty Acid Supplementation in Adolescents with Borderline Personality Disorder and Ultra-High Risk Criteria for Psychosis: A Post Hoc Subgroup Analysis of a Double-Blind, Randomized Controlled Trial","volume":"58","author":"Amminger","year":"2013","journal-title":"Can. J. Psychiatry Rev. Can. Psychiatr."},{"key":"ref_14","first-page":"230","article-title":"Treatment of Borderline Personality Disorder in Youth","volume":"22","author":"Biskin","year":"2013","journal-title":"J. Can. Acad. Child Adolesc. Psychiatry J. Acad. Can. Psychiatr. Enfant Adolesc."},{"key":"ref_15","unstructured":"National Health & Medical Research Council (2013). Clinical Practice Guideline for the Management of Borderline Personality Disorder."},{"key":"ref_16","unstructured":"National Collaborating Centre for Mental Health (UK) (2009). Borderline Personality Disorder: Treatment and Management, British Psychological Society. National Institute for Health and Care Excellence: Guidelines."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1097\/YIC.0b013e3282f94ae2","article-title":"Methylphenidate in the Treatment of Female Adolescents with Cooccurrence of Attention Deficit\/Hyperactivity Disorder and Borderline Personality Disorder: A Preliminary Open-Label Trial","volume":"23","author":"Golubchik","year":"2008","journal-title":"Int. Clin. Psychopharmacol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1111\/jcpp.13785","article-title":"Melatonin Use and the Risk of Self-Harm and Unintentional Injuries in Youths with and without Psychiatric Disorders","volume":"64","author":"Leone","year":"2023","journal-title":"J. Child Psychol. Psychiatry"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1007\/s00787-020-01551-2","article-title":"Mentalization-Based Treatment in Groups for Adolescents with Borderline Personality Disorder: 3- and 12-Month Follow-up of a Randomized Controlled Trial","volume":"30","author":"Bo","year":"2021","journal-title":"Eur. Child Adolesc. Psychiatry"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.copsyc.2020.05.006","article-title":"General Psychiatric Management for Adolescents (GPM-A) with Borderline Personality Disorder","volume":"37","author":"Ilagan","year":"2021","journal-title":"Curr. Opin. Psychol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1001\/jamapsychiatry.2018.1109","article-title":"Efficacy of Dialectical Behavior Therapy for Adolescents at High Risk for Suicide: A Randomized Clinical Trial","volume":"75","author":"McCauley","year":"2018","journal-title":"JAMA Psychiatry"},{"key":"ref_22","unstructured":"Ryle, A., Leighton, T., and Pollock, P. (1997). Cognitive Analytic Therapy and Borderline Personality Disorder: The Model and the Method, John Wiley & Sons Inc."},{"key":"ref_23","unstructured":"McCutcheon, L.K., Kerr, I.B., and Chanen, A.M. (2019). Case Formulation for Personality Disorders, Academic Press."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1192\/bjp.bp.107.048934","article-title":"Early Intervention for Adolescents with Borderline Personality Disorder Using Cognitive Analytic Therapy: Randomised Controlled Trial","volume":"193","author":"Chanen","year":"2008","journal-title":"Br. J. Psychiatry J. Ment. Sci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1001\/jamapsychiatry.2021.3637","article-title":"Effect of 3 Forms of Early Intervention for Young People with Borderline Personality Disorder: The MOBY Randomized Clinical Trial","volume":"79","author":"Chanen","year":"2022","journal-title":"JAMA Psychiatry"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1002\/cpp.637","article-title":"Effectiveness of an Emotion Regulation Group Training for Adolescents\u2014A Randomized Controlled Pilot Study","volume":"16","author":"Schuppert","year":"2009","journal-title":"Clin. Psychol. Psychother."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1016\/j.jaac.2012.09.002","article-title":"Emotion Regulation Training for Adolescents with Borderline Personality Disorder Traits: A Randomized Controlled Trial","volume":"51","author":"Schuppert","year":"2012","journal-title":"J. Am. Acad. Child Adolesc. Psychiatry"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1017\/S0954579409990198","article-title":"A Developmental, Mentalization-Based Approach to the Understanding and Treatment of Borderline Personality Disorder","volume":"21","author":"Fonagy","year":"2009","journal-title":"Dev. Psychopathol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1017\/S0954579405050455","article-title":"The Implications of Attachment Theory and Research for Understanding Borderline Personality Disorder","volume":"17","author":"Levy","year":"2005","journal-title":"Dev. Psychopathol."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Sharp, C., and Tackett, J.L. (2014). Handbook of Borderline Personality Disorder in Children and Adolescents, Springer.","DOI":"10.1007\/978-1-4939-0591-1"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Simonsen, S., Hestb\u00e6k, E., and Juul, S. (2023). Adapting Short-Term Mentalization-Based Therapy to ICD-11 Personality Disorder in Adolescents. Child. Basel Switz., 10.","DOI":"10.3390\/children10010093"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1016\/j.jaac.2012.09.018","article-title":"Mentalization-Based Treatment for Self-Harm in Adolescents: A Randomized Controlled Trial","volume":"51","author":"Rossouw","year":"2012","journal-title":"J. Am. Acad. Child Adolesc. Psychiatry"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1111\/jcpp.13152","article-title":"Mentalization-Based Treatment in Groups for Adolescents with Borderline Personality Disorder: A Randomized Controlled Trial","volume":"61","author":"Beck","year":"2020","journal-title":"J. Child Psychol. Psychiatry"},{"key":"ref_34","unstructured":"Linehan, M.M. (1993). Cognitive-Behavioral Treatment of Borderline Personality Disorder, Guilford Press."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1001\/jamapsychiatry.2014.3039","article-title":"Dialectical Behavior Therapy for High Suicide Risk in Individuals with Borderline Personality Disorder: A Randomized Clinical Trial and Component Analysis","volume":"72","author":"Linehan","year":"2015","journal-title":"JAMA Psychiatry"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1753-2000-5-3","article-title":"Dialectical Behavioral Therapy for Adolescents (DBT-A): A Clinical Trial for Patients with Suicidal and Self-Injurious Behavior and Borderline Symptoms with a One-Year Follow-Up","volume":"5","author":"Fleischhaker","year":"2011","journal-title":"Child Adolesc. Psychiatry Ment. Health"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.neurenf.2016.12.005","article-title":"Adaptation de La Th\u00e9rapie Comportementale Dialectique Aux Adolescents Francophones, Une Exp\u00e9rience Pilote Aupr\u00e8s d\u2019adolescentes Avec D\u00e9pression et Trouble de Personnalit\u00e9 Limite","volume":"65","author":"Naepels","year":"2017","journal-title":"Neuropsychiatr. Enfance Adolesc."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Schiffler, T., Seiler-Ramadas, R., \u0160tefanac, S., Haider, S., M\u00fces, H.M., and Grabovac, I. (2022). Implementation of a Mobile DBT App and Its Impact on Suicidality in Transitional Age Youth with Borderline Personality Disorder: A Qualitative Study. Int. J. Environ. Res. Public. Health, 19.","DOI":"10.3390\/ijerph19020701"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.jaac.2016.01.005","article-title":"Dialectical Behavior Therapy Compared With Enhanced Usual Care for Adolescents with Repeated Suicidal and Self-Harming Behavior: Outcomes over a One-Year Follow-Up","volume":"55","author":"Mehlum","year":"2016","journal-title":"J. Am. Acad. Child Adolesc. Psychiatry"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1016\/j.jaac.2014.07.003","article-title":"Dialectical Behavior Therapy for Adolescents with Repeated Suicidal and Self-Harming Behavior: A Randomized Trial","volume":"53","author":"Mehlum","year":"2014","journal-title":"J. Am. Acad. Child Adolesc. Psychiatry"},{"key":"ref_41","unstructured":"Bateman, A.W., and Fonagy, P. (2019). Handbook of Mentalizing in Mental Health Practice, American Psychiatric Association Publishing."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1037\/pst0000173","article-title":"Cohesion in Group Therapy: A Meta-Analysis","volume":"55","author":"Burlingame","year":"2018","journal-title":"Psychotherapy"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1037\/pst0000211","article-title":"Group Psychotherapy for Borderline Personality Disorder: A Meta-Analysis of Randomized-Controlled Trials","volume":"56","author":"McLaughlin","year":"2019","journal-title":"Psychotherapy"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1097\/01.pra.0000351876.51098.f0","article-title":"The HYPE Clinic: An Early Intervention Service for Borderline Personality Disorder","volume":"15","author":"Chanen","year":"2009","journal-title":"J. Psychiatr. Pract."},{"key":"ref_45","first-page":"151","article-title":"Mindful Parenting per Madri Di Bambini Con Disturbi Del Comportamento: Studio Pilota","volume":"26","author":"Muratori","year":"2022","journal-title":"Psicol. Clin. Svilupp."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.jad.2017.12.054","article-title":"A Naturalistic Longitudinal Study of Extended Inpatient Treatment for Adults with Borderline Personality Disorder: An Examination of Treatment Response, Remission and Deterioration","volume":"235","author":"Fowler","year":"2018","journal-title":"J. Affect. Disord."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1186\/s13063-022-06531-2","article-title":"Study Protocol for a Multi-Center RCT Testing a Group-Based Parenting Intervention Tailored to Mothers with Borderline Personality Disorder against a Waiting Control Group (ProChild*-SP1)","volume":"23","author":"Rosenbach","year":"2022","journal-title":"Trials"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1177\/1063426615621050","article-title":"Long-Term Effects of Pre-Placement Risk Factors on Children\u2019s Psychological Symptoms and Parenting Stress among Families Adopting Children from Foster Care","volume":"25","author":"Nadeem","year":"2017","journal-title":"J. Emot. Behav. Disord."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.chiabu.2015.02.003","article-title":"Over Three Decades of Longitudinal Research on the Development of Foster Children: A Meta-Analysis","volume":"42","author":"Goemans","year":"2015","journal-title":"Child Abuse Negl."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Benarous, X., Lahaye, H., Pellerin, H., Consoli, A., Cohen, D., Labelle, R., Renaud, J., Gerardin, P., El-Khoury, F., and Van der Waerden, J. (2023). Hard-to-Treat or Hard-to-Catch? Clinical Features and Therapeutic Outcomes of Help-Seeking Foster Care Youths with Mood Disorders. Front. Psychiatry, in press.","DOI":"10.3389\/fpsyt.2023.1211516"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1177\/0706743719878975","article-title":"Psychotherapies for Adolescents with Subclinical and Borderline Personality Disorder: A Systematic Review and Meta-Analysis","volume":"65","author":"Wong","year":"2020","journal-title":"Can. J. Psychiatry Rev. Can. Psychiatr."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"J\u00f8rgensen, M.S., Storeb\u00f8, O.J., Stoffers-Winterling, J.M., Faltinsen, E., Todorovac, A., and Simonsen, E. (2021). Psychological Therapies for Adolescents with Borderline Personality Disorder (BPD) or BPD Features-A Systematic Review of Randomized Clinical Trials with Meta-Analysis and Trial Sequential Analysis. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0245331"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.3389\/fpsyg.2017.02054","article-title":"How Do Stress Exposure and Stress Regulation Relate to Borderline Personality Disorder?","volume":"8","author":"Bourvis","year":"2017","journal-title":"Front. Psychol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1111\/papt.12033","article-title":"Treatment Planning: A Key Milestone to Prevent Treatment Dropout in Adolescents with Borderline Personality Disorder","volume":"88","author":"Desrosiers","year":"2015","journal-title":"Psychol. Psychother."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1176\/appi.ajp.160.2.274","article-title":"The Longitudinal Course of Borderline Psychopathology: 6-Year Prospective Follow-Up of the Phenomenology of Borderline Personality Disorder","volume":"160","author":"Zanarini","year":"2003","journal-title":"Am. J. Psychiatry"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1016\/j.jpsychires.2013.06.009","article-title":"Differences between Older and Younger Adults with Borderline Personality Disorder on Clinical Presentation and Impairment","volume":"47","author":"Morgan","year":"2013","journal-title":"J. Psychiatr. Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1176\/ajp.2007.164.6.929","article-title":"The Subsyndromal Phenomenology of Borderline Personality Disorder: A 10-Year Follow-up Study","volume":"164","author":"Zanarini","year":"2007","journal-title":"Am. J. Psychiatry"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s11920-019-1040-1","article-title":"A Life Span Perspective on Borderline Personality Disorder","volume":"21","author":"Videler","year":"2019","journal-title":"Curr. Psychiatry Rep."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Bourvis, N., Aouidad, A., Spodenkiewicz, M., Palestra, G., Aigrain, J., Baptista, A., Benoliel, J.-J., Chetouani, M., and Cohen, D. (2021). Adolescents with Borderline Personality Disorder Show a Higher Response to Stress but a Lack of Self-Perception: Evidence through Affective Computing. Prog. Neuropsychopharmacol. Biol. Psychiatry, 111.","DOI":"10.1016\/j.pnpbp.2020.110095"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.pnpbp.2015.07.002","article-title":"Resting State Vagal Tone in Borderline Personality Disorder: A Meta-Analysis","volume":"64","author":"Koenig","year":"2016","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"721361","DOI":"10.3389\/fpsyt.2021.721361","article-title":"The Role of Trauma in Early Onset Borderline Personality Disorder: A Biopsychosocial Perspective","volume":"12","author":"Bozzatello","year":"2021","journal-title":"Front. Psychiatry"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1016\/j.psyneuen.2012.02.012","article-title":"Associations of Childhood Trauma with Hypothalamic-Pituitary-Adrenal Function in Borderline Personality Disorder and Major Depression","volume":"37","author":"Beblo","year":"2012","journal-title":"Psychoneuroendocrinology"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"348","DOI":"10.14704\/nq.2016.14.2.948","article-title":"The Neural Mechanisms Underlying Personality Disorders","volume":"14","author":"Gawda","year":"2016","journal-title":"NeuroQuantology"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1016\/S0006-3223(02)01395-1","article-title":"Hyperresponsiveness of Hypothalamic-Pituitary-Adrenal Axis to Combined Dexamethasone\/Corticotropin-Releasing Hormone Challenge in Female Borderline Personality Disorder Subjects with a History of Sustained Childhood Abuse","volume":"52","author":"Rinne","year":"2002","journal-title":"Biol. Psychiatry"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1001\/jama.284.5.592","article-title":"Pituitary-Adrenal and Autonomic Responses to Stress in Women after Sexual and Physical Abuse in Childhood","volume":"284","author":"Heim","year":"2000","journal-title":"JAMA"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1007\/s11065-014-9254-9","article-title":"Facial Emotion Processing in Borderline Personality Disorder: A Systematic Review and Meta-Analysis","volume":"24","author":"Mitchell","year":"2014","journal-title":"Neuropsychol. Rev."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/nn0309-241","article-title":"How Adversity Gets under the Skin","volume":"12","author":"Hyman","year":"2009","journal-title":"Nat. Neurosci."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1038\/nn.2436","article-title":"Dynamic DNA Methylation Programs Persistent Adverse Effects of Early-Life Stress","volume":"12","author":"Murgatroyd","year":"2009","journal-title":"Nat. Neurosci."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/nn.2270","article-title":"Epigenetic Regulation of the Glucocorticoid Receptor in Human Brain Associates with Childhood Abuse","volume":"12","author":"McGowan","year":"2009","journal-title":"Nat. Neurosci."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1176\/appi.ajp.162.4.648","article-title":"Mind, Brain, and Personality Disorders","volume":"162","author":"Gabbard","year":"2005","journal-title":"Am. J. Psychiatry"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1016\/j.neubiorev.2010.11.007","article-title":"The Adaptive Calibration Model of Stress Responsivity","volume":"35","author":"Ellis","year":"2011","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1093\/emph\/eow002","article-title":"Borderline Personality Disorder: Why \u201cFast and Furious\u201d?","volume":"2016","year":"2016","journal-title":"Evol. Med. Public Health"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"715153","DOI":"10.3389\/fpsyg.2021.715153","article-title":"Borderline Personality Disorder in a \u201cLife History Theory\u201d Perspective: Evidence for a Fast \u201cPace-of-Life-Syndrome\u201d","volume":"12","author":"Otto","year":"2021","journal-title":"Front. Psychol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1001\/jamapsychiatry.2023.0694","article-title":"Associations Between Early Life Adversity, Reproduction-Oriented Life Strategy, and Borderline Personality Disorder","volume":"80","author":"Baptista","year":"2023","journal-title":"JAMA Psychiatry"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"940827","DOI":"10.3389\/frcha.2022.940827","article-title":"Homo Developmentalis: An Evolutionary Proposal Relevant for Child and Adolescent Mental Health","volume":"1","author":"Cohen","year":"2022","journal-title":"Front. Child Adolesc. Psychiatry"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s40479-022-00187-9","article-title":"Improving Treatment Outcomes for Adolescents with Borderline Personality Disorder through a Socioecological Approach","volume":"9","author":"Bo","year":"2022","journal-title":"Borderline Personal. Disord. Emot. Dysregulation"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/s44220-023-00071-7","article-title":"Overmedicalization of Young People\u2019s Distress Is Undermining and Disempowering Families","volume":"1","author":"Fergusson","year":"2023","journal-title":"Nat. Ment. 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