{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T22:36:25Z","timestamp":1783377385508,"version":"3.54.6"},"reference-count":37,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T00:00:00Z","timestamp":1698019200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>TAVI requires a large-bore arteriotomy. Closure is usually performed by the suture system. Some studies report a vascular complication rate of up to 21%. MANTA is a recently developed percutaneous closure system dedicated to large caliber vessels based on an anchoring system. Early studies report a lower rate of vascular complications with MANTA devices. This single-center retrospective study included all patients who underwent femoral TAVI at the Brest University Hospital from 20 November 2019 to 31 March 2021. The primary endpoint is the rate of vascular complications (major and minor) pre and post-TAVI procedure. In total, 264 patients were included. There were no significant differences in vascular complications (major and minor) between the two groups (13.6% in the MANTA group versus 21.2% in the PROSTAR group; p = 0.105), although there was a tendency to have fewer minor vascular complications in the Manta group (12.1% versus 20.5%; p = 0.067). Manta was associated with a lower rate of bleeding complications (3.8% versus 15.2%; p = 0.002), predominantly minor complications with fewer closure failures (4.5% versus 13.6%; p = 0.01), less use of covered stents (4.5% versus 12.9%; p = 0.016), and with no difference in the need for vascular surgery compared to the Prostar group (1.5% versus 2.3%; p = 0.652). On the other hand, Manta was associated with a higher rate of femoral stenosis (4.5% versus 0%; p = 0.013) without clinical significance (1.5% versus 0%; p = 0.156). The Manta and Prostar devices are equivalent in terms of vascular complications. The Manta, compared to the Prostar, is associated with fewer bleeding complications.<\/jats:p>","DOI":"10.3390\/jcm12206697","type":"journal-article","created":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T10:32:24Z","timestamp":1698057144000},"page":"6697","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Vascular Complications Following Transcatheter Aortic Valve Implantation, Using MANTA (Collagen Plug-Based) versus PROSTAR (Suture-Based), from a French Single-Center Retrospective Registry"],"prefix":"10.3390","volume":"12","author":[{"given":"Cl\u00e9ment","family":"Benic","sequence":"first","affiliation":[{"name":"Department of Cardiology, University Hospital of Brest, 29200 Brest, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre Philippe","family":"Nicol","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital of Brest, 29200 Brest, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinda","family":"Hannachi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital of Brest, 29200 Brest, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine","family":"Gilard","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital of Brest, 29200 Brest, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Didier","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital of Brest, 29200 Brest, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6672-9764","authenticated-orcid":false,"given":"Bahaa","family":"Nasr","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, University Hospital of Brest, 29200 Brest, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/nrcardio.2010.202","article-title":"Epidemiology of valvular heart disease in the adult","volume":"8","author":"Iung","year":"2011","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1093\/eurheartj\/9.suppl_E.57","article-title":"The natural history of aortic valve stenosis","volume":"9","author":"Horstkotte","year":"1988","journal-title":"Eur. Heart J."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.echo.2017.02.009","article-title":"Recommendations on the Echocardiographic Assessment of Aortic Valve Stenosis: A Focused Update from the European Association of Cardiovascular Imaging and the American Society of Echocardiography","volume":"30","author":"Baumgartner","year":"2017","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1583\/05-1719R.1","article-title":"Fascia suturing of large access sites after endovascular treatment of aortic aneurysms and dissections","volume":"13","author":"Larzon","year":"2006","journal-title":"J. Endovasc. Ther."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1056\/NEJMoa1514616","article-title":"Transcatheter or Surgical Aortic-Valve Replacement in Intermediate-Risk Patients","volume":"374","author":"Leon","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1056\/NEJMoa1814052","article-title":"Transcatheter Aortic-Valve Replacement with a Balloon-Expandable Valve in Low-Risk Patients","volume":"380","author":"Mack","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s42155-018-0026-0","article-title":"Access site complications after transfemoral aortic valve implantation\u2014A comparison of Manta and ProGlide","volume":"1","author":"Hoffmann","year":"2018","journal-title":"CVIR Endovasc."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1002\/ccd.27595","article-title":"Impact of percutaneous femoral arteriotomy closure using the MANTATM device on vascular and bleeding complications after transcatheter aortic valve replacement","volume":"92","author":"Settergren","year":"2018","journal-title":"Catheter. Cardiovasc. Interv."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e1558","DOI":"10.4244\/EIJ-D-18-00769","article-title":"Propensity-matched comparison of vascular closure devices after transcatheter aortic valve replacement using MANTA versus ProGlide","volume":"14","author":"Moriyama","year":"2019","journal-title":"EuroIntervention"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ijcard.2018.04.065","article-title":"MANTA versus ProGlide vascular closure devices in transfemoral transcatheter aortic valve implantation","volume":"263","author":"Biancari","year":"2018","journal-title":"Int. J. Cardiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1016\/j.amjcard.2019.07.030","article-title":"Early Outcomes After Percutaneous Closure of Access Site in Transfemoral Transcatheter Valve Implantation Using the Novel Vascular Closure Device Collagen Plug-Based MANTA","volume":"124","author":"Gheorghe","year":"2019","journal-title":"Am. J. Cardiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jcin.2020.09.052","article-title":"Suture- or Plug-Based Large-Bore Arteriotomy Closure: A Pilot Randomized Controlled Trial","volume":"14","author":"Ooms","year":"2021","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"690","DOI":"10.4244\/EIJV11I6A137","article-title":"Comparison of suture-based vascular closure devices in transfemoral transcatheter aortic valve implantation","volume":"11","author":"Barbanti","year":"2015","journal-title":"EuroIntervention"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"3370","DOI":"10.1093\/eurheartj\/ehv417","article-title":"Comparison of vascular closure devices for access site closure after transfemoral aortic valve implantation","volume":"36","author":"Barbash","year":"2015","journal-title":"Eur. Heart J."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1002\/ccd.25975","article-title":"Impact of Mixed Aortic Valve Stenosis on VARC-2 Outcomes and Postprocedural Aortic Regurgitation in Patients Undergoing Transcatheter Aortic Valve Implantation: Results From the International Multicentric Study PRAGMATIC (Pooled Rotterdam-Milan-Toulouse in Collaboration)","volume":"86","author":"Chieffo","year":"2015","journal-title":"Catheter. Cardiovasc. Interv."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1016\/j.amjcard.2012.06.042","article-title":"Incidence, predictors, and implications of access site complications with transfemoral transcatheter aortic valve implantation","volume":"110","author":"Tchetche","year":"2012","journal-title":"Am. J. Cardiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.jacc.2012.07.003","article-title":"Vascular complications after transcatheter aortic valve replacement: Insights from the PARTNER (Placement of AoRTic TraNscathetER Valve) trial","volume":"60","author":"Webb","year":"2012","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1161\/CIRCOUTCOMES.115.002541","article-title":"Vancouver Transcatheter Aortic Valve Replacement Clinical Pathway: Minimalist Approach, Standardized Care, and Discharge Criteria to Reduce Length of Stay","volume":"9","author":"Lauck","year":"2016","journal-title":"Circ. Cardiovasc. Qual. Outcomes"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.jcin.2016.12.277","article-title":"Percutaneous Plug-Based Arteriotomy Closure Device for Large-Bore Access: A Multicenter Prospective Study","volume":"10","author":"Latib","year":"2017","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e007258","DOI":"10.1161\/CIRCINTERVENTIONS.119.007258","article-title":"Pivotal Clinical Study to Evaluate the Safety and Effectiveness of the MANTA Percutaneous Vascular Closure Device","volume":"12","author":"Wood","year":"2019","journal-title":"Circ. Cardiovasc. Interv."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1016\/j.jcin.2019.06.049","article-title":"Insights From a Multidisciplinary Introduction of the MANTA Vascular Closure Device","volume":"12","author":"Moccetti","year":"2019","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1007\/s12471-020-01465-3","article-title":"Assessment of the MANTA closure device in transfemoral transcatheter aortic valve replacement: A single-centre observational study","volume":"28","author":"Halim","year":"2020","journal-title":"Neth. Heart J."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1002\/ccd.29439","article-title":"Dedicated plug based closure for large bore access\u2014The MARVEL prospective registry","volume":"97","author":"Kroon","year":"2021","journal-title":"Catheter. Cardiovasc. Interv."},{"key":"ref_24","first-page":"E737","article-title":"Vascular complications with a plug-based vascular closure device after transcatheter aortic valve replacement: Predictors and bail-outs","volume":"98","author":"Kroon","year":"2021","journal-title":"Catheter. Cardiovasc. Interv."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.17140\/HROJ-8-156","article-title":"A Comparison of Efficacy, Safety and Cost Between MANTATM and Proglide Vascular Closure Devices Following Transfemoral Transcatheter Aortic Valve Implantation","volume":"8","author":"Ali","year":"2021","journal-title":"Heart Res. Open J."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.carrev.2021.06.134","article-title":"Manta versus Perclose ProGlide vascular closure device after transcatheter aortic valve implantation: Initial experience from a large European center","volume":"37","author":"Dumpies","year":"2022","journal-title":"Cardiovasc. Revasc. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1080\/24748706.2021.1872818","article-title":"Large Bore Vascular Access Closure Device Strategies","volume":"5","author":"Sarathy","year":"2021","journal-title":"Struct. Heart"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1161\/CIRCULATIONAHA.121.057856","article-title":"Comparison of a Pure Plug-Based Versus a Primary Suture-Based Vascular Closure Device Strategy for Transfemoral Transcatheter Aortic Valve Replacement: The CHOICE-CLOSURE Randomized Clinical Trial","volume":"145","author":"Hartung","year":"2022","journal-title":"Circulation"},{"key":"ref_29","first-page":"100397","article-title":"MANTA Versus Suture-based Closure Devices Following Transcatheter Aortic Valve Replacement: An Updated Meta-analysis","volume":"1","author":"Abusnina","year":"2022","journal-title":"J. Soc. Cardiovasc. Angiogr. Interv."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.amjcard.2022.01.010","article-title":"Meta-Analysis Investigating the Efficacy and Safety of the MANTA Versus ProGlide Vascular Closure Devices After Transcatheter Aortic Valve Implantation","volume":"169","author":"Saleh","year":"2022","journal-title":"Am. J. Cardiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.ihj.2022.03.003","article-title":"Meta-analysis of ProGlide versus MANTA vascular closure devices for large-bore access site management","volume":"74","author":"Mahalwar","year":"2022","journal-title":"Indian Heart J."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.ihj.2023.01.007","article-title":"Clinical outcomes of MANTA vs suture-based vascular closure devices after transcatheter aortic valve replacement: An updated meta-analysis","volume":"75","author":"Doshi","year":"2023","journal-title":"Indian Heart J."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.jcin.2011.03.019","article-title":"Transfemoral aortic valve implantation new criteria to predict vascular complications","volume":"4","author":"Hayashida","year":"2011","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.amjcard.2016.11.009","article-title":"Incidence, Predictors, and Mid-Term Outcomes of Percutaneous Closure Failure After Transfemoral Aortic Valve Implantation Using an Expandable Sheath (from the Optimized Transcatheter Valvular Intervention [OCEAN-TAVI] Registry)","volume":"119","author":"Nara","year":"2017","journal-title":"Am. J. Cardiol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.jvs.2005.11.009","article-title":"Evaluation of risk factors associated with femoral pseudoaneurysms after cardiac catheterization","volume":"43","author":"Ates","year":"2006","journal-title":"J. Vasc. Surg."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.jcin.2010.04.015","article-title":"Real-time ultrasound guidance facilitates femoral arterial access and reduces vascular complications: FAUST (Femoral Arterial Access With Ultrasound Trial)","volume":"3","author":"Seto","year":"2010","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2564","DOI":"10.1016\/j.jcin.2019.09.018","article-title":"The Efficacy of the Ultrasound-Navigated MANTA Deployment Following Transfemoral Transcatheter Aortic Valve Replacement","volume":"12","author":"Moriyama","year":"2019","journal-title":"JACC Cardiovasc. Interv."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/20\/6697\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:10:27Z","timestamp":1760130627000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/20\/6697"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,23]]},"references-count":37,"journal-issue":{"issue":"20","published-online":{"date-parts":[[2023,10]]}},"alternative-id":["jcm12206697"],"URL":"https:\/\/doi.org\/10.3390\/jcm12206697","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,23]]}}}