{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:31:56Z","timestamp":1791937916651,"version":"4.3.4"},"reference-count":103,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T00:00:00Z","timestamp":1698192000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Alcon-FOM-UVEG Cathedra"},{"name":"Foundation of Ophthalmology Medicine"},{"name":"Universitat de Val\u00e8ncia"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>This systematic review investigates the prevalence and underlying causes of corneal edema following cataract surgery employing manual phacoemulsification. A comprehensive search encompassing databases such as PubMed, Embase, ProQuest, Cochrane Library, and Scopus was conducted, focusing on variables encompassing cataract surgery and corneal edema. Two independent reviewers systematically extracted pertinent data from 103 articles, consisting of 62 theoretical studies and 41 clinical trials. These studies delved into various aspects related to corneal edema after cataract surgery, including endothelial cell loss, pachymetry measurements, visual performance, surgical techniques, supplies, medications, and assessments of endothelial and epithelial barriers. This review, encompassing an extensive analysis of 3060 records, revealed significant correlations between corneal edema and endothelial cell loss during phacoemulsification surgery. Factors such as patient age, cataract grade, and mechanical stress were identified as contributors to endothelial cell loss. Furthermore, pachymetry and optical coherence tomography emerged as valuable diagnostic tools for assessing corneal edema. In conclusion, this systematic review underscores the link between corneal edema and endothelial cell loss in manual phacoemulsification cataract surgery. It highlights the relevance of factors like patient demographics and diagnostic modalities. However, further research is essential to unravel the complexities of refractive changes and the underlying mechanisms.<\/jats:p>","DOI":"10.3390\/jcm12216751","type":"journal-article","created":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T09:54:08Z","timestamp":1698227648000},"page":"6751","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Corneal Edema after Cataract Surgery"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9363-5482","authenticated-orcid":false,"given":"Celeste","family":"Briceno-Lopez","sequence":"first","affiliation":[{"name":"Department of Optics and Optometry and Vision Sciences, Faculty of Physics, Universitat de Val\u00e8ncia, Dr. Moliner 50, E-46100 Burjassot, Spain"},{"name":"C\u00e1tedra Alcon\u2014FOM\u2014UVEG, Universitat de Val\u00e8ncia, Dr. Moliner 50, E-46100 Burjassot, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0508-1431","authenticated-orcid":false,"given":"Neus","family":"Burguera-Gim\u00e9nez","sequence":"additional","affiliation":[{"name":"Department of Optics and Optometry and Vision Sciences, Faculty of Physics, Universitat de Val\u00e8ncia, Dr. Moliner 50, E-46100 Burjassot, Spain"},{"name":"C\u00e1tedra Alcon\u2014FOM\u2014UVEG, Universitat de Val\u00e8ncia, Dr. Moliner 50, E-46100 Burjassot, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8736-0214","authenticated-orcid":false,"given":"M. Carmen","family":"Garc\u00eda-Domene","sequence":"additional","affiliation":[{"name":"Department of Optics and Optometry and Vision Sciences, Faculty of Physics, Universitat de Val\u00e8ncia, Dr. Moliner 50, E-46100 Burjassot, Spain"},{"name":"C\u00e1tedra Alcon\u2014FOM\u2014UVEG, Universitat de Val\u00e8ncia, Dr. Moliner 50, E-46100 Burjassot, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8146-4039","authenticated-orcid":false,"given":"M. Amparo","family":"D\u00edez-Ajenjo","sequence":"additional","affiliation":[{"name":"Department of Optics and Optometry and Vision Sciences, Faculty of Physics, Universitat de Val\u00e8ncia, Dr. Moliner 50, E-46100 Burjassot, Spain"},{"name":"C\u00e1tedra Alcon\u2014FOM\u2014UVEG, Universitat de Val\u00e8ncia, Dr. Moliner 50, E-46100 Burjassot, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5992-5006","authenticated-orcid":false,"given":"Cristina","family":"Peris-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Anterior Segment and Cornea and External Eye Diseases Unit, Fundaci\u00f3n de Oftalmolog\u00eda M\u00e9dica, Av. P\u00edo Baroja 12, E-46015 Valencia, Spain"},{"name":"Surgery Department, Faculty of Medicine, Universitat de Val\u00e8ncia, Av. Blasco Ib\u00e1\u00f1ez 15, E-46010 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5918-8429","authenticated-orcid":false,"given":"M. Jos\u00e9","family":"Luque","sequence":"additional","affiliation":[{"name":"Department of Optics and Optometry and Vision Sciences, Faculty of Physics, Universitat de Val\u00e8ncia, Dr. Moliner 50, E-46100 Burjassot, Spain"},{"name":"C\u00e1tedra Alcon\u2014FOM\u2014UVEG, Universitat de Val\u00e8ncia, Dr. Moliner 50, E-46100 Burjassot, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,25]]},"reference":[{"key":"ref_1","first-page":"523","article-title":"Corneal Edema: Introduction","volume":"8","author":"Cogan","year":"1968","journal-title":"Int. Ophthalmol. 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