{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T07:06:38Z","timestamp":1779174398280,"version":"3.51.4"},"reference-count":48,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T00:00:00Z","timestamp":1698537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Wroc\u0142aw Medical University","award":["STM.C240.20.044"],"award-info":[{"award-number":["STM.C240.20.044"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Ocular manifestations have been described in the course of various types of vasculitis. However, there seems to be no routine ophthalmological examinations for patients suffering from those diseases. To ensure holistic care we aimed to investigate any retinal and choroidal abnormalities in patients suffering from primary vasculitis. The objective was to use non-invasive methods, which would not be time- and cost-consuming, yet would be helpful in routine tests. We conducted a prospective and observational study in 41 patients (78 eyes) with 5 types of primary vasculitis, including: Takayasu\u2019s arteritis; giant cell arteritis; Buerger\u2019s disease; granulomatosis with polyangiitis; and polyarteritis nodosa. A total of 44 healthy individuals were enrolled in the control group for comparison (88 eyes). With the use of optical coherence tomography, optical coherence tomography angiography, and MATLAB, the following parameters were assessed: choroidal thickness; vascularity index; area and perimeter of foveal avascular zone; and circularity index. The following parameters were lower in the study group compared to the control group: mean nasal and temporal CTs; mean central, temporal, and nasal CVI; and mean CI. In contrast, the results of mean central CT as well as the area and perimeter of FAZ were higher in the study group. The differences were statistically significant in the case of all parameters except for CI. Conducting routine ophthalmological examinations in patients diagnosed with vasculitis by assessment of the retina and choroid by measuring parameters like CT, CVI, area and perimeter of FAZ, and CI could be beneficial, as it may detect pathological changes before any ocular symptoms alarm the patients. CVI seems to be especially promising for choroidal evaluation, as it appears to be less influenced by various factors compared to CT.<\/jats:p>","DOI":"10.3390\/jcm12216827","type":"journal-article","created":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T05:01:08Z","timestamp":1698555668000},"page":"6827","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Evaluation of Choroidal and Retinal Features in Patients with Primary Vasculitis\u2014An Original Optical Coherence Tomography and Optical Coherence Tomography Angiography Study"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5374-8192","authenticated-orcid":false,"given":"Urszula","family":"Szyde\u0142ko-Pa\u015bko","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Wroc\u0142aw Medical University, 50-556 Wroc\u0142aw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1099-4876","authenticated-orcid":false,"given":"Joanna","family":"Prze\u017adziecka-Do\u0142yk","sequence":"additional","affiliation":[{"name":"Department of Optics and Photonics, Wroc\u0142aw Univeristy of Science and Technology, 50-370 Wroc\u0142aw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrzej","family":"Do\u0142yk","sequence":"additional","affiliation":[{"name":"Clinic of Angiology, Systemic Hypertension and Diabetology, Wroc\u0142aw Teaching Hospital, 50-556 Wroc\u0142aw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Artur","family":"Ma\u0142yszczak","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Wroc\u0142aw Medical University, 50-556 Wroc\u0142aw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4020-3203","authenticated-orcid":false,"given":"Marta","family":"Misiuk-Hoj\u0142o","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Wroc\u0142aw Medical University, 50-556 Wroc\u0142aw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,29]]},"reference":[{"key":"ref_1","unstructured":"Jatwani, S., and Goyal, A. (2023, August 01). Vasculitis. StatPearls 2023, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK545186\/."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.jaci.2009.07.002","article-title":"Vasculitis","volume":"125","author":"Langford","year":"2010","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1002\/jgf2.4","article-title":"Vasculitis syndrome-diagnosis and therapy","volume":"18","author":"Okazaki","year":"2017","journal-title":"J. Gen. Fam. Med."},{"key":"ref_4","first-page":"817","article-title":"Pathophysiology and therapy of systemic vasculitides","volume":"19","author":"Ralli","year":"2020","journal-title":"EXCLI J."},{"key":"ref_5","first-page":"153","article-title":"The Association of HLA-A, B and DRB1 with Buerger\u2019s Disease","volume":"8","author":"Mohammadi","year":"2019","journal-title":"Rep. Biochem. Mol. Biol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1186\/ar2193","article-title":"Vasculitis: Mechanisms involved and clinical manifestations","volume":"9","author":"Guillevin","year":"2007","journal-title":"Arthritis Res. Ther."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3899\/jrheum.190768","article-title":"Ocular Manifestations in Rheumatoid Arthritis, Connective Tissue Disease, and Vasculitis: A Systematic Review and Metaanalysis","volume":"48","author":"Turk","year":"2021","journal-title":"J. Rheumatol."},{"key":"ref_8","unstructured":"Go Lee, A., Charoenkijkajorn, C., Stoutin, J., Pakracan, M., Shamim, H., Lee, V., Al-Zubidi, N., and Albreiki, D. (2023, August 05). Neuro-ophthalmic manifestations of Polyarteritis Nodosa. American Academy of Ophthalmology. EyeWiki. Available online: https:\/\/eyewiki.aao.org\/Neuro-ophthalmic_manifestations_of_Polyarteritis_Nodosa."},{"key":"ref_9","unstructured":"Fichtner, J., Puente, M.A., O\u2019Keefe, G.D., Prakalapakorn, S.G., and Saboo, U.S. (2023, August 05). Kawasaki Disease, American Academy of Ophthalmology. EyeWiki. Available online: https:\/\/eyewiki.org\/Kawasaki_Disease."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Szyde\u0142ko-Pa\u015bko, U., Prze\u017adziecka-Do\u0142yk, J., Nowak, \u0141., Ma\u0142yszczak, A., and Misiuk-Hoj\u0142o, M. (2023). Ocular Manifestations of Takayasu\u2019s Arteritis-A Case-Based Systematic Review and Meta-Analysis. J. Clin. Med., 12.","DOI":"10.3390\/jcm12113745"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Gardner, T.W., Cooper, B.A., Reynolds, S.A., Huvard, M., Shah, A.R., and Wu, R. (2022). A Practical Guide to Diabetes-Related Eye Care, American Diabetes Association.","DOI":"10.2337\/db20223"},{"key":"ref_12","unstructured":"Sousa, D.C., O\u2019Keefe, G.D., Breda, J., Tripathy, K., Pinto, L.A., Palestine, A., Bhagat, N., Lim, J.I., Green, K.M., and Hossain, H.A. (2023, August 10). Optical Coherence Aniography. American Academy of Ophthalmology. EyeWiki. Available online: https:\/\/eyewiki.aao.org\/Optical_Coherence_Tomography_Angiography."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1136\/bjophthalmol-2021-318782","article-title":"Choroidal vascularity index: A step towards software as a medical device","volume":"106","author":"Betzler","year":"2022","journal-title":"Br. J. Ophthalmol."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Evereklioglu, C., Polat, O.A., Sevim, D.G., Gahramanov, K., Sener, H., Sonmez, H.K., Arda, H., Arslantas, E.E., and Horozoglu, F. (Can. J. Ophthalmol, 2023). Choroidal vascularity index and submacular choroidal thickness are decreased in patients with active and inactive ocular Beh\u00e7et disease assessed with enhanced-depth imaging optical coherence tomography, Can. J. Ophthalmol, Online ahead of print.","DOI":"10.1016\/j.jcjo.2023.09.003"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"185","DOI":"10.51329\/mehdiophthal1403","article-title":"Glaucomatous Macular Vasculature; A Quantitative Analysis","volume":"9","author":"Arede","year":"2020","journal-title":"Med. Hypothesis Discov. Innov. Ophthalmol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"21090","DOI":"10.1038\/srep21090","article-title":"Choroidal vascularity index as a measure of vascular status of the choroid: Measurements in healthy eyes from a population-based study","volume":"6","author":"Agrawal","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Muhiddin, H.S., Mayasari, A.R., Umar, B.T., Sirajuddin, J., Patellongi, I., Islam, I.C., and Ichsan, A.M. (2022). Choroidal Thickness in Correlation with Axial Length and Myopia Degree. Vision, 6.","DOI":"10.3390\/vision6010016"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1080\/02713683.2018.1428995","article-title":"Sex-Dependent Choroidal Thickness Differences in Healthy Adults: A Study Based on Original and Synthesized Data","volume":"43","author":"Wang","year":"2018","journal-title":"Curr. Eye Res."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Wakatsuki, Y., Shinojima, A., Kawamura, A., and Yuzawa, M. (2015). Correlation of Aging and Segmental Choroidal Thickness Measurement using Swept Source Optical Coherence Tomography in Healthy Eyes. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0144156"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Iovino, C., Pellegrini, M., Bernabei, F., Borrelli, E., Sacconi, R., Govetto, A., Vagge, A., Di Zazzo, A., Forlini, M., and Finocchio, L. (2020). Choroidal Vascularity Index: An In-Depth Analysis of This Novel Optical Coherence Tomography Parameter. J. Clin. Med., 9.","DOI":"10.3390\/jcm9020595"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1080\/09273948.2022.2084421","article-title":"Experts Opinion: OCTA vs. FFA\/ICG in Uveitis\u2013Which Will Survive?","volume":"31","author":"Invernizzi","year":"2023","journal-title":"Ocul. Immunol. Inflamm."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1167\/tvst.7.5.16","article-title":"Measurable range of sub- foveal choroidal thickness with con-ventional spectral domain optical coherence tomography","volume":"7","author":"Kong","year":"2018","journal-title":"Trans. Vis. Sci. Tech."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.ajo.2010.04.018","article-title":"Choroidal thickness in normal eyes measured using Cirrus HD optical coherence tomography","volume":"150","author":"Manjunath","year":"2010","journal-title":"Am. J. Ophthalmol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1167\/iovs.09-4383","article-title":"Choroidal thickness in healthy Japanese subjects","volume":"51","author":"Ikuno","year":"2010","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"9555","DOI":"10.1167\/iovs.11-8076","article-title":"Choroidal thickness in healthy Chinese subjects","volume":"52","author":"Ding","year":"2011","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Akhtar, Z., Rishi, P., Srikanth, R., Rishi, E., Bhende, M., and Raman, R. (2018). Choroidal thickness in normal Indian subjects using Swept source optical coherence tomography. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0197457"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s12969-020-0417-3","article-title":"Choroidal vascularity index as a biomarker of systemic inflammation in childhood Polyarteritis Nodosa and adenosine deaminase-2 deficiency","volume":"18","author":"Demir","year":"2020","journal-title":"Pediatr. Rheumatol. Online J."},{"key":"ref_28","first-page":"323224","article-title":"Distribution and determinants of choroidal vascularity index in healthy eyes from deep-learning choroidal analysis: A population-based SS-OCT study","volume":"2023","author":"Xuan","year":"2023","journal-title":"Br. J. Ophthalmol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e612","DOI":"10.1111\/aos.13044","article-title":"Choroidal vascularity index\u2013a novel optical coherence tomography parameter for disease monitoring in diabetes mellitus?","volume":"94","author":"Tan","year":"2016","journal-title":"Acta Ophthalmol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/s41598-017-18511-7","article-title":"Choroidal vascularity index in type-2 diabetes analyzed by swept-source optical coherence tomography","volume":"8","author":"Kim","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.joco.2017.06.004","article-title":"The quantitative measurements of foveal avascular zone using optical coherence tomography angiography in normal volunteers","volume":"29","author":"Ghassemi","year":"2017","journal-title":"J. Curr. Ophthalmol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"3000605211014994","DOI":"10.1177\/03000605211014994","article-title":"Quantitative assessment and determinants of foveal avascular zone in healthy volunteers","volume":"49","author":"Zhou","year":"2021","journal-title":"J. Int. Med. Res."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Fujiwara, A., Morizane, Y., Hosokawa, M., Kimura, S., Shiode, Y., Hirano, M., Doi, S., Toshima, S., Takahashi, K., and Hosogi, M. (2017). Factors affecting foveal avascular zone in healthy eyes: An examination using swept-source optical coherence tomography angiography. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0188572"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Zhou, Y., Zhou, M., Gao, M., Liu, H., and Sun, X. (2020). Factors Affecting the Foveal Avascular Zone Area in Healthy Eyes among Young Chinese Adults. Biomed. Res. Int., 2020.","DOI":"10.1155\/2020\/7361492"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2824","DOI":"10.1177\/11206721211073446","article-title":"Normative data on the foveal avascular zone in a young healthy Irish population using optical coherence tomography angiography","volume":"32","author":"Scanlon","year":"2022","journal-title":"Eur. J. Ophthalmol."},{"key":"ref_36","first-page":"e27669","article-title":"Evaluating the Quantitative Foveal Avascular Zone and Retino-Choroidal Vessel Density Using Optical Coherence Tomography Angiography in a Healthy Indian Population","volume":"14","author":"Sodhi","year":"2022","journal-title":"Cureus"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Choi, J., Kwon, J., Shin, J.W., Lee, J., Lee, S., and Kook, M.S. (2017). Quantitative optical coherence tomography angiography of macular vascular structure and foveal avascular zone in glaucoma. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0184948"},{"key":"ref_38","unstructured":"Acosta, C.P., Gonzalez, D., Sardi, C., Gonzalez, N., Lavaque, A., Jimenez, J.M., and Garcia, V. (2021). Measurement and Evaluation of the FAZ in a Healthy Latino Population. Retin. Today, 20\u201324."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1111\/jdi.13712","article-title":"Measuring the foveal avascular zone in diabetes: A study using optical coherence tomography angiography","volume":"13","author":"Aitchison","year":"2022","journal-title":"J. Diabetes Investig."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/sj.eye.6701456","article-title":"Foveal avascular zone in diabetic retinopathy: Quantitative vs qualitative assessment","volume":"19","author":"Conrath","year":"2005","journal-title":"Eye"},{"key":"ref_41","first-page":"5497","article-title":"Assessment of Foveal Avascular Zone (FAZ) Area in Normal and Diabetic Retinopathy Eyes using OCT Angiography (OCTA)","volume":"57","author":"Soules","year":"2016","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_42","first-page":"OCT224-34","article-title":"Optical Coherence Tomography Angiography Evaluation of the Parafoveal Vasculature and Its Relationship with Ocular Factors","volume":"57","author":"Tan","year":"2016","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1038\/s41433-022-02146-8","article-title":"Age-related assessment of foveal avascular zone and surrounding capillary networks with swept source optical coherence tomography angiography in healthy eyes","volume":"36","author":"Verma","year":"2022","journal-title":"Eye"},{"key":"ref_44","first-page":"1007-F0254","article-title":"Optical coherence tomography angiography evaluation of the fovea avascular zone","volume":"63","author":"Chay","year":"2022","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1136\/bjophthalmol-2017-311149","article-title":"Optical coherence tomography angiography analysis of foveal microvascular changes and inner retinal layer thinning in patients with diabetes","volume":"102","author":"Kim","year":"2018","journal-title":"Br. J. Ophthalmol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"429","DOI":"10.2147\/OPTH.S353426","article-title":"Evaluation of Microvascular and Visual Acuity Changes in Patients with Early Diabetic Retinopathy: Optical Coherence Tomography Angiography Study","volume":"16","year":"2022","journal-title":"Clin. Ophthalmol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1097\/IJG.0000000000000800","article-title":"Glaucoma Diagnostic Capabilities of Foveal Avascular Zone Parameters Using Optical Coherence Tomography Angiography According to Visual Field Defect Location","volume":"26","author":"Kwon","year":"2017","journal-title":"J. Glaucoma"},{"key":"ref_48","first-page":"464","article-title":"Comparison of foveal avascular zone and retinal vascular density in healthy Chinese and Caucasian adults","volume":"98","author":"Wang","year":"2020","journal-title":"Acta Ophthalmol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/21\/6827\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:13:40Z","timestamp":1760130820000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/21\/6827"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,29]]},"references-count":48,"journal-issue":{"issue":"21","published-online":{"date-parts":[[2023,11]]}},"alternative-id":["jcm12216827"],"URL":"https:\/\/doi.org\/10.3390\/jcm12216827","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,29]]}}}