{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T18:56:01Z","timestamp":1789584961075,"version":"build-2803163510"},"reference-count":54,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2023,11,4]],"date-time":"2023-11-04T00:00:00Z","timestamp":1699056000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Introduction: The adrenocortical oncocytic neoplasms (AONs) are rare tumors of the adrenal gland, classified as oncocytoma (AO), oncocytic neoplasm of uncertain malignant potential (AONUMP) and oncocytic carcinoma (AOC). The aim of this study was to perform a review of the literature, in order to evaluate the prognosis of these rare cancers. We also reported the oldest patient with AON. Methods: A comprehensive literature review using as key words \u201cadrenal oncocytoma\u201d, \u201cadrenal oncocytic neoplasm\u201d, and \u201cadrenal oncocytic carcinoma\u201d was performed. Report of the case: We report the case of an 88-year-old woman receiving a left open adrenalectomy for an AON (15 \u00d7 10 \u00d7 8 cm). The considerable size and weight together with the presence of necrosis were indicative for a lesion with an uncertain potential for malignancy, according to Weiss modified criteria. After two years, the patient was free from any sign of recurrence. Results: Only 287 AONs were detected in the scientific literature, exploring OVID, MEDLINE, PubMed and SCOPUS as dataset. These tumors are usually incidentalomas with an unpredictable malignant potential. Surgical resection remains the mainstay of treatment for AON. Conclusion: AO and AONUMP have an excellent prognosis and a low mortality rate, with only three cases of recurrence reported in the literature and one metastatic case four years after first adrenal surgery. In contrast, AOC carries a high risk of local relapses, distant metastasis, and a significantly higher mortality rate (30%). Surgical resection remains the primary treatment for adrenal oncocytic neoplasms.<\/jats:p>","DOI":"10.3390\/jcm12216925","type":"journal-article","created":{"date-parts":[[2023,11,4]],"date-time":"2023-11-04T15:41:41Z","timestamp":1699112501000},"page":"6925","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Prognosis of Adrenal Oncocytic Neoplasms (AONs): Literature Review of 287 Cases and Presentation of the Oldest Patient"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8041-2045","authenticated-orcid":false,"given":"Enrico","family":"Coppola Bottazzi","sequence":"first","affiliation":[{"name":"Oncological and General Surgery Unit, \u201cSt. Giuseppe Moscati\u201d Hospital of National Relevance and High Specialty, 83100 Avellino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2277-2960","authenticated-orcid":false,"given":"Claudio","family":"Gambardella","sequence":"additional","affiliation":[{"name":"Division of General, Oncological, Mini-Invasive and Obesity Surgery, University of Study of Campania \u201cLuigi Vanvitelli\u201d, 80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4980-0335","authenticated-orcid":false,"given":"Federico Maria","family":"Mongardini","sequence":"additional","affiliation":[{"name":"Division of General, Oncological, Mini-Invasive and Obesity Surgery, University of Study of Campania \u201cLuigi Vanvitelli\u201d, 80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6599-8225","authenticated-orcid":false,"given":"Serafino","family":"Vanella","sequence":"additional","affiliation":[{"name":"Oncological and General Surgery Unit, \u201cSt. Giuseppe Moscati\u201d Hospital of National Relevance and High Specialty, 83100 Avellino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adele","family":"Noviello","sequence":"additional","affiliation":[{"name":"Oncological and General Surgery Unit, \u201cSt. Giuseppe Moscati\u201d Hospital of National Relevance and High Specialty, 83100 Avellino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommaso","family":"Palma","sequence":"additional","affiliation":[{"name":"Oncological and General Surgery Unit, \u201cSt. Giuseppe Moscati\u201d Hospital of National Relevance and High Specialty, 83100 Avellino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Murano","sequence":"additional","affiliation":[{"name":"Oncological and General Surgery Unit, \u201cSt. Giuseppe Moscati\u201d Hospital of National Relevance and High Specialty, 83100 Avellino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"De Chiara","sequence":"additional","affiliation":[{"name":"Pathological Anatomy and Histology Unit, \u201cSt. Giuseppe Moscati\u201d Hospital of National Relevance and High Specialty, 83100 Avellino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Conzo","sequence":"additional","affiliation":[{"name":"Division of General, Oncological, Mini-Invasive and Obesity Surgery, University of Study of Campania \u201cLuigi Vanvitelli\u201d, 80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludovico","family":"Docimo","sequence":"additional","affiliation":[{"name":"Division of General, Oncological, Mini-Invasive and Obesity Surgery, University of Study of Campania \u201cLuigi Vanvitelli\u201d, 80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2038-625X","authenticated-orcid":false,"given":"Francesco","family":"Crafa","sequence":"additional","affiliation":[{"name":"Oncological and General Surgery Unit, \u201cSt. Giuseppe Moscati\u201d Hospital of National Relevance and High Specialty, 83100 Avellino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,4]]},"reference":[{"key":"ref_1","first-page":"563","article-title":"Oncocytes and the so-called hurthle cell tumor","volume":"49","author":"Hamperl","year":"1950","journal-title":"Arch. 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