{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:50:41Z","timestamp":1787028641346,"version":"build-2736575974"},"reference-count":23,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T00:00:00Z","timestamp":1699488000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>This study aims to compare the surgical efficacy and safety of the Tanito microhook trabeculotomy (TMH-CE) and iStent inject W (Inject-CE) when performed in combination with cataract surgery on the eyes of glaucoma patients. A total of 78 glaucomatous eyes from 39 participants were retrospectively analyzed. Intraocular pressure (IOP), the number of antiglaucoma medications, best-corrected visual acuity (BCVA), anterior chamber flare (ACF), and corneal endothelial cell density (CECD) were all evaluated preoperatively and at multiple postoperative time points. The preoperative IOP was significantly higher in the TMH-CE (19.6 \u00b1 6.7 mmHg) than in the Inject-CE (15.7 \u00b1 3.8 mmHg) (p &lt; 0.0001). At the 12-month follow-up, reductions in IOP and the number of medications were more pronounced in the TMH-CE (6.6 mmHg, 27.6% and \u22121.1, respectively) group than Inject-CE (2.7 mmHg, 12.4% and \u22120.7, respectively) (p &lt; 0.0001 and p = 0.0034), while the IOP and medication-number levels were identical between TMH-CE (13.0 \u00b1 3.3 mmHg and 1.3 \u00b1 0.9, respectively) and Inject-CE (12.9 \u00b1 2.6 mmHg and 1.9 \u00b1 0.9, respectively) (p = 0.88 and p &gt; 0.99, respectively). The TMH-CE group exhibited a higher ACF, a higher frequency of layered hyphema, and a greater anterior chamber floating red blood cells score in the early postoperative periods. Despite these differences, the changes in BCVA, ACF, and CECD were equivalent between the two groups in later follow-up periods. TMH-CE provides a more significant IOP reduction and medication-number reduction compared to Inject-CE, while Inject-CE shows quicker BCVA recovery. This study provides valuable insights for ophthalmologists choosing the most suitable surgical approach for glaucoma and cataract patients.<\/jats:p>","DOI":"10.3390\/jcm12227005","type":"journal-article","created":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T10:19:27Z","timestamp":1699525167000},"page":"7005","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Fellow-Eye Comparison between Phaco-Tanito Microhook Trabeculotomy and Phaco-iStent Inject W"],"prefix":"10.3390","volume":"12","author":[{"given":"Akiko","family":"Harano","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Shimane University Faculty of Medicine, Izumo 693-8501, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayaka","family":"Shimada","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shimane University Faculty of Medicine, Izumo 693-8501, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sho","family":"Ichioka","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shimane University Faculty of Medicine, Izumo 693-8501, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunobu","family":"Sugihara","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shimane University Faculty of Medicine, Izumo 693-8501, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6512-7203","authenticated-orcid":false,"given":"Masaki","family":"Tanito","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shimane University Faculty of Medicine, Izumo 693-8501, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e489","DOI":"10.1016\/S2214-109X(20)30488-5","article-title":"The Lancet Global Health Commission on Global Eye Health: Vision beyond 2020","volume":"9","author":"Burton","year":"2021","journal-title":"Lancet Glob. Health"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1016\/j.ophtha.2015.06.022","article-title":"MIGS and the FDA: What\u2019s in a Name?","volume":"122","author":"Ahmed","year":"2015","journal-title":"Ophthalmology"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Tanito, M., Sugihara, K., Tsutsui, A., Hara, K., Manabe, K., and Matsuoka, Y. (2021). Effects of Preoperative Intraocular Pressure Level on Surgical Results of Microhook Ab Interno Trabeculotomy. J. Clin. Med., 10.","DOI":"10.3390\/jcm10153327"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"8754730","DOI":"10.1155\/2020\/8754730","article-title":"Use of iStent as a Standalone Operation in Patients with Open-Angle Glaucoma","volume":"2020","author":"Chen","year":"2020","journal-title":"J. Ophthalmol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.1007\/s12325-019-01025-1","article-title":"12-Month Retrospective Comparison of Kahook Dual Blade Excisional Goniotomy with Istent Trabecular Bypass Device Implantation in Glaucomatous Eyes at the Time of Cataract Surgery","volume":"36","author":"ElMallah","year":"2019","journal-title":"Adv. Ther."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1097\/IJG.0000000000001143","article-title":"Surgical Outcomes of Phacoemulsification Followed by iStent Implantation Versus Goniotomy with the Kahook Dual Blade in Patients with Mild Primary Open-angle Glaucoma with a Minimum of 12-Month Follow-up","volume":"28","author":"Le","year":"2019","journal-title":"J. Glaucoma"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.2147\/OPTH.S224109","article-title":"Comparison of Surgical Outcomes between Excisional Goniotomy Using the Kahook Dual Blade and iStent Trabecular Micro-Bypass Stent in Combination with Phacoemulsification","volume":"13","author":"Lee","year":"2019","journal-title":"Clin. Ophthalmol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"941","DOI":"10.18240\/ijo.2020.06.13","article-title":"Performances of glaucoma operations with Kahook Dual Blade or iStent combined with phacoemulsification in Japanese open angle glaucoma patients","volume":"13","author":"Iwasaki","year":"2020","journal-title":"Int. J. Ophthalmol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e121","DOI":"10.1097\/IJG.0000000000002243","article-title":"Outcomes of iStent Inject Versus Kahook Dual Blade Surgery in Glaucoma Patients Undergoing Cataract Surgery","volume":"32","author":"Barkander","year":"2023","journal-title":"J. Glaucoma"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Takayanagi, Y., Ichioka, S., Ishida, A., Tsutsui, A., and Tanito, M. (2021). Fellow-Eye Comparison between Phaco-Microhook Ab-Interno Trabeculotomy and Phaco-iStent Trabecular Micro-Bypass Stent. J. Clin. Med., 10.","DOI":"10.3390\/jcm10102129"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1097\/j.jcrs.0000000000000325","article-title":"iStent inject: Comprehensive review","volume":"47","author":"Shalaby","year":"2021","journal-title":"J. Cataract. Refract. Surg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.1007\/s40123-023-00777-y","article-title":"Which is More Effective and Safer? Comparison of Propensity Score-Matched Microhook Ab Interno Trabeculotomy and iStent Inject","volume":"12","author":"Asaoka","year":"2023","journal-title":"Ophthalmol. Ther."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Ishida, A., Ichioka, S., Takayanagi, Y., Tsutsui, A., Manabe, K., and Tanito, M. (2021). Comparison of Postoperative Hyphemas between Microhook Ab Interno Trabeculotomy and iStent Using a New Hyphema Scoring System. J. Clin. Med., 10.","DOI":"10.3390\/jcm10235541"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1016\/S0161-6420(99)90342-1","article-title":"Visual acuity impairment in patients with retinitis pigmentosa at age 45 years or older","volume":"106","author":"Grover","year":"1999","journal-title":"Ophthalmology"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s00417-016-3514-8","article-title":"Contralateral eye comparison study in MICS & MIGS: Trabectome\u00ae vs. iStent inject\u00ae","volume":"255","author":"Gonnermann","year":"2017","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"541","DOI":"10.2147\/OPTH.S284687","article-title":"Kahook Dual Blade Goniotomy vs iStent inject: Long-Term Results in Patients with Open-Angle Glaucoma","volume":"15","author":"Arnljots","year":"2021","journal-title":"Clin. Ophthalmol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s12325-020-01543-3","article-title":"Comparison of Surgical Outcomes Between Microhook Ab Interno Trabeculotomy and Goniotomy with the Kahook Dual Blade in Combination with Phacoemulsification: A Retrospective, Comparative Case Series","volume":"38","author":"Aoki","year":"2021","journal-title":"Adv. Ther."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Okada, N., Hirooka, K., Onoe, H., Okumichi, H., and Kiuchi, Y. (2023). Comparison of Mid-Term Outcomes between Microhook ab Interno Trabeculotomy and Goniotomy with the Kahook Dual Blade. J. Clin. Med., 12.","DOI":"10.3390\/jcm12020558"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1097\/IJG.0000000000001273","article-title":"A Prospective Analysis of iStent Inject Microstent Positioning: Schlemm Canal Dilatation and Intraocular Pressure Correlations","volume":"28","author":"Gillmann","year":"2019","journal-title":"J. Glaucoma"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2797","DOI":"10.1007\/s12325-019-01067-5","article-title":"One-Year Comparative Evaluation of iStent or iStent inject Implantation Combined with Cataract Surgery in a Single Center","volume":"36","author":"Guedes","year":"2019","journal-title":"Adv. Ther."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s40123-019-00208-x","article-title":"Real-world Case Series of iStent or iStent inject Trabecular Micro-Bypass Stents Combined with Cataract Surgery","volume":"8","author":"Manning","year":"2019","journal-title":"Ophthalmol. Ther."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1111\/aos.14787","article-title":"Comparison of efficacy and early surgery-related complications between one-quadrant and two-quadrant microhook ab interno trabeculotomy: A propensity score matched study","volume":"99","author":"Mori","year":"2021","journal-title":"Acta Ophthalmol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.ajo.2023.08.002","article-title":"Influence of Goniotomy Size on Treatment Safety and Efficacy for Primary Open-Angle Glaucoma: A Multicenter Study","volume":"256","author":"Zhang","year":"2023","journal-title":"Am. J. Ophthalmol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/22\/7005\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:20:14Z","timestamp":1760131214000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/22\/7005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,9]]},"references-count":23,"journal-issue":{"issue":"22","published-online":{"date-parts":[[2023,11]]}},"alternative-id":["jcm12227005"],"URL":"https:\/\/doi.org\/10.3390\/jcm12227005","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,9]]}}}