{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T14:08:48Z","timestamp":1773065328966,"version":"3.50.1"},"reference-count":30,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T00:00:00Z","timestamp":1699833600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"JW Pharmaceutical Corporation, Seoul, Republic of Korea","award":["NCR 2019-6"],"award-info":[{"award-number":["NCR 2019-6"]}]},{"name":"JW Pharmaceutical Corporation, Seoul, Republic of Korea","award":["4-2019-0771"],"award-info":[{"award-number":["4-2019-0771"]}]},{"name":"JW Pharmaceutical Corporation, Seoul, Republic of Korea","award":["6-2022-0084"],"award-info":[{"award-number":["6-2022-0084"]}]},{"name":"CELLTRION PHARM, Inc., Chungcheongbuk-do, Republic of Korea","award":["NCR 2019-6"],"award-info":[{"award-number":["NCR 2019-6"]}]},{"name":"CELLTRION PHARM, Inc., Chungcheongbuk-do, Republic of Korea","award":["4-2019-0771"],"award-info":[{"award-number":["4-2019-0771"]}]},{"name":"CELLTRION PHARM, Inc., Chungcheongbuk-do, Republic of Korea","award":["6-2022-0084"],"award-info":[{"award-number":["6-2022-0084"]}]},{"name":"Chong Kun Dang Pharmaceutical Corp., Seoul, Republic of Korea","award":["NCR 2019-6"],"award-info":[{"award-number":["NCR 2019-6"]}]},{"name":"Chong Kun Dang Pharmaceutical Corp., Seoul, Republic of Korea","award":["4-2019-0771"],"award-info":[{"award-number":["4-2019-0771"]}]},{"name":"Chong Kun Dang Pharmaceutical Corp., Seoul, Republic of Korea","award":["6-2022-0084"],"award-info":[{"award-number":["6-2022-0084"]}]},{"name":"Handok Corporation","award":["NCR 2019-6"],"award-info":[{"award-number":["NCR 2019-6"]}]},{"name":"Handok Corporation","award":["4-2019-0771"],"award-info":[{"award-number":["4-2019-0771"]}]},{"name":"Handok Corporation","award":["6-2022-0084"],"award-info":[{"award-number":["6-2022-0084"]}]},{"DOI":"10.13039\/501100008005","name":"faculty research grant of Yonsei University College of Medicine","doi-asserted-by":"publisher","award":["NCR 2019-6"],"award-info":[{"award-number":["NCR 2019-6"]}],"id":[{"id":"10.13039\/501100008005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008005","name":"faculty research grant of Yonsei University College of Medicine","doi-asserted-by":"publisher","award":["4-2019-0771"],"award-info":[{"award-number":["4-2019-0771"]}],"id":[{"id":"10.13039\/501100008005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008005","name":"faculty research grant of Yonsei University College of Medicine","doi-asserted-by":"publisher","award":["6-2022-0084"],"award-info":[{"award-number":["6-2022-0084"]}],"id":[{"id":"10.13039\/501100008005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>We investigated the IL-6 receptor (IL-6R) expression on the surface of T cells isolated from peripheral blood mononuclear cells (PBMCs) of microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA) patients and measured the serum soluble IL-6R (sIL-6R) levels in these patients. Sera and PBMCs were obtained from 51 patients with MPA (n = 32) and GPA (n = 19), with 25 patients having active disease (defined as a Birmingham Vasculitis Activity Score [BVAS] \u2265 5). The median age of patients was 67.0 years, and 52.9% were women. Serum IL-6 levels were significantly correlated with the BVAS (r = 0.384); however, IL-6R expression on the surface of T cells did not significantly differ based on disease activity. Meanwhile, IL-6R expression on the surface of stimulated CD4+ (median mean fluorescence intensity [MFI] 588.0 vs. 1314.8; p &lt; 0.001), CD4+CD25+ (MFI 853.3 vs. 1527.3; p &lt; 0.001), and CD4+CD45RO+ (MFI 679.5 vs. 1241.5; p &lt; 0.001) T cells was significantly reduced compared with unstimulated conditions. Conversely, patients with active disease exhibited a significantly higher median serum sIL-6R level than those with inactive disease (38.1 ng\/mL vs. 34.7 ng\/mL; p = 0.029). These results imply that the trans-signalling IL-6 pathway may be more activated than the classical signalling pathway in patients with MPA and GPA, suggesting the therapeutic potential of targeting sIL-6R.<\/jats:p>","DOI":"10.3390\/jcm12227059","type":"journal-article","created":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T02:46:47Z","timestamp":1699843607000},"page":"7059","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["IL-6 Receptor Expression on the Surface of T Cells and Serum Soluble IL-6 Receptor Levels in Patients with Microscopic Polyangiitis and Granulomatosis with Polyangiitis"],"prefix":"10.3390","volume":"12","author":[{"given":"Taejun","family":"Yoon","sequence":"first","affiliation":[{"name":"BK21 Plus Project, Department of Medical Science, College of Medicine, Yonsei University, Seoul 03772, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9002-9880","authenticated-orcid":false,"given":"Sung Soo","family":"Ahn","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Yongin Severance Hospital, College of Medicine, Yonsei University, Yongin 16995, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eunhee","family":"Ko","sequence":"additional","affiliation":[{"name":"BK21 Plus Project, Department of Medical Science, College of Medicine, Yonsei University, Seoul 03772, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason Jungsik","family":"Song","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Severance Hospital, College of Medicine, Yonsei University, Seoul 03772, Republic of Korea"},{"name":"Institute for Immunology and Immunological Diseases, College of Medicine, Yonsei University, Seoul 03772, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-Beom","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Severance Hospital, College of Medicine, Yonsei University, Seoul 03772, Republic of Korea"},{"name":"Institute for Immunology and Immunological Diseases, College of Medicine, Yonsei University, Seoul 03772, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8038-3341","authenticated-orcid":false,"given":"Sang-Won","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Severance Hospital, College of Medicine, Yonsei University, Seoul 03772, Republic of Korea"},{"name":"Institute for Immunology and Immunological Diseases, College of Medicine, Yonsei University, Seoul 03772, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1002\/art.37715","article-title":"2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides","volume":"65","author":"Jennette","year":"2013","journal-title":"Arthritis Rheum."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3349\/ymj.2019.60.1.10","article-title":"Antineutrophil Cytoplasmic Antibody-Associated Vasculitis in Korea: A Narrative Review","volume":"60","author":"Choi","year":"2019","journal-title":"Yonsei Med. 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