{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T01:00:28Z","timestamp":1787792428707,"version":"build-2784847793"},"reference-count":47,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T00:00:00Z","timestamp":1700092800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: To compare corneal densitometry (CD) patterns at the graft\u2013host interface between Descemet Membrane Endothelial Keratoplasty (DMEK) and Descemet Stripping Automated Endothelial Keratoplasty (DSAEK). Corneal densitometry is a quantitative assessment that objectively evaluates corneal clarity and optical quality by measuring the light backscatter from the cornea. Methods: Fifty-one eyes that received DMEK or DSAEK surgery for corneal endothelium dysfunction were evaluated. The primary endpoint included CD patterns at the graft\u2013host interface, which were assessed by the Pentacam HR device at the center point of the corneal horizontal meridian (CDcentral), and at six points on the central circumference of the cornea (with a total diameter of 4 mm) (CDI,II,III,IV,V,VI). Secondary endpoints included the best-corrected distance visual acuity (BCDVA), central corneal thickness (CCT), and graft thickness (GT). All of the evaluations were performed at follow-up appointments one, three, six and twelve months after the procedure. Results: DMEK showed a significant overall CD reduction of \u22127.9 \u00b1 8.5 grayscale unit (GSU) compared to DSAEK (p &lt; 0.001). In addition, the DMEK group showed significantly lower CDCentral,I,II,III,IV,V,VI values at follow-up appointments one, three, six and twelve months after the procedure compared to the DSAEK group (p &lt; 0.001). BCDVA, CCT and GT were in favor of the DMEK group with a mean value of 0.39 \u00b1 0.35 LogMar, 552.2 \u00b1 71.1 \u00b5m and 11.03 \u00b1 1.4 \u00b5m, respectively (p &lt; 0.001). Conclusions: CD patterns at the graft\u2013host interface seem to be different depending on the endothelial keratoplasty procedure. This provides specific insight into CD changes in this critical region of surgery, which may provide a better understanding of the postoperative evolution of these patients.<\/jats:p>","DOI":"10.3390\/jcm12227133","type":"journal-article","created":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T08:19:43Z","timestamp":1700122783000},"page":"7133","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Scheimpflug Corneal Densitometry Patterns at the Graft\u2013Host Interface in DMEK and DSAEK: A 12-Month Longitudinal Comparative Study"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9248-8685","authenticated-orcid":false,"given":"Antonio","family":"Ballesteros-S\u00e1nchez","sequence":"first","affiliation":[{"name":"Department of Physics of Condensed Matter, Optics Area, University of Seville, 41004 Seville, Spain"},{"name":"Department of Ophthalmology, Novovision Ophthalmologic Clinic, 30008 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Peraza-Nieves","sequence":"additional","affiliation":[{"name":"Anterior Segment Department, Institut Clinic D\u2019Oftalmologia, Hospital Clinic Barcelona, 08036 Barcelona, Spain"},{"name":"Department of Ophthalmology, Castellar Clinic, 08017 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3950-1828","authenticated-orcid":false,"given":"Anna","family":"Casablanca-Pi\u00f1era","sequence":"additional","affiliation":[{"name":"Anterior Segment Department, Institut Clinic D\u2019Oftalmologia, Hospital Clinic Barcelona, 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Rodr\u00edguez-Calvo-De-Mora","sequence":"additional","affiliation":[{"name":"Qvision, Ophthalmology Department, VITHAS Almeria Hospital, 04120 Almeria, Spain"},{"name":"Ophthalmology Department, VITHAS Malaga, 29016 Malaga, Spain"},{"name":"Department of Ophthalmology, Hospital Regional Universitario, 29011 Malaga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saray","family":"Catal\u00e1n-Coronado","sequence":"additional","affiliation":[{"name":"Anterior Segment Department, Institut Clinic D\u2019Oftalmologia, Hospital Clinic Barcelona, 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6995-1291","authenticated-orcid":false,"given":"Josep","family":"Torras-Sanvicens","sequence":"additional","affiliation":[{"name":"Anterior Segment Department, Institut Clinic D\u2019Oftalmologia, Hospital Clinic Barcelona, 08036 Barcelona, Spain"},{"name":"School of Medicine and Health Sciences, University of Barcelona, 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6952-5647","authenticated-orcid":false,"given":"Davide","family":"Borroni","sequence":"additional","affiliation":[{"name":"Department of Doctoral Studies, Riga Stradins University, LV-1007 Riga, Latvia"},{"name":"Advalia Vision, Cornea Research Unit, 20145 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0450-7717","authenticated-orcid":false,"given":"Jos\u00e9-Mar\u00eda","family":"S\u00e1nchez-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Department of Physics of Condensed Matter, Optics Area, University of Seville, 41004 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7464-2493","authenticated-orcid":false,"given":"Carlos","family":"Rocha-De-Lossada","sequence":"additional","affiliation":[{"name":"Qvision, Ophthalmology Department, VITHAS Almeria Hospital, 04120 Almeria, Spain"},{"name":"Ophthalmology Department, VITHAS Malaga, 29016 Malaga, Spain"},{"name":"Department of Ophthalmology, Hospital Regional Universitario, 29011 Malaga, Spain"},{"name":"Department of Surgery, Ophthalmology Area, University of Seville, 41009 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1001\/jamaophthalmol.2015.4776","article-title":"Global Survey of Corneal Transplantation and Eye Banking","volume":"134","author":"Gain","year":"2016","journal-title":"JAMA Ophthalmol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1097\/ICO.0000000000002565","article-title":"Endothelial Keratoplasty Update 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