{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:40:38Z","timestamp":1760150438355,"version":"build-2065373602"},"reference-count":68,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T00:00:00Z","timestamp":1700265600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Rheumatoid arthritis (RA) increases the risk of cardiovascular mortality and morbidity, including a 50\u201360% increased risk of cardiovascular disease (CVD). Arterial hypertension (HT) is considered the major contributing risk factor for CVD development in RA patients. In this investigation, we compared the incidence and prevalence of HT between RA and osteoarthritis (OA) and the influence of HT on CVD development in CVD-naive patients in both groups. This was a prospective clinical cohort investigation with an 8-year follow-up period. A total of 201 participants, 124 with RA (investigation group) and 77 with OA (control group), without diagnosed CVD or symptomatic heart failure were included. After selection according to inclusion and exclusion criteria, both groups underwent initial and final visits, and the investigation group underwent annual visits to assess disease activity. Case report forms were completed for each visit. The obtained data were analyzed by a statistician. No difference in the incidence or prevalence of HT was found between the investigation and control groups. No difference in the prevalence of HT was reported between the study groups and age-standardized data from the general population. The investigation group had a higher incidence of CVD than the control group. RA participants with long-term remission had a marginally lower HT prevalence. Although previous studies reported a higher HT prevalence in RA than in OA and the general population, our findings did not support this. The RA group had a higher incidence of CVD, but it is possible that optimal disease control with long-term remission could reduce HT incidence and prevalence while also having beneficial effects on other cardiovascular risk factors (CV) and, consequently, CVD occurrence.<\/jats:p>","DOI":"10.3390\/jcm12227158","type":"journal-article","created":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T07:33:18Z","timestamp":1700292798000},"page":"7158","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Influence of Rheumatoid Arthritis and Osteoarthritis on the Occurrence of Arterial Hypertension: An 8-Year Prospective Clinical Observational Cohort Study"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8076-4398","authenticated-orcid":false,"given":"Dra\u017een","family":"Bedekovi\u0107","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Diseases, Internal Medicine Clinic, University Hospital Osijek, J. Huttlera 4, 31000 Osijek, Croatia"},{"name":"Faculty of Medicine Osijek, Department of Internal Medicine, J. J. Strossmayer University, J. Huttlera 4, 31000 Osijek, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damir","family":"Kirner","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases, Internal Medicine Clinic, University Hospital Osijek, J. Huttlera 4, 31000 Osijek, Croatia"},{"name":"Faculty of Medicine Osijek, Department of Internal Medicine, J. J. Strossmayer University, J. Huttlera 4, 31000 Osijek, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0223-4287","authenticated-orcid":false,"given":"Ivica","family":"Bo\u0161njak","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases, Internal Medicine Clinic, University Hospital Osijek, J. Huttlera 4, 31000 Osijek, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandar","family":"Kibel","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases, Internal Medicine Clinic, University Hospital Osijek, J. Huttlera 4, 31000 Osijek, Croatia"},{"name":"Faculty of Medicine Osijek, Department of Physiology and Immunology, J. J. Strossmayer University, J. Huttlera 4, 31000 Osijek, Croatia"},{"name":"Scientific Centre of Excellence for Personalized Health Care, J. J. Strossmayer University of Osijek, J. Huttlera 4, 31000 Osijek, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"\u0160ari\u0107","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases, Internal Medicine Clinic, University Hospital Osijek, J. Huttlera 4, 31000 Osijek, Croatia"},{"name":"Faculty of Medicine Osijek, Department of Internal Medicine, J. J. Strossmayer University, J. Huttlera 4, 31000 Osijek, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sr\u0111an","family":"Novak","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, University Hospital Rijeka, 51000 Rijeka, Croatia"},{"name":"Faculty of Medicine Rijeka, Department of Internal Medicine, University of Rijeka, Bra\u0107e Branchetta 20\/1, 51000 Rijeka, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3959-7225","authenticated-orcid":false,"given":"Vi\u0161nja","family":"Prus","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Internal Medicine Clinic, University Hospital Osijek J. Huttlera 4, 31000 Osijek, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1002\/art.1780290602","article-title":"Survival, prognosis, and causes of death in rheumatoid arthritis","volume":"29","author":"Mitchell","year":"1986","journal-title":"Arthritis Rheum."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1016\/S0140-6736(87)91672-2","article-title":"Long-term outcome of treating rheumatoid arthritis: Results after 20 years","volume":"329","author":"Scott","year":"1987","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/art.1780310302","article-title":"The american rheumatism association 1987 revised criteria for the classification of rheumatoid arthritis","volume":"31","author":"Arnett","year":"1988","journal-title":"Arthritis Rheum."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1136\/ard.2010.138461","article-title":"2010 Rheumatoid arthritis classification criteria: An American College of Rheumatology\/European League Against Rheumatism collaborative initiative","volume":"69","author":"Aletaha","year":"2010","journal-title":"Ann. Rheum. Dis."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/S0140-6736(01)06075-5","article-title":"Rheumatoid arthritis","volume":"358","author":"Lee","year":"2001","journal-title":"Lancet"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1053\/berh.2002.0257","article-title":"Epidemiology of rheumatoid arthritis: Determinants of onset, persistence and outcome","volume":"16","author":"Symmons","year":"2002","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"522","DOI":"10.3109\/14397595.2015.1106682","article-title":"High prevalence of cardiovascular comorbidities in patients with rheumatoid arthritis from a population-based cross-sectional study of a Japanese health insurance database","volume":"26","author":"Sakai","year":"2016","journal-title":"Mod. Rheumatol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1007\/s10067-009-1278-9","article-title":"Causes of death in patients with rheumatoid arthritis from 1971 to 1991 with special reference to autopsy","volume":"28","author":"Koivuniemi","year":"2009","journal-title":"Clin. Rheumatol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1002\/art.20855","article-title":"Cardiovascular death in rheumatoid arthritis: A population-based study","volume":"52","author":"Nicola","year":"2005","journal-title":"Arthritis Rheum."},{"key":"ref_10","first-page":"S35","article-title":"Mortality in rheumatoid arthritis: 2008 update","volume":"26","author":"Sokka","year":"2008","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1093\/rheumatology\/kep252","article-title":"Trends in cardiovascular mortality in patients with rheumatoid arthritis over 50 years: A systematic review and meta-analysis of cohort studies","volume":"48","author":"Meune","year":"2009","journal-title":"Rheumatology"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.acvd.2010.03.007","article-title":"High risk of clinical cardiovascular events in rheumatoid arthritis: Levels of associations of myocardial infarction and stroke through a systematic review and meta-analysis","volume":"103","author":"Meune","year":"2010","journal-title":"Arch. Cardiovasc. Dis."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1002\/art.24092","article-title":"Risk of cardiovascular mortality in patients with rheumatoid arthritis: A meta-analysis of observational studies","volume":"59","author":"Choi","year":"2008","journal-title":"Arthritis Care Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"317","DOI":"10.5830\/CVJA-2018-018","article-title":"Rheumatoid arthritis and risk of cardiovascular disease","volume":"29","author":"Meyer","year":"2018","journal-title":"Cardiovasc. J. Afr."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e000267","DOI":"10.1136\/rmdopen-2016-000267","article-title":"Characteristics of rheumatoid arthritis and its association with major comorbid conditions: Cross-sectional study of 502 649 UK Biobank participants","volume":"2","author":"Siebert","year":"2016","journal-title":"RMD Open"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1002\/art.10089","article-title":"Accelerated atherosclerosis: An extraarticular feature of rheumatoid arthritis?","volume":"46","author":"McColl","year":"2002","journal-title":"Arthritis Rheum."},{"key":"ref_17","first-page":"221","article-title":"Kardiovaskul\u00e4re Komorbidit\u00e4ten bei rheumatoider Arthritis","volume":"78","year":"2019","journal-title":"Rheuma Plus"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1093\/rheumatology\/ken159","article-title":"Hypertension in rheumatoid arthritis","volume":"47","author":"Panoulas","year":"2008","journal-title":"Rheumatology"},{"key":"ref_19","first-page":"244","article-title":"THU0139 Cardiovascular Risk Factor Profile in an Italian Cohort of Patients with Rheumatoid Arthritis: Results of a Three Year Follow-up","volume":"74","author":"Grosso","year":"2015","journal-title":"Rheumatology"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e000128","DOI":"10.1136\/rmdopen-2015-000128","article-title":"Cardiovascular and selected comorbidities in early arthritis and early spondyloarthritis, a comparative study: Results from the ESPOIR and DESIR cohorts","volume":"1","author":"Gherghe","year":"2015","journal-title":"RMD Open"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.freeradbiomed.2018.05.085","article-title":"Hypertension: Focus on autoimmunity and oxidative stress","volume":"125","author":"Small","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"236","DOI":"10.3899\/jrheum.100564","article-title":"Cardiovascular Disease Is Related to Hypertension in Patients with Rheumatoid Arthritis: A Greek Cohort Study","volume":"38","author":"Serelis","year":"2011","journal-title":"J. Rheumatol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s13075-016-0928-y","article-title":"Co-morbidity in patients with early rheumatoid arthritis\u2014Inflammation matters","volume":"18","author":"Innala","year":"2016","journal-title":"Arthritis Res. Ther."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/acr.23014","article-title":"Secular Changes in Clinical Features at Presentation of Rheumatoid Arthritis: Increase in Comorbidity But Improved Inflammatory States","volume":"69","author":"Nikiphorou","year":"2017","journal-title":"Arthritis Care Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/acr.23094","article-title":"Incidence and Management of Cardiovascular Risk Factors in Psoriatic Arthritis and Rheumatoid Arthritis: A Population-Based Study","volume":"69","author":"Jafri","year":"2017","journal-title":"Arthritis Care Res."},{"key":"ref_26","first-page":"A12720","article-title":"Trends of Cardiac Complications in Patients With Rheumatoid Arthritis: An Insight From National Inpatient Sample; 2005\u20132014","volume":"138","author":"Bandyopadhyay","year":"2018","journal-title":"Circulation"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1038\/s41371-020-0348-y","article-title":"Hypertension in rheumatic diseases: Prevalence, awareness, treatment, and control rates according to current hypertension guidelines","volume":"35","author":"Anyfanti","year":"2021","journal-title":"J. Hum. Hypertens."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"R142","DOI":"10.1186\/ar4324","article-title":"Arterial hypertension assessed \u201cout-of-office\u201d in a contemporary cohort of rheumatoid arthritis patients free of cardiovascular disease is characterized by high prevalence, low awareness, poor control and increased vascular damage-associated \u201cwhite coat\u201d phenomenon","volume":"15","author":"Protogerou","year":"2013","journal-title":"Arthritis Res. Ther."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.semarthrit.2011.07.004","article-title":"Prevalence of Traditional Modifiable Cardiovascular Risk Factors in Patients with Rheumatoid Arthritis: Comparison with Control Subjects from the Multi-Ethnic Study of Atherosclerosis","volume":"41","author":"Chung","year":"2012","journal-title":"Semin. Arthritis Rheum."},{"key":"ref_30","first-page":"2167","article-title":"Bala Cardiovascular disease and risk factors in patients with rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis","volume":"33","author":"Han","year":"2006","journal-title":"J. Rheumatol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"R131","DOI":"10.1186\/ar3442","article-title":"Cardiovascular events in early RA are a result of inflammatory burden and traditional risk factors: A five year prospective study","volume":"13","author":"Innala","year":"2011","journal-title":"Arthritis Res. Ther."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1210\/rp.59.1.169","article-title":"Hypertension and Obesity","volume":"59","author":"Aneja","year":"2004","journal-title":"Recent Prog. Horm. Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1093\/rheumatology\/kem169","article-title":"Prevalence and associations of hypertension and its control in patients with rheumatoid arthritis","volume":"46","author":"Panoulas","year":"2007","journal-title":"Rheumatology"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1136\/annrheumdis-2012-202398","article-title":"Cardiovascular comorbidities antedating the diagnosis of rheumatoid arthritis","volume":"72","author":"Kerola","year":"2013","journal-title":"Ann. Rheum. Dis."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jbspin.2010.07.016","article-title":"Traditional cardiovascular risk factors in rheumatoid arthritis: A meta-analysis","volume":"78","author":"Boyer","year":"2011","journal-title":"Jt. Bone Spine"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1007\/s00296-012-2522-1","article-title":"Is the prevalence of arterial hypertension in rheumatoid arthritis and osteoarthritis associated with disease?","volume":"33","author":"Kehler","year":"2013","journal-title":"Rheumatol. Int."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.berh.2008.11.007","article-title":"Cardiovascular co-morbidity in early rheumatoid arthritis","volume":"23","author":"John","year":"2009","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.1002\/art.39198","article-title":"Rheumatoid Arthritis, Anti\u2013Cyclic Citrullinated Peptide Positivity, and Cardiovascular Disease Risk in the Women\u2019s Health Initiative","volume":"67","author":"Mackey","year":"2015","journal-title":"Arthritis Rheumatol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jbspin.2015.12.003","article-title":"Gout and rheumatoid arthritis, both to keep in mind in cardiovascular risk management: A primary care retrospective cohort study","volume":"84","author":"Janssens","year":"2017","journal-title":"Jt. Bone Spine"},{"key":"ref_40","first-page":"673","article-title":"Incidence and risk of fatal myocardial infarction and stroke events in rheumatoid arthritis patients. A systematic review of the literature","volume":"26","author":"Fautrel","year":"2008","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"4750","DOI":"10.1016\/j.ijcard.2013.07.233","article-title":"Rheumatoid arthritis and risk of acute myocardial infarction\u2014A nationwide retrospective cohort study","volume":"168","author":"Chung","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"ref_42","unstructured":"Verdecchia, P., Angeli, F., Mazzotta, G., Gentile, G., and Reboldi, G. (2010). Optimising the Manegement of Osteoarthritis: Emeging Therapies, BMJ Group."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1177\/1759720X14541668","article-title":"Comparative evaluation of cardiovascular outcomes in patients with osteoarthritis and rheumatoid arthritis on recommended doses of nonsteroidal anti-inflammatory drugs","volume":"6","author":"Fabule","year":"2014","journal-title":"Ther. Adv. Musculoskelet. Dis."},{"key":"ref_44","first-page":"S383","article-title":"Prevalence of cardiovascular disease risk factors among US adults with self-reported osteoarthritis: Data from the Third National Health and Nutrition Examination Survey","volume":"8","author":"Singh","year":"2002","journal-title":"Am. J. Manag. Care"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1093\/rheumatology\/kem311","article-title":"Long-term exposure to medium-dose glucocorticoid therapy associates with hypertension in patients with rheumatoid arthritis","volume":"47","author":"Panoulas","year":"2008","journal-title":"Rheumatology"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1002\/acr.22302","article-title":"Impact of Rheumatoid Arthritis on Receiving a Diagnosis of Hypertension Among Patients With Regular Primary Care","volume":"66","author":"Bartels","year":"2014","journal-title":"Arthritis Care Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1093\/rheumatology\/kew039","article-title":"Marked underdiagnosis and undertreatment of hypertension and hypercholesterolaemia in rheumatoid arthritis","volume":"55","author":"Stoep","year":"2016","journal-title":"Rheumatology"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1001\/jama.289.18.2363","article-title":"Hypertension Prevalence and Blood Pressure Levels in 6 European Countries, Canada, and the United States","volume":"289","author":"Cooper","year":"2003","journal-title":"JAMA"},{"key":"ref_49","unstructured":"DAS-Score (2009, January 12). Nl. Disease Activity Score in Rheumatic Arthritis. Available online: http\/\/www.das-score.nl."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/0049-0172(91)90027-W","article-title":"Indices of severity and disease activity for osteoarthritis","volume":"20","author":"Lequesne","year":"1991","journal-title":"Semin. Arthritis Rheum."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1093\/rheumatology\/25.2.206","article-title":"Stanford Health Assessment Questionnaire modified to assess disability in British patients with rheumatoid arthritis","volume":"25","author":"Kirwan","year":"1986","journal-title":"Rheumatology"},{"key":"ref_52","first-page":"137","article-title":"Epidemiology of Arterial Hypertension in Croatia and Worldwide","volume":"16","author":"Dika","year":"2007","journal-title":"Medicus"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"894577","DOI":"10.3389\/fcvm.2022.894577","article-title":"Vascular Age, Metabolic Panel, Cardiovascular Risk and Inflammaging in Patients With Rheumatoid Arthritis Compared With Patients With Osteoarthritis","volume":"9","author":"Echeverri","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"261","DOI":"10.2174\/1874609812666190226151500","article-title":"Impact of Cardiovascular Factors on Pulse Wave Velocity and T otal Vascular Resistance in Different Age Group Patients with Cardiovascular Disorders","volume":"11","author":"Ghosh","year":"2019","journal-title":"Curr. Aging Sci."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"4543","DOI":"10.1038\/s41598-019-41069-5","article-title":"Assessment of arterial stiffness variables in patients with rheumatoid arthritis: A mediation analysis","volume":"9","author":"Taverner","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_56","first-page":"36","article-title":"Increase in cardiovascular and cerebrovascular disease prevalence in rheumatoid arthritis","volume":"30","author":"Wolfe","year":"2003","journal-title":"J. Rheumatol."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Jeong, H., Baek, S.Y., Kim, S.W., Eun, Y.H., Kim, I.Y., Kim, H., Lee, J., Koh, E.-M., and Cha, H.-S. (2017). Comorbidities of rheumatoid arthritis: Results from the Korean National Health and Nutrition Examination Survey. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0178309"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1093\/rheumatology\/kes243","article-title":"Traditional cardiovascular risk factors, inflammation and cardiovascular risk in rheumatoid arthritis","volume":"52","author":"Liao","year":"2013","journal-title":"Rheumatology"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/acr.22932","article-title":"Impact of Obesity on Remission and Disease Activity in Rheumatoid Arthritis: A Systematic Review and Meta-Analysis","volume":"69","author":"Liu","year":"2017","journal-title":"Arthritis Care Res."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Crepaldi, G., Scir\u00e8, C.A., Carrara, G., Sakellariou, G., Caporali, R., Hmamouchi, I., Dougados, M., and Montecucco, C. (2016). Cardiovascular Comorbidities Relate More than Others with Disease Activity in Rheumatoid Arthritis. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0146991"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"R5","DOI":"10.1186\/ar428","article-title":"Cardiovascular risk in rheumatoid arthritis versus osteoarthritis: Acute phase response related decreased insulin sensitivity and high-density lipoprotein cholesterol as well as clustering of metabolic syndrome features in rheumatoid arthritis","volume":"4","author":"Dessein","year":"2002","journal-title":"Arthritis Res. Ther."},{"key":"ref_62","first-page":"646","article-title":"Burden of major musculoskeletal conditions","volume":"81","author":"Woolf","year":"2003","journal-title":"Bull. World Health Organ."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.2174\/138161212799504759","article-title":"Adverse Cardiovascular Effects of Antirheumatic Drugs: Implications for Clinical Practice and Research","volume":"18","author":"Gasparyan","year":"2012","journal-title":"Curr. Pharm. Des."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"730.e9","DOI":"10.1016\/j.amjmed.2013.02.016","article-title":"Cardiovascular Risk in Rheumatoid Arthritis: Comparing TNF-\u03b1 Blockade with Nonbiologic DMARDs","volume":"126","author":"Solomon","year":"2013","journal-title":"Am. J. Med."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"3133","DOI":"10.1161\/01.CIR.0000077913.60364.D2","article-title":"Randomized, double-blind, placebo-controlled, pilot trial of infliximab, a chimeric monoclonal antibody to tumor necrosis factor-\u03b1, in patients with moderate-to-severe heart failure: Results of the anti-TNF Therapy Against Congestive Heart Failure (ATTACH) trial","volume":"107","author":"Chung","year":"2003","journal-title":"Circulation"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0167-5273(02)00470-9","article-title":"How to RECOVER from RENAISSANCE? The significance of the results of RECOVER, RENAISSANCE, RENEWAL and ATTACH","volume":"86","author":"Anker","year":"2002","journal-title":"Int. J. Cardiol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"e731","DOI":"10.1097\/MD.0000000000000731","article-title":"Association Between Anti-TNF Therapy for Rheumatoid Arthritis and Hypertension: A meta-analysis of randomized controlled trials","volume":"94","author":"Zhao","year":"2015","journal-title":"Medicine"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1002\/art.38894","article-title":"Lipid profile changes in patients with chronic inflam-matory arthritis treated with biologic agents and tofacitinib in randomized clinical trials: A systematic review and meta-analysis","volume":"67","author":"Souto","year":"2015","journal-title":"Arthritis Rheumatol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/22\/7158\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:25:11Z","timestamp":1760131511000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/22\/7158"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,18]]},"references-count":68,"journal-issue":{"issue":"22","published-online":{"date-parts":[[2023,11]]}},"alternative-id":["jcm12227158"],"URL":"https:\/\/doi.org\/10.3390\/jcm12227158","relation":{},"ISSN":["2077-0383"],"issn-type":[{"type":"electronic","value":"2077-0383"}],"subject":[],"published":{"date-parts":[[2023,11,18]]}}}