{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T01:47:17Z","timestamp":1792374437193,"version":"4.4.0"},"reference-count":91,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T00:00:00Z","timestamp":1700524800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Neural Therapy Research Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>The use of low-dose local anesthetics (LAs) has significantly transformed patient care by providing rapid and effective relief of pain and other clinical conditions while minimizing recovery time. This study aims to identify and describe the existing scientific evidence on the therapeutic use of low-dose LAs in various conditions and to identify gaps in the current literature in order to prioritize future research. This systematic scoping review adhered to the methodological guidelines outlined in the Arksey and O\u2019Malley framework, which includes five distinct stages. Of the 129 studies included, 37.98% (n = 49) were clinical trials, 55.03% (n = 71) were observational studies, and 6.97% (n = 9) were systematic reviews. The most commonly reported indication for the use of low-dose LAs was chronic pain management (72.86%), followed by acute pain management (13.17%). Additionally, non-pain-related indications were also identified (13.95%). Overall, the administration of low-dose, short-acting LAs demonstrated favorable outcomes in terms of pain management and reduction in anxiety and depression scales, thereby having a positive impact on the patients\u2019 quality of life. This review represents the first systematic scoping review regarding the therapeutic role of LAs. To substantiate the reported positive effects on efficacy and safety, further rigorous research comprising larger, well-designed randomized controlled trials (RCTs) and long-term outcome monitoring is imperative.<\/jats:p>","DOI":"10.3390\/jcm12237221","type":"journal-article","created":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T12:12:13Z","timestamp":1700568733000},"page":"7221","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Therapeutic Use of Low-Dose Local Anesthetics in Pain, Inflammation, and Other Clinical Conditions: A Systematic Scoping Review"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4226-7654","authenticated-orcid":false,"given":"David","family":"Vinyes","sequence":"first","affiliation":[{"name":"Institute of Neural Therapy and Regulatory Medicine, 08202 Sabadell, Spain"},{"name":"Master of Permanent Training in Medical and Dental Neural Therapy, University of Barcelona\u2014IL3, 08018 Barcelona, Spain"},{"name":"Neural Therapy Research Foundation, 08202 Sabadell, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9973-9304","authenticated-orcid":false,"given":"Montserrat","family":"Mu\u00f1oz-Sellart","sequence":"additional","affiliation":[{"name":"Institute of Neural Therapy and Regulatory Medicine, 08202 Sabadell, Spain"},{"name":"Master of Permanent Training in Medical and Dental Neural Therapy, University of Barcelona\u2014IL3, 08018 Barcelona, Spain"},{"name":"Neural Therapy Research Foundation, 08202 Sabadell, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6809-5550","authenticated-orcid":false,"given":"Lorenz","family":"Fischer","sequence":"additional","affiliation":[{"name":"Formerly Neural Therapy, Institute of Complementary and Integrative Medicine (IKIM), University of Bern, 3012 Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1213\/00000539-192801000-00004","article-title":"Personal reminiscences of the first use of cocaine as local anesthetic in eye surgery","volume":"7","author":"Koller","year":"1928","journal-title":"Curr. Res. Anesth. Analg."},{"key":"ref_2","first-page":"345","article-title":"Die Bedeutung der An\u00e4sthesie in der Entz\u00fcndungstheorie","volume":"53","author":"Spiess","year":"1906","journal-title":"M\u00fcnch Med. Wschr."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.arthe.2012.12.004","article-title":"Neural therapy-Areview of the therapeutic use of local anesthetics","volume":"1","author":"Weinschenk","year":"2012","journal-title":"Acupunct. Relat. Ther."},{"key":"ref_4","unstructured":"Barop, H. (2018). Textbook and Atlas of Neural Therapy: Diagnosis and Therapy with Local Anesthetics, Thieme. [1st ed.]."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Fischer, L. (2019). Neuraltherapie: Neurophysiologie, Injektionstechnik und Therapievorschl\u00e4ge, Thieme. [5th ed.].","DOI":"10.1055\/b-006-163231"},{"key":"ref_6","first-page":"1013","article-title":"Unbekannte Fernwirkung der Neuraltherapie","volume":"27","author":"Huneke","year":"1928","journal-title":"Die Med. Welt"},{"key":"ref_7","first-page":"849","article-title":"L\u2019anesth\u00e9sie du ganglion \u00e9toile: Sa technique, ses indications, ses r\u00e9sultats","volume":"42","author":"Leriche","year":"1934","journal-title":"Presse M\u00e9d."},{"key":"ref_8","unstructured":"Dosch, P. (1995). Lehrbuch der Neuraltherapie nach Huneke, Haug. 14. Aufl."},{"key":"ref_9","unstructured":"Fischer, L., Barop, H., and Maxion-Bergemann, S. (2005). Health Technology Assessment HTA Neural Therapy, A nationwide evaluation funded by the Swiss Federal Office of Public Health, submited to the Swiss Federal Office of Public Health, Bern, Switzerland."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Mermod, J., Fischer, L., Staub, L., and Busato, A. (2008). Patient satisfaction of primary care for musculoskeletal diseases: A comparison between Neural Therapy and conventional medicine. BMC Complement. Altern. Med., 8.","DOI":"10.1186\/1472-6882-8-33"},{"key":"ref_11","unstructured":"D\u00f6nges, A., Fischer, L., Marian, F., Widmer, M., Herren, S., and Busato, A. (2005). Evaluation of Neural Therapy and Comparison with Conventional Medicine: Structure, Process an Outcomes. A Nationwide Evaluation Funded by the Swiss Federal Office of Public Health. [Ph.D. Thesis, University of Bern]."},{"key":"ref_12","unstructured":"Bissig, P., Schoeni-Affolter, F., Fischer, L., and Busato, A. (2008). Is Neural Therapy Cheaper than Conventional Medicine? A Comparison of Cost Structure in Swiss Primary Care Providers. An Observational Study as a Part of a Nationwide Evaluation Funded by the Swiss Federal Office of Public Health. [Ph.D. Thesis, University of Bern]."},{"key":"ref_13","first-page":"595","article-title":"The sympathetic nerve\u2013an integrative interface between two supersystems: The brain and the immune system","volume":"52","author":"Elenkov","year":"2000","journal-title":"Pharmacol. Rev."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1038\/nri2566","article-title":"Reflex control of immunity","volume":"9","author":"Tracey","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1146\/annurev-immunol-042617-053158","article-title":"Molecular and Functional Neuroscience in Immunity","volume":"36","author":"Pavlov","year":"2018","journal-title":"Annu. Rev. Immunol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"J\u00e4nig, W. (2022). The Integrative Action of the Autonomic Nervous System, Cambridge University Press. [2nd ed.].","DOI":"10.1017\/9781108778411"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"102903","DOI":"10.1016\/j.autneu.2021.102903","article-title":"Regulation of acute reflectory hyperinflammation in viral and other diseases by means of stellate ganglion block. A conceptual view with a focus on COVID-19","volume":"237","author":"Fischer","year":"2022","journal-title":"Auton. Neurosci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1159\/000522391","article-title":"The Influence of Modern Neurophysiology on the Previous Definitions of \u201cSegment\u201d and \u201cInterference Field\u201d in Neural Therapy","volume":"29","author":"Engel","year":"2022","journal-title":"Complement. Med. Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"697335","DOI":"10.3389\/fphys.2021.697335","article-title":"Investigation of the Sympathetic Regulation in Delayed Onset Muscle Soreness: Results of an RCT","volume":"12","author":"Fleckenstein","year":"2021","journal-title":"Front. Physiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.autneu.2016.04.002","article-title":"Effects on hemodynamic variables and echocardiographic parameters after stellate ganglion block in 15 healthy volunteers","volume":"197","author":"Roqueta","year":"2016","journal-title":"Auton. Neurosci."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Egli, S., Pfister, M., Ludin, S.M., Puente de la Vega, K., Busato, A., and Fischer, L. (2015). Long-term results of therapeutic local anesthesia (neural therapy) in 280 referred refractory chronic pain patients. BMC Complement. Altern. Med., 15.","DOI":"10.1186\/s12906-015-0735-z"},{"key":"ref_22","first-page":"9137215","article-title":"Severe case of chronic pelvic pain syndrome: Recovery after injection of procaine into the vesicoprostatic plexus-case report and discussion of pathophysiology and mechanisms of action","volume":"2018","author":"Kronenberg","year":"2018","journal-title":"Case Rep. Urol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1159\/000529293","article-title":"Chronic Therapy-Resistant Neck Pain in a Fifty-Year-Old Man: The Role of Partially Impacted Third Molars\u2014Case Report and New Pathophysiological Insights","volume":"30","author":"Fischer","year":"2023","journal-title":"Complement. Med. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"3000605231164479","DOI":"10.1177\/03000605231164479","article-title":"A case of severe trigeminal neuralgia: Recovery by means of stellate ganglion block with procaine. Discussion of possible mechanisms of action","volume":"51","author":"Lopes","year":"2023","journal-title":"J. Int. Med. Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1024\/0369-8394.92.48.2051","article-title":"Pathophysiology of pain and neural therapy","volume":"92","author":"Fischer","year":"2003","journal-title":"Praxis"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1186\/s13075-014-0470-8","article-title":"Nociceptive neurons detect cytokines in arthritis","volume":"16","author":"Schaible","year":"2014","journal-title":"Arthritis Res. Ther."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.autneu.2013.12.004","article-title":"Function of the sympathetic supply in acute and chronic experimental joint inflammation","volume":"182","author":"Schaible","year":"2014","journal-title":"Auton. Neurosci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1038\/nature01321","article-title":"The inflammatory reflex","volume":"420","author":"Tracey","year":"2002","journal-title":"Nature"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Wood, J.N. (2018). The Oxford Handbook of the Neurobiology of Pain, Oxford University Press.","DOI":"10.1093\/oxfordhb\/9780190860509.001.0001"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e29358","DOI":"10.1097\/MD.0000000000029358","article-title":"Local anesthetics as a therapeutic tool for post COVID-19 patients: A case report","volume":"101","author":"Vinyes","year":"2022","journal-title":"Medicine"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1159\/000514945","article-title":"Treatment of Localized Vulvar Pain with Neural Therapy: A Case Series and Literature Review","volume":"28","author":"Rey","year":"2021","journal-title":"Complement. Med. Res."},{"key":"ref_32","first-page":"565","article-title":"Effect of Neural Therapy on shoulder dysfunction and pain in supraspinatus tendinopathy","volume":"38 Pt I","author":"Bashan","year":"2022","journal-title":"Pak. J. Med. Sci."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.3233\/BMR-170980","article-title":"Evaluation of neural therapy effect in patients with piriformis syndrome","volume":"31","author":"Ural","year":"2018","journal-title":"J. Back Musculoskelet. Rehabil."},{"key":"ref_34","first-page":"pnad011","article-title":"Stellate Ganglion Block for Non-Pain Indications: A Scoping Review","volume":"2","author":"Feigin","year":"2023","journal-title":"Pain Med."},{"key":"ref_35","unstructured":"Fischer, L., Ludin, S.M., Thommen, D., and Hausammann, R. (2010). Application for the Adoption of Interference Field Therapy (Huneke\u2019s Neural Therapy) into the Health Benefit Basket of the Compulsory Health Insurance, submitted to the Federal Commission for General Health Insurance Benefits and Fundamental Health Issues and the Federal Department of Home Affaires (EDI) in the Federal Office of Public Health (BAG), submited to\u00a0BAG."},{"key":"ref_36","first-page":"35","article-title":"Therapy of articular and periarticular pain with local anesthetics (neural therapy a. t. Huneke). Long and short term results","volume":"64","author":"Barbagli","year":"1998","journal-title":"Minerva Anesth."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1089\/acm.1999.5.543","article-title":"Neural therapy in the treatment of multiple sclerosis","volume":"5","author":"Gibson","year":"1999","journal-title":"J. Altern. Complement. Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"194","DOI":"10.12659\/MSM.883833","article-title":"Cervical sympathetic block regulates early systemic inflammatory response in severe trauma patients","volume":"19","author":"Liu","year":"2013","journal-title":"Med. Sci. Monit."},{"key":"ref_39","first-page":"15630","article-title":"Impacts of stellate ganglion block on plasma NF-\u03baB and inflammatory factors of TBI patients","volume":"8","author":"Yang","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"533","DOI":"10.3748\/wjg.v23.i3.533","article-title":"Efficacy and safety of stellate ganglion block in chronic ulcerative colitis","volume":"23","author":"Zhao","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"351","DOI":"10.5114\/wiitm.2019.89653","article-title":"Faiz SHR: Effects of ultrasound guided ganglion stellate blockade on intraoperative and postoperative hemodynamic responses in laparoscopic gynecologic surgery","volume":"15","author":"Rahimzadeh","year":"2020","journal-title":"Videosurgery Miniinv"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.ijcard.2017.10.042","article-title":"Bilateral sphenopalatine ganglion block reduces blood pressure in never treated patients with essential hypertension. A randomized controlled single-blinded study","volume":"250","author":"Triantafyllidi","year":"2018","journal-title":"Int. J. Cardiol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/j.1445-2197.2010.05573.x","article-title":"Intraperitoneal local anaesthetic in abdominal surgery\u2014A systematic review","volume":"81","author":"Kahokehr","year":"2011","journal-title":"ANZ J. Surg."},{"key":"ref_44","first-page":"431","article-title":"Comparison of efficacy of neural therapy and physical therapy in chronic low back pain","volume":"10","author":"Atalay","year":"2013","journal-title":"Afr. J. Tradit. Complement. Altern. Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.7205\/MILMED-D-15-00518","article-title":"Effect of Stellate Ganglion Block on Specific Symptom Clusters for Treatment of Post-Traumatic Stress Disorder","volume":"181","author":"Lynch","year":"2016","journal-title":"Mil. Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/j.1533-2500.2008.00238.x","article-title":"Nerve stimulator-guided occipital nerve blockade for postdural puncture headache","volume":"9","author":"Naja","year":"2009","journal-title":"Pain Pract."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.3906\/sag-2009-101","article-title":"Comparison of greater occipital nerve and greater occipital nerve + supraorbital nerve block effect in chronic medication overuse headache","volume":"51","author":"Tepe","year":"2021","journal-title":"Turk. J. Med. Sci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3344\/kjp.2017.30.1.3","article-title":"Effects of applying nerve blocks to prevent postherpetic neuralgia in patients with acute herpes zoster: A systematic review and meta-analysis","volume":"30","author":"Kim","year":"2017","journal-title":"Korean J. Pain"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.clineuro.2017.12.026","article-title":"The efficacy of greater occipital nerve block for the treatment of migraine: A systematic review and meta-analysis","volume":"165","author":"Zhang","year":"2018","journal-title":"Clin. Neurol. Neurosurg."},{"key":"ref_50","first-page":"57","article-title":"Treatment of acute orofacial pain with lower cervical intramuscular bupivacaine injections: A 1-year retrospective review of 114 patients","volume":"22","author":"Mellick","year":"2008","journal-title":"J. Orofac. Pain"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Vinyes, D., Hermosilla Traverso, P., Murillo, J.H., S\u00e1nchez-Padilla, M., and Mu\u00f1oz-Sellart, M. (2023). Improvement in post-orthodontic chronic musculoskeletal pain after local anesthetic injections in the trigeminal area: A case series. J. Int. Med. Res., in\u00a0press.","DOI":"10.1177\/03000605231214064"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"467","DOI":"10.7326\/M18-0850","article-title":"PRISMA Extension for Scoping Reviews (PRISMA-ScR): Checklist and Explanation","volume":"169","author":"Tricco","year":"2018","journal-title":"Ann. Intern. Med."},{"key":"ref_53","first-page":"359","article-title":"Evaluation of PICO as a knowledge representation for clinical questions","volume":"2006","author":"Huang","year":"2006","journal-title":"AMIA Annu. Symp. Proc."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Fischer, L., and Peuker, E.T. (2011). Lehrbuch der Integrativen Schmerztherapie, Haug.","DOI":"10.1007\/978-3-8348-8333-9"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1097\/ACO.0b013e328339eef2","article-title":"Update on local anesthetics","volume":"23","author":"Borgeat","year":"2010","journal-title":"Curr. Opin. Anaesthesiol."},{"key":"ref_56","first-page":"119","article-title":"Influence of regional anesthesia, local anesthetics, and sympathicomimetics on the pathophysiology of deep vein thrombosis","volume":"550","author":"Modig","year":"1989","journal-title":"Acta Chir. Scand. Suppl."},{"key":"ref_57","first-page":"4984","article-title":"Procaine is a DNA-demethylating agent with growth-inhibitory effects in human cancer cells","volume":"63","author":"Fraga","year":"2003","journal-title":"Cancer Res."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"3617042","DOI":"10.1155\/2021\/3617042","article-title":"Procaine-The Controversial Geroprotector Candidate: New Insights Regarding its Molecular and Cellular Effects","volume":"2021","author":"Gradinaru","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Zhu, G., Zhang, L., Dan, J., and Zhu, Q. (2020). Differential effects and mechanisms of local anesthetics on esophaeal carcinoma cell migration, growth, survival and chemosensitivity. BMC Anesthesiol., 20.","DOI":"10.1186\/s12871-020-01039-1"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"3318","DOI":"10.1200\/JCO.22.01966","article-title":"Effect of Peritumoral Infiltration of Local Anesthetic Before Surgery on Survival in Early Breast Cancer","volume":"41","author":"Badwe","year":"2023","journal-title":"J. Clin. Oncol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1097\/00000542-200009000-00038","article-title":"Local anaesthetics and the inflammatory response: A new therapeutic indication?","volume":"93","author":"Hollmann","year":"2000","journal-title":"Anaesthesiology"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/j.1399-6576.2006.00936.x","article-title":"Anti-inflammatory properties of local anesthetics and their present and potential clinical implications","volume":"50","author":"Cassuto","year":"2006","journal-title":"Acta Anaesthesiol. Scand."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1213\/01.ANE.0000078586.82810.3B","article-title":"The effects of postoperative pain management on immune response to surgery","volume":"97","author":"Beilin","year":"2003","journal-title":"Anesth. Analg."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1097\/EJA.0000000000000137","article-title":"Local anaesthetics: 10 essentials","volume":"31","author":"Lirk","year":"2014","journal-title":"Eur. J. Anaesthesiol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1213\/01.ANE.0000060454.34258.D3","article-title":"Local anesthetics differentially inhibit sympathetic neuron-mediated and C fiber-mediated synovial neurogenic plasma extravasation","volume":"96","author":"Pietruck","year":"2003","journal-title":"Anesth. Analg."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Ricker, G. (1924). Pathologie als Naturwissenschaft, Relationspathologie, Springer.","DOI":"10.1007\/978-3-642-51342-8"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1126\/science.150.3699.971","article-title":"Pain mechanisms; a new theory","volume":"150","author":"Melzack","year":"1965","journal-title":"Science"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1007\/s001010050517","article-title":"Schmerzsyndrome mit kausaler Beteiligung des Sympathikus","volume":"47","author":"Baron","year":"1998","journal-title":"Anaesthesist"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1126\/science.2011742","article-title":"Adrenergic excitation of cutaneous pain receptors incuced by peripheral nerve injury","volume":"251","author":"Sato","year":"1991","journal-title":"Science"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1111\/j.1469-7793.1999.533ac.x","article-title":"Expression of alpha2-adrenergic receptors in rat primary afferent neurones after peripheral nerve injury or inflammation","volume":"515","author":"Birder","year":"1999","journal-title":"J. Physiol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.autneu.2014.01.006","article-title":"Autonomic regulation of cellular immune function","volume":"182","author":"Bellinger","year":"2014","journal-title":"Auton. Neurosci."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/363543a0","article-title":"Peripheral nerve injury triggers noradrenergic sprouting within dorsal root ganglia","volume":"363","author":"McLachlan","year":"1993","journal-title":"Nature"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/S0006-8993(01)02092-3","article-title":"Sympathetic sprouting in the dorsal root ganglion after spinal nerve ligation: Evidence of regenerative collateral sprouting","volume":"895","author":"Chung","year":"2001","journal-title":"Brain Res."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0304-3959(97)03331-9","article-title":"Rapid sprouting of sympathetic axons in dorsal root ganglia of rats with a chronic constriction injury","volume":"70","author":"Ramer","year":"1997","journal-title":"Pain"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1213\/01.ane.0000194334.69103.50","article-title":"Local anesthetics suppress nerve growth factor-mediated neurite outgrowth by inhibition of tyrosine kinase activity of TrkA","volume":"102","author":"Takatori","year":"2006","journal-title":"Anesth. Analg."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.pain.2004.01.033","article-title":"Decreasing sympathetic sprouting in pathologic sensory ganglia: A new mechanism for treating neuropathic pain using lidocaine","volume":"109","author":"Zhang","year":"2004","journal-title":"Pain"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0304-3959(00)00424-3","article-title":"Learning and memory in pain pathways","volume":"88","year":"2000","journal-title":"Pain"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.pneurobio.2005.02.002","article-title":"Plasticity of synaptic transmission in autonomic ganglia","volume":"75","author":"Alkadhi","year":"2005","journal-title":"Prog. Neurobiol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1097\/00000542-199912000-00034","article-title":"Dibucaine and tetracaine inhibit the activation of mitogen-activated protein kinase mediated by L-type calcium channels in PC12 cells","volume":"91","author":"Kansha","year":"1999","journal-title":"Anesthesiology"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1097\/00000542-199910000-00022","article-title":"Local anaesthetics inhibit muscarinic receptor-mediated activation of extracellular sign regulated kinases in rat feochromocytoma PC12 cells","volume":"91","author":"Tan","year":"1999","journal-title":"Anesthesiology"},{"key":"ref_81","unstructured":"Fischer Land Peuker, E.T. (2011). Lehrbuch Integrative Schmerztherapie, Haug."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1046\/j.1365-201X.2003.01075.x","article-title":"Transmission of signals through sympathetic ganglia\u2014Modulation, integration or simply distribution?","volume":"177","author":"McLachlan","year":"2003","journal-title":"Acta Physiol. Scand."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1186\/ar3305","article-title":"Update on peripheral mechanisms of pain: Beyond prostaglandins and cytokines","volume":"13","author":"Schaible","year":"2011","journal-title":"Arthritis Res. Ther."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1111\/anae.12774","article-title":"Analgesic efficacy of pre-operative stellate ganglion block on postoperative pain relief: A randomised controlled trial","volume":"69","author":"Kumar","year":"2014","journal-title":"Anaesthesia"},{"key":"ref_85","first-page":"595","article-title":"Electrical storm secondary to acute myocardial infarction and heart failure treated with left stellate ganglion block","volume":"66","year":"2013","journal-title":"Rev. Esp. Cardiol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"9505","DOI":"10.7314\/APJCP.2014.15.21.9505","article-title":"Effects of stellate ganglion block on the peri-operative vasomotor cytokine content and intrapulmonary shunt in patients with esophagus cancer","volume":"15","author":"Guo","year":"2014","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.mehy.2012.11.017","article-title":"Stellate ganglion block may prevent the development of neurogenic pulmonary edema and improve the outcome","volume":"80","author":"Zhang","year":"2013","journal-title":"Med. Hypotheses"},{"key":"ref_88","first-page":"676","article-title":"Neuraltherapie in der Notfallmedizin","volume":"9","author":"Fischer","year":"1995","journal-title":"\u00c4rztez f NHV"},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Patel, R.A., Priore, D.L., Szeto, W.Y., and Slevin, K.A. (2011). Left Stellate Ganglion Blockade for the Management of Drug-Resistant Electrical Storm. Pain Med., 4610\u20134637.","DOI":"10.1111\/j.1526-4637.2011.01167.x"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"e473","DOI":"10.7205\/MILMED-D-12-00386","article-title":"Efficacy of stellate ganglion block in the treatment of anxiety symptoms from combat-related post-traumatic stress disorder: A case series","volume":"178","author":"Alino","year":"2013","journal-title":"Mil. Med."},{"key":"ref_91","first-page":"e35174","article-title":"A review of Stellate Ganglion Block as an Adjunctive Treatment Modality","volume":"15","author":"Kirkpatrick","year":"2023","journal-title":"Cureus"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/23\/7221\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:26:30Z","timestamp":1760131590000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/23\/7221"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,21]]},"references-count":91,"journal-issue":{"issue":"23","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["jcm12237221"],"URL":"https:\/\/doi.org\/10.3390\/jcm12237221","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,21]]}}}