{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:42:54Z","timestamp":1760150574742,"version":"build-2065373602"},"reference-count":67,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T00:00:00Z","timestamp":1700697600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Edwards Lifesciences (Nyon, Switzerland)","award":["THV-I23-092"],"award-info":[{"award-number":["THV-I23-092"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Introduction: Due to the selective criteria and short-term follow-up of previous transcatheter aortic valve implantation (TAVI) trials, the coronary revascularization incidence after TAVI has been difficult to determine. This study investigated the epidemiology of coronary revascularization after surgical aortic valve replacement (SAVR) and TAVI in patients with severe aortic valve stenosis (AS), with and without coronary artery disease (CAD), in a mid-term follow-up, single-center, real-world setting. Methods: Between 2010 to 2020, 1486 patients with AS underwent SAVR or TAVI with balloon-expandable Edwards\u00ae transcatheter heart valves (THVs). Using hospital discharge records, we could estimate for each patient resident in Emilia Romagna the rate of ischemic events treated with percutaneous coronary intervention (PCI). A subgroup without CAD was also analyzed. Results: The 5-year overall survival was 78.2%. Freedom from PCI after AVR and TAVI at 5 years was 96.9% and 96.9%, respectively, with previous PCI as a predictor (HR 4.86, 95% CI 2.57\u20139.21 p &lt; 0.001). The freedom from PCI curves were not significantly different. Conclusions: Notwithstanding the aged population, the revascularization incidence was only 2.4%, requiring further evaluation even in younger patients with longer follow-up. Despite the profile frame raise due to the evolution of Edwards\u00ae balloon-expandable THVs, PCI or coronarography feasibility were not compromised in our population.<\/jats:p>","DOI":"10.3390\/jcm12237257","type":"journal-article","created":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T06:06:23Z","timestamp":1700719583000},"page":"7257","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Coronary Revascularization after Transcatheter and Surgical Aortic Valve Replacement"],"prefix":"10.3390","volume":"12","author":[{"given":"Davide","family":"Gabbieri","sequence":"first","affiliation":[{"name":"Cardiac Surgery Unit, Department of Medical-Surgical Cardiology, Hesperia Hospital Modena, 41125 Modena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6154-9111","authenticated-orcid":false,"given":"Federico","family":"Giorgi","sequence":"additional","affiliation":[{"name":"Cardiac Surgery Unit, Department of Surgical, Medical and Molecular Pathology and Critical Care, Azienda Ospedaliero Universitaria Pisana, University of Pisa, 56126 Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Greta","family":"Mascheroni","sequence":"additional","affiliation":[{"name":"Cardiac Surgery Unit, Department of Medical-Surgical Cardiology, Hesperia Hospital Modena, 41125 Modena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1299-7496","authenticated-orcid":false,"given":"Matteo","family":"Chiarabelli","sequence":"additional","affiliation":[{"name":"Edwards Lifesciences, 20141 Milano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"D\u2019Anniballe","sequence":"additional","affiliation":[{"name":"Cardiac Surgery Unit, Department of Medical-Surgical Cardiology, Hesperia Hospital Modena, 41125 Modena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Meli","sequence":"additional","affiliation":[{"name":"Cardiac Surgery Unit, Department of Medical-Surgical Cardiology, Hesperia Hospital Modena, 41125 Modena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clorinda","family":"Labia","sequence":"additional","affiliation":[{"name":"Cardiac Surgery Unit, Department of Medical-Surgical Cardiology, Hesperia Hospital Modena, 41125 Modena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Italo","family":"Ghidoni","sequence":"additional","affiliation":[{"name":"Cardiac Surgery Unit, Department of Medical-Surgical Cardiology, Hesperia Hospital Modena, 41125 Modena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1056\/NEJMoa1008232","article-title":"Transcatheter aortic-valve implantation for aortic stenosis in patients who cannot undergo surgery","volume":"363","author":"Leon","year":"2010","journal-title":"N. 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