{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:05:33Z","timestamp":1790730333624,"version":"4.1.0"},"reference-count":25,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T00:00:00Z","timestamp":1700697600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Open Access Publication Fund of the University of M\u00fcnster"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>We compare the short- and mid-term postoperative outcomes of the iStent inject\u00ae with its successor, the iStent inject\u00ae W. A retrospective monocentric study was performed to compare the iStent inject\u00ae used for cataract surgery with the iStent inject\u00ae W, also used for cataract surgery. The primary study endpoint was intraocular pressure (IOP) reduction six months after surgery. Six-month follow-up results were available for 35 eyes from 27 patients in the iStent inject\u00ae group and for 32 eyes from 25 patients in the iStent inject\u00ae W group. IOP reduction at six months post surgery was significantly greater in the iStent inject\u00ae W group (\u22122.2 mmHg [iStent inject\u00ae W] vs. \u22120.06 mmHg [iStent inject\u00ae], p = 0.037). There was a statistically greater decrease in glaucoma medication administration at six months in the iStent inject\u00ae group than in the iStent inject\u00ae W group (\u22121.28 agents vs. \u22120.62 agents, p = 0.007). These findings support the hypothesis that the superior positioning of the iStent inject\u00ae W (due to its larger base diameter) compared to the iStent Inject\u00ae leads to greater IOP reduction. Because of the short follow-up period, small study cohort, and differences in the number of glaucoma patients, the study results must be interpreted carefully.<\/jats:p>","DOI":"10.3390\/jcm12237259","type":"journal-article","created":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T06:06:23Z","timestamp":1700719583000},"page":"7259","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Comparison of the iStent Inject\u00ae versus the iStent Inject\u00ae W\u2014Both in Combination with Cataract Surgery\u2014In Open-Angle Glaucoma"],"prefix":"10.3390","volume":"12","author":[{"given":"Steffen","family":"Deneri","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, University M\u00fcnster, 48149 M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph-Laurent","family":"Mert\u00e9","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University M\u00fcnster, 48149 M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Eter","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University M\u00fcnster, 48149 M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5536-8043","authenticated-orcid":false,"given":"Viktoria C.","family":"Br\u00fccher","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University M\u00fcnster, 48149 M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1016\/j.ophtha.2015.02.029","article-title":"Special Commentary: Supporting Innovation for Safe and Effective Minimally Invasive Glaucoma Surgery: Summary of a Joint Meeting of the American Glaucoma Society and the Food and Drug Administration, Washington, DC, 26 February 2014","volume":"122","author":"Caprioli","year":"2015","journal-title":"Ophthalmology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1016\/j.ophtha.2011.03.028","article-title":"Novel glaucoma procedures: A report by the American Academy of Ophthalmology","volume":"118","author":"Francis","year":"2011","journal-title":"Ophthalmology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"67","DOI":"10.5005\/jp-journals-10028-1248","article-title":"Efficacy and Adverse Event Profile of the iStent and iStent Inject Trabecular Micro-bypass for Open-angle Glaucoma: A Meta-analysis","volume":"12","author":"Popovic","year":"2018","journal-title":"J. Curr. Glaucoma Pract."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2731856","DOI":"10.1155\/2016\/2731856","article-title":"iStent\u00ae Trabecular Microbypass Stent: An Update","volume":"2016","author":"Resende","year":"2016","journal-title":"J. Ophthalmol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.ogla.2019.03.004","article-title":"Five-Year, Prospective, Randomized, Multi-Surgeon Trial of Two Trabecular Bypass Stents versus Prostaglandin for Newly Diagnosed Open-Angle Glaucoma","volume":"2","author":"Fechtner","year":"2019","journal-title":"Ophthalmol. Glaucoma"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1097\/IJG.0000000000002141","article-title":"Effectiveness and Safety of iStent Infinite Trabecular Micro-Bypass for Uncontrolled Glaucoma","volume":"32","author":"Sarkisian","year":"2023","journal-title":"J. Glaucoma"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"105","DOI":"10.5005\/jp-journals-10078-1374","article-title":"Efficacy and Safety of iStent Inject Implantation in Manual and Femtosecond Laser-assisted Cataract Surgery before Lens Extraction","volume":"16","author":"Manning","year":"2022","journal-title":"J. Curr. Glaucoma Pract."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Malvankar-Mehta, M.S., Iordanous, Y., Chen, Y.N., Wang, W.W., Patel, S.S., Costella, J., and Hutnik, C.M.L. (2015). iStent with Phacoemulsification versus Phacoemulsification Alone for Patients with Glaucoma and Cataract: A Meta-Analysis. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0131770"},{"key":"ref_9","unstructured":"Glaukos Corporation (2022, May 05). iStent Inject\u00ae W. Available online: https:\/\/www.glaukos.com\/glaucoma\/products\/istent-inject-w\/."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1016\/j.ajo.2011.12.017","article-title":"Second-generation trabecular meshwork bypass stent (iStent inject) increases outflow facility in cultured human anterior segments","volume":"153","author":"Bahler","year":"2012","journal-title":"Am. J. Ophthalmol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.jcrs.2017.02.029","article-title":"Trabecular microbypass stent implantation with cataract extraction in pseudoexfoliation glaucoma","volume":"43","author":"Ferguson","year":"2017","journal-title":"J. Cataract. Refract. Surg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s40123-018-0152-8","article-title":"Prospective, Non-randomized, 36-Month Study of Second-Generation Trabecular Micro-Bypass Stents with Phacoemulsification in Eyes with Various Types of Glaucoma","volume":"7","author":"Hengerer","year":"2018","journal-title":"Ophthalmol. Ther."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2488","DOI":"10.4103\/ijo.IJO_308_21","article-title":"iStent versus iStent inject implantation combined with phacoemulsification in open angle glaucoma","volume":"69","author":"Shalaby","year":"2021","journal-title":"Indian J. Ophthalmol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s40123-019-0166-x","article-title":"Intermediate Results of iStent or iStent inject Implantation Combined with Cataract Surgery in a Real-World Setting: A Longitudinal Retrospective Study","volume":"8","author":"Guedes","year":"2019","journal-title":"Ophthalmol. Ther."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s40123-019-00208-x","article-title":"Real-world Case Series of iStent or iStent inject Trabecular Micro-Bypass Stents Combined with Cataract Surgery","volume":"8","author":"Manning","year":"2019","journal-title":"Ophthalmol. Ther."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/j.jcrs.2012.03.025","article-title":"Cataract surgery with trabecular micro-bypass stent implantation in patients with mild-to-moderate open-angle glaucoma and cataract: Two-year follow-up","volume":"38","author":"Craven","year":"2012","journal-title":"J. Cataract. Refract. Surg."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.ophtha.2010.07.007","article-title":"Randomized evaluation of the trabecular micro-bypass stent with phacoemulsification in patients with glaucoma and cataract","volume":"118","author":"Samuelson","year":"2011","journal-title":"Ophthalmology"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1111\/ceo.12098","article-title":"Manchester iStent study: Early results from a prospective UK case series","volume":"41","author":"Patel","year":"2013","journal-title":"Clin. Exp. Ophthalmol."},{"key":"ref_19","first-page":"321","article-title":"One-year analysis of the iStent trabecular microbypass in secondary glaucoma","volume":"5","author":"Buchacra","year":"2011","journal-title":"Clin. Ophthalmol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1097\/IJG.0000000000001805","article-title":"Standalone iStent Trabecular Micro-bypass Glaucoma Surgery: A Systematic Review and Meta-Analysis","volume":"30","author":"Healey","year":"2021","journal-title":"J. Glaucoma"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/ceo.14048","article-title":"Comparative study of 2-year outcomes for Hydrus or iStent inject microinvasive glaucoma surgery implants with cataract surgery","volume":"50","author":"Holmes","year":"2022","journal-title":"Clin. Exp. Ophthalmol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"3035","DOI":"10.1007\/s00417-021-05133-z","article-title":"Comparison of 1-year surgical outcomes of combined cataract surgery and gonioscopy-assisted transluminal trabeculotomy (GATT) versus cataract surgery and iStent Inject","volume":"259","author":"Hamze","year":"2021","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1007\/s00417-020-04621-y","article-title":"Dynamics of structural reversal in Bruch\u2019s membrane opening-based morphometrics after glaucoma drainage device surgery","volume":"258","author":"Gietzelt","year":"2020","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.ogla.2019.09.003","article-title":"Effect of Trabeculectomy on OCT Measurements of the Optic Nerve Head Neuroretinal Rim Tissue","volume":"3","author":"Sanchez","year":"2020","journal-title":"Ophthalmol. Glaucoma"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.2147\/OPTH.S298045","article-title":"Changes of Neuroretinal Rim and Retinal Nerve Fiber Layer Thickness Assessed by Optical Coherence Tomography After Filtration Surgery in Glaucomatous Eyes","volume":"15","author":"Koenig","year":"2021","journal-title":"Clin. Ophthalmol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/23\/7259\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:28:18Z","timestamp":1760131698000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/23\/7259"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,23]]},"references-count":25,"journal-issue":{"issue":"23","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["jcm12237259"],"URL":"https:\/\/doi.org\/10.3390\/jcm12237259","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,23]]}}}