{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:42:02Z","timestamp":1760150522146,"version":"build-2065373602"},"reference-count":40,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T00:00:00Z","timestamp":1701129600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>The relationships between CEUS parameters of adnexal tumours and postoperative immunohistochemical assessments of CD34, CD105 and bcl-2 were analysed. This study aimed to investigate whether contrast-enhanced ultrasonography (CEUS) parameters depend on the microvascular density of the tumour lesion found after surgery. Fifty-one patients with a diagnosis of adnexal tumours were included in this single-centre, prospective study. Participants underwent preoperative CEUS (contrast-enhanced ultrasound). Colour Doppler enhancement characterisation parameters (Ystart, Ymax and S) were determined. Immunohistochemical examination of histological specimens of the adnexal lesions was then carried out to determine the expression levels of the CD34, CD105 and bcl-2 proteins. Relationships between the aforementioned parameters were investigated. No significant statistical correlations were observed between CD34, CD105 and bcl2 expression levels and CEUS parameters, independently of whether the operated lesion was malignant or benign. Transvaginal CEUS is diagnostic for the detection of pathological neoplastic vascularisation of an adnexal lesion independent of the density of microcapillaries found postoperatively.<\/jats:p>","DOI":"10.3390\/jcm12237372","type":"journal-article","created":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T07:41:32Z","timestamp":1701157292000},"page":"7372","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Relationships between CD34-, CD105- and bcl-2-Expression Levels and Contrast-Enhanced Ultrasound-Based Differential Diagnosis of Adnexal Tumours"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3937-5710","authenticated-orcid":false,"given":"Marek","family":"Szymanski","sequence":"first","affiliation":[{"name":"Clinic of Gynaecology, Oncological Gynaecology and Gynaecological Endocrinology, 10th Military Research Hospital and Polyclinic, IPHC, Powsta\u0144c\u00f3w Warszawy Str. 5, 85-681 Bydgoszcz, Poland"},{"name":"Department of Obstetrics, Female Pathology and Oncological Gynaecology, University Hospital No. 2, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus, University in Toru\u0144, Ujejskiego St. 75, 85-168 Bydgoszcz, Poland"},{"name":"NZOZ Centrum Medyczne \u201eGenesis\u201d-Clinic of Infertility Treatment, Waleniowa Str., 24, 85-435 Bydgoszcz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iwona","family":"Florczyk","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Independent Public Health Care, Tadeusza Ko\u015bciuszki 6, 88-300 Mogilno, Poland"},{"name":"Individual Medical Practice Iwona Florczyk, Wesolowskich 5\/3, 88-300 Mogilno, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radoslaw","family":"Janicki","sequence":"additional","affiliation":[{"name":"Clinic of Gynaecology, Oncological Gynaecology and Gynaecological Endocrinology, 10th Military Research Hospital and Polyclinic, IPHC, Powsta\u0144c\u00f3w Warszawy Str. 5, 85-681 Bydgoszcz, Poland"},{"name":"NZOZ Centrum Medyczne \u201eGenesis\u201d-Clinic of Infertility Treatment, Waleniowa Str., 24, 85-435 Bydgoszcz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piotr","family":"Bernard","sequence":"additional","affiliation":[{"name":"Clinic of Gynaecology, Oncological Gynaecology and Gynaecological Endocrinology, 10th Military Research Hospital and Polyclinic, IPHC, Powsta\u0144c\u00f3w Warszawy Str. 5, 85-681 Bydgoszcz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2745-530X","authenticated-orcid":false,"given":"Piotr","family":"Domaracki","sequence":"additional","affiliation":[{"name":"Clinic of Gynaecology, Oncological Gynaecology and Gynaecological Endocrinology, 10th Military Research Hospital and Polyclinic, IPHC, Powsta\u0144c\u00f3w Warszawy Str. 5, 85-681 Bydgoszcz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lukasz","family":"Brycht","sequence":"additional","affiliation":[{"name":"Clinic of Gynaecology, Oncological Gynaecology and Gynaecological Endocrinology, 10th Military Research Hospital and Polyclinic, IPHC, Powsta\u0144c\u00f3w Warszawy Str. 5, 85-681 Bydgoszcz, Poland"},{"name":"Department of General and Oncological Surgery, Specialist Hospital in W\u0142oc\u0142awek, 49 Wieniecka Street, 87-800 W\u0142oc\u0142awek, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Szyca","sequence":"additional","affiliation":[{"name":"Clinic of Surgery and Oncological Surgery, 10th Military Research Hospital and Polyclinic, IPHC, 85-681 Bydgoszcz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelika","family":"Szymanska","sequence":"additional","affiliation":[{"name":"NZOZ Centrum Medyczne \u201eGenesis\u201d-Clinic of Infertility Treatment, Waleniowa Str., 24, 85-435 Bydgoszcz, Poland"},{"name":"Faculty of Medicine, Medical University in Pozna\u0144, 61-701 Pozna\u0144, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0217-0247","authenticated-orcid":false,"given":"Julia","family":"Paniutycz","sequence":"additional","affiliation":[{"name":"Gynecology, Obstetrics and Pregnancy Pathology Department, Multi-Speciality City Hospital in Bydgoszcz, 19 Szpitalna Street, 85-172 Bydgoszcz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J 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