{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:43:06Z","timestamp":1760150586683,"version":"build-2065373602"},"reference-count":24,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2023,12,3]],"date-time":"2023-12-03T00:00:00Z","timestamp":1701561600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Retinal vein occlusion (RVO) results in ischemia followed by an inflammatory response. Both processes affect tissue temperature in opposite directions. Here, we evaluate the effect of RVO on the ocular surface temperature (OST) profile. Subjects with RVO were prospectively recruited. Healthy subjects without any ocular disease served as controls. The OST was determined using the Therm-App thermal imaging camera, and image processing software was employed to compute the mean temperature values of the medial canthus, lateral canthus, and cornea. We obtained thermographic images from 30 RVO subjects (30 eyes) and 148 controls (148 eyes). A univariate analysis found that eyes with RVO had significantly elevated OSTs compared to the controls (mean difference of 0.6 \u00b1 0.3 Celsius, p &lt; 0.05). However, this distinction between the groups lost statistical significance upon adjusting for possible confounders, including patient and environmental factors. These findings were confirmed with a post hoc case\u2013control matched comparison. In conclusion, RVO does not seem to affect the OST. This might be due to the balance between inflammatory thermogenesis and heat constriction from ischemia in RVO. It is also possible that, in our cohort, the RVO pathophysiological processes involved were localized and did not extend to the anterior segment. Patient and environmental factors must be considered when interpreting the OST.<\/jats:p>","DOI":"10.3390\/jcm12237479","type":"journal-article","created":{"date-parts":[[2023,12,3]],"date-time":"2023-12-03T04:59:16Z","timestamp":1701579556000},"page":"7479","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ocular Surface Temperature Profile of Eyes with Retinal Vein Occlusion"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2683-7787","authenticated-orcid":false,"given":"Shany","family":"Shperling","sequence":"first","affiliation":[{"name":"Goldschleger Eye Institute, Sheba Medical Center, Tel Hashomer, Ramat Gan 5262000, Israel"},{"name":"Adelson School of Medicine, Ariel University, Ariel 40700, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tommy","family":"Mordo","sequence":"additional","affiliation":[{"name":"Goldschleger Eye Institute, Sheba Medical Center, Tel Hashomer, Ramat Gan 5262000, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel","family":"Katz","sequence":"additional","affiliation":[{"name":"Goldschleger Eye Institute, Sheba Medical Center, Tel Hashomer, Ramat Gan 5262000, Israel"},{"name":"Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir","family":"Alhalel","sequence":"additional","affiliation":[{"name":"Goldschleger Eye Institute, Sheba Medical Center, Tel Hashomer, Ramat Gan 5262000, Israel"},{"name":"Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alon","family":"Skaat","sequence":"additional","affiliation":[{"name":"Goldschleger Eye Institute, Sheba Medical Center, Tel Hashomer, Ramat Gan 5262000, Israel"},{"name":"Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2418-9202","authenticated-orcid":false,"given":"Gal Yaakov","family":"Cohen","sequence":"additional","affiliation":[{"name":"Goldschleger Eye Institute, Sheba Medical Center, Tel Hashomer, Ramat Gan 5262000, Israel"},{"name":"Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ofira","family":"Zloto","sequence":"additional","affiliation":[{"name":"Goldschleger Eye Institute, Sheba Medical Center, Tel Hashomer, Ramat Gan 5262000, Israel"},{"name":"Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel"},{"name":"The Sheba Talpiot Medical Leadership Program, Sheba Medical Center, Tel Hashomer, Ramat Gan 52621, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8717-1659","authenticated-orcid":false,"given":"Ari","family":"Leshno","sequence":"additional","affiliation":[{"name":"Goldschleger Eye Institute, Sheba Medical Center, Tel Hashomer, Ramat Gan 5262000, Israel"},{"name":"Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel"},{"name":"The Sheba Talpiot Medical Leadership Program, Sheba Medical Center, Tel Hashomer, Ramat Gan 52621, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"43509","DOI":"10.1038\/srep43509","article-title":"A Pharmacological Approach in Newly Established Retinal Vein Occlusion Model","volume":"7","author":"Fuma","year":"2017","journal-title":"Sci. Rep."},{"unstructured":"Blair, K., and Czyz, C.N. (2023). Central Retinal Vein Occlusion, StatPearls.","key":"ref_2"},{"key":"ref_3","first-page":"40","article-title":"Retinal Vein Occlusion Review","volume":"7","author":"Ip","year":"2018","journal-title":"Asia-Pac. J. Ophthalmol."},{"doi-asserted-by":"crossref","unstructured":"Pauk, J., Wasilewska, A., and Ihnatouski, M. (2019). Infrared Thermography Sensor for Disease Activity Detection in Rheumatoid Arthritis Patients. Sensors, 19.","key":"ref_4","DOI":"10.3390\/s19163444"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/724780","article-title":"Risk Factors for Central and Branch Retinal Vein Occlusion: A Meta-Analysis of Published Clinical Data","volume":"2014","author":"Kolar","year":"2014","journal-title":"J. Ophthalmol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1111\/j.1445-5994.2008.01720.x","article-title":"Retinal Vein Occlusion: An Approach to Diagnosis, Systemic Risk Factors and Management","volume":"38","author":"Yau","year":"2008","journal-title":"Intern. Med. J."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1097\/IAE.0000000000003278","article-title":"Ocular Surface Temperature Differences In Retinal Vascular Diseases","volume":"42","author":"Moisseiev","year":"2022","journal-title":"Retina"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1136\/jech.44.2.112","article-title":"Thermography in Screening for Breast Cancer","volume":"44","author":"Williams","year":"1990","journal-title":"J. Epidemiol. Community Health"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"43","DOI":"10.4103\/0971-6203.48720","article-title":"Infrared Thermal Imaging for Detection of Peripheral Vascular Disorders","volume":"34","author":"Philip","year":"2009","journal-title":"J. Med. Phys."},{"doi-asserted-by":"crossref","unstructured":"Cohen, G.Y., Ben-David, G., Singer, R., Benyosef, S., Shemesh, R., Leshno, A., Barkana, Y., and Skaat, A. (2021). Ocular Surface Temperature: Characterization in a Large Cohort of Healthy Human Eyes and Correlations to Systemic Cardiovascular Risk Factors. Diagnostics, 11.","key":"ref_10","DOI":"10.3390\/diagnostics11101877"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1136\/bjo.52.12.917","article-title":"Corneal Thermal Patterns in Anterior Uveitis","volume":"52","author":"Mapstone","year":"1968","journal-title":"Br. J. Ophthalmol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1177\/11206721211023723","article-title":"Ocular Surface Temperature Differences in Glaucoma","volume":"32","author":"Leshno","year":"2022","journal-title":"Eur. J. Ophthalmol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1136\/bjo.2007.114397","article-title":"Evaluation of Ocular Surface Temperature and Retrobulbar Haemodynamics by Infrared Thermography and Colour Doppler Imaging in Patients with Glaucoma","volume":"91","author":"Galassi","year":"2007","journal-title":"Br. J. Ophthalmol."},{"doi-asserted-by":"crossref","unstructured":"Browning, D.J. (2012). Retinal Vein Occlusions, Springer.","key":"ref_14","DOI":"10.1007\/978-1-4614-3439-9"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1167\/tvst.7.3.14","article-title":"Cornea Thermography: Optimal Evaluation of the Outcome and the Resulting Reproducibility","volume":"7","author":"Konieczka","year":"2018","journal-title":"Transl. Vis. Sci. Technol."},{"unstructured":"Morgan, P.B. (1994). Ocular Thermography in Health and Disease. [Ph.D. Thesis, The Department of Optometry and Vision Sciences, The University of Manchester].","key":"ref_16"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"045003","DOI":"10.1088\/1361-6579\/ab6b48","article-title":"Infrared Thermographic Investigation on the Ocular Surface Temperature of Normal Subjects","volume":"41","author":"Matteoli","year":"2020","journal-title":"Physiol. Meas."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1177\/112067210701700511","article-title":"Ocular surface temperature in central retinal vein occlusion: Preliminary data","volume":"17","author":"Sodi","year":"2007","journal-title":"Eur. J. Ophthalmol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"207","DOI":"10.4103\/ijo.IJO_698_17","article-title":"Prevalence and Risk Factors of Dry Eye Disease in North India: Ocular Surface Disease Index-Based Cross-Sectional Hospital Study","volume":"66","author":"Titiyal","year":"2018","journal-title":"Indian J. Ophthalmol."},{"doi-asserted-by":"crossref","unstructured":"Kapelushnik, N., Benyosef, S., Skaat, A., Abdelkader, A., Landau Prat, D., Blum-Meirovitch, S., and Leshno, A. (2022). The Effect of Face Masks during COVID-19 Pandemic on Ocular Surface Temperature\u2014A Clinical Thermographic Analysis. Diagnostics, 12.","key":"ref_20","DOI":"10.3390\/diagnostics12061431"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"4600","DOI":"10.1210\/jc.2014-1957","article-title":"Novel Thermal Imaging Analysis Technique for Detecting Inflammation in Thyroid Eye Disease","volume":"99","author":"Allen","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"doi-asserted-by":"crossref","unstructured":"Harshvardhan, G., Venkateswaran, N., and Padmapriya, N. (2016, January 23\u201325). Assessment of Glaucoma with Ocular Thermal Images Using GLCM Techniques and Logistic Regression Classifier. Proceedings of the 2016 International Conference on Wireless Communications, Signal Processing and Networking (WiSPNET), Chennai, India.","key":"ref_22","DOI":"10.1109\/WiSPNET.2016.7566393"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"582060","DOI":"10.1155\/2015\/582060","article-title":"Diabetic Retinopathy: Vascular and Inflammatory Disease","volume":"2015","author":"Semeraro","year":"2015","journal-title":"J. Diabetes Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"809","DOI":"10.2147\/OPTH.S7631","article-title":"Retinal Vein Occlusion: Pathophysiology and Treatment Options","volume":"4","author":"Karia","year":"2010","journal-title":"Clin. Ophthalmol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/23\/7479\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:36:55Z","timestamp":1760132215000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/23\/7479"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,3]]},"references-count":24,"journal-issue":{"issue":"23","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["jcm12237479"],"URL":"https:\/\/doi.org\/10.3390\/jcm12237479","relation":{},"ISSN":["2077-0383"],"issn-type":[{"type":"electronic","value":"2077-0383"}],"subject":[],"published":{"date-parts":[[2023,12,3]]}}}