{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:50:03Z","timestamp":1792083003581,"version":"4.4.0"},"reference-count":161,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2023,12,4]],"date-time":"2023-12-04T00:00:00Z","timestamp":1701648000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["82173421"],"award-info":[{"award-number":["82173421"]}]},{"name":"National Natural Science Foundation of China","award":["23ZR1408600"],"award-info":[{"award-number":["23ZR1408600"]}]},{"name":"National Natural Science Foundation of China","award":["20Y11905700"],"award-info":[{"award-number":["20Y11905700"]}]},{"name":"Natural Science Foundation of Shanghai","award":["82173421"],"award-info":[{"award-number":["82173421"]}]},{"name":"Natural Science Foundation of Shanghai","award":["23ZR1408600"],"award-info":[{"award-number":["23ZR1408600"]}]},{"name":"Natural Science Foundation of Shanghai","award":["20Y11905700"],"award-info":[{"award-number":["20Y11905700"]}]},{"name":"Shanghai Science and Technology Commission","award":["82173421"],"award-info":[{"award-number":["82173421"]}]},{"name":"Shanghai Science and Technology Commission","award":["23ZR1408600"],"award-info":[{"award-number":["23ZR1408600"]}]},{"name":"Shanghai Science and Technology Commission","award":["20Y11905700"],"award-info":[{"award-number":["20Y11905700"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Electromagnetic radiation, notably visible light (VL), has complicated effects on human skin, particularly pigmentation, which have been largely overlooked. In this review, we discuss the photobiological mechanisms, pathological effects, clinical applications and therapeutic strategies of VL at varying wavelengths on melanocyte biology and skin pigmentary disorders. Different VL wavelengths may impose positive or negative effects, depending on their interactions with specific chromophores, photoaging, ROS production, circadian rhythm and other photon-mediated reactions. Further in vivo and in vitro studies are required to establish the pathologic mechanisms and application principles of VL in pigmentary disorders, as well as optimal photoprotection with coverage against VL wavelengths.<\/jats:p>","DOI":"10.3390\/jcm12237488","type":"journal-article","created":{"date-parts":[[2023,12,4]],"date-time":"2023-12-04T05:28:21Z","timestamp":1701667701000},"page":"7488","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["The Emerging Role of Visible Light in Melanocyte Biology and Skin Pigmentary Disorders: Friend or Foe?"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-0423-4604","authenticated-orcid":false,"given":"Xuanxuan","family":"He","sequence":"first","affiliation":[{"name":"Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanglin","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxi","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leihong","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1302-5667","authenticated-orcid":false,"given":"Chengfeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1034\/j.1600-0781.2002.180203.x","article-title":"What is light?","volume":"18","author":"Diffey","year":"2002","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1016\/j.jaad.2021.02.048","article-title":"Visible light. Part I: Properties and cutaneous effects of visible light","volume":"84","author":"Austin","year":"2021","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.jaad.2021.12.065","article-title":"Disorders of hyperpigmentation. Part II. Review of management and treatment options for hyperpigmentation","volume":"88","author":"Ko","year":"2023","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.clindermatol.2003.08.005","article-title":"The modern paradigm of phototherapy","volume":"21","author":"Zanolli","year":"2003","journal-title":"Clin. Dermatol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1111\/j.1751-1097.2007.00286.x","article-title":"Effects of Visible Light on the Skin","volume":"84","author":"Mahmoud","year":"2008","journal-title":"Photochem. Photobiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1038\/jid.2010.95","article-title":"Impact of long-wavelength UVA and visible light on melanocompetent skin","volume":"130","author":"Mahmoud","year":"2010","journal-title":"J. Investig. Dermatol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1109\/JSTQE.2016.2561201","article-title":"Proposed Mechanisms of Photobiomodulation or Low-Level Light Therapy","volume":"22","author":"Hamblin","year":"2016","journal-title":"IEEE J. Sel. Top. Quantum Electron."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jid.2017.09.025","article-title":"Opsin3-A Link to Visible Light-Induced Skin Pigmentation","volume":"138","author":"Setty","year":"2018","journal-title":"J. Investig. Dermatol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.jid.2017.07.833","article-title":"Melanocytes Sense Blue Light and Regulate Pigmentation through Opsin-3","volume":"138","author":"Regazzetti","year":"2018","journal-title":"Investig. Dermatol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"11508","DOI":"10.1073\/pnas.1902825116","article-title":"Human nonvisual opsin 3 regulates pigmentation of epidermal melanocytes through functional interaction with melanocortin 1 receptor","volume":"116","author":"Ozdeslik","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1111\/ics.12637","article-title":"Pigmentation effects of blue light irradiation on skin and how to protect against them","volume":"42","author":"Campiche","year":"2020","journal-title":"Int. J. Cosmet. Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/1523-1747.ep12479191","article-title":"The Optics of Human Skin","volume":"77","author":"Anderson","year":"1981","journal-title":"J. Investig. Dermatol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"247","DOI":"10.3389\/fgene.2018.00247","article-title":"Biomarkers of Cellular Senescence and Skin Aging","volume":"9","author":"Wang","year":"2018","journal-title":"Front. Genet."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1038\/jid.2011.476","article-title":"Irradiation of skin with visible light induces reactive oxygen species and matrix-degrading enzymes","volume":"132","author":"Liebel","year":"2012","journal-title":"J. Investig. Dermatol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/phpp.12736","article-title":"Effects of visible light on mechanisms of skin photoaging","volume":"38","author":"Pourang","year":"2022","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1097\/DSS.0000000000000744","article-title":"Resveratrol Prevents Reactive Oxygen Species\u2013Induced Effects of Light-Emitting Diode\u2013Generated Blue Light in Human Skin Fibroblasts","volume":"42","author":"Mamalis","year":"2016","journal-title":"Dermatol. Surg."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.freeradbiomed.2017.03.010","article-title":"Blue light-induced oxidative stress in live skin","volume":"108","author":"Nakashima","year":"2017","journal-title":"Free. Radic. Biol. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"9065","DOI":"10.1002\/jcp.27584","article-title":"Hydroxytyrosol from olive fruits prevents blue-light-induced damage in human keratinocytes and fibroblasts","volume":"234","author":"Avola","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/phpp.12523","article-title":"High-energy visible light at ambient doses and intensities induces oxidative stress of skin-Protective effects of the antioxidant and Nrf2 inducer Licochalcone A in vitro and in vivo","volume":"36","author":"Mann","year":"2020","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Chiarelli-Neto, O., Ferreira, A.S., Martins, W.K., Pavani, C., Severino, D., Fai\u00e3o-Flores, F., Maria-Engler, S.S., Aliprandini, E., Martinez, G.R., and Di Mascio, P. (2014). Melanin photosensitization and the effect of visible light on epithelial cells. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0113266"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Lorrio, S., Rodr\u00edguez-Luna, A., Delgado-Wicke, P., Mascaraque, M., Gallego, M., P\u00e9rez-Dav\u00f3, A., Gonz\u00e1lez, S., and Juarranz, \u00c1. (2020). Protective Effect of the Aqueous Extract of Deschampsia antarctica (EDAFENCE\u00ae) on Skin Cells against Blue Light Emitted from Digital Devices. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21030988"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.jdermsci.2015.02.018","article-title":"LED 590 nm photomodulation reduces UVA-induced metalloproteinase-1 expression via upregulation of antioxidant enzyme catalase","volume":"78","author":"Ho","year":"2015","journal-title":"J. Dermatol. Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1002\/lsm.20107","article-title":"Clinical trial of a novel non-thermal LED array for reversal of photoaging: Clinical, histologic, and surface profilometric results","volume":"36","author":"Weiss","year":"2005","journal-title":"Lasers Surg. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1111\/ced.12902","article-title":"Skin photorejuvenation effects of light-emitting diodes (LEDs): A comparative study of yellow and red LEDs in vitro and in vivo","volume":"41","author":"You","year":"2016","journal-title":"Clin. Exp. Dermatol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2751","DOI":"10.1038\/jid.2009.186","article-title":"Regulation of skin collagen metabolism in vitro using a pulsed 660 nm LED light source: Clinical correlation with a single-blinded study","volume":"129","author":"Barolet","year":"2009","journal-title":"J. Investig. Dermatol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1046\/j.1523-1747.2003.12133.x","article-title":"cDNA microarray analysis of gene expression profiles in human fibroblast cells irradiated with red light","volume":"120","author":"Song","year":"2003","journal-title":"J. Investig. Dermatol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.jdermsci.2017.06.018","article-title":"Precise role of dermal fibroblasts on melanocyte pigmentation","volume":"88","author":"Wang","year":"2017","journal-title":"J. Dermatol. Sci."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1111\/pcmr.12684","article-title":"Melasma, a photoaging disorder","volume":"31","author":"Passeron","year":"2018","journal-title":"Pigment. Cell Melanoma Res."},{"key":"ref_29","first-page":"42","article-title":"Circadian Rhythm and the Skin: A Review of the Literature","volume":"12","author":"Lyons","year":"2019","journal-title":"J. Clin. Aesthetic Dermatol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"31ra33","DOI":"10.1126\/scitranslmed.3000741","article-title":"Spectral responses of the human circadian system depend on the irradiance and duration of exposure to light","volume":"2","author":"Gooley","year":"2010","journal-title":"Sci. Transl. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1152\/japplphysiol.00165.2011","article-title":"Evening exposure to a light-emitting diodes (LED)-backlit computer screen affects circadian physiology and cognitive performance","volume":"110","author":"Cajochen","year":"2011","journal-title":"J. Appl. Physiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1080\/07420528.2017.1324878","article-title":"Evening light exposure to computer screens disrupts human sleep, biological rhythms, and attention abilities","volume":"34","author":"Green","year":"2017","journal-title":"Chronobiol. Int."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1177\/0748730408328973","article-title":"Age-related changes in acute and phase-advancing responses to monochromatic light","volume":"24","author":"Sletten","year":"2009","journal-title":"J. Biol. Rhythm."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Ho Mien, I., Chua EC, P., Lau, P., Tan, L.C., Lee IT, G., Yeo, S.C., Tan, S.S., and Gooley, J.J. (2014). Effects of exposure to intermittent versus continuous red light on human circadian rhythms, melatonin suppression, and pupillary constriction. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0096532"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1111\/ics.12572","article-title":"Blue light disrupts the circadian rhythm and create damage in skin cells","volume":"41","author":"Dong","year":"2019","journal-title":"Int. J. Cosmet. Sci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1038\/jid.2014.442","article-title":"The peripheral clock regulates human pigmentation","volume":"135","author":"Hardman","year":"2015","journal-title":"J. Investig. Dermatol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s11010-016-2781-3","article-title":"Estradiol differently affects melanin synthesis of malignant and normal melanocytes: A relationship with clock and clock-controlled genes","volume":"421","author":"Poletini","year":"2016","journal-title":"Mol. Cell. Biochem."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1111\/pcmr.12998","article-title":"Circadian clock protein BMAL1 regulates melanogenesis through MITF in melanoma cells","volume":"34","author":"Sarkar","year":"2021","journal-title":"Pigment. Cell Melanoma Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.1002\/1873-3468.14192","article-title":"The circadian clock and diseases of the skin","volume":"595","author":"Duan","year":"2021","journal-title":"FEBS Lett."},{"key":"ref_40","first-page":"305","article-title":"Direct and Indirect Effects of Blue Light Exposure on Skin: A Review of Published Literature","volume":"35","author":"Suitthimeathegorn","year":"2022","journal-title":"Ski. Pharmacol. Physiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1111\/bjd.15940","article-title":"Synergistic effects of long-wavelength ultraviolet A1 and visible light on pigmentation and erythema","volume":"178","author":"Kohli","year":"2018","journal-title":"Br. J. Dermatol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1111\/php.13157","article-title":"Long-wavelength Ultraviolet A1 and Visible Light Photoprotection: A Multimodality Assessment of Dose and Response","volume":"96","author":"Kohli","year":"2020","journal-title":"Photochem. Photobiol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1111\/pcmr.12273","article-title":"Differences in visible light-induced pigmentation according to wavelengths: A clinical and histological study in comparison with UVB exposure","volume":"27","author":"Duteil","year":"2014","journal-title":"Pigment. Cell Melanoma Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1039\/c1pp05202k","article-title":"Are there mechanistic differences between ultraviolet and visible radiation induced skin pigmentation?","volume":"1","author":"Ramasubramaniam","year":"2011","journal-title":"Photochem. Photobiol. Sci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1039\/c2pp25152c","article-title":"Effects of ultraviolet radiation, visible light, and infrared radiation on erythema and pigmentation: A review","volume":"12","author":"Sklar","year":"2013","journal-title":"Photochem. Photobiol. Sci."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1159\/000517644","article-title":"Blue Light and the Skin","volume":"55","author":"Schutz","year":"2021","journal-title":"Curr. Probl. Dermatol."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Randhawa, M., Seo, I., Liebel, F., Southall, M.D., Kollias, N., and Ruvolo, E. (2015). Visible Light Induces Melanogenesis in Human Skin through a Photoadaptive Response. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0130949"},{"key":"ref_48","first-page":"130","article-title":"clinical effects of LED blue light on skin pigmentation and carotenoid depletion","volume":"5","author":"Vollhardt","year":"2019","journal-title":"J. Investig. Dermatol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.1468-3083.2011.04039.x","article-title":"Efficacy of blue light vs. red light in the treatment of psoriasis: A double-blind, randomized comparative study","volume":"26","author":"Kleinpenning","year":"2012","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.1111\/jocd.13508","article-title":"Clinical evaluation method for blue light (456 nm) protection of skin","volume":"19","author":"Jo","year":"2020","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/j.1600-0781.2009.00474.x","article-title":"Clinical and histological effects of blue light on normal skin","volume":"26","author":"Kleinpenning","year":"2010","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1111\/phpp.12367","article-title":"Effects of blue light on inflammation and skin barrier recovery following acute perturbation. Pilot study results in healthy human subjects","volume":"34","author":"Falcone","year":"2018","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1111\/exd.14400","article-title":"Visible light and human skin pigmentation: The importance of skin phototype","volume":"30","author":"Moreiras","year":"2021","journal-title":"Exp. Dermatol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1016\/j.jaad.2020.04.079","article-title":"Photoprotection beyond ultraviolet radiation: A review of tinted sunscreens","volume":"84","author":"Lyons","year":"2021","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.jaad.2010.12.046","article-title":"Melasma: A comprehensive update: Part I","volume":"65","author":"Sheth","year":"2011","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s40257-013-0038-4","article-title":"Treatment of melasma with topical agents, peels and lasers: An evidence-based review","volume":"14","author":"Rivas","year":"2013","journal-title":"Am. J. Clin. Dermatol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.abd.2020.02.015","article-title":"Evaluation of ex vivo melanogenic response to UVB, UVA, and visible light in facial melasma and unaffected adjacent skin","volume":"95","author":"Alcantara","year":"2020","journal-title":"An. Bras. Dermatol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/j.jaad.2019.12.047","article-title":"Short-term exposure to blue light emitted by electronic devices does not worsen melasma","volume":"83","author":"Duteil","year":"2020","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_59","first-page":"149","article-title":"Visible light photopatch testing of common photocontactants in female filipino adults with and without melasma: A cross-sectional study","volume":"7","author":"Pua","year":"2008","journal-title":"J. Drugs Dermatol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.jaad.2014.08.023","article-title":"Prevention of melasma relapses with sunscreen combining protection against UV and short wavelengths of visible light: A prospective randomized comparative trial","volume":"72","author":"Boukari","year":"2015","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.jdermsci.2017.10.001","article-title":"Light-emitting diode 585nm photomodulation inhibiting melanin synthesis and inducing autophagy in human melanocytes","volume":"89","author":"Chen","year":"2018","journal-title":"J. Dermatol. Sci."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1002\/lsm.20412","article-title":"Blue and red light combination LED phototherapy for acne vulgaris in patients with skin phototype IV","volume":"39","author":"Lee","year":"2007","journal-title":"Lasers Surg. Med."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/phpp.12276","article-title":"Inhibitory effect of 660-nm LED on melanin synthesis in in vitro and in vivo","volume":"33","author":"Oh","year":"2017","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1111\/j.1346-8138.2010.00834.x","article-title":"Vitiligo following intense pulsed light treatment","volume":"37","author":"Shin","year":"2010","journal-title":"J. Dermatol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1046\/j.1365-2133.1998.02059.x","article-title":"The Koebner phenomenon in vitiligo following treatment of a port-wine stain naevus by pulsed dye laser","volume":"138","author":"Sommer","year":"1998","journal-title":"Br. J. Dermatol."},{"key":"ref_66","first-page":"169","article-title":"Koebner phenomenon in vitiligo after treatment with dye laser","volume":"3","author":"Mazzotta","year":"2006","journal-title":"Eur. J. Pediatr. Dermatol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1755-148X.2011.00922.x","article-title":"In vivo vitiligo induction and therapy model: Double-blind, randomized clinical trial","volume":"25","author":"Speeckaert","year":"2012","journal-title":"Pigment. Cell Melanoma Res."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1159\/000520540","article-title":"A Case Report of Vitiligo Induced by Alexandrite Hair Removal Laser","volume":"13","author":"Alkhalifah","year":"2021","journal-title":"Case Rep. Dermatol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1111\/jocd.15576","article-title":"The impact of blue light and digital screens on the skin","volume":"22","author":"Kumari","year":"2023","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/j.jaad.2020.11.074","article-title":"Visible light. Part II: Photoprotection against visible and ultraviolet light","volume":"84","author":"Geisler","year":"2021","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1007\/s10552-011-9780-1","article-title":"Hat, shade, long sleeves, or sunscreen? Rethinking US sun protection messages based on their relative effectiveness","volume":"22","author":"Linos","year":"2011","journal-title":"Cancer Causes Control"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/phpp.12022","article-title":"Current status of photoprotection by window glass, automobile glass, window films, and sunglasses","volume":"29","author":"Almutawa","year":"2013","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.jaad.2005.11.1082","article-title":"Photoprotection by window glass, automobile glass, and sunglasses","volume":"54","author":"Tuchinda","year":"2006","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1111\/ics.12502","article-title":"Photoprotection against visible light-induced pigmentation","volume":"40","author":"Ruvolo","year":"2018","journal-title":"Int. J. Cosmet. Sci."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/phpp.12377","article-title":"Influence of visible light on cutaneous hyperchromias: Clinical efficacy of broad-spectrum sunscreens","volume":"34","author":"Martini","year":"2018","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/jocd.13007","article-title":"Beyond sun protection factor: An approach to environmental protection with novel mineral coatings in a vehicle containing a blend of skincare ingredients","volume":"19","author":"Bernstein","year":"2020","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/phpp.12086","article-title":"Near-visible light and UV photoprotection in the treatment of melasma: A double-blind randomized trial","volume":"30","year":"2014","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"712","DOI":"10.36849\/JDD.2020.5032","article-title":"Impact of Iron-Oxide Containing Formulations Against Visible Light-Induced Skin Pigmentation in Skin of Color Individuals","volume":"19","author":"Dumbuya","year":"2020","journal-title":"J. Drugs Dermatol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"AB20","DOI":"10.1016\/j.jaad.2020.06.168","article-title":"Prevention of melasma intensification with sunscreen","volume":"6","author":"Moyal","year":"2020","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1016\/j.jaad.2021.12.024","article-title":"Impact of visible light on skin health: The role of antioxidants and free radical quenchers in skin protection","volume":"86","author":"Lim","year":"2022","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_81","first-page":"1389","article-title":"Light\u2014Instead of UV Protection: New Requirements for Skin Cancer Prevention","volume":"36","author":"Zastrow","year":"2016","journal-title":"Anticancer Res."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"87","DOI":"10.2165\/11536930-000000000-00000","article-title":"Postinflammatory hyperpigmentation: Etiologic and therapeutic considerations","volume":"12","author":"Callender","year":"2011","journal-title":"Am. J. Clin. Dermatol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.3390\/cimb43020083","article-title":"Antioxidant and Anti-Melanogenic Activities of Heat-Treated Licorice (Wongam, Glycyrrhiza glabra \u00d7 G. uralensis) Extract","volume":"43","author":"Kang","year":"2021","journal-title":"Curr. Issues Mol. Biol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1111\/jocd.14202","article-title":"Invitro effect of pine bark extract on melanin synthesis, tyrosinase activity, production of endothelin-1, and PPAR in cultured melanocytes exposed to Ultraviolet, Infrared, and Visible light radiation","volume":"21","author":"Eberlin","year":"2022","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1111\/ics.12785","article-title":"Evaluation of efficacy of antioxidant-enriched sunscreen prodcuts against long wavelength ultraviolet A1 and visible light","volume":"44","author":"Ruvolo","year":"2022","journal-title":"Int. J. Cosmet. Sci."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/php.13525","article-title":"Mitigating Visible Light and Long Wavelength UVA1-induced Effects with Topical Antioxidants","volume":"98","author":"Lyons","year":"2022","journal-title":"Photochem. Photobiol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"517","DOI":"10.36849\/JDD.6503","article-title":"Evaluation of an SPF50 Sunscreen Containing Photolyase and Antioxidants for its Anti-Photoaging Properties and Photoprotection","volume":"21","author":"Kern","year":"2022","journal-title":"J. Drugs Dermatol."},{"key":"ref_88","first-page":"1198","article-title":"Oral Polypodium Leucotomos Extract and Its Impact on Visible Light-Induced Pigmentation in Human Subjects","volume":"18","author":"Mohammad","year":"2019","journal-title":"J. Drugs Dermatol."},{"key":"ref_89","first-page":"2","article-title":"A Pilot Study to Assess the Effects of an Oral Photo Protector of Botanical Origin against Visible and Infrared Radiations in Human Volunteers","volume":"6","author":"Truchuelo","year":"2019","journal-title":"Dermatol. Dermatol. Dis."},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Zamarr\u00f3n, A., Lorrio, S., Gonz\u00e1lez, S., and Juarranz, \u00c1. (2018). Fernblock Prevents Dermal Cell Damage Induced by Visible and Infrared A Radiation. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19082250"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1111\/phpp.12423","article-title":"The potential role of antioxidants in mitigating skin hyperpigmentation resulting from ultraviolet and visible light-induced oxidative stress","volume":"35","author":"Nahhas","year":"2019","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"325","DOI":"10.2147\/CCID.S115519","article-title":"Overall skin tone and skin-lightening-improving effects with oral supplementation of lutein and zeaxanthin isomers: A double-blind, placebo-controlled clinical trial","volume":"9","author":"Juturu","year":"2016","journal-title":"Clin. Cosmet. Investig. Dermatol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.colsurfb.2019.01.042","article-title":"Effect of blue light irradiation on the stability of phospholipid molecules in the presence of epigallocatechin-3-gallate","volume":"177","author":"Pires","year":"2019","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Togni, S., Maramaldi, G., Cavagnino, A., Corti, A., and Giacomelli, L. (2019). Vitachelox Protection of the Skin Against Blue Light-Induced Protein Carbonylation. Cosmetics, 3.","DOI":"10.3390\/cosmetics6030049"},{"key":"ref_95","first-page":"41","article-title":"Low-level laser (light) therapy (LLLT) in skin: Stimulating, healing, restoring","volume":"32","author":"Avci","year":"2013","journal-title":"Semin. Cutan. Med. Surg."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/lsm.20326","article-title":"Laser versus intense pulsed light: Competing technologies in dermatology","volume":"38","author":"Ross","year":"2006","journal-title":"Lasers Surg. Med."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1126\/science.6836297","article-title":"Selective photothermolysis: Precise microsurgery by selective absorption of pulsed radiation","volume":"4569","author":"Anderson","year":"1983","journal-title":"Science"},{"key":"ref_98","first-page":"672","article-title":"Split-face treatment of facial dyschromia: Pulsed dye laser with a compression handpiece versus intense pulsed light","volume":"34","author":"Galeckas","year":"2008","journal-title":"Dermatol. Surg."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1002\/lsm.20982","article-title":"Pulsed dye laser treatment of pigmented lesions: A randomized clinical pilot study comparison of 607- and 595-nm wavelength lasers","volume":"42","author":"Chern","year":"2010","journal-title":"Lasers Surg. Med."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"48","DOI":"10.4103\/0019-5154.77552","article-title":"Efficacy and safety of long-pulse pulsed dye laser delivered with compression versus cryotherapy for treatment of solar lentigines","volume":"56","author":"Fateh","year":"2011","journal-title":"Indian J. Dermatol."},{"key":"ref_101","first-page":"33","article-title":"Solar Lentigines: Evaluating Pulsed Dye Laser (PDL) as an Effective Treatment Option","volume":"4","author":"Ghaninejhadi","year":"2013","journal-title":"J. Lasers Med. Sci."},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Allemanna, I.B., and Goldberg, D.J. (2011). Basics in Dermatological Laser Applications, S. Karger Publishing. Part of: Current Problems in Dermatology.","DOI":"10.1159\/isbn.978-3-8055-9789-0"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1080\/09546634.2020.1755415","article-title":"The clinical and electron microscopic evaluation of the impact of pulsed dye laser techniques on solar lentigines (randomized clinical trial)","volume":"33","author":"Hawwam","year":"2022","journal-title":"J. Dermatolog. Treat."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1002\/lsm.23009","article-title":"Long pulsed dye laser with a back-to-back double-pulse technique and compression for the treatment of epidermal pigmented lesions","volume":"51","author":"Labadie","year":"2019","journal-title":"Lasers Surg. Med."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1002\/lsm.22518","article-title":"Retrospective analysis of the treatment of melasma lesions exhibiting increased vascularity with the 595-nm pulsed dye laser combined with the 1927-nm fractional low-powered diode laser","volume":"49","author":"Geddes","year":"2017","journal-title":"Lasers Surg. Med."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1080\/09546634.2018.1441487","article-title":"Pulsed dye laser versus intense pulsed light in melasma: A split-face comparative study","volume":"29","author":"Hassan","year":"2018","journal-title":"J. Dermatolog. Treat."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5021\/ad.2018.30.1.1","article-title":"Treatment of Melasma with Pulsed-Dye Laser and 1,064-nm Q-Switched Nd:YAG Laser: A Split-Face Study","volume":"30","author":"Kong","year":"2018","journal-title":"Ann. Dermatol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1001\/jamadermatol.2014.5580","article-title":"Copper Bromide Laser vs Triple-Combination Cream for the Treatment of Melasma: A Randomized Clinical Trial","volume":"151","author":"Ghorbel","year":"2015","journal-title":"JAMA Dermatol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"e5","DOI":"10.34172\/jlms.2021.05","article-title":"Treatment of Congenital Melanocytic Nevi With a Dual-Wavelengths Copper Vapor Laser: A Case Series","volume":"12","author":"Ponomarev","year":"2021","journal-title":"J. Lasers Med. Sci."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1111\/ced.12267","article-title":"Therapeutic outcome of melasma treatment by dual-wavelength (511 and 578 nm) laser in patients with skin phototypes III-V","volume":"39","author":"Eimpunth","year":"2014","journal-title":"Clin. Exp. Dermatol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1111\/j.1524-4725.2010.01564.x","article-title":"Clinicopathologic efficacy of copper bromide plus\/yellow laser (578 nm with 511 nm) for treatment of melasma in Asian patients","volume":"36","author":"Lee","year":"2010","journal-title":"Dermatol. Surg."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1097\/DSS.0000000000000922","article-title":"Picosecond 532 nm Neodymium-Doped Yttrium Aluminium Garnet Laser for the Treatment of Solar Lentigines in Darker Skin Types: Safety and Efficacy","volume":"43","author":"Guss","year":"2017","journal-title":"Dermatol. Surg."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1002\/lsm.22820","article-title":"Prospective study of removing solar lentigines in Asians using a novel dual-wavelength and dual-pulse width picosecond laser","volume":"50","author":"Negishi","year":"2018","journal-title":"Lasers Surg. Med."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1007\/s10103-018-2560-3","article-title":"Q-switched double frequency Nd:YAG 532-nm nanosecond laser vs. double frequency Nd:YAG 532-nm picosecond laser for the treatment of solar lentigines in Asians","volume":"33","author":"Vachiramon","year":"2018","journal-title":"Lasers Med. Sci."},{"key":"ref_115","first-page":"41","article-title":"Efficacy of Q-switched Nd:YAG Frequency Doubling 532nm Laser Combined with Photorejuvenation on Freckles","volume":"21","author":"Hom","year":"2020","journal-title":"Med. Aesthet. Beauty"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"203","DOI":"10.4103\/JCAS.JCAS_7_20","article-title":"Efficacy of 532-nm Q-switched Nd:YAG Laser in the Treatment of Lip Melanosis","volume":"14","author":"Kerkar","year":"2021","journal-title":"J. Cutan. Aesthet. Surg."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1080\/09546634.2020.1805400","article-title":"Q-switched 532\u2009nm Nd:YAG laser therapy for physiological lip hyperpigmentation: Novel classification, efficacy, and safety","volume":"33","author":"Altalhab","year":"2022","journal-title":"J. Dermatol. Treat."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/lsm.22354","article-title":"Clearance of yellow tattoo ink with a novel 532-nm picosecond laser","volume":"47","author":"Alabdulrazzaq","year":"2015","journal-title":"Lasers Surg. Med."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1002\/lsm.22391","article-title":"A novel dual-wavelength, Nd:YAG, picosecond-domain laser safely and effectively removes multicolor tattoos","volume":"47","author":"Bernstein","year":"2015","journal-title":"Lasers Surg. Med."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1046\/j.1523-1747.2003.12011.x","article-title":"Helium-neon laser irradiation stimulates migration and proliferation in melanocytes and induces repigmentation in segmental-type vitiligo","volume":"120","author":"Yu","year":"2003","journal-title":"J. Investig. Dermatol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s00109-011-0822-7","article-title":"Induction of primitive pigment cell differentiation by visible light (helium\u2013neon laser): A photoacceptor-specific response not replicable by UVB irradiation","volume":"90","author":"Lan","year":"2012","journal-title":"J. Mol. Med."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1038\/sj.jid.5700372","article-title":"Low-energy helium-neon laser induces locomotion of the immature melanoblasts and promotes melano genesis of the more differentiated melanoblasts: Recapitulation of vitiligo repigmentation in vitro","volume":"126","author":"Lan","year":"2006","journal-title":"J. Investig. Dermatol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.1365-2133.2009.09152.x","article-title":"Low-energy helium\u2014Neon laser induces melanocyte proliferation via interaction with type IV collagen: Visible light as a therapeutic option for vitiligo","volume":"2","author":"Lan","year":"2009","journal-title":"Br. J. Dermatol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1097\/DSS.0000000000001597","article-title":"Laser_Depigmentation_in_Extensive_Vitiligo.26","volume":"4","author":"Boen","year":"2019","journal-title":"Dermatol. Surg."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1111\/j.1365-4362.1993.tb01417.x","article-title":"Treatment of Benign Pigmented Epidermal Lesions by Q-Switched Ruby Laser","volume":"32","author":"Taylor","year":"1993","journal-title":"Int. J. Dermatol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/S0190-9622(08)81505-8","article-title":"Treatment of nevus of Ota by Q-switched ruby laser","volume":"30","author":"Taylor","year":"1994","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1056\/NEJM199412293312604","article-title":"Treatment of nevus of ota with the q-switched rubylaser","volume":"26","author":"Watanabe","year":"1994","journal-title":"N. Engl. J. Med."},{"key":"ref_128","first-page":"27","article-title":"Skin markings methods and guidelines: A reality in image guidance radiotherapy era","volume":"1","author":"Rathod","year":"2020","journal-title":"South Asian J. Cancer"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1080\/14764172.2022.2049311","article-title":"Split-face comparison of the efficacy of picosecond 532 nm Nd:YAG laser and Q-switched 755 nm Alexandrite laser for treatment of freckles","volume":"24","author":"Ma","year":"2022","journal-title":"J. Cosmet. Laser Ther."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"254","DOI":"10.5582\/ddt.2022.01062","article-title":"Nevus of Ota on the auricle successfully treated with Q-switched ruby laser","volume":"16","author":"Jinnin","year":"2022","journal-title":"Drug Discov. Ther."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1111\/j.1524-4725.1994.tb00152.x","article-title":"Ineffective treatment of refractory melasma and postinflammatory hyperpigmentation by Q-switched ruby laser","volume":"20","author":"Taylor","year":"1994","journal-title":"J. Dermatol. Surg. Oncol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1111\/j.1524-4725.2011.02018.x","article-title":"Efficacy of 694-nm Q-Switched Ruby Fractional Laser Treatment of Melasma in Female Korean Patients","volume":"37","author":"Jang","year":"2011","journal-title":"Dermatol. Surg."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/2047-783X-18-43","article-title":"Treatment of melasma in Caucasian patients using a novel 694-nm Q-switched ruby fractional laser","volume":"18","author":"Hilton","year":"2013","journal-title":"Eur. J. Med. Res."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1007\/s10103-016-1938-3","article-title":"Efficacy of 694-nm fractional Q-switched ruby laser (QSRL) combined with sonophoresis on levorotatory vitamin C for treatment of melasma in Chinese patients","volume":"31","author":"Zhou","year":"2016","journal-title":"Lasers Med. Sci."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1111\/j.1600-0781.2012.00672.x","article-title":"Q-switched alexandrite laser treatment of facial and labial lentigines associated with Peutz-Jeghers syndrome","volume":"28","author":"Li","year":"2012","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1002\/lsm.22263","article-title":"A randomized, split-face clinical trial of low-fluence Q-switched neodymium-doped yttrium aluminum garnet (1064\u2009nm) laser versus low-fluence Q-switched alexandrite laser (755\u2009nm) for the treatment of facial melasma","volume":"46","author":"Wattanakrai","year":"2014","journal-title":"Lasers Surg. Med."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1002\/lsm.23097","article-title":"Treatment of Caf\u00e9-Au-Lait Spots Using Q-Switched Alexandrite Laser: Analysis of Clinical Characteristics of 471 Children in Mainland China","volume":"51","author":"Zhang","year":"2019","journal-title":"Lasers Surg. Med."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1002\/lsm.23312","article-title":"A Prospective, Split-Face, Randomized Study Comparing a 755-nm Picosecond Laser With and Without Diffractive Lens Array in the Treatment of Melasma in Asians","volume":"53","author":"Manuskiatti","year":"2021","journal-title":"Lasers Surg. Med."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"4370","DOI":"10.1111\/jocd.14831","article-title":"Randomized, evaluator-blinded comparative study of a potassium titanyl phosphate (KTP) 532-nm picosecond laser and an alexandrite 755-nm picosecond laser for the treatment of solar lentigines in Asians","volume":"21","author":"Vachiramon","year":"2022","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1002\/lsm.10145","article-title":"IPL technology: A review","volume":"32","author":"Raulin","year":"2003","journal-title":"Lasers Surg. Med."},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Kim, J., Lee, J., and Choi, H. (2021). Intense Pulsed Light Attenuates UV-Induced Hyperimmune Response and Pigmentation in Human Skin Cells. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22063173"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1080\/146288300750163745","article-title":"Intense pulsed light source for treatment of small melanocytic nevi and solar lentigines","volume":"2","author":"Bjerring","year":"2000","journal-title":"J. Cutan. Laser Ther."},{"key":"ref_143","first-page":"504","article-title":"Clinical improvement of solar lentigines and ephelides with an intense pulsed light source","volume":"28","author":"Kawada","year":"2002","journal-title":"Dermatol. Surg."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1111\/j.1529-8019.2012.01426.x","article-title":"Clinical effectiveness of intense pulsed light therapy for solar lentigines of the hands","volume":"24","author":"Sasaya","year":"2011","journal-title":"Dermatol. Ther."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1002\/lsm.23056","article-title":"Efficacy and safety of intense pulsed light with a KTP filter for the treatment of solar lentigines","volume":"51","author":"Friedmann","year":"2019","journal-title":"Lasers Surg. Med."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1111\/jocd.13981","article-title":"Comparison between the use of intense pulsed light and Q-switched neodymium-doped yttrium aluminum garnet laser for the treatment of axillary hyperpigmentation","volume":"20","author":"Amornpetkul","year":"2021","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1111\/jocd.13558","article-title":"The efficacy of intense pulsed light for Becker\u2019s nevus: A retrospective analysis of 45 cases","volume":"20","author":"Zhong","year":"2021","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1002\/lsm.20877","article-title":"Intense pulsed light (IPL): A review","volume":"42","author":"Babilas","year":"2010","journal-title":"Lasers Surg. Med."},{"key":"ref_149","first-page":"693","article-title":"Efficacy and Safety of Intense Pulsed Light in Treatment of Melasma in Chinese Patients","volume":"34","author":"Li","year":"2008","journal-title":"Dermatol. Surg."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1007\/s00266-020-01637-x","article-title":"A Meta-analysis-Based Assessment of Intense Pulsed Light for Treatment of Melasma","volume":"44","author":"Yi","year":"2020","journal-title":"Aesthetic Plast. Surg."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1529-8019.2005.05019.x","article-title":"Visible light treatment of photoaging","volume":"18","author":"Dierickx","year":"2005","journal-title":"Dermatol. Ther."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1111\/j.1524-4725.2005.31926","article-title":"Clinical experience with light-emitting diode (LED) photomodulation","volume":"31","author":"Weiss","year":"2005","journal-title":"Dermatol. Surg."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1039\/c8pp00176f","article-title":"Photobiomodulation: Lasers vs. light emitting diodes?","volume":"17","author":"Heiskanen","year":"2018","journal-title":"Photochem. Photobiol. Sci."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.jdermsci.2020.03.002","article-title":"585 nm light-emitting diodes inhibit melanogenesis through upregulating H19\/miR-675 axis in LEDs-irradiated keratinocytes by paracrine effect","volume":"98","author":"Jin","year":"2020","journal-title":"J. Dermatol. Sci."},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Dai, X., Jin, S., Xuan, Y., Yang, Y., Lu, X., Wang, C., Chen, L., Xiang, L., and Zhang, C. (2022). 590 nm LED Irradiation Improved Erythema through Inhibiting Angiogenesis of Human Microvascular Endothelial Cells and Ameliorated Pigmentation in Melasma. Cells, 11.","DOI":"10.3390\/cells11243949"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1089\/pho.2018.4486","article-title":"The Management of Melasma on Skin Types V and VI Using Light Emitting Diode Treatment","volume":"36","author":"Mpofana","year":"2018","journal-title":"Photomed. Laser Surg."},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"Xuan, Y.J., Dai, X.X., Chen, L., Xiang, L.H., Jin, S.L., and Zhang, C.F. (J. Eur. Acad. Dermatol. Venereol., 2023). Efficacy and safety of home-based 590 nm light-emitting diodes and in-hospital 1064 nm Q-switched Nd:YAG laser in the treatment of facial melasma: A single-centre, prospective, randomized clinical trial, J. Eur. Acad. Dermatol. Venereol., ahead of print.","DOI":"10.1111\/jdv.19510"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jphotobiol.2007.04.008","article-title":"A prospective, randomized, placebo-controlled, double-blinded, and split-face clinical study on LED phototherapy for skin rejuvenation: Clinical, profilometric, histologic, ultrastructural, and biochemical evaluations and comparison of three different treatment settings","volume":"88","author":"Lee","year":"2007","journal-title":"J. Photochem. Photobiol. B"},{"key":"ref_159","first-page":"605","article-title":"A novel non-thermal non-ablative full panel LED photomodulation device for reversal of photoaging: Digital microscopic and clinical results in various skin types","volume":"3","author":"Geronemus","year":"2004","journal-title":"J. Drugs Dermatol."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"102456","DOI":"10.1016\/j.pdpdt.2021.102456","article-title":"Photochemical reaction to increase melanogenesis using Buddleja officinalis and blue light-emitting diode irradiation in B16F10","volume":"35","author":"Cho","year":"2021","journal-title":"Photodiagn. Photodyn. Ther."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1111\/jocd.15567","article-title":"Blue light-emitting diodes for the treatment of localized vitiligo: A retrospective study","volume":"22","author":"Lodi","year":"2023","journal-title":"J. Cosmet. 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