{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:26:39Z","timestamp":1790483199794,"version":"4.1.0"},"reference-count":20,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2023,12,5]],"date-time":"2023-12-05T00:00:00Z","timestamp":1701734400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Data on eye diseases in rheumatic patients are limited. The aim of this study was to retrospectively assess the prevalence of ophthalmologic diseases in patients at a rheumatology outpatient clinic who also visited the ophthalmologic clinic. For this retrospective observational cohort study, a chart review was performed according to the STROBE guidelines. In this cohort, an ophthalmologic diagnosis was made in 26.9% of the 1529 rheumatic outpatients, whereas from a rheumatologic perspective, inflammatory non-infectious diagnoses dominated, at 71.7%. From an ophthalmologic perspective, diagnoses without inflammatory pathophysiologic backgrounds dominated, at 54.9%. Inflammatory non-infectious ophthalmologic disease was diagnosed in 24.2% of patients with rheumatoid arthritis and 29.3% of patients with peripheral spondyloarthritis. Not a single rheumatoid arthritis patient was diagnosed with anterior uveitis; however, 16.5% of spondyloarthritis patients were diagnosed with anterior uveitis (p &lt; 0.001). The prevalence of uveitis was 16.3% in axial and 20.1% in peripheral spondyloarthritis. In conclusion, an interdisciplinary rheumatologic\u2013ophthalmologic setting appears justified to further improve the management of patients with rheumatic diseases.<\/jats:p>","DOI":"10.3390\/jcm12247510","type":"journal-article","created":{"date-parts":[[2023,12,5]],"date-time":"2023-12-05T02:55:32Z","timestamp":1701744932000},"page":"7510","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Eye Disease in Patients with Rheumatic Diseases: A Retrospective Observational Cohort Study"],"prefix":"10.3390","volume":"12","author":[{"given":"Ralf","family":"Altenberger","sequence":"first","affiliation":[{"name":"Clinic II, Department of Internal Medicine, Medical University of Innsbruck, 6020 Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3439-6333","authenticated-orcid":false,"given":"Teresa","family":"Rauchegger","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Optometry, Medical University of Innsbruck, 6020 Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gertrud","family":"Haas","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Optometry, Medical University of Innsbruck, 6020 Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Teuchner","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Optometry, Medical University of Innsbruck, 6020 Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9208-7809","authenticated-orcid":false,"given":"Michael","family":"Schirmer","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Optometry, Medical University of Innsbruck, 6020 Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1016\/S0140-6736(11)60071-8","article-title":"Spondyloarthritis","volume":"377","author":"Dougados","year":"2011","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1136\/ard.2010.133645","article-title":"The Assessment of SpondyloArthritis International Society classification criteria for peripheral spondyloarthritis and for spondyloarthritis in general","volume":"70","author":"Rudwaleit","year":"2011","journal-title":"Ann. Rheum. Dis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1080\/1744666X.2016.1205486","article-title":"Behcet\u2019s disease: Epidemiology, clinical manifestations, and diagnosis","volume":"13","author":"Davatchi","year":"2017","journal-title":"Expert Rev. Clin. Immunol."},{"key":"ref_4","first-page":"53","article-title":"Ophthalmic manifestations of rheumatologic disease: Diagnosis and management","volume":"109","author":"Petris","year":"2012","journal-title":"MO Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/s10792-019-01183-9","article-title":"Ocular manifestations of rheumatic diseases","volume":"40","author":"Szodoray","year":"2020","journal-title":"Int. Ophthalmol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Shakib, S., Dundon, B.K., Maddison, J., Thomas, J., Stanners, M., Caughey, G.E., and Clark, R.A. (2016). Effect of a Multidisciplinary Outpatient Model of Care on Health Outcomes in Older Patients with Multimorbidity: A Retrospective Case Control Study. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0161382"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1053\/sarh.2001.16639","article-title":"Ophthalmologic manifestations of rheumatic diseases","volume":"30","author":"Hamideh","year":"2001","journal-title":"Semin. Arthritis Rheum."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.jtos.2017.05.003","article-title":"TFOS DEWS II Epidemiology Report","volume":"15","author":"Stapleton","year":"2017","journal-title":"Ocul. Surf."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"139","DOI":"10.15344\/2456-8007\/2019\/139","article-title":"Ocular Manifestations of Rheumatoid Arthritis: Implications of Recent Clinical Trials","volume":"4","author":"Bhamra","year":"2019","journal-title":"Int. J. Clin. Res. Trials."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1097\/ICO.0b013e3182a407c3","article-title":"Incidence and prevalence of episcleritis and scleritis in Northern California","volume":"32","author":"Honik","year":"2013","journal-title":"Cornea"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.ophtha.2011.07.013","article-title":"Clinical characteristics of a large cohort of patients with scleritis and episcleritis","volume":"119","author":"Molina","year":"2012","journal-title":"Ophthalmology"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/nrrheum.2013.185","article-title":"Ocular inflammatory diseases associated with rheumatoid arthritis","volume":"10","author":"Artifoni","year":"2014","journal-title":"Nat. Rev. Rheumatol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"705","DOI":"10.5301\/ejo.5000278","article-title":"Review on the worldwide epidemiology of uveitis","volume":"23","author":"Miserocchi","year":"2013","journal-title":"Eur. J. Ophthalmol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1136\/ard.2007.075754","article-title":"Prevalence and characteristics of uveitis in the spondyloarthropathies: A systematic literature review","volume":"67","author":"Zeboulon","year":"2008","journal-title":"Ann. Rheum. Dis."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.jclinepi.2007.11.008","article-title":"The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE)statement: Guidelines for reporting observational studies","volume":"61","author":"Altman","year":"2008","journal-title":"J. Clin. Epidemiol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Kampik, L., and Schirmer, M. (2023). Unexpected High Need for Genetic Testing in Rheumatology: A Cross-Sectional Cohort Study. Genes, 14.","DOI":"10.3390\/genes14101858"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1759720X20951733","DOI":"10.1177\/1759720X20951733","article-title":"Uveitis in spondyloarthritis","volume":"12","author":"Rademacher","year":"2020","journal-title":"Ther. Adv. Musculoskelet. Dis."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Tsubota, K., Pflugfelder, S.C., Liu, Z., Baudouin, C., Kim, H.M., Messmer, E.M., Kruse, F., Liang, L., Carreno-Galeano, J.T., and Rolando, M. (2020). Defining Dry Eye from a Clinical Perspective. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21239271"},{"key":"ref_19","first-page":"S103","article-title":"Fast track pathway reduces sight loss in giant cell arteritis: Results of a longitudinal observational cohort study","volume":"33","author":"Patil","year":"2015","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1007\/s40123-022-00459-1","article-title":"Autoinflammatory Diseases Alliance (AIDA) Network. Development and Implementation of the AIDA International Registry for Patients with Non-Infectious Uveitis","volume":"11","author":"Casa","year":"2022","journal-title":"Ophthalmol Ther."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/24\/7510\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:33:24Z","timestamp":1760132004000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/12\/24\/7510"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,5]]},"references-count":20,"journal-issue":{"issue":"24","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["jcm12247510"],"URL":"https:\/\/doi.org\/10.3390\/jcm12247510","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,5]]}}}