{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T20:49:13Z","timestamp":1781729353428,"version":"3.54.5"},"reference-count":35,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T00:00:00Z","timestamp":1701820800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["81571022"],"award-info":[{"award-number":["81571022"]}]},{"name":"National Natural Science Foundation of China","award":["DLY201808"],"award-info":[{"award-number":["DLY201808"]}]},{"name":"National Natural Science Foundation of China","award":["23ZR1438100"],"award-info":[{"award-number":["23ZR1438100"]}]},{"name":"Shanghai Jiao Tong University School of Medicine","award":["81571022"],"award-info":[{"award-number":["81571022"]}]},{"name":"Shanghai Jiao Tong University School of Medicine","award":["DLY201808"],"award-info":[{"award-number":["DLY201808"]}]},{"name":"Shanghai Jiao Tong University School of Medicine","award":["23ZR1438100"],"award-info":[{"award-number":["23ZR1438100"]}]},{"name":"Shanghai Natural Science Foundation","award":["81571022"],"award-info":[{"award-number":["81571022"]}]},{"name":"Shanghai Natural Science Foundation","award":["DLY201808"],"award-info":[{"award-number":["DLY201808"]}]},{"name":"Shanghai Natural Science Foundation","award":["23ZR1438100"],"award-info":[{"award-number":["23ZR1438100"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Hemifacial Microsomia (HFM) is the second most common congenital craniofacial malformation syndrome, and the complexity of HFM makes its treatment challenging. The present study aimed to introduce a new approach of utilization of virtual surgical planning (VSP) and 3D-printed surgical adjuncts for maxillofacial reconstruction. Five HFM patients were included in this study. All participants were provided with a full VSP, including the design of osteotomy lines, the design and fabrication of 3D-printed cutting guides, fixation plates, and titanium mesh for implantation. With the assistance of 3D-printed cutting guides and fixation plates, the orbital deformities were corrected, and a 3D-printed titanium mesh combined with iliac cancellous bone graft was applied to reconstruct the zygomatic arch. The surgical accuracy, effectiveness, and bone absorption rate were evaluated. All patients completed the entirely digital treatment process without experiencing severe complications. The surgical adjuncts were effective in aligning the movement of the bone segments with the surgical plan, resulting in mean 3D deviations (1.0681 \u00b1 0.15 mm) and maximum 3D deviations (3.1127 \u00b1 0.44 mm). The image fusion results showed that the patients\u2019 postoperative position of the maxilla, zygoma, and orbital rim was consistent with the virtual surgical plan, with only a slight increase in the area of bone grafting. The postoperative measurements showed significant improvement in the asymmetry indices of Er (AI of Er: from 17.91 \u00b1 3.732 to 5.427 \u00b1 1.389 mm, p = 0.0001) and FZ (AI of FZ: from 7.581 \u00b1 1.435 to 4.070 \u00b1 1.028 mm, p = 0.0009) points. In addition, the observed bone resorption rate at the 6-month follow-up across the five patients was 45.24% \u00b1 3.13%. In conclusion, the application of VSP and 3D-printed surgical adjuncts demonstrates significant value in enhancing the precision and effectiveness of surgical treatments for HFM. A 3D-printed titanium mesh combined with iliac cancellous bone graft can be considered an ideal alternative for the reconstruction of the zygomatic arch.<\/jats:p>","DOI":"10.3390\/jcm12247538","type":"journal-article","created":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T08:48:32Z","timestamp":1701852512000},"page":"7538","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Integrating Virtual Surgical Planning and 3D-Printed Tools with Iliac Bone Grafts for Orbital and Zygomatic Reconstruction in Hemifacial Microsomia Patients"],"prefix":"10.3390","volume":"12","author":[{"given":"Zhiyang","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Oral and Craniomaxillofacial Surgery, Shanghai Ninth People\u2019s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, No. 639, Zhizaoju Road, Shanghai 200011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahao","family":"Bao","sequence":"additional","affiliation":[{"name":"Department of Oral and Craniomaxillofacial Surgery, Shanghai Ninth People\u2019s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, No. 639, Zhizaoju Road, Shanghai 200011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guofang","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Oral and Craniomaxillofacial Surgery, Shanghai Ninth People\u2019s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, No. 639, Zhizaoju Road, Shanghai 200011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Oral and Craniomaxillofacial Surgery, Shanghai Ninth People\u2019s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, No. 639, Zhizaoju Road, Shanghai 200011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbo","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Oral and Craniomaxillofacial Surgery, Shanghai Ninth People\u2019s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, No. 639, Zhizaoju Road, Shanghai 200011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"149e","DOI":"10.1097\/PRS.0000000000000843","article-title":"Clarifying the Relationships among the Different Features of the OMENS plus Classification in Craniofacial Microsomia","volume":"135","author":"Tuin","year":"2015","journal-title":"Plast. 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