{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T17:07:27Z","timestamp":1791565647030,"version":"4.3.4"},"reference-count":69,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T00:00:00Z","timestamp":1701993600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Inflammatory Bowel Diseases (IBD), mainly Ulcerative Colitis (UC) and Crohn\u2019s Disease (CD), are disorders characterized by chronic inflammation with severe morbidity and long-term disabling quality of life outcomes. UC mainly affects the mucosal and sub-mucosal layers of the colon, without embracing the peri-intestinal structures. Considering the predominant mucosal location of UC inflammation, the implementation of transmural evaluation by cross-sectional imaging techniques, mainly Intestinal Ultrasound (IUS), has been left behind for ages, especially if compared to CD. Nevertheless, studies analyzing intestinal ultrasound parameters accuracy in disease activity detection reported a good-to-optimal correlation of IUS markers with colonic inflammation, suggesting comparable feasibility of IUS monitoring in UC as in CD. The easy-to-use, costless and point-of-care available status of IUS is therefore crucial in order to improve the diagnostic process and, according to the recent literature, to monitor the response to treatment leading to speeding up decision making and therapy adjustments. Recent studies have demonstrated the correlation between transmural healing in UC with favorable outcomes even in the long term. An evidence gap still exists in the assessment of the rectum, with trans-perineal ultrasound (TPUS) a potential answer to reach a more precise evaluation of rectal inflammation. Eventually, IUS is also increasingly showing promises in emergent or post-surgical UC settings, considering various efforts put in line to demonstrate its feasibility in predicting response to salvage therapy for surgery avoidance and in studying inflammation relapse after procto-colectomy with ileo-pouch\u2013anal anastomosis (IPAA) creation.<\/jats:p>","DOI":"10.3390\/jcm12247569","type":"journal-article","created":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T05:47:30Z","timestamp":1702014450000},"page":"7569","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Leaving behind the Mucosa: Advances and Future Directions of Intestinal Ultrasound in Ulcerative Colitis"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0179-8929","authenticated-orcid":false,"given":"Alberto","family":"Barchi","sequence":"first","affiliation":[{"name":"Gastroenterology and Endoscopy, IRCCS Ospedale San Raffaele, Vita-Salute San Raffaele University, 20132 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8543-4355","authenticated-orcid":false,"given":"Arianna","family":"Dal Buono","sequence":"additional","affiliation":[{"name":"IBD Center, Humanitas Research Hospital-IRCCS, Via Manzoni 56, Rozzano, 20089 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8591-6995","authenticated-orcid":false,"given":"Ferdinando","family":"D\u2019Amico","sequence":"additional","affiliation":[{"name":"Gastroenterology and Endoscopy, IRCCS Ospedale San Raffaele, Vita-Salute San Raffaele University, 20132 Milan, Italy"},{"name":"Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, 20072 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Furfaro","sequence":"additional","affiliation":[{"name":"Gastroenterology and Endoscopy, IRCCS Ospedale San Raffaele, Vita-Salute San Raffaele University, 20132 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Zilli","sequence":"additional","affiliation":[{"name":"Gastroenterology and Endoscopy, IRCCS Ospedale San Raffaele, Vita-Salute San Raffaele University, 20132 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gionata","family":"Fiorino","sequence":"additional","affiliation":[{"name":"Gastroenterology and Endoscopy, IRCCS Ospedale San Raffaele, Vita-Salute San Raffaele University, 20132 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommaso Lorenzo","family":"Parigi","sequence":"additional","affiliation":[{"name":"Gastroenterology and Endoscopy, IRCCS Ospedale San Raffaele, Vita-Salute San Raffaele University, 20132 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Peyrin-Biroulet","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Inserm NGERE U1256, University Hospital of Nancy, University of Lorraine, 54500 Vandoeuvre-l\u00e8s-Nancy, France"},{"name":"Department of Gastroenterology, Nancy University Hospital, 54500 Vand\u0153uvre-l\u00e8s-Nancy, France"},{"name":"INFINY Institute, Nancy University Hospital, 54500 Vand\u0153uvre-l\u00e8s-Nancy, France"},{"name":"Federation Hospitalo-Univeristaire-CURE, Nancy University Hospital, 54500 Vand\u0153uvre-l\u00e8s-Nancy, France"},{"name":"Groupe Hospitalier Priv\u00e9 Ambroise Par\u00e9-Hartmann, Paris IBD Center, 92200 Neuilly-sur-Seine, France"},{"name":"Division of Gastroenterology and Hepatology, McGill University Health Centre, Montreal, QC H4A 3J1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvio","family":"Danese","sequence":"additional","affiliation":[{"name":"Gastroenterology and Endoscopy, IRCCS Ospedale San Raffaele, Vita-Salute San Raffaele University, 20132 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariangela","family":"Allocca","sequence":"additional","affiliation":[{"name":"Gastroenterology and Endoscopy, IRCCS Ospedale San Raffaele, Vita-Salute San Raffaele University, 20132 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1056\/NEJMra1102942","article-title":"Ulcerative colitis","volume":"365","author":"Danese","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1038\/ajg.2015.233","article-title":"Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE): Determining Therapeutic Goals for Treat-to-Target","volume":"110","author":"Sandborn","year":"2015","journal-title":"Am. J. Gastroenterol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1053\/j.gastro.2020.12.031","article-title":"STRIDE-II: An Update on the Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) Initiative of the International Organization for the Study of IBD (IOIBD): Determining Therapeutic Goals for Treat-to-Target strategies in IBD","volume":"160","author":"Turner","year":"2021","journal-title":"Gastroenterology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.cgh.2016.10.040","article-title":"Use of intestinal ultrasound to monitor crohn\u2019s disease activity","volume":"15","author":"Kucharzik","year":"2017","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1111\/j.1572-0241.2004.40267.x","article-title":"Bowel wall thickness at abdominal ultrasound and the one-year-risk of surgery in patients with Crohn\u2019s disease","volume":"99","author":"Castiglione","year":"2004","journal-title":"Am. J. Gastroenterol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1093\/ecco-jcc\/jjab173","article-title":"Defining transabdominal intestinal ultrasound treatment response and remission in inflammatory bowel disease: Systematic review and expert consensus statement","volume":"16","author":"Ilvemark","year":"2022","journal-title":"J. Crohns Colitis"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1053\/j.gastro.2022.10.005","article-title":"The Use of Intestinal Ultrasound in Ulcerative Colitis-More Than a Mucosal Disease?","volume":"163","author":"Palmela","year":"2022","journal-title":"Gastroenterology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1055\/s-0043-125329","article-title":"EFSUMB recommendations and clinical guidelines for intestinal ultrasound (GIUS) in inflammatory bowel diseases","volume":"39","author":"Maconi","year":"2018","journal-title":"Ultraschall. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1093\/ecco-jcc\/jjy113","article-title":"ECCO-ESGAR Guideline for Diagnostic Assessment in IBD Part 1: Initial diagnosis, monitoring of known IBD, detection of complications","volume":"13","author":"Maaser","year":"2019","journal-title":"J. Crohns Colitis"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0009-9260(84)80141-5","article-title":"Ultrasound demonstration of bowel wall thickness in inflammatory bowel disease","volume":"35","author":"Dubbins","year":"1984","journal-title":"Clin. Radiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/jcu.1870170106","article-title":"Diagnosis of acute ulcerative colitis and colonic Crohn\u2019s disease by colonic sonography","volume":"17","author":"Limberg","year":"1989","journal-title":"J. Clin. Ultrasound."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Furfaro, F., Dal Buono, A., Allocca, M., D\u2019Amico, F., Zilli, A., Gabbiadini, R., and Danese, S. (2021). Bowel ultrasound in inflammatory bowel disease: How far in the grayscale?. Life, 11.","DOI":"10.3390\/life11070649"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"299","DOI":"10.11152\/mu-2162","article-title":"EFSUMB Gastrointestinal Ultrasound (GIUS) Task Force Group: Celiac sprue and other rare gastrointestinal diseases ultrasound features","volume":"21","author":"Dietrich","year":"2019","journal-title":"Med. Ultrason."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.dld.2019.10.004","article-title":"Impact of intestinal ultrasound on the management of patients with inflammatory bowel disease: How to apply scientific evidence to clinical practice","volume":"52","author":"Fraquelli","year":"2020","journal-title":"Dig. Liver Dis."},{"key":"ref_15","first-page":"495","article-title":"Diagnosis of chronic inflammatory bowel disease by ultrasonography","volume":"37","author":"Limberg","year":"1999","journal-title":"Z. Gastroenterol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1093\/ecco-jcc\/jjz163","article-title":"Systematic review: Clinical utility of gastrointestinal ultrasound in the diagnosis, assessment and management of patients with ulcerative colitis","volume":"14","author":"Smith","year":"2020","journal-title":"J. Crohns Colitis"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1046\/j.1365-2036.2003.01796.x","article-title":"Role of early ultrasound in detecting inflammatory intestinal disorders and identifying their anatomical location within the bowel","volume":"18","author":"Parente","year":"2003","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/s00535-018-01534-w","article-title":"Usefulness of transabdominal ultrasonography for assessing ulcerative colitis: A prospective, multicenter study","volume":"54","author":"Kinoshita","year":"2019","journal-title":"J. Gastroenterol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1093\/ecco-jcc\/jjab002","article-title":"Intestinal Ultrasound to Assess Disease Activity in Ulcerative Colitis: Development of a novel UC-Ultrasound Index","volume":"15","author":"Bots","year":"2021","journal-title":"J. Crohns Colitis"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1093\/ecco-jcc\/jjy107","article-title":"Accuracy of humanitas ultrasound criteria in assessing disease activity and severity in ulcerative colitis: A prospective study","volume":"12","author":"Allocca","year":"2018","journal-title":"J. Crohns Colitis"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/BF02485168","article-title":"Application of color Doppler ultrasonography to ulcerative colitis","volume":"30","author":"Shirahama","year":"2003","journal-title":"J. Med. Ultrason."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1080\/003655299750024904","article-title":"Ultrasonography in the evaluation of extension, activity, and follow-up of ulcerative colitis","volume":"34","author":"Maconi","year":"1999","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1111\/apt.16700","article-title":"Bowel ultrasound score is accurate in assessing response to therapy in patients with Crohn\u2019s disease","volume":"55","author":"Allocca","year":"2022","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1097\/00054725-200407000-00008","article-title":"Clinical relevance of transabdominal ultrasonography and magnetic resonance imaging in patients with inflammatory bowel disease of the terminal ileum and large bowel","volume":"10","author":"Pascu","year":"2004","journal-title":"Inflamm. Bowel. Dis."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1038\/ajg.2009.672","article-title":"Are colonoscopy and bowel ultrasound useful for assessing response to short-term therapy and predicting disease outcome of moderate-to-severe forms of ulcerative colitis?: A prospective study","volume":"105","author":"Parente","year":"2010","journal-title":"Am. J. Gastroenterol."},{"key":"ref_26","first-page":"2163","article-title":"Management of severe ulcerative colitis with the help of high resolution ultrasonography","volume":"91","author":"Arienti","year":"1996","journal-title":"Am. J. Gastroenterol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1093\/ecco-jcc\/jjad024","article-title":"Hocus pocus: The role of handheld ultrasonography in predicting disease extension and endoscopic activity in ulcerative colitis","volume":"17","author":"Rispo","year":"2023","journal-title":"J. Crohns Colitis"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/ueg2.12196","article-title":"Ultrasonography in inflammatory bowel disease\u2014So far we are?","volume":"10","author":"Christian","year":"2022","journal-title":"United. Eur. Gastroenterol. J."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"29. Sagami, S., Kobayashi, T., Miyatani, Y., Okabayashi, S., Yamazaki, H., Takada, T., Kinoshita, K., Allocca, M., Kunisaki, R., and Ramaswamy, P.K. (2021). Accuracy of Ultrasound for Evaluation of Colorectal Segments in Patients With Inflammatory Bowel Diseases: A Systematic Review and Meta-analysis. Clin. Gastroenterol. Hepatol, 19, 908\u2013921.e6.","DOI":"10.1016\/j.cgh.2020.07.067"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1136\/gutjnl-2021-326562","article-title":"Recent advances in clinical practice: Advances in cross-sectional imaging in inflammatory bowel disease","volume":"71","author":"Rimola","year":"2022","journal-title":"Gut"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"19","DOI":"10.7863\/jum.2004.23.1.19","article-title":"Detection and characterization of perianal inflammatory disease: Accuracy of transperineal combined gray scale and color Doppler sonography","volume":"23","author":"Mallouhi","year":"2004","journal-title":"J. Ultrasound. Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1111\/apt.15767","article-title":"Transperineal ultrasound predicts endoscopic and histological healing in ulcerative colitis","volume":"51","author":"Sagami","year":"2020","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"33. Tokushima, K., Jimbo, K., Suzuki, M., Endo, Y., Hibio, M., Maruyama, K., Kashiwagi, K., Arai, N., Sato, M., and Kudo, T. (2023). Differentiation of active ulcerative colitis vs noninflammatory bowel disease proctitis by transperineal superb microvascular imaging. Inflamm. Bowel. Dis., izad186.","DOI":"10.1093\/ibd\/izad186"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1093\/ecco-jcc\/jjaa151","article-title":"Point-of-Care Ultrasound in Inflammatory Bowel Disease","volume":"15","author":"Allocca","year":"2021","journal-title":"J. Crohns. Colitis."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1053\/j.gastro.2023.01.021","article-title":"Intestinal ultrasound in the assessment and management of inflammatory bowel disease: Is it ready for standard practice?","volume":"164","author":"Allocca","year":"2023","journal-title":"Gastroenterology"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1159\/000228562","article-title":"Bowel ultrasound and mucosal healing in ulcerative colitis","volume":"27","author":"Parente","year":"2009","journal-title":"Dig. Dis."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1080\/00365520902839659","article-title":"Predicting the clinical response to cytapheresis in steroid-refractory or -dependent ulcerative colitis using contrast-enhanced ultrasonography","volume":"44","author":"Yamaguchi","year":"2009","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1002\/ueg2.12206","article-title":"Predictive value of Milan ultrasound criteria in ulcerative colitis: A prospective observational cohort study","volume":"10","author":"Allocca","year":"2022","journal-title":"United Eur. Gastroenterol. J."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1177\/2050640620980203","article-title":"Milan ultrasound criteria are accurate in assessing disease activity in ulcerative colitis: External validation","volume":"9","author":"Allocca","year":"2021","journal-title":"United Eur. Gastroenterol. J."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Piazza OSed, N., Noviello, D., Filippi, E., Conforti, F., Furfaro, F., Fraquelli, M., Costantino, A., Danese, S., Vecchi, M., and Fiorino, G. (2023). Superior predictive value of transmural over endoscopic severity for colectomy risk in ulcerative colitis: A multicenter prospective cohort study. J. Crohns Colitis, jjad152.","DOI":"10.1093\/ecco-jcc\/jjad152"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1002\/ueg2.12336","article-title":"Treat-to-target and sequencing therapies in Crohn\u2019s disease","volume":"10","author":"Garcia","year":"2022","journal-title":"United Eur. Gastroenterol. J."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1136\/gutjnl-2019-319451","article-title":"Intestinal ultrasound for monitoring therapeutic response in patients with ulcerative colitis: Results from the TRUST&UC study","volume":"69","author":"Maaser","year":"2020","journal-title":"Gut"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1093\/ecco-jcc\/jjad071","article-title":"Early intestinal ultrasound predicts long-term endoscopic response to biologics in ulcerative colitis","volume":"17","author":"Allocca","year":"2023","journal-title":"J. Crohns Colitis"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1053\/j.gastro.2022.08.038","article-title":"Intestinal ultrasound is accurate to determine endoscopic response and remission in patients with moderate to severe ulcerative colitis: A longitudinal prospective cohort study","volume":"163","author":"Mookhoek","year":"2022","journal-title":"Gastroenterology"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1056\/NEJMoa1606910","article-title":"Tofacitinib as induction and maintenance therapy for ulcerative colitis","volume":"376","author":"Sandborn","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.crohns.2010.02.001","article-title":"The pattern and outcome of acute severe colitis","volume":"4","author":"Dinesen","year":"2010","journal-title":"J. Crohns Colitis"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1053\/j.gastro.2020.01.006","article-title":"AGA clinical practice guidelines on the management of moderate to severe ulcerative colitis","volume":"158","author":"Feuerstein","year":"2020","journal-title":"Gastroenterology"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.crohns.2014.08.012","article-title":"European evidence based consensus on surgery for ulcerative colitis","volume":"9","author":"Bemelman","year":"2015","journal-title":"J. Crohns Colitis"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1097\/MPG.0000000000002677","article-title":"Bowel ultrasound scan predicts corticosteroid failure in children with acute severe colitis","volume":"71","author":"Scarallo","year":"2020","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1093\/ecco-jcc\/jjac083","article-title":"Early intestinal ultrasound predicts intravenous corticosteroid response in hospitalised patients with severe ulcerative colitis","volume":"16","author":"Ilvemark","year":"2022","journal-title":"J. Crohns Colitis"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1136\/gutjnl-2017-315655","article-title":"Gastrointestinal ultrasound in inflammatory bowel disease: An underused resource with potential paradigm-changing application","volume":"67","author":"Bryant","year":"2018","journal-title":"Gut"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"3557","DOI":"10.1007\/s10620-022-07532-6","article-title":"Clinical Challenge: Proactive Precise Management of Active Ulcerative Colitis During Pregnancy-Advantages of Point-of-Care Intestinal Ultrasound and Therapeutic Drug Monitoring","volume":"67","author":"Gottlieb","year":"2022","journal-title":"Dig. Dis. Sci."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1093\/ecco-jcc\/jjaa082","article-title":"Monitoring inflammatory bowel disease in pregnancy using gastrointestinal ultrasonography","volume":"14","author":"Flanagan","year":"2020","journal-title":"J. Crohns Colitis"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1093\/ibd\/izab216","article-title":"Intestinal ultrasound to evaluate treatment response during pregnancy in patients with inflammatory bowel disease","volume":"28","author":"Joshi","year":"2022","journal-title":"Inflamm. Bowel. Dis."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1038\/ajg.2016.418","article-title":"Histological Disease Activity as a Predictor of Clinical Relapse Among Patients With Ulcerative Colitis: Systematic Review and Meta-Analysis","volume":"111","author":"Park","year":"2016","journal-title":"Am. J. Gastroenterol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1136\/gut.32.2.174","article-title":"Microscopic activity in ulcerative colitis: What does it mean?","volume":"32","author":"Riley","year":"1991","journal-title":"Gut"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.14309\/ajg.0000000000001912","article-title":"Impact of endoscopic and histologic activity on disease relapse in ulcerative colitis","volume":"117","author":"Bessissow","year":"2022","journal-title":"Am. J. Gastroenterol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1136\/gutjnl-2015-310393","article-title":"Development and validation of a histological index for UC","volume":"66","author":"Mosli","year":"2017","journal-title":"Gut"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1053\/j.gastro.2015.06.001","article-title":"Postoperative Mortality Among Patients With Inflammatory Bowel Diseases: A Systematic Review and Meta-analysis of Population-Based Studies","volume":"149","author":"Singh","year":"2015","journal-title":"Gastroenterology"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1093\/ecco-jcc\/jjy056","article-title":"S-ECCO collaborators. Evolving role of IBD surgery","volume":"12","author":"Bemelman","year":"2018","journal-title":"J. Crohns Colitis"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"e761","DOI":"10.1016\/j.cgh.2021.05.033","article-title":"Ileal pouch anal anastomosis for the management of ulcerative colitis is associated with significant disability","volume":"20","author":"Kayal","year":"2022","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1097\/SLA.0b013e31827d99a2","article-title":"Ileal pouch anal anastomosis: Analysis of outcome and quality of life in 3707 patients","volume":"257","author":"Fazio","year":"2013","journal-title":"Ann. Surg."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/j.1572-0241.2005.40778.x","article-title":"Comprehensive evaluation of inflammatory and noninflammatory sequelae of ileal pouch-anal anastomoses","volume":"100","author":"Shen","year":"2005","journal-title":"Am. J. Gastroenterol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0025-6196(12)61634-6","article-title":"Pouchitis after ileal pouch-anal anastomosis: A Pouchitis Disease Activity Index","volume":"69","author":"Sandborn","year":"1994","journal-title":"Mayo. Clin. Proc."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1093\/ecco-jcc\/jjab125","article-title":"Accuracy of Gastrointestinal Ultrasound and Calprotectin in the Assessment of Inflammation and its Location in Patients with an Ileoanal Pouch","volume":"16","author":"Ardalan","year":"2022","journal-title":"J. Crohns Colitis"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/S2468-1253(21)00096-0","article-title":"Transmural healing as a therapeutic goal in Crohn\u2019s disease: A systematic review","volume":"6","author":"Geyl","year":"2021","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1016\/S0140-6736(12)60150-0","article-title":"Ulcerative colitis","volume":"380","author":"Eckmann","year":"2012","journal-title":"Lancet"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.dld.2018.03.023","article-title":"Usefulness of contrast-enhanced ultrasound (CEUS) in Inflammatory Bowel Disease (IBD)","volume":"50","author":"Pecere","year":"2018","journal-title":"Dig. Liver Dis."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1093\/ecco-jcc\/jjac082","article-title":"Ultrasound Elastography in Inflammatory Bowel Diseases: A Systematic Review of Accuracy Compared with Histopathological Assessment","volume":"16","author":"Faita","year":"2022","journal-title":"J. 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