{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:46:36Z","timestamp":1760150796681,"version":"build-2065373602"},"reference-count":68,"publisher":"MDPI AG","issue":"24","license":[{"start":{"date-parts":[[2023,12,17]],"date-time":"2023-12-17T00:00:00Z","timestamp":1702771200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fonds Erasme pour la recherche m\u00e9dicale"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>The 3\/7 resistance training (RT) method involves performing sets with increasing numbers of repetitions, and shorter rest periods than the 3x9 method. Therefore, it could induce more metabolic stress in people with heart failure with reduced ejection fraction (HFrEF) or coronary artery disease (CAD). This randomized cross-over study tested this hypothesis. Eleven individuals with HFrEF and thirteen with CAD performed high-intensity interval training (HIIT) for 30 min, followed by 3x9 or 3\/7 RT according to group allocation. pH, HCO3\u2212, lactate, and growth hormone were measured at baseline, after HIIT, and after RT. pH and HCO3\u2212 decreased, and lactate increased after both RT methods. In the CAD group, lactate increased more (6.99 \u00b1 2.37 vs. 9.20 \u00b1 3.57 mmol\/L, p = 0.025), pH tended to decrease more (7.29 \u00b1 0.06 vs. 7.33 \u00b1 0.04, p = 0.060), and HCO3\u2212 decreased more (18.6 \u00b1 3.1 vs. 21.1 \u00b1 2.5 mmol\/L, p = 0.004) after 3\/7 than 3x9 RT. In the HFrEF group, lactate, pH, and HCO3\u2212 concentrations did not differ between RT methods (all p &gt; 0.248). RT did not increase growth hormone in either patient group. In conclusion, the 3\/7 RT method induced more metabolic stress than the 3x9 method in people with CAD but not HFrEF.<\/jats:p>","DOI":"10.3390\/jcm12247743","type":"journal-article","created":{"date-parts":[[2023,12,18]],"date-time":"2023-12-18T10:04:47Z","timestamp":1702893887000},"page":"7743","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of High-Intensity Interval Training Using the 3\/7 Resistance Training Method on Metabolic Stress in People with Heart Failure and Coronary Artery Disease: A Randomized Cross-Over Study"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8377-0814","authenticated-orcid":false,"given":"Alexis","family":"Gillet","sequence":"first","affiliation":[{"name":"Department of Cardiology, CUB H\u00f4pital Erasme, H\u00f4pital Universitaire de Bruxelles (H.U.B), Universit\u00e9 Libre de Bruxelles (ULB), 1050 Brussels, Belgium"},{"name":"Department of Physiotherapy, CUB H\u00f4pital Erasme, H\u00f4pital Universitaire de Bruxelles (H.U.B), Universit\u00e9 Libre de Bruxelles (ULB), 1050 Brussels, Belgium"},{"name":"Research Unit in Rehabilitation Sciences, Faculty of Motor Skills Science, Universit\u00e9 Libre de Bruxelles, 1070 Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7904-8127","authenticated-orcid":false,"given":"Kevin","family":"Forton","sequence":"additional","affiliation":[{"name":"Department of Cardiology, CUB H\u00f4pital Erasme, H\u00f4pital Universitaire de Bruxelles (H.U.B), Universit\u00e9 Libre de Bruxelles (ULB), 1050 Brussels, Belgium"},{"name":"Department of Physiotherapy, CUB H\u00f4pital Erasme, H\u00f4pital Universitaire de Bruxelles (H.U.B), Universit\u00e9 Libre de Bruxelles (ULB), 1050 Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6456-1403","authenticated-orcid":false,"given":"Michel","family":"Lamotte","sequence":"additional","affiliation":[{"name":"Department of Cardiology, CUB H\u00f4pital Erasme, H\u00f4pital Universitaire de Bruxelles (H.U.B), Universit\u00e9 Libre de Bruxelles (ULB), 1050 Brussels, Belgium"},{"name":"Department of Physiotherapy, CUB H\u00f4pital Erasme, H\u00f4pital Universitaire de Bruxelles (H.U.B), Universit\u00e9 Libre de Bruxelles (ULB), 1050 Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8011-3341","authenticated-orcid":false,"given":"Francesca","family":"Macera","sequence":"additional","affiliation":[{"name":"Department of Cardiology, CUB H\u00f4pital Erasme, H\u00f4pital Universitaire de Bruxelles (H.U.B), Universit\u00e9 Libre de Bruxelles (ULB), 1050 Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Roussouli\u00e8res","sequence":"additional","affiliation":[{"name":"Department of Cardiology, CUB H\u00f4pital Erasme, H\u00f4pital Universitaire de Bruxelles (H.U.B), Universit\u00e9 Libre de Bruxelles (ULB), 1050 Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pauline","family":"Louis","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy, CUB H\u00f4pital Erasme, H\u00f4pital Universitaire de Bruxelles (H.U.B), Universit\u00e9 Libre de Bruxelles (ULB), 1050 Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malko","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Research Unit in Rehabilitation Sciences, Faculty of Motor Skills Science, Universit\u00e9 Libre de Bruxelles, 1070 Brussels, 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Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4505-7815","authenticated-orcid":false,"given":"Ga\u00ebl","family":"Deboeck","sequence":"additional","affiliation":[{"name":"Research Unit in Rehabilitation Sciences, Faculty of Motor Skills Science, Universit\u00e9 Libre de Bruxelles, 1070 Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1093\/eurheartj\/ehad118","article-title":"Cardiac Rehabilitation for Heart Failure: \u2018Cinderella\u2019 or Evidence-Based Pillar of Care?","volume":"44","author":"Taylor","year":"2023","journal-title":"Eur. 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