{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T10:21:09Z","timestamp":1780395669630,"version":"3.54.1"},"reference-count":143,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,12,24]],"date-time":"2023-12-24T00:00:00Z","timestamp":1703376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Psoriasis is a chronic, complex, and immunologically mediated systemic disease that not only affects the skin, but also the joints and nails. It may coexist with various other disorders, such as depression, psoriatic arthritis, cardiovascular diseases, diabetes mellitus, and metabolic syndrome. In particular, the potential link between psoriasis and metabolic syndrome is an issue worthy of attention. The dysregulation of growth factors could potentially contribute to the disturbances of keratinocyte proliferation, inflammation, and itch severity. However, the pathophysiology of psoriasis and its comorbidities, such as metabolic syndrome, remains incompletely elucidated. Growth factors and their abnormal metabolism may be a potential link connecting these conditions. Overall, the objective of this review is to analyze the role of growth factor disturbances in both psoriasis and metabolic syndrome.<\/jats:p>","DOI":"10.3390\/jcm13010109","type":"journal-article","created":{"date-parts":[[2023,12,24]],"date-time":"2023-12-24T20:42:30Z","timestamp":1703450550000},"page":"109","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["An Overview of Growth Factors as the Potential Link between Psoriasis and Metabolic Syndrome"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2873-4001","authenticated-orcid":false,"given":"Mateusz","family":"Matwiejuk","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology, Medical University of Bialystok, 15-089 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"My\u015bliwiec","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Medical University of Bialystok, 15-089 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7407-8156","authenticated-orcid":false,"given":"Adrian","family":"Chabowski","sequence":"additional","affiliation":[{"name":"Department of Physiology, Medical University of Bialystok, 15-089 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5923-910X","authenticated-orcid":false,"given":"Iwona","family":"Flisiak","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Medical University of Bialystok, 15-089 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2231847","DOI":"10.1080\/07853890.2023.2231847","article-title":"Life quality among psoriasis patients based on Dermatology Life Quality Index evaluation and its association with psoriasis severity in China: A cross-sectional study","volume":"55","author":"Chen","year":"2023","journal-title":"Ann. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"m1590","DOI":"10.1136\/bmj.m1590","article-title":"National, regional, and worldwide epidemiology of psoriasis: Systematic analysis and modelling study","volume":"369","author":"Parisi","year":"2020","journal-title":"BMJ"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.abd.2022.10.011","article-title":"Resistin serum levels and its association with clinical profile and carotid intima-media thickness in psoriasis: A cross-sectional study","volume":"98","author":"Schlenker","year":"2023","journal-title":"An. Bras. Dermatol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/nm0595-442","article-title":"Response of psoriasis to a lymphocyte-selective toxin (DAB389IL-2) suggests a primary immune, but not keratinocyte, pathogenic basis","volume":"1","author":"Gottlieb","year":"1995","journal-title":"Nat. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.2147\/DMSO.S402618","article-title":"Effects of Metabolic Syndrome on Cardiovascular Outcomes of Psoriatic Patients with Coronary Artery Disease: A Single Center Retrospective Cohort Study","volume":"16","author":"Zhao","year":"2023","journal-title":"Diabetes Metab. Syndr. Obes."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/jid.2011.365","article-title":"Prevalence of metabolic syndrome in patients with psoriasis: A population-based study in the United Kingdom","volume":"132","author":"Langan","year":"2012","journal-title":"J. Investig. Dermatol."},{"key":"ref_7","first-page":"520","article-title":"Recent advances on the roles of epidermal growth factor receptor in psoriasis","volume":"11","author":"Wang","year":"2019","journal-title":"Am. J. Transl. Res."},{"key":"ref_8","first-page":"278","article-title":"Diagnosis and management of psoriasis","volume":"63","author":"Kim","year":"2017","journal-title":"Can. Fam. Physician"},{"key":"ref_9","first-page":"39","article-title":"Biologic Treatments of Psoriasis: An Update for the Clinician","volume":"15","author":"Brownstone","year":"2021","journal-title":"Biologics"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"W65","DOI":"10.7326\/0003-4819-151-4-200908180-00136","article-title":"The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: Explanation and elaboration","volume":"151","author":"Liberati","year":"2009","journal-title":"Ann. Intern. Med."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Page, M.J., McKenzie, J.E., Bossuyt, P.M., Boutron, I., Hoffmann, T.C., Mulrow, C.D., Shamseer, L., Tetzlaff, J.M., Akl, E.A., and Brennan, S.E. (2021). The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. PLoS Med., 18.","DOI":"10.1371\/journal.pmed.1003583"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"S70","DOI":"10.1016\/S0923-1811(00)00144-4","article-title":"Growth regulation of skin fibroblasts","volume":"24","author":"Takehara","year":"2000","journal-title":"J. Dermatol. Sci."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1111\/j.1365-2133.2009.09581.x","article-title":"Basic fibroblast growth factor stimulates the proliferation of human dermal fibroblasts via the ERK1\/2 and JNK pathways","volume":"162","author":"Makino","year":"2010","journal-title":"Br. J. Dermatol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"3336","DOI":"10.3892\/mmr.2016.5646","article-title":"Distribution of fibroblast growth factors and their roles in skin fibroblast cell migration","volume":"14","author":"Song","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1159\/000343208","article-title":"Topical treatment with basic fibroblast growth factor promotes wound healing and barrier recovery induced by skin abrasion","volume":"26","author":"Nakamizo","year":"2013","journal-title":"Ski. Pharmacol. Physiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1002\/term.2691","article-title":"The dual delivery of KGF and bFGF by collagen membrane to promote skin wound healing","volume":"12","author":"Qu","year":"2018","journal-title":"J. Tissue Eng. Regen. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3109\/08977199509003211","article-title":"Effects of oxygen on wound responses to growth factors: Kaposi\u2019s FGF, but not basic FGF stimulates repair in ischemic wounds","volume":"12","author":"Wu","year":"1995","journal-title":"Growth Factors"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"64","DOI":"10.2337\/diacare.18.1.64","article-title":"Effect of topical basic fibroblast growth factor on the healing of chronic diabetic neuropathic ulcer of the foot. A pilot, randomized, double-blind, placebo-controlled study","volume":"18","author":"Richard","year":"1995","journal-title":"Diabetes Care"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1111\/1346-8138.16588","article-title":"Serum levels of angiogenesis-related factors in patients with psoriasis","volume":"50","author":"Watanabe","year":"2023","journal-title":"J. Dermatol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1001\/archderm.1989.01670220055007","article-title":"Cyclosporine inhibits basic fibroblast growth factor-driven proliferation of human endothelial cells and keratinocytes","volume":"125","author":"Sharpe","year":"1989","journal-title":"Arch. Dermatol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"297","DOI":"10.20452\/pamw.1772","article-title":"Serum levels of angiogenic cytokines in psoriatic arthritis and SAPHO syndrome","volume":"123","author":"Fischer","year":"2013","journal-title":"Pol. Arch. Intern. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"19","DOI":"10.17116\/terarkh2015871019-25","article-title":"Risk factors and glycation end products in patients with different forms of coronary heart disease and type 2 diabetes mellitus","volume":"87","author":"Ivannikova","year":"2015","journal-title":"Ter. Arkh."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.jdermsci.2017.08.003","article-title":"Cell-size-dependent upregulation of HGF expression in dermal fibroblasts: Impact on human skin connective tissue aging","volume":"88","author":"Qin","year":"2017","journal-title":"J. Dermatol. Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1034\/j.1600-0463.2002.1101208.x","article-title":"Oral fibroblasts produce more HGF and KGF than skin fibroblasts in response to co-culture with keratinocytes","volume":"110","author":"Stoltze","year":"2002","journal-title":"APMIS"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1038\/sj.onc.1205150","article-title":"Hepatocyte growth factor\/scatter factor activates proliferation in melanoma cells through p38 MAPK, ATF-2 and cyclin D1","volume":"21","author":"Recio","year":"2002","journal-title":"Oncogene"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"25203","DOI":"10.1074\/jbc.M201598200","article-title":"Hepatocyte growth factor inhibits anoikis in head and neck squamous cell carcinoma cells by activation of ERK and Akt signaling independent of NFkappa B","volume":"277","author":"Zeng","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1016\/j.jid.2020.12.019","article-title":"Dermal Adipose Tissue Secretes HGF to Promote Human Hair Growth and Pigmentation","volume":"141","author":"Nicu","year":"2021","journal-title":"J. Investig. Dermatol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1002\/path.1578","article-title":"Diverse and potent activities of HGF\/SF in skin wound repair","volume":"203","author":"Bevan","year":"2004","journal-title":"J. Pathol."},{"key":"ref_29","first-page":"5157","article-title":"c-Met autocrine activation induces development of malignant melanoma and acquisition of the metastatic phenotype","volume":"58","author":"Otsuka","year":"1998","journal-title":"Cancer Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1089\/scd.2021.0129","article-title":"Overexpression of Hepatocyte Growth Factor in Dental Pulp Stem Cells Ameliorates the Severity of Psoriasis by Reducing Inflammatory Responses","volume":"30","author":"Meng","year":"2021","journal-title":"Stem Cells Dev."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"237","DOI":"10.4103\/0019-5154.55631","article-title":"Cell proliferation and cytokine induction by tnf-alpha of psoriatic keratinocytes are not different from normal keratinocytes in vitro","volume":"54","author":"Takahashi","year":"2009","journal-title":"Indian J. Dermatol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S1665-2681(19)32027-7","article-title":"Metabolic syndrome, non-alcoholic steatohepatitis (NASH), and hepatocyte growth factor (HGF)","volume":"5","author":"Balaban","year":"2006","journal-title":"Ann Hepatol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2927","DOI":"10.1210\/jc.2004-1588","article-title":"Strong association between serum hepatocyte growth factor and metabolic syndrome","volume":"90","author":"Hiratsuka","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/eci.12054","article-title":"Hepatocyte growth factor and interferon-\u03b3 inducible protein-10 are related to visceral adiposity","volume":"43","author":"Faber","year":"2013","journal-title":"Eur. J. Clin. Investig."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1007\/s00380-022-02198-6","article-title":"Improvement of physical activity significantly reduced serum hepatocyte growth factor levels in a general population: 10 year prospective study","volume":"38","author":"Sakaue","year":"2023","journal-title":"Heart Vessel."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1365-2265.2012.04496.x","article-title":"Independent association of elevated serum hepatocyte growth factor levels with development of insulin resistance in a 10-year prospective study","volume":"79","author":"Tsukagawa","year":"2013","journal-title":"Clin. Endocrinol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1007\/s13105-015-0444-6","article-title":"Targeted delivery of HGF to the skeletal muscle improves glucose homeostasis in diet-induced obese mice","volume":"71","author":"Perdomo","year":"2015","journal-title":"J. Physiol. Biochem."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1291\/hypres.27.247","article-title":"Association between hepatocyte growth factor gene polymorphism and essential hypertension","volume":"27","author":"Motone","year":"2004","journal-title":"Hypertens. Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1002\/jbm.a.32445","article-title":"Collagen scaffolds loaded with collagen-binding NGF-beta accelerate ulcer healing","volume":"92","author":"Sun","year":"2010","journal-title":"J. Biomed. Mater. Res. A"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jtv.2020.10.001","article-title":"Validity of skin blot examination for albumin and nerve growth factor \u03b2 to detect itching of the skin in Indonesian older adults","volume":"30","author":"Sari","year":"2021","journal-title":"J. Tissue Viability"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"21490","DOI":"10.1038\/s41598-021-00935-x","article-title":"Microinjection of pruritogens in NGF-sensitized human skin","volume":"11","author":"Solinski","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1182\/blood-2012-12-469882","article-title":"Increased circulating levels of neurotrophins and elevated expression of their high-affinity receptors on skin and gut mast cells in mastocytosis","volume":"122","author":"Peng","year":"2013","journal-title":"Blood"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1111\/bjd.12175","article-title":"Ustekinumab improves psoriasis-related gene expression in noninvolved psoriatic skin without inhibition of the antimicrobial response","volume":"168","author":"Baerveldt","year":"2013","journal-title":"Br. J. Dermatol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"961","DOI":"10.2353\/ajpath.2008.070710","article-title":"Revisiting the Koebner phenomenon: Role of NGF and its receptor system in the pathogenesis of psoriasis","volume":"172","author":"Raychaudhuri","year":"2008","journal-title":"Am. J. Pathol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"154948","DOI":"10.1016\/j.cyto.2019.154948","article-title":"Interactions among thyroid hormone (FT4), chemokine (MCP-1) and neurotrophin (NGF-\u03b2) levels studied in Hungarian postmenopausal and obese women","volume":"127","year":"2020","journal-title":"Cytokine"},{"key":"ref_46","first-page":"108106","article-title":"Potential novel biomarkers for diabetic testicular damage in streptozotocin-induced diabetic rats: Nerve growth factor Beta and vascular endothelial growth factor","volume":"2014","author":"Sisman","year":"2014","journal-title":"Dis. Mark."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"S26","DOI":"10.1111\/j.1440-1681.1995.tb02907.x","article-title":"Altered production of nerve growth factor in cultured vascular smooth muscle cells from genetically hypertensive rats","volume":"22","author":"Ueyama","year":"1995","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Selvaraju, V., Babu, J.R., and Geetha, T. (2022). Salivary Neurotrophins Brain-Derived Neurotrophic Factor and Nerve Growth Factor Associated with Childhood Obesity: A Multiplex Magnetic Luminescence Analysis. Diagnostics, 12.","DOI":"10.3390\/diagnostics12051130"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Franke, K., Bal, G., Li, Z., Zuberbier, T., and Babina, M. (2023). CREB Is Activated by the SCF\/KIT Axis in a Partially ERK-Dependent Manner and Orchestrates Survival and the Induction of Immediate Early Genes in Human Skin Mast Cells. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24044135"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1369\/0022155420938031","article-title":"The Mast Cell\u2013SCF\u2013CB1 Interaction Is a Key Player in Seborrheic Keratosis","volume":"68","author":"Sugawara","year":"2020","journal-title":"J. Histochem. Cytochem."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/j.bbrc.2017.04.141","article-title":"Th17 cell-mediated immune responses promote mast cell proliferation by triggering stem cell factor in keratinocytes","volume":"487","author":"Cho","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0923-1811(00)00095-5","article-title":"Possible contribution of stem cell factor in psoriasis vulgaris","volume":"24","author":"Yamamoto","year":"2000","journal-title":"J. Dermatol. Sci."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"21732","DOI":"10.1038\/s41598-020-78244-y","article-title":"Skin wound closure delay in metabolic syndrome correlates with SCF deficiency in keratinocytes","volume":"10","author":"Wang","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1016\/j.amjcard.2010.07.039","article-title":"Circulating Levels of Endothelial Progenitor Cell Mobilizing Factors in The Metabolic Syndrome","volume":"106","author":"Jialal","year":"2010","journal-title":"Am. J. Cardiol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"e52036","DOI":"10.15252\/embr.202052036","article-title":"SCFJFK is functionally linked to obesity and metabolic syndrome","volume":"22","author":"He","year":"2021","journal-title":"EMBO Rep."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1053\/j.gastro.2005.12.027","article-title":"Reduced stem cell factor links smooth myopathy and loss of interstitial cells of cajal in murine diabetic gastroparesis","volume":"130","author":"Vittal","year":"2006","journal-title":"Gastroenterology"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"232","DOI":"10.24920\/J1001-9294.2017.035","article-title":"Plasma SCF\/c-kit Levels in Patients with Dipper and Non-Dipper Hypertension","volume":"32","author":"Zhong","year":"2017","journal-title":"Chin. Med. Sci. J."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Takematsu, E., Massidda, M., Howe, G., Goldman, J., Felli, P., Mei, L., Callahan, G., Sligar, A.D., Smalling, R., and Baker, A.B. (2023). Transmembrane Stem Factor Nanodiscs Enhanced Revascularization in a Hind Limb Ischemia Model in Diabetic, Hyperlipidemic Rabbits. bioRxiv.","DOI":"10.21203\/rs.3.rs-2997323\/v1"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.3727\/096368912X637064","article-title":"Adipose tissue-derived mesenchymal cells support skin reepithelialization through secretion of KGF-1 and PDGF-BB: Comparison with dermal fibroblasts","volume":"21","author":"Alexaki","year":"2012","journal-title":"Cell Transplant."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.actbio.2016.07.001","article-title":"Syndecan-4 enhances PDGF-BB activity in diabetic wound healing","volume":"42","author":"Das","year":"2016","journal-title":"Acta Biomater."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/s41536-021-00189-1","article-title":"VEGF-A, PDGF-BB and HB-EGF engineered for promiscuous super affinity to the extracellular matrix improve wound healing in a model of type 1 diabetes","volume":"6","author":"White","year":"2021","journal-title":"NPJ Regen. Med."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1172\/JCI118169","article-title":"Detection of platelet-derived growth factor (PDGF)-AA in actively healing human wounds treated with recombinant PDGF-BB and absence of PDGF in chronic nonhealing wounds","volume":"96","author":"Pierce","year":"1995","journal-title":"J. Clin. Investig."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Jian, K., Yang, C., Li, T., Wu, X., Shen, J., Wei, J., Yang, Z., Yuan, D., Zhao, M., and Shi, J. (2022). PDGF-BB-derived supramolecular hydrogel for promoting skin wound healing. J. Nanobiotechnol., 20.","DOI":"10.1186\/s12951-022-01390-0"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"e173","DOI":"10.1111\/j.1600-0625.2009.01036.x","article-title":"Zeaxanthin inhibits PDGF-BB-induced migration in human dermal fibroblasts","volume":"19","author":"Wu","year":"2010","journal-title":"Exp. Dermatol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1080\/08977190701803885","article-title":"Collagen membranes loaded with collagen-binding human PDGF-BB accelerate wound healing in a rabbit dermal ischemic ulcer model","volume":"25","author":"Sun","year":"2007","journal-title":"Growth Factors"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"306","DOI":"10.5603\/EP.2014.0042","article-title":"VEGF-A and PDGF-BB--angiogenic factors and the stage of diabetic foot syndrome advancement","volume":"65","author":"Drela","year":"2014","journal-title":"Endokrynol. Pol."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Park, S.A., Raghunathan, V.K., Shah, N.M., Teixeira, L., Motta, M.J., Covert, J., Dubielzig, R., Schurr, M., Isseroff, R.R., and Abbott, N.L. (2014). PDGF-BB Does Not Accelerate Healing in Diabetic Mice with Splinted Skin Wounds. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0104447"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/1523-1747.ep12515921","article-title":"Effect of retinoic acid on platelet-derived growth factor (PDGF) bioactivity and type-B PDGF receptors in normal and psoriatic human fibroblasts","volume":"96","author":"Raynaud","year":"1991","journal-title":"J. Investig. Dermatol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.clnu.2012.07.003","article-title":"Patients affected by metabolic syndrome show decreased levels of circulating platelet derived growth factor (PDGF)-BB","volume":"32","author":"Tisato","year":"2013","journal-title":"Clin. Nutr."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.bbrc.2019.06.048","article-title":"Enhanced PDGF signaling in gestational diabetes mellitus is involved in pancreatic \u03b2-cell dysfunction","volume":"516","author":"Shan","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1155\/2007\/962892","article-title":"Low plasma levels of FGF-2 and PDGF-BB are associated with cardiovascular events in type II diabetes mellitus (diabetes heart study)","volume":"23","author":"Yeboah","year":"2007","journal-title":"Dis. Markers"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.diabres.2009.05.008","article-title":"The changes of platelet-derived growth factor-BB (PDGF-BB) in T2DM and its clinical significance for early diagnosis of diabetic nephropathy","volume":"85","author":"Wang","year":"2009","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_73","first-page":"S195","article-title":"Urinary excretion of TGF-beta 1, PDGF-BB and fibronectin in insulin-dependent diabetes mellitus patients","volume":"63","author":"Fagerudd","year":"1997","journal-title":"Kidney Int. Suppl."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"670","DOI":"10.3109\/0886022X.2012.674438","article-title":"Urinary platelet-derived growth factor-BB as an early marker of nephropathy in patients with type 2 diabetes: An Egyptian study","volume":"34","author":"Bessa","year":"2012","journal-title":"Ren. Fail."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/j.1365-2362.1993.tb00745.x","article-title":"Diabetes mellitus induces accelerated growth of aortic smooth muscle cells: Association with overexpression of PDGF beta-receptors","volume":"23","author":"Kawano","year":"1993","journal-title":"Eur. J. Clin. Investig."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/S0895-7061(98)00124-1","article-title":"Increased plasma levels of platelet-derived growth factor (PDGF-BB + PDGF-AB) in patients with never-treated mild essential hypertension","volume":"11","author":"Rossi","year":"1998","journal-title":"Am. J. Hypertens."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.orcp.2021.04.003","article-title":"Regular aerobic exercise activates PDGF-BB\/PDGFR-\u03b2 signaling and modulates the inflammatory-anti-inflammatory balance in diet-induced obese mice","volume":"15","author":"Wang","year":"2021","journal-title":"Obes. Res. Clin. Pract."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1016\/j.yjmcc.2010.03.008","article-title":"PDGF-BB protects cardiomyocytes from apoptosis and improves contractile function of engineered heart tissue","volume":"48","author":"Vantler","year":"2010","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"e12711","DOI":"10.1111\/ijpo.12711","article-title":"A combination of circulating chemokines as biomarkers of obesity-induced insulin resistance at puberty","volume":"16","author":"Rivera","year":"2021","journal-title":"Pediatr. Obes."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.jaci.2021.02.018","article-title":"Basophils promote barrier dysfunction and resolution in the atopic skin","volume":"148","author":"Pellefigues","year":"2021","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Li, Y., Alnojeidi, H., Kilani, R.T., and Ghahary, A. (2022). M-CSF-stimulated myeloid cells can convert into epithelial cells to participate in re-epithelialization and hair follicle regeneration during dermal wound healing. PLoS ONE, 17.","DOI":"10.1371\/journal.pone.0262060"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"613975","DOI":"10.3389\/fimmu.2020.613975","article-title":"GM-CSF Expression and Macrophage Polarization in Joints of Undifferentiated Arthritis Patients Evolving to Rheumatoid Arthritis or Psoriatic Arthritis","volume":"11","author":"Cuervo","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1186\/s13075-017-1417-7","article-title":"Serum bone-turnover biomarkers are associated with the occurrence of peripheral and axial arthritis in psoriatic disease: A prospective cross-sectional comparative study","volume":"19","author":"Jadon","year":"2017","journal-title":"Arthritis Res. Ther."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Cubillos, S., Krieg, N., and Norgauer, J. (2016). Effect of Vitamin D on Peripheral Blood Mononuclear Cells from Patients with Psoriasis Vulgaris and Psoriatic Arthritis. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0153094"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1080\/02713680802650369","article-title":"Expression of macrophage colony-stimulating factor (M-CSF) and its receptor in streptozotocin-induced diabetic rats","volume":"34","author":"Liu","year":"2009","journal-title":"Curr. Eye Res."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"H1789","DOI":"10.1152\/ajpheart.01118.2006","article-title":"Resistance artery remodeling in deoxycorticosterone acetate-salt hypertension is dependent on vascular inflammation: Evidence from m-CSF-deficient mice","volume":"292","author":"Ko","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"100010","DOI":"10.1016\/j.cytox.2019.100010","article-title":"The change in the circadian rhythm of macrophage colony-stimulating factor content in the blood of patients with essential hypertension","volume":"1","author":"Radaeva","year":"2019","journal-title":"Cytokine X"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1189\/jlb.3A0514-251R","article-title":"Distinct role of FoxO1 in M-CSF- and GM-CSF-differentiated macrophages contributes LPS-mediated IL-10: Implication in hyperglycemia","volume":"97","author":"Chung","year":"2015","journal-title":"J. Leukoc. Biol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1038\/oby.2007.237","article-title":"Macrophage-colony stimulating factor in obese adipose tissue: Studies with heterozygous op\/+ mice","volume":"15","author":"Sugita","year":"2007","journal-title":"Obesity"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/1056-8727(95)80025-A","article-title":"The effect of macrophage colony-stimulating factor (M-CSF) on the progression of lipid-induced nephrotoxicity in diabetic nephropathy","volume":"9","author":"Utsunomiya","year":"1995","journal-title":"J. Diabetes Complicat."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1111\/j.1749-6632.1990.tb00177.x","article-title":"Plasma cholesterol-lowering activity of monocyte colony-stimulating factor (M-CSF)","volume":"587","author":"Shimano","year":"1990","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0021-9150(92)90261-E","article-title":"Macrophage colony stimulating factor prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbits","volume":"93","author":"Inouea","year":"1992","journal-title":"Atherosclerosis"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1002\/(SICI)1098-2795(199701)46:1<92::AID-MRD14>3.0.CO;2-5","article-title":"Immunoreactive macrophage colony-stimulating factor is increased in atherosclerotic lesions of Watanabe heritable hyperlipidemic rabbits after recombinant human macrophage colony-stimulating factor therapy","volume":"46","author":"Donnelly","year":"1997","journal-title":"Mol. Reprod. Dev."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1055\/s-2007-979090","article-title":"Effect of macrophage colony stimulating factor on the advanced atherosclerosis in Watanabe heritable hyperlipidemic rabbits","volume":"29","author":"Watanabe","year":"1997","journal-title":"Horm. Metab. Res."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1126\/science.2479986","article-title":"Vascular endothelial growth factor is a secreted angiogenic mitogen","volume":"246","author":"Leung","year":"1989","journal-title":"Science"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1172\/JCI11317","article-title":"Control of hair growth and follicle size by VEGF-mediated angiogenesis","volume":"107","author":"Yano","year":"2001","journal-title":"J. Clin. Investig."},{"key":"ref_97","first-page":"1529","article-title":"Elevated vascular endothelial growth factor in systemic sclerosis","volume":"30","author":"Choi","year":"2003","journal-title":"J. Rheumatol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1111\/j.1398-9995.2009.02069.x","article-title":"Plasma levels and skin-eosinophil-expression of vascular endothelial growth factor in patients with chronic urticaria","volume":"64","author":"Tedeschi","year":"2009","journal-title":"Allergy"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/sj.jid.5700096","article-title":"Interaction between genetic control of vascular endothelial growth factor production and retinoid responsiveness in psoriasis","volume":"126","author":"Young","year":"2006","journal-title":"J. Investig. Dermatol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"e202","DOI":"10.1111\/j.1365-2230.2008.02991.x","article-title":"Complete remission of psoriasis following bevacizumab therapy for colon cancer","volume":"34","author":"Akman","year":"2009","journal-title":"Clin. Exp. Dermatol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1016\/S0002-9149(01)01486-2","article-title":"Plasma vascular endothelial growth factor and its receptor Flt-1 in patients with hyperlipidemia and atherosclerosis and the effects of fluvastatin or fenofibrate","volume":"87","author":"Blann","year":"2001","journal-title":"Am. J. Cardiol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1161\/HYPERTENSIONAHA.109.129973","article-title":"Vascular endothelial growth factor receptor 2 controls blood pressure by regulating nitric oxide synthase expression","volume":"54","author":"Facemire","year":"2009","journal-title":"Hypertension"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.forsciint.2004.08.021","article-title":"Transforming growth factors (TGF-alpha and TGF-beta1) in the determination of vitality and wound age: Immunohistochemical study on human skin wounds","volume":"153","author":"Grellner","year":"2005","journal-title":"Forensic Sci. Int."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/BF01213299","article-title":"Transforming growth factor-alpha (TGF alpha)-producing gastric carcinoma with acanthosis nigricans: An endocrine effect of TGF alpha in the pathogenesis of cutaneous paraneoplastic syndrome and epithelial hyperplasia of the esophagus","volume":"32","author":"Koyama","year":"1997","journal-title":"J. Gastroenterol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/bjc.1989.310","article-title":"Production of TGF-alpha and TGF-beta by cultured keratinocytes, skin and oral squamous cell carcinomas--potential autocrine regulation of normal and malignant epithelial cell proliferation","volume":"60","author":"Partridge","year":"1989","journal-title":"Br. J. Cancer"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1126\/science.2916128","article-title":"Overexpression of transforming growth factor alpha in psoriatic epidermis","volume":"243","author":"Elder","year":"1989","journal-title":"Science"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/j.1346-8138.1991.tb03053.x","article-title":"Increased production of transforming growth factor-alpha in psoriatic epidermis","volume":"18","author":"Higashiyama","year":"1991","journal-title":"J. Dermatol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1016\/j.immuni.2019.03.002","article-title":"Keratinocyte-Mediated Activation of the Cytokine TGF-\u03b2 Maintains Skin Recirculating Memory CD8+ T Cells","volume":"50","author":"Hirai","year":"2019","journal-title":"Immunity"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1002\/path.1711710307","article-title":"TGF-\u03b2S and TGF-\u03b2 type II receptor in human epidermis: Differential expression in acute and chronic skin wounds","volume":"171","author":"Schmid","year":"1993","journal-title":"J. Pathol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1111\/j.0022-202X.2005.23859.x","article-title":"Topical application of a peptide inhibitor of transforming growth factor-beta1 ameliorates bleomycin-induced skin fibrosis","volume":"125","author":"Santiago","year":"2005","journal-title":"J. Investig. Dermatol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/art.22289","article-title":"Recombinant human anti-transforming growth factor beta1 antibody therapy in systemic sclerosis: A multicenter, randomized, placebo-controlled phase I\/II trial of CAT-192","volume":"56","author":"Denton","year":"2007","journal-title":"Arthritis Rheum."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/0923-1811(95)00438-6","article-title":"Differential localization of TGF-beta-precursor isotypes in psoriatic human skin","volume":"11","author":"Hashimoto","year":"1996","journal-title":"J. Dermatol. Sci."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1006\/cyto.2002.1953","article-title":"Association between psoriasis severity and transforming growth factor beta(1) and beta (2) in plasma and scales from psoriatic lesions","volume":"19","author":"Flisiak","year":"2002","journal-title":"Cytokine"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"13589","DOI":"10.1038\/s41598-017-14025-4","article-title":"Transforming growth factor-\u03b2 signaling pathway-associated genes SMAD2 and TGFBR2 are implicated in metabolic syndrome in a Taiwanese population","volume":"7","author":"Lin","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.2337\/dc09-0476","article-title":"Transforming growth factor-beta1 and incident type 2 diabetes: Results from the MONICA\/KORA case-cohort study, 1984\u20132002","volume":"32","author":"Herder","year":"2009","journal-title":"Diabetes Care"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1016\/S0021-9258(19)83739-0","article-title":"Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the new-born animal","volume":"237","author":"COHEN","year":"1962","journal-title":"J. Biol. Chem."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1006\/jsre.1995.1160","article-title":"Effect of growth factors on cell proliferation and epithelialization in human skin","volume":"59","author":"Bhora","year":"1995","journal-title":"J. Surg. Res."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Choi, S.Y., Lee, Y.J., Kim, J.M., Kang, H.J., Cho, S.H., and Chang, S.E. (2018). Epidermal Growth Factor Relieves Inflammatory Signals in Staphylococcus aureus-Treated Human Epidermal Keratinocytes and Atopic Dermatitis-Like Skin Lesions in Nc\/Nga Mice. Biomed. Res. Int., 2018.","DOI":"10.1155\/2018\/9439182"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1111\/exd.12182","article-title":"Pretreatment of epidermal growth factor promotes primary hair recovery via the dystrophic anagen pathway after chemotherapy-induced alopecia","volume":"22","author":"Paik","year":"2013","journal-title":"Exp. Dermatol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1111\/ced.12356","article-title":"Effect of psoriasis activity on epidermal growth factor (EGF) and the concentration of soluble EGF receptor in serum and plaque scales","volume":"39","author":"Flisiak","year":"2014","journal-title":"Clin. Exp. Dermatol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1111\/1523-1747.ep12285389","article-title":"Altered [125I] epidermal growth factor binding and receptor distribution in psoriasis","volume":"86","author":"Nanney","year":"1986","journal-title":"J. Investig. Dermatol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s13098-020-00591-7","article-title":"Soluble EGFR, a hepatokine, and adipsin, an adipokine, are biomarkers correlated with distinct aspects of insulin resistance in type 2 diabetes subjects","volume":"12","author":"Kyohara","year":"2020","journal-title":"Diabetol. Metab. Syndr."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.2337\/db07-0739","article-title":"Elevated epidermal growth factor receptor phosphorylation induces resistance artery dysfunction in diabetic db\/db mice","volume":"57","author":"Belmadani","year":"2008","journal-title":"Diabetes"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1111\/1523-1747.ep12616668","article-title":"Expression of growth hormone receptor, insulin-like growth factor 1 (IGF-1) and IGF-1 receptor mRNA and proteins in human skin","volume":"99","author":"Tavakkol","year":"1992","journal-title":"J. Investig. Dermatol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1038\/onc.2009.440","article-title":"The IGF-1\/IGF-1R signalling axis in the skin: A new role for the dermis in ageing-associated skin cancer","volume":"29","author":"Lewis","year":"2010","journal-title":"Oncogene"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.jaad.2016.05.019","article-title":"Association of insulin-like growth factor (IGF)-1 gene polymorphisms with plasma levels of IGF-1 and acne severity","volume":"75","author":"Rahaman","year":"2016","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"4867368","DOI":"10.1155\/2016\/4867368","article-title":"Altered Autophagy-Associated Genes Expression in T Cells of Oral Lichen Planus Correlated with Clinical Features","volume":"2016","author":"Tan","year":"2016","journal-title":"Mediat. Inflamm."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1007\/s004030000188","article-title":"Involvement of insulin-like growth factor-I in psoriasis as a paracrine growth factor: Dermal fibroblasts play a regulatory role in developing psoriatic lesions","volume":"292","author":"Miura","year":"2000","journal-title":"Arch. Dermatol. Res."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1111\/j.1468-3083.2010.03966.x","article-title":"Insulin-like growth factor-1 in psoriatic plaques treated with PUVA and methotrexate","volume":"25","author":"Amin","year":"2011","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1007\/s10552-009-9351-x","article-title":"Association of metabolic syndrome with insulin-like growth factors among adults in the US","volume":"20","author":"Saydah","year":"2009","journal-title":"Cancer Causes Control."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1177\/000331970605700306","article-title":"Total serum insulin-like growth factor-1 and C-reactive protein in metabolic syndrome with or without diabetes","volume":"57","author":"Efstratiadis","year":"2006","journal-title":"Angiology"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/ajd.12044","article-title":"Weight gain and tumour necrosis factor-alpha inhibitors in patients with psoriasis","volume":"54","author":"Tan","year":"2013","journal-title":"Australas. J. Dermatol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1093\/rheumatology\/kew326","article-title":"The influence of obesity on response to tumour necrosis factor-\u03b1 inhibitors in psoriatic arthritis: Results from the DANBIO and ICEBIO registries","volume":"55","author":"Glintborg","year":"2016","journal-title":"Rheumatology"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1159\/000156599","article-title":"Impact of body mass index and obesity on clinical response to systemic treatment for psoriasis. Evidence from the Psocare project","volume":"217","author":"Naldi","year":"2008","journal-title":"Dermatology"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1111\/1346-8138.14526","article-title":"Effects of tumour necrosis factor-\u03b1, interleukin-23 and interleukin-17A inhibitors on body weight and body mass index in patients with psoriasis","volume":"45","author":"Takamura","year":"2018","journal-title":"J. Dermatol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.jaad.2018.02.074","article-title":"Ixekizumab treatment shows a neutral impact on cardiovascular parameters in patients with moderate-to-severe plaque psoriasis: Results from UNCOVER-1, UNCOVER-2, and UNCOVER-3","volume":"79","author":"Egeberg","year":"2018","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1111\/jdv.14252","article-title":"The effect of body weight on the efficacy and safety of ixekizumab: Results from an integrated database of three randomised, controlled Phase 3 studies of patients with moderate-to-severe plaque psoriasis","volume":"31","author":"Reich","year":"2017","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Piros, \u00c9.A., Szab\u00f3, \u00c1., Rencz, F., Brodszky, V., Wikonk\u00e1l, N., Miheller, P., Horv\u00e1th, M., and Holl\u00f3, P. (2021). Anti-Interleukin-17 Therapy of Severe Psoriatic Patients Results in an Improvement of Serum Lipid and Inflammatory Parameters\u2019 Levels, but Has No Effect on Body Composition Parameters. Life, 11.","DOI":"10.3390\/life11060535"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1111\/bjd.12235","article-title":"Ustekinumab does not increase body mass index in patients with chronic plaque psoriasis: A prospective cohort study","volume":"168","author":"Gisondi","year":"2013","journal-title":"Br. J. Dermatol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.jaad.2009.11.012","article-title":"Impact of weight on the efficacy and safety of ustekinumab in patients with moderate to severe psoriasis: Rationale for dosing recommendations","volume":"63","author":"Lebwohl","year":"2010","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1016\/S0140-6736(08)60726-6","article-title":"Efficacy and safety of ustekinumab, a human interleukin-12\/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 2)","volume":"371","author":"Papp","year":"2008","journal-title":"Lancet"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1586\/eci.10.92","article-title":"The ACCEPT study: Ustekinumab versus etanercept in moderate-to-severe psoriasis patients","volume":"7","author":"Young","year":"2011","journal-title":"Expert. Rev. Clin. Immunol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1111\/bjd.14552","article-title":"Body mass index predicts discontinuation due to ineffectiveness and female sex predicts discontinuation due to side-effects in patients with psoriasis treated with adalimumab, etanercept or ustekinumab in daily practice: A prospective, comparative, long-term drug-survival study from the BioCAPTURE registry","volume":"175","author":"Zweegers","year":"2016","journal-title":"Br. J. Dermatol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/1\/109\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:41:26Z","timestamp":1760132486000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/1\/109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,24]]},"references-count":143,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,1]]}},"alternative-id":["jcm13010109"],"URL":"https:\/\/doi.org\/10.3390\/jcm13010109","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,24]]}}}