{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T07:43:51Z","timestamp":1788248631289,"version":"build-2803163510"},"reference-count":26,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,12,25]],"date-time":"2023-12-25T00:00:00Z","timestamp":1703462400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>(1) Background: Over the past several years, there has been a renewed interest with regard to the effect of pre-operative vitamin D levels on post-surgical outcomes. Pre-operative vitamin D deficiency has been associated with many negative post-operative outcomes. However, the role of vitamin D in postoperative outcomes in colorectal liver metastasis (CRLM) resection is relatively uninvestigated. Our study investigated the correlation between preoperative vitamin D levels and postoperative complications in patients undergoing resection for CRLM. (2) Methods: We retrospectively examined the post-operative course of 109 patients, who were evaluated based upon preoperative vitamin D levels: the first group had vitamin D levels less than 25 nmol\/L (VIT D &lt; 25 nmol\/L) (n = 12) vs. the second group who had vitamin D levels equal to or greater than 25 nmol\/L (VIT D \u2265 25 nmol\/L) (n = 97). (3) Results: Patients with lower pre-operative vitamin D levels (VIT D &lt; 25 nmol\/L) had significantly higher rates of blood transfusions (33.3% vs. 10.3%, p = 0.01), post-operative surgical complications (50% vs. 17.5%, p = 0.009), and infectious complications (25% vs. 7.2%, p = 0.04). However, there was no difference in overall survival seen between the two groups. (4) Conclusions: The results of our study indicate that patients with preoperative vitamin D deficiency (defined as preoperative vitamin D levels less than 25 nmol\/L) may have an increased risk of postoperative complications in patients undergoing liver surgery for metastatic colorectal cancer.<\/jats:p>","DOI":"10.3390\/jcm13010115","type":"journal-article","created":{"date-parts":[[2023,12,25]],"date-time":"2023-12-25T03:42:12Z","timestamp":1703475732000},"page":"115","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Association between Preoperative Vitamin D Levels and Postoperative Complications in Patients Undergoing Colorectal Liver Metastasis Surgery"],"prefix":"10.3390","volume":"13","author":[{"given":"Ahmad","family":"Mahamid","sequence":"first","affiliation":[{"name":"Department of Surgery, Carmel Medical Center, Haifa 3436212, Israel"},{"name":"The Ruth and Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa 3200003, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Kazlow","sequence":"additional","affiliation":[{"name":"Department of Surgery, Carmel Medical Center, Haifa 3436212, Israel"},{"name":"The Ruth and Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa 3200003, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariel Matan","family":"David","sequence":"additional","affiliation":[{"name":"Department of Surgery, Carmel Medical Center, Haifa 3436212, Israel"},{"name":"The Ruth and Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa 3200003, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Abu-Zaydeh","sequence":"additional","affiliation":[{"name":"Department of Surgery, Carmel Medical Center, Haifa 3436212, Israel"},{"name":"The Ruth and Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa 3200003, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aasem","family":"Abu Shtaya","sequence":"additional","affiliation":[{"name":"The Ruth and Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa 3200003, Israel"},{"name":"Department of Gastroenterology, Carmel Medical Center, Haifa 3436212, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dvir","family":"Froylich","sequence":"additional","affiliation":[{"name":"Department of Surgery, Carmel Medical Center, Haifa 3436212, Israel"},{"name":"The Ruth and Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa 3200003, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wissam","family":"Khoury","sequence":"additional","affiliation":[{"name":"Department of Surgery, Carmel Medical Center, Haifa 3436212, Israel"},{"name":"The Ruth and Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa 3200003, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eran","family":"Sadot","sequence":"additional","affiliation":[{"name":"Department of Surgery, Rabin Medical Center, Petch Tikvah 4941492, Israel"},{"name":"Sackler School of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3138-5495","authenticated-orcid":false,"given":"Riad","family":"Haddad","sequence":"additional","affiliation":[{"name":"Department of Surgery, Carmel Medical Center, Haifa 3436212, Israel"},{"name":"The Ruth and Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa 3200003, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Ivey, G.D., Johnston, F.M., Azad, N.S., Christenson, E.S., Lafaro, K.J., and Shubert, C.R. 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