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Our cohort comprised 133 MI patients (62.71 \u00b1 11.3 years, 82% male) treated with atorvastatin 80 mg o.d. during admission. Basal LDL-C levels before admission were analyzed. We compared lipid profile variables before and during admission, and LLT at discharge was registered. Achieved theoretical LDL-C levels were estimated using LDL-C during admission and basal LDL-C as references and compared to LDL-C on first blood sample 4\u20136 weeks after discharge. A significant reduction in cholesterol from basal levels was noted during admission, including total cholesterol, triglycerides, HDL-C, non-HDL-C, and LDL-C (\u221239.23 \u00b1 34.89 mg\/dL, p &lt; 0.001). LDL-C levels were reduced by 30% in days 1\u20132 and 40\u201345% in subsequent days (R2 0.766, p &lt; 0.001). Using LDL-C during admission as a reference, most patients (88.7%) would theoretically achieve an LDL-C &lt; 55 mg\/dL with discharge LLT. However, if basal LDL-C levels were considered as a reference, only a small proportion of patients (30.1%) would achieve this lipid target, aligned with the proportion of patients with LDL-C &lt; 55 mg\/dL 4\u20136 weeks after discharge (36.8%). We conclude that statin treatment during admission for MI can induce a significant reduction in LDL-C and LLT at discharge is usually prescribed using LDL-C during admission as the reference, which leads to insufficient LDL-C reduction after discharge. Basal LDL-C before admission should be considered as the reference value for tailored LLT prescription.<\/jats:p>","DOI":"10.3390\/jcm13010127","type":"journal-article","created":{"date-parts":[[2023,12,25]],"date-time":"2023-12-25T22:59:09Z","timestamp":1703545149000},"page":"127","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Short-Course High-Intensity Statin Treatment during Admission for Myocardial Infarction and LDL-Cholesterol Reduction\u2014Impact on Tailored Lipid-Lowering Therapy at Discharge"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5565-5547","authenticated-orcid":false,"given":"V\u00edctor","family":"Marcos-Garc\u00e9s","sequence":"first","affiliation":[{"name":"Department of Cardiology, Hospital Clinico Universitario de Valencia, 46010 Valencia, Spain"},{"name":"INCLIVA Health Research Institute, 46010 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1734-0381","authenticated-orcid":false,"given":"H\u00e9ctor","family":"Merenciano-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Clinico Universitario de Valencia, 46010 Valencia, Spain"},{"name":"INCLIVA Health Research Institute, 46010 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Luz","family":"Mart\u00ednez Mas","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Clinico Universitario de Valencia, 46010 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Palau","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Clinico Universitario de Valencia, 46010 Valencia, Spain"},{"name":"INCLIVA Health Research Institute, 46010 Valencia, Spain"},{"name":"Department of Medicine, Faculty 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46010 Valencia, Spain"},{"name":"Department of Medicine, Faculty of Medicine and Odontology, University of Valencia, 46010 Valencia, Spain"},{"name":"Network Biomedical Research Center for Cardiovascular Diseases (CIBER-CV), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicente","family":"Bodi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Clinico Universitario de Valencia, 46010 Valencia, Spain"},{"name":"INCLIVA Health Research Institute, 46010 Valencia, Spain"},{"name":"Department of Medicine, Faculty of Medicine and Odontology, University of Valencia, 46010 Valencia, Spain"},{"name":"Network Biomedical Research Center for Cardiovascular Diseases (CIBER-CV), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Amini, M., Zayeri, F., and Salehi, M. 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