{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T05:13:49Z","timestamp":1788585229598,"version":"build-2803163510"},"reference-count":38,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,12,27]],"date-time":"2023-12-27T00:00:00Z","timestamp":1703635200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>This review investigates the intricate relationship between hyperparathyroidism (HPT) and thyroid carcinoma (TC), aiming to elucidate their coexistence, potential pathogenetic mechanisms, and clinical implications. A systematic search strategy, employing the MeSH terms \u2018Hyperparathyroidism\u2019 and \u2018Thyroid Carcinoma\u2019, spanned publications from 2013 to 2023 across the PubMed, Web of Science, and Scopus databases. Fifteen selected articles were analyzed. Studies unanimously confirm the notable association between primary hyperparathyroidism (PHPT) and thyroid nodules\/cancer, with incidences ranging from 2.8% to 47.1%. Key findings reveal a predilection for papillary thyroid carcinoma (PTC) in this association, showcasing varying tumor characteristics and gender disparities. Lower preoperative serum parathyroid hormone (PTH) levels are a potential risk factor for thyroid cancer in PHPT patients. Diverse surgical approaches and tumor characteristics between PHPT and secondary hyperparathyroidism (SHPT) cases were noted. Moreover, this review underscores the scarcity of definitive guidelines in managing concurrent PHPT and thyroid conditions, advocating for comprehensive assessments to enhance diagnostic accuracy and refine therapeutic interventions. Rare coincidental associations, as highlighted by case reports, shed light on unique clinical scenarios. In essence, this review amalgamates evidence to deepen the understanding of the interplay between HPT and TC, emphasizing the need for further research to elucidate underlying mechanisms and guide clinical management.<\/jats:p>","DOI":"10.3390\/jcm13010147","type":"journal-article","created":{"date-parts":[[2023,12,27]],"date-time":"2023-12-27T02:58:12Z","timestamp":1703645892000},"page":"147","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The Nexus of Hyperparathyroidism and Thyroid Carcinoma: Insights into Pathogenesis and Diagnostic Challenges\u2014A Narrative Review"],"prefix":"10.3390","volume":"13","author":[{"given":"Gregorio","family":"Scerrino","sequence":"first","affiliation":[{"name":"Unit of Endocrine Surgery, Department of Surgical Oncology and Oral Sciences, University of Palermo, 90127 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nunzia Cinzia","family":"Paladino","sequence":"additional","affiliation":[{"name":"Department of General Endocrine and Metabolic Surgery, Conception Hospital, Aix-Marseille University, 147, Boulevard Baille, 13005 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppina","family":"Orlando","sequence":"additional","affiliation":[{"name":"Unit of General and Emergency Surgery, Department of Surgical Oncology and Oral Sciences, University of Palermo, 90127 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2658-1950","authenticated-orcid":false,"given":"Giuseppe","family":"Salamone","sequence":"additional","affiliation":[{"name":"Unit of General and Emergency Surgery, Department of Surgical Oncology and Oral Sciences, University of Palermo, 90127 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierina","family":"Richiusa","sequence":"additional","affiliation":[{"name":"Section of Endocrinology, Department of Health Promotion Sciences Maternal and Infantile Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, 90127 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Radellini","sequence":"additional","affiliation":[{"name":"Section of Endocrinology, Department of Health Promotion Sciences Maternal and Infantile Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, 90127 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9439-3073","authenticated-orcid":false,"given":"Giuseppina","family":"Melfa","sequence":"additional","affiliation":[{"name":"Unit of General and Emergency Surgery, Department of Surgical Oncology and Oral Sciences, University of Palermo, 90127 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppa","family":"Graceffa","sequence":"additional","affiliation":[{"name":"Unit of General and Oncology Surgery, Department of Surgical Oncology and Oral Sciences, University of Palermo, 90127 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1001\/jamasurg.2016.2310","article-title":"The American Association of Endocrine Surgeons Guidelines for Definitive Management of Primary Hyperparathyroidism","volume":"151","author":"Wilhelm","year":"2016","journal-title":"JAMA Surg."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1007\/s00268-019-04920-4","article-title":"Does Primary Hyperparathyroidism Have an Association with Thyroid Papillary Cancer? A Retrospective Cohort Study","volume":"43","author":"Temizkan","year":"2019","journal-title":"World J. Surg."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"925","DOI":"10.3803\/EnM.2020.725","article-title":"Association of Hyperparathyroidism and Papillary Thyroid Cancer: A Multicenter Retrospective Study","volume":"35","author":"Jeong","year":"2020","journal-title":"Endocrinol. Metab."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.mehy.2017.04.016","article-title":"Papillary carcinoma of the thyroid in patients with primary hyperparathyroidism: Is there a link?","volume":"103","author":"Beebeejaun","year":"2017","journal-title":"Med. Hypotheses"},{"key":"ref_5","first-page":"9461079","article-title":"Symptomatic primary hyperparathyroidism as a risk factor for differentiated thyroid cancer","volume":"2018","author":"Mercado","year":"2018","journal-title":"J. Thyroid. Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.nut.2017.04.004","article-title":"Micronutrient status (calcium, zinc, vitamins D and E) in patients with medullary thyroid carcinoma: A cross-sectional study","volume":"41","author":"Emami","year":"2017","journal-title":"Nutrition"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1677\/erc.1.01261","article-title":"The association between primary hyperparathyroidism and malignancy: Nationwide cohort analysis on cancer incidence after parathyroidectomy","volume":"14","author":"Nilsson","year":"2007","journal-title":"Endocr.-Relat. Cancer"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ejim.2017.06.001","article-title":"Occurrence of malignant neoplasia in patients with primary hyperparathyroidism","volume":"43","author":"Palmieri","year":"2017","journal-title":"Eur. Intern. Med."},{"key":"ref_9","first-page":"42","article-title":"Is Primary Hyperparathyroidism a Risk Factor for Papillary Thyroid Cancer? An Exemplar Study and Literature Review","volume":"19","author":"Chinamon","year":"2015","journal-title":"Int. Arch. Otorhinolaryngol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"125","DOI":"10.5152\/UCD.2014.2685","article-title":"Thyroid pathologies accompanying primary hyperparathyroidism: A high rate of papillary thyroid microcarcinoma thyroid pathologies accompanying primary hyperparathyroidism: A high rate of papillary thyroid microcarcinoma","volume":"30","author":"Kutluturk","year":"2014","journal-title":"Turkish J. Surg."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1055\/s-0033-1345184","article-title":"Coincidence of Primary Hyperparathyroidism and Nonmedullary thyroid carcinoma","volume":"45","author":"Lehwald","year":"2013","journal-title":"Horm. Metab. Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2707","DOI":"10.1245\/s10434-014-4283-4","article-title":"Morbidity Associated with Concomitant Thyroid Surgery in Patients with Primary Hyperparathyroidism","volume":"22","author":"Riss","year":"2015","journal-title":"Ann. Surg. Oncol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"194","DOI":"10.5152\/eurasianjmed.2015.119","article-title":"Incidental Finding of Papillary Thyroid Carcinoma in the Patients with Primary Hyperparathyroidism","volume":"47","author":"Yazici","year":"2015","journal-title":"Eurasian J. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"4482","DOI":"10.12659\/MSM.898138","article-title":"Serum Calcium and Risk of Nonmedullary Thyroid Cancer in Patients with Primary Hyperparathyroidism","volume":"22","author":"Xue","year":"2016","journal-title":"Med. Sci. Monit."},{"key":"ref_15","first-page":"123","article-title":"The coexistence of primary hyperparathyroidism and thyroid nodules: Should the preoperative work-up of the parathyroid and the thyroid diseases be specifically adjusted?","volume":"37","author":"Scerrino","year":"2016","journal-title":"G. Chir."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Shen, J., Wu, Q., and Wang, Y. (2019). The role of ultrasound in the diagnosis of the coexistence of primary hyperparathyroidism and non-medullary thyroid carcinoma. BMC Med. Imaging, 19.","DOI":"10.1186\/s12880-019-0306-8"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.bj.2019.05.010","article-title":"Long-term therapeutic outcomes of papillary thyroid carcinoma with concomitant hyperparathyroidism: A single center case-control study","volume":"43","author":"Tsai","year":"2020","journal-title":"Biomed. J."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"9917694","DOI":"10.1155\/2021\/9917694","article-title":"Differences in Clinicopathological Characteristics of Papillary Thyroid Carcinoma between Symptomatic and Asymptomatic Patients with Primary Hyperparathyroidism","volume":"2021","author":"Liu","year":"2021","journal-title":"Int. J. Endocrinol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1530\/EC-21-0217","article-title":"Increased thyroid malignancy in patients with primary hyperparathyroidism","volume":"10","author":"Li","year":"2021","journal-title":"Endocr. Connect."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"577","DOI":"10.21037\/gs-22-635","article-title":"Clinical characteristics of primary parathyroid adenoma and its relationship with coexisting papillary thyroid carcinoma: A clinical retrospective study","volume":"12","author":"Hu","year":"2023","journal-title":"Gland. Surg."},{"key":"ref_21","first-page":"250","article-title":"Primary huperparathyroidism with thyroid cancer: Clinicopathologic features","volume":"56","author":"Karaisli","year":"2022","journal-title":"Med. Bull. Sisli Etfal Hosp."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"De Falco, N., Santangelo, G., Chirico, F., Cangiano, A., Sommella, M.G., Cosenza, A., Ronchi, A., Accardo, M., Pellino, G., and Parmeggiani, D. (2021). Synchronous intrathyroidal parathyroid carcinoma and thyroid carcinoma: Case report and review of the literature. BMC Endocr. Disord., 21.","DOI":"10.1186\/s12902-021-00724-7"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"5426","DOI":"10.12998\/wjcc.v8.i21.5426","article-title":"Synchronous parathyroid adenoma, papillary thyroid carcinoma and thyroid adenoma in pregnancy: A case report","volume":"6","author":"Li","year":"2020","journal-title":"World J. Clin. Cases"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"e00091","DOI":"10.1016\/j.crwh.2018.e00091","article-title":"Coexistence of a large functioning parathyroid cyst with papillary thyroid carcinoma: A case report and review of the literature","volume":"21","author":"Anagnostis","year":"2018","journal-title":"Case Rep. Women\u2019s Health"},{"key":"ref_25","first-page":"2387","article-title":"A rare coexistence of parathyroid adenoma and medullary and papillary thyroid carcinoma","volume":"13","author":"Wang","year":"2020","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1097\/CM9.0000000000000018","article-title":"Synchronous primary hyperparathyroidism, follicular thyroid carcinoma, and papillary thyroid carcinoma","volume":"132","author":"Dai","year":"2019","journal-title":"Chin. Med. J."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.ijscr.2020.04.025","article-title":"First ever case report of co-occurrence of hobnail variant of papillary thyroid carcinoma and intrathyroid parathyroid adenoma in the same thyroid lobe","volume":"70","author":"Abdelaal","year":"2020","journal-title":"Int. J. Surg. Case Rep."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Preda, C., Branisteanu, D., Armasu, I., Danila, R., Velicescu, C., Ciobanu, D., Covic, A., and Grigorovici, A. (2019). Coexistent papillary thyroid carcinoma diagnosed in surgically treated patients for primary versus secondary hyperparathyroidism: Same incidence, different characteristics. BMC Surg., 19.","DOI":"10.1186\/s12893-019-0556-y"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Ma, J., Mao, Z., Yao, Y., Lu, Y., Wang, H., Yang, Y., Yang, J., Wang, W., and Teng, L. (2021). Coexistence of papillary thyroid carcinoma and secondary hyperparathyroidism. BMC Surg., 21.","DOI":"10.1186\/s12893-021-01330-z"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1007\/s40618-023-02018-2","article-title":"Parathyroid diseases and metabolic syndrome","volume":"46","author":"Modica","year":"2023","journal-title":"J. Endocrinol. Investig."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"4787","DOI":"10.3390\/curroncol30050361","article-title":"Recent Advances in the Surgical Management of Thyroid Cancer","volume":"5","author":"Scheller","year":"2023","journal-title":"Curr. Oncol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1007\/s12020-021-02909-5","article-title":"Familial hypocalciuric hypercalcemia: The challenge of diagnosis","volume":"75","author":"Lasbleiz","year":"2022","journal-title":"Endocrine"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.amjsurg.2018.06.027","article-title":"Value of 123I\/99mTc-sestamibi parathyroid scintigraphy with subtraction SPECT\/CT in primary hyperparathyroidism for directing minimally invasive parathyroidectomy","volume":"217","author":"Asseeva","year":"2019","journal-title":"Am. J. Surg."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1007\/s00268-022-06629-3","article-title":"Diagnostic Rechallenge with 18F-FCH PET\/CT Often Allows Minimally Invasive Parathyroidectomy While Maintaining Exceptional Cure Rates","volume":"46","author":"Goren","year":"2022","journal-title":"World J. Surg."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"130","DOI":"10.23736\/S1824-4785.23.03514-8","article-title":"[18F]F-Choline PET\/CT and 4D-CT in the evaluation of primary hyperparathyroidism: Rivals or allies?","volume":"67","author":"Fiz","year":"2023","journal-title":"Q. J. Nucl. Med. Mol. Imaging"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"3333","DOI":"10.1038\/s41598-022-07380-4","article-title":"Interpretation of intraoperative parathyroid hormone monitoring according to the Rome criterion in primary hyperparathyroidism","volume":"28","author":"Graceffa","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s13304-017-0447-7","article-title":"Persistent and recurrent hyperparathyroidism","volume":"69","author":"Guerin","year":"2017","journal-title":"Updates Surg."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1283397","DOI":"10.3389\/fendo.2023.1283397","article-title":"Editorial: Recent advances in papillary thyroid carcinoma: Diagnosis and predictive factors","volume":"15","author":"Volpi","year":"2023","journal-title":"Front. Endocrinol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/1\/147\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:42:33Z","timestamp":1760132553000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/1\/147"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,27]]},"references-count":38,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,1]]}},"alternative-id":["jcm13010147"],"URL":"https:\/\/doi.org\/10.3390\/jcm13010147","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,27]]}}}