{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T12:03:05Z","timestamp":1773316985130,"version":"3.50.1"},"reference-count":33,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T00:00:00Z","timestamp":1703808000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>We aimed to characterize and compare the occurrence of peripapillary microvasculature dropout (MvD) between glaucoma suspects and patients with glaucoma. In addition, the factors related to the development of parapapillary MvD in glaucoma suspects and patients with glaucoma were investigated. Of a total 150 eyes, 68 eyes of glaucoma suspects and 82 eyes of glaucoma patients were analyzed in this study. Univariate and multivariate logistic regression analyses were used to identify factors associated with MvD development. The classification of glaucoma patients or glaucoma suspects was not significantly associated with MvD development (beta 1.368, 95% CI, 0.718\u20132.608, p = 0.341). In the regression analysis of the glaucoma suspect group, greater axial length (beta 1.520, 95% CI, 1.008\u20132.291, p = 0.046) and baseline cup volume (beta 3.993, 95% CI, 1.292\u201312.345, p = 0.035) among the baseline factors and the slope of ganglion cell\u2013inner plexiform layer (GCIPL) thickness (beta 0.027, 95% CI, 0.072\u20130.851, p = 0.027) and central visual field (VF) progression (beta 7.040, 95% CI, 1.781\u201316.306, p = 0.014) among follow-up factors were significantly associated with MvD development. In the glaucoma group, central VF progression (beta 5.985, 95% CI, 1.474\u201324.083, p = 0.012) and ONH depression (beta 3.765, 95% CI, 1.301\u201310.895, p = 0.014) among follow-up elements were observed as significant factors and the baseline factor had little relationship. MvD appears not only as a result of the progression of axonal loss of RGC in glaucoma but may also be developed due to structural changes and mechanical susceptibility of the ONH associated with baseline characteristics. Analyzing the structural susceptibility of the ONH can predict the occurrence of MvD, which can be helpful in predicting the progression of glaucoma.<\/jats:p>","DOI":"10.3390\/jcm13010204","type":"journal-article","created":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T09:15:11Z","timestamp":1703841311000},"page":"204","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Factors Contributing to the Development of Choroidal Microvasculature Dropout in Glaucoma Suspects and Patients with Glaucoma"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8243-5627","authenticated-orcid":false,"given":"Hee Jong","family":"Shin","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Seoul St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Si Eun","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Seoul St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong Ah","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Seoul St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chan Kee","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Seoul St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4536-5332","authenticated-orcid":false,"given":"Hae-Young Lopilly","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Seoul St. Mary\u2019s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1016\/S0140-6736(04)16257-0","article-title":"Primary open-angle glaucoma","volume":"363","author":"Weinreb","year":"2004","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4103\/ojo.OJO_91_2018","article-title":"A Glimpse into the mysteries of glaucoma: From theories to clinics","volume":"12","author":"Faiq","year":"2019","journal-title":"Oman J. Ophthalmol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.tjo.2016.05.009","article-title":"Controversies in the vascular theory of glaucomatous optic nerve degeneration","volume":"6","author":"Ahmad","year":"2016","journal-title":"Taiwan J. Ophthalmol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S0002-9394(14)71078-5","article-title":"Indocyanine green angiography of the peripapillary region in glaucomatous eyes by confocal scanning laser ophthalmoscopy","volume":"123","author":"Bartsch","year":"1997","journal-title":"Am. J. Ophthalmol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/0039-6257(94)90041-8","article-title":"The vascular concept of glaucoma","volume":"38","author":"Flammer","year":"1994","journal-title":"Surv. Ophthalmol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1097\/IJG.0000000000000587","article-title":"Microvascular Compromise Develops Following Nerve Fiber Layer Damage in Normal-Tension Glaucoma Without Choroidal Vasculature Involvement","volume":"26","author":"Lee","year":"2017","journal-title":"J. Glaucoma"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"3004","DOI":"10.1167\/iovs.17-21918","article-title":"Parapapillary Deep-Layer Microvasculature Dropout in Glaucoma: Topographic Association With Glaucomatous Damage","volume":"58","author":"Lee","year":"2017","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e754","DOI":"10.1111\/aos.14385","article-title":"Parapapillary choroidal microvasculature dropout in nonglaucomatous healthy eyes","volume":"98","author":"Kim","year":"2020","journal-title":"Acta Ophthalmol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.ophtha.2017.10.036","article-title":"Central Visual Field Damage and Parapapillary Choroidal Microvasculature Dropout in Primary Open-Angle Glaucoma","volume":"125","author":"Lee","year":"2018","journal-title":"Ophthalmology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.ophtha.2018.01.016","article-title":"Choroidal Microvasculature Dropout Is Associated with Progressive Retinal Nerve Fiber Layer Thinning in Glaucoma with Disc Hemorrhage","volume":"125","author":"Park","year":"2018","journal-title":"Ophthalmology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/s41598-020-80705-3","article-title":"Nocturnal blood pressure dip and parapapillary choroidal microvasculature dropout in normal-tension glaucoma","volume":"11","author":"Shin","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1016\/j.ophtha.2020.06.001","article-title":"Glaucoma-like Parapapillary Choroidal Microvasculature Dropout in Patients with Compressive Optic Neuropathy","volume":"127","author":"Lee","year":"2020","journal-title":"Ophthalmology"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.ajo.2022.07.020","article-title":"Microvasculature Dropout and Development of Normal Tension Glaucoma in Glaucoma Suspects: The Normal Tension Glaucoma Suspect Cohort Study","volume":"243","author":"Jung","year":"2022","journal-title":"Am. J. Ophthalmol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/j.ophtha.2011.12.014","article-title":"Glaucoma diagnostic accuracy of ganglion cell-inner plexiform layer thickness: Comparison with nerve fiber layer and optic nerve head","volume":"119","author":"Mwanza","year":"2012","journal-title":"Ophthalmology"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.ophtha.2010.06.036","article-title":"Ability of cirrus HD-OCT optic nerve head parameters to discriminate normal from glaucomatous eyes","volume":"118","author":"Mwanza","year":"2011","journal-title":"Ophthalmology"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1167\/iovs.12-10329","article-title":"Changes in the lamina and prelamina after intraocular pressure reduction in patients with primary open-angle glaucoma and acute primary angle-closure","volume":"55","author":"Park","year":"2014","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1167\/iovs.08-2457","article-title":"Optic disc progression in glaucoma: Comparison of confocal scanning laser tomography to optic disc photographs in a prospective study","volume":"50","author":"Chauhan","year":"2009","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1016\/j.ophtha.2009.04.031","article-title":"Incidence and rates of visual field progression after longitudinally measured optic disc change in glaucoma","volume":"116","author":"Chauhan","year":"2009","journal-title":"Ophthalmology"},{"key":"ref_19","unstructured":"Fleiss, J.L. (1986). The Design and Analysis of Clinical Experiments, Wiley."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1167\/iovs.10-5803","article-title":"Initial arcuate defects within the central 10 degrees in glaucoma","volume":"52","author":"Hood","year":"2011","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e142","DOI":"10.1097\/IJG.0000000000000540","article-title":"Capillary Dropout at the Retinal Nerve Fiber Layer Defect in Glaucoma: An Optical Coherence Tomography Angiography Study","volume":"26","author":"Ichiyama","year":"2017","journal-title":"J. Glaucoma"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1016\/j.ophtha.2016.09.002","article-title":"Deep Retinal Layer Microvasculature Dropout Detected by the Optical Coherence Tomography Angiography in Glaucoma","volume":"123","author":"Suh","year":"2016","journal-title":"Ophthalmology"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.1016\/j.ophtha.2016.07.023","article-title":"Optical Coherence Tomography Angiography Vessel Density in Glaucomatous Eyes with Focal Lamina Cribrosa Defects","volume":"123","author":"Suh","year":"2016","journal-title":"Ophthalmology"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"9941","DOI":"10.1038\/s41598-021-89428-5","article-title":"Determinants of vessel defects in superficial and deep vascular layers in normal-tension glaucoma using optical coherence tomography angiography","volume":"11","author":"Lee","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_25","first-page":"775","article-title":"Technique for detecting serial topographic changes in the optic disc and peripapillary retina using scanning laser tomography","volume":"41","author":"Chauhan","year":"2000","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1167\/iovs.08-2136","article-title":"Performance of confocal scanning laser tomograph Topographic Change Analysis (TCA) for assessing glaucomatous progression","volume":"50","author":"Bowd","year":"2009","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"11677","DOI":"10.1038\/s41598-021-90588-7","article-title":"Corneal hysteresis as a risk factor for optic nerve head surface depression and retinal nerve fiber layer thinning in glaucoma patients","volume":"11","author":"Xu","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1016\/j.ophtha.2014.06.035","article-title":"Optic nerve head deformation in glaucoma: The temporal relationship between optic nerve head surface depression and retinal nerve fiber layer thinning","volume":"121","author":"Xu","year":"2014","journal-title":"Ophthalmology"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1016\/j.ophtha.2011.02.013","article-title":"Initial parafoveal versus peripheral scotomas in glaucoma: Risk factors and visual field characteristics","volume":"118","author":"Park","year":"2011","journal-title":"Ophthalmology"},{"key":"ref_30","first-page":"1480746","article-title":"Ocular and Systemic Risk Factors of Different Morphologies of Scotoma in Patients with Normal-Tension Glaucoma","volume":"2017","year":"2017","journal-title":"J. Ophthalmol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"16009","DOI":"10.1038\/s41598-018-34417-4","article-title":"Effect of Macular Vascular Density on Central Visual Function and Macular Structure in Glaucoma Patients","volume":"8","author":"Jeon","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s13167-017-0124-4","article-title":"Heart rate variability: The comparison between high tension and normal tension glaucoma","volume":"9","author":"Kurysheva","year":"2018","journal-title":"EPMA J."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1167\/iovs.13-13742","article-title":"Central visual field progression in normal-tension glaucoma patients with autonomic dysfunction","volume":"55","author":"Park","year":"2014","journal-title":"Investig. Ophthalmol. Vis. Sci."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/1\/204\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:44:16Z","timestamp":1760132656000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/1\/204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,29]]},"references-count":33,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,1]]}},"alternative-id":["jcm13010204"],"URL":"https:\/\/doi.org\/10.3390\/jcm13010204","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,29]]}}}