{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T14:33:06Z","timestamp":1773239586195,"version":"3.50.1"},"reference-count":21,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T00:00:00Z","timestamp":1705017600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Aims: Radiation proctitis (RP), a well-known complication of pelvic radiation therapy, may lead to recurrent hospitalizations. We aimed to assess readmissions of RP in the United States. Methods: We analyzed the Nationwide Readmission Database from 2016 to 2020 to identify all 30-, 60-, and 90-day readmissions of RP in the United States. Hospitalization characteristics, predictors, clinical outcomes, and healthcare burdens were assessed. Results: From 2016 to 2020, we noted a declining trend of 30-, 60-, and 90-day readmissions of RP in the US. However, the all-cause 30-, 60-, and 90-day readmission rates of RP were still high at 13.7%, 19.4%, and 23.16%, respectively. On readmission, RP was identified as the admitting diagnosis in only 20.61%, 17.87%, and 15.76% of 30-, 60-, and 90-day readmissions, respectively. The mean age for all readmissions was 70 years with a significant male dominance. Lower endoscopy at index admission reduced the risk of readmissions within 90 days, but this was not statistically significant. However, the Charlson Comorbidity Index (CCI) score was an independent predictor of all readmissions. Furthermore, the mean length of stay was 5.57 (95% CI 5.15\u20136), 5.50 (95% CI 5.12\u20135.89), and 5.47 (95% CI 5.07\u20135.87) days and the mean hospitalization charge was USD 60,451 (95% CI USD 54,728\u201366,174), USD 62,671 (95% CI USD 57,326\u201368,015), and USD 62,144 (95% CI USD 57,144\u201367,144) for 30-, 60-, and 90-day readmissions. The all-cause inpatient mortality for 30-, 60-, and 90-day readmissions was 3.58%, 3.89%, and 3.46%, respectively. Conclusions: RP readmissions are a significant healthcare burden. Further efforts must be directed toward improving management strategies to reduce readmission rates.<\/jats:p>","DOI":"10.3390\/jcm13020423","type":"journal-article","created":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T03:54:34Z","timestamp":1705031674000},"page":"423","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Early and Late Readmissions of Radiation Proctitis in the United States: Are We Getting Better?"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8544-9039","authenticated-orcid":false,"given":"Dushyant Singh","family":"Dahiya","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Hepatology & Motility, The University of Kansas School of Medicine, 2000 Olathe Blvd, Kansas City, KS 66160, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhanu Siva Mohan","family":"Pinnam","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, John H. Stroger Jr. Hospital of Cook County, Chicago, IL 60612, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Ishaya","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, John H. Stroger Jr. Hospital of Cook County, Chicago, IL 60612, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2661-6693","authenticated-orcid":false,"given":"Saurabh","family":"Chandan","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, CHI Creighton University Medical Center, Omaha, NE 68178, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manesh Kumar","family":"Gangwani","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, The University of Toledo, Toledo, OH 43606, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sahib","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Sinai Hospital, Baltimore, MD 21215, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hassam","family":"Ali","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hepatology and Nutrition, East Carolina University\/Brody School of Medicine, Greenville, NC 27858, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4231-6447","authenticated-orcid":false,"given":"Amir Humza","family":"Sohail","sequence":"additional","affiliation":[{"name":"Complex Surgical Oncology, Department of Surgery, University of New Mexico, Albuquerque, NM 87106, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Canakis","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, University of Maryland School of Medicine, Baltimore, MD 21201, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daryl","family":"Ramai","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, The University of Utah School of Medicine, Salt Lake City, UT 84112, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Zelt","sequence":"additional","affiliation":[{"name":"Interventional Oncology & Surgical Endoscopy (IOSE) Division, GI Oncology Tumor Site Team, Parkview Cancer Institute, Parkview Health, Fort Wayne, IN 46845, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumant","family":"Inamdar","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Al-Haddad","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, IN 46202, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariajose","family":"Rojas-DeLeon","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Parkview Health System, Fort Wayne, IN 46845, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil R.","family":"Sharma","sequence":"additional","affiliation":[{"name":"Interventional Oncology & Surgical Endoscopy (IOSE) Division, GI Oncology Tumor Site Team, Parkview Cancer Institute, Parkview Health, Fort Wayne, IN 46845, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.eururo.2019.08.005","article-title":"Recent Global Patterns in Prostate Cancer Incidence and Mortality Rates","volume":"77","author":"Culp","year":"2020","journal-title":"Eur. 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