{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T10:53:49Z","timestamp":1792234429031,"version":"4.4.0"},"reference-count":32,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,1,14]],"date-time":"2024-01-14T00:00:00Z","timestamp":1705190400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Right heart failure (RHF) is associated with poor outcomes, especially in patients undergoing left ventricular assist device (LVAD) implantation. The aim of this study was to identify predictors of RHF after LVAD implantation. Of 129 consecutive patients (mean age 56 \u00b1 11 years, 89% male) undergoing LVAD implantation, 34 developed RHF. Compared to patients without RHF, those with RHF required longer invasive mechanical ventilation and had longer intensive care unit and hospital stays (p &lt; 0.01). One-year all-cause mortality was significantly higher in patients with versus without RHF after LVAD implantation (29.4% vs. 1.2%; hazard ratio 35.4; 95% confidence interval 4.5\u2013277; p &lt; 0.001). Mortality was highest in patients with delayed RHF after initial LVAD-only implantation (66.7%). Patients who did versus did not develop RHF had significantly higher baseline pulmonary vascular resistance (PVR; 404 \u00b1 375 vs. 234 \u00b1 162 dyn\/s\/cm5; p = 0.01). PVR &gt; 250 dyn\/s\/cm5 was a significant predictor of survival in patients with RHF after LVAD implantation. These data confirm the negative impact of RHF on morbidity and mortality after LVAD implantation. Preoperative PVR &gt; 250 dyn\/s\/cm5 determined using invasive right heart catheterization was an independent predictor of developing RHF after LVAD implantation, and of subsequent mortality, and could be used for risk stratification in the setting for deciding between single or biventricular support strategy.<\/jats:p>","DOI":"10.3390\/jcm13020462","type":"journal-article","created":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T07:25:07Z","timestamp":1705303507000},"page":"462","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Pulmonary Vascular Resistance to Predict Right Heart Failure in Patients Undergoing Left Ventricular Assist Device Implantation"],"prefix":"10.3390","volume":"13","author":[{"given":"Ren\u00e9","family":"Schramm","sequence":"first","affiliation":[{"name":"Clinic for Thoracic and Cardiovascular Surgery, Herz- und Diabeteszentrum NRW, Ruhr-Universit\u00e4t Bochum, Georgstra\u00dfe 11, 32545 Bad Oeynhausen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Kirchner","sequence":"additional","affiliation":[{"name":"Clinic for General and Interventional Cardiology\/Angiology, Herz- und Diabeteszentrum NRW, Ruhr-Universit\u00e4t Bochum, Georgstra\u00dfe 11, 32545 Bad Oeynhausen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Clinic for Thoracic and Cardiovascular Surgery, Herz- und Diabeteszentrum NRW, Ruhr-Universit\u00e4t Bochum, Georgstra\u00dfe 11, 32545 Bad Oeynhausen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9505-1358","authenticated-orcid":false,"given":"Sebastian V.","family":"Rojas","sequence":"additional","affiliation":[{"name":"Clinic for Thoracic and Cardiovascular Surgery, Herz- und Diabeteszentrum NRW, Ruhr-Universit\u00e4t Bochum, Georgstra\u00dfe 11, 32545 Bad Oeynhausen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiel","family":"Morshuis","sequence":"additional","affiliation":[{"name":"Clinic for Thoracic and Cardiovascular Surgery, Herz- und Diabeteszentrum NRW, Ruhr-Universit\u00e4t Bochum, Georgstra\u00dfe 11, 32545 Bad Oeynhausen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker","family":"Rudolph","sequence":"additional","affiliation":[{"name":"Clinic for General and Interventional Cardiology\/Angiology, Herz- und Diabeteszentrum NRW, Ruhr-Universit\u00e4t Bochum, Georgstra\u00dfe 11, 32545 Bad Oeynhausen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan F.","family":"Gummert","sequence":"additional","affiliation":[{"name":"Clinic for Thoracic and Cardiovascular Surgery, Herz- und Diabeteszentrum NRW, Ruhr-Universit\u00e4t Bochum, Georgstra\u00dfe 11, 32545 Bad Oeynhausen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2187-8715","authenticated-orcid":false,"given":"Henrik","family":"Fox","sequence":"additional","affiliation":[{"name":"Clinic for Thoracic and Cardiovascular Surgery, Herz- und Diabeteszentrum NRW, Ruhr-Universit\u00e4t Bochum, Georgstra\u00dfe 11, 32545 Bad Oeynhausen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3272","DOI":"10.1093\/cvr\/cvac013","article-title":"Global burden of heart failure: A comprehensive and updated review of epidemiology","volume":"118","author":"Savarese","year":"2023","journal-title":"Cardiovasc. Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1056\/NEJMoa2306037","article-title":"Catheter Ablation in End-Stage Heart Failure with Atrial Fibrillation","volume":"389","author":"Sohns","year":"2023","journal-title":"N. Engl. J. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jointm.2022.10.004","article-title":"Long-term assist device patients admitted to ICU: Tips and pitfalls","volume":"3","author":"Morshuis","year":"2023","journal-title":"J. Intensive Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1097\/MAT.0000000000001804","article-title":"Characteristics and Predictors of Late Right Heart Failure after Left Ventricular Assist Device Implantation","volume":"69","author":"Alkhunaizi","year":"2023","journal-title":"ASAIO J."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.healun.2005.07.008","article-title":"Right heart failure after left ventricular assist device implantation in patients with chronic congestive heart failure","volume":"25","author":"Dang","year":"2006","journal-title":"J. Heart Lung Transplant."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1016\/j.jtcvs.2009.11.020","article-title":"Right ventricular failure in patients with the HeartMate II continuous-flow left ventricular assist device: Incidence, risk factors, and effect on outcomes","volume":"139","author":"Kormos","year":"2010","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.healun.2016.08.010","article-title":"The incidence, risk factors, and outcomes associated with late right-sided heart failure in patients supported with an axial-flow left ventricular assist device","volume":"36","author":"Rich","year":"2017","journal-title":"J. Heart Lung Transplant."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1016\/j.jacc.2023.03.392","article-title":"Multimodality Imaging of Right Heart Function: JACC Scientific Statement","volume":"81","author":"Hahn","year":"2023","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1093\/ehjci\/jeu313","article-title":"Accuracy of cardiac CT, radionucleotide and invasive ventriculography, two- and three-dimensional echocardiography, and SPECT for left and right ventricular ejection fraction compared with cardiac MRI: A meta-analysis","volume":"16","author":"Pickett","year":"2015","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jcct.2014.11.007","article-title":"Analysis of ventricular function by CT","volume":"9","author":"Rizvi","year":"2015","journal-title":"J. Cardiovasc. Comput. Tomogr."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jcmg.2009.09.017","article-title":"Multimodality comparison of quantitative volumetric analysis of the right ventricle","volume":"3","author":"Sugeng","year":"2010","journal-title":"JACC Cardiovasc. Imaging"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1016\/j.ijcard.2016.07.014","article-title":"Echocardiographic assessment of the right ventricle: Impact of the distinctly load dependency of its size, geometry and performance","volume":"221","author":"Dandel","year":"2016","journal-title":"Int. J. Cardiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1093\/ejcts\/ezaa461","article-title":"Cardiac recovery following left ventricular assist device therapy: Experience of complete device explantation including ventricular patch plasty","volume":"59","author":"Gyoten","year":"2021","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1016\/j.chest.2020.02.035","article-title":"Pulmonary Hypertension by the Method of Paul Wood","volume":"158","author":"Newman","year":"2020","journal-title":"Chest"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/S2213-2600(20)30317-9","article-title":"Pulmonary vascular resistance and clinical outcomes in patients with pulmonary hypertension: A retrospective cohort study","volume":"8","author":"Maron","year":"2020","journal-title":"Lancet Respir. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1111\/echo.14125","article-title":"Pulmonary vascular resistance versus pulmonary artery pressure for predicting right ventricular remodeling and functional tricuspid regurgitation","volume":"35","author":"Teis","year":"2018","journal-title":"Echocardiography"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jcin.2020.09.033","article-title":"Cardiopulmonary Hemodynamic Profile Predicts Mortality After Transcatheter Tricuspid Valve Repair in Chronic Heart Failure","volume":"14","author":"Stocker","year":"2021","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1002\/lt.25341","article-title":"Predictive Value of Intraoperative Pulmonary Vascular Resistance in Liver Transplantation","volume":"24","author":"Park","year":"2018","journal-title":"Liver Transpl."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1056\/NEJM199602013340504","article-title":"A comparison of continuous intravenous epoprostenol (prostacyclin) with conventional therapy for primary pulmonary hypertension","volume":"334","author":"Barst","year":"1996","journal-title":"N. Engl. J. Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1056\/NEJMoa2213558","article-title":"Phase 3 Trial of Sotatercept for Treatment of Pulmonary Arterial Hypertension","volume":"388","author":"Hoeper","year":"2023","journal-title":"N. Engl. J. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1016\/j.healun.2008.09.006","article-title":"Risk score derived from pre-operative data analysis predicts the need for biventricular mechanical circulatory support","volume":"27","author":"Fitzpatrick","year":"2008","journal-title":"J. Heart Lung Transplant."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1016\/j.jacc.2008.03.009","article-title":"The right ventricular failure risk score a pre-operative tool for assessing the risk of right ventricular failure in left ventricular assist device candidates","volume":"51","author":"Matthews","year":"2008","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1056\/NEJMoa1409077","article-title":"Angiotensin-neprilysin inhibition versus enalapril in heart failure","volume":"371","author":"McMurray","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1056\/NEJMoa1911303","article-title":"Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction","volume":"381","author":"McMurray","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1161\/CIRCULATIONAHA.117.030543","article-title":"Derivation and Validation of a Novel Right-Sided Heart Failure Model After Implantation of Continuous Flow Left Ventricular Assist Devices: The EUROMACS (European Registry for Patients with Mechanical Circulatory Support) Right-Sided Heart Failure Risk Score","volume":"137","author":"Soliman","year":"2018","journal-title":"Circulation"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1093\/ehjci\/jeab005","article-title":"The structural heart disease interventional imager rationale, skills and training: A position paper of the European Association of Cardiovascular Imaging","volume":"22","author":"Agricola","year":"2021","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"3599","DOI":"10.1093\/eurheartj\/ehab368","article-title":"2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure","volume":"42","author":"McDonagh","year":"2021","journal-title":"Eur. Heart J."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1093\/ejcts\/ezz098","article-title":"2019 EACTS Expert Consensus on long-term mechanical circulatory support","volume":"56","author":"Potapov","year":"2019","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"ref_29","first-page":"862","article-title":"Survival after biventricular assist device implantation: An analysis of the Interagency Registry for Mechanically Assisted Circulatory Support database","volume":"30","author":"Cleveland","year":"2011","journal-title":"J. Heart Lung Transplant."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Rojas, S.V., Junghans, S., Fox, H., Lazouski, K., Schramm, R., Morshuis, M., Gummert, J.F., and Gross, J. (2022). Bacteriophage-Enriched Galenic for Intrapericardial Ventricular Assist Device Infection. Antibiotics, 11.","DOI":"10.3390\/antibiotics11050602"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/j.healun.2020.05.007","article-title":"Clinical impact of concomitant tricuspid valve procedures during left ventricular assist device implantation","volume":"39","author":"Mullan","year":"2020","journal-title":"J. Heart Lung Transplant."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1097\/01.MAT.0000398944.12757.eb","article-title":"Tricuspid valve repair in patients supported with left ventricular assist devices","volume":"57","author":"Potapov","year":"2011","journal-title":"Asaio J."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/2\/462\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T13:46:27Z","timestamp":1760103987000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/2\/462"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,14]]},"references-count":32,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,1]]}},"alternative-id":["jcm13020462"],"URL":"https:\/\/doi.org\/10.3390\/jcm13020462","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,14]]}}}