{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T03:21:40Z","timestamp":1792466500419,"version":"4.5.0"},"reference-count":53,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T00:00:00Z","timestamp":1705363200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fundaci\u00f3n IIS Arag\u00f3n","award":["ESG99426132"],"award-info":[{"award-number":["ESG99426132"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Introduction: Psoriasis is a chronic disease of the skin with a prevalence of 2% in the general population. The high prevalence of psoriasis has prompted the study of its comorbidities in recent decades. We designed a study to determine the prevalence of psoriasis in a large-scale, population-based cohort, to exhaustively describe its comorbidities, and to analyze which diseases are associated with psoriasis. Methods: Retrospective, observational study based on the clinical information contained in the electronic health records of the individuals in the EpiChron Cohort with a diagnosis of psoriasis (31,178 individuals) in 2019. We used logistic regression models and calculated the likelihood of the occurrence of each comorbidity based on the presence of psoriasis (p-value &lt; 0.05). Results: The prevalence of psoriasis was 2.84%, and it was more prevalent in men (3.31% vs. 2.43%). The most frequent chronic comorbidities were disorders of lipid metabolism (35.87%), hypertension (35.50%), and other nutritional-endocrine-metabolic disorders (21.79%). The conditions most associated with psoriasis were (odds ratio; 95% confidence interval) tuberculosis (2.36; 1.24\u20134.49), cystic fibrosis (2.15; 1.25\u20133.69), amongst others. We did not find a significant association between psoriasis and hypertension or neoplasms (0.90; 0.86\u20130.95). Conclusions: This study revealed significant associations between psoriasis and cardiac, psychological, and musculoskeletal comorbidities.<\/jats:p>","DOI":"10.3390\/jcm13020492","type":"journal-article","created":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T04:03:30Z","timestamp":1705377810000},"page":"492","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Multimorbidity of Psoriasis: A Large-Scale Population Study of Its Associated Comorbidities"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4350-401X","authenticated-orcid":false,"given":"Manuel","family":"Almenara-Blasco","sequence":"first","affiliation":[{"name":"Department of Dermatology, Miguel Servet University Hospital, IIS Aragon, Paseo Isabel la Cat\u00f3lica 1-3, 50009 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0523-2076","authenticated-orcid":false,"given":"Tamara","family":"Gracia-Caza\u00f1a","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Miguel Servet University Hospital, IIS Aragon, Paseo Isabel la Cat\u00f3lica 1-3, 50009 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5119-5093","authenticated-orcid":false,"given":"Beatriz","family":"Poblador-Plou","sequence":"additional","affiliation":[{"name":"EpiChron Research Group, Aragon Health Sciences Institute (IACS), Aragon Health Research Institute (IIS Arag\u00f3n), Miguel Servet University Hospital, 50009 Zaragoza, Spain"},{"name":"Research Network on Chronicity, Primary Care, and Health Promotion (RICAPPS), Institute of Health Carlos III (ISCIII), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2903-8159","authenticated-orcid":false,"given":"Clara","family":"Laguna-Berna","sequence":"additional","affiliation":[{"name":"EpiChron Research Group, Aragon Health Sciences Institute (IACS), Aragon Health Research Institute (IIS Arag\u00f3n), Miguel Servet University Hospital, 50009 Zaragoza, Spain"},{"name":"Research Network on Chronicity, Primary Care, and Health Promotion (RICAPPS), Institute of Health Carlos III (ISCIII), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6268-8803","authenticated-orcid":false,"given":"Jon\u00e1s","family":"Carmona-P\u00edrez","sequence":"additional","affiliation":[{"name":"EpiChron Research Group, Aragon Health Sciences Institute (IACS), Aragon Health Research Institute (IIS Arag\u00f3n), Miguel Servet University Hospital, 50009 Zaragoza, Spain"},{"name":"Research Network on Chronicity, Primary Care, and Health Promotion (RICAPPS), Institute of Health Carlos III (ISCIII), 28029 Madrid, Spain"},{"name":"Subdirecci\u00f3n T\u00e9cnica Asesora de Gesti\u00f3n de la Informaci\u00f3n, Andalusian Health Service, 41071 Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1171-6007","authenticated-orcid":false,"given":"Alba","family":"Navarro-Bielsa","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Miguel Servet University Hospital, IIS Aragon, Paseo Isabel la Cat\u00f3lica 1-3, 50009 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5704-6056","authenticated-orcid":false,"given":"Alexandra","family":"Prados-Torres","sequence":"additional","affiliation":[{"name":"EpiChron Research Group, Aragon Health Sciences Institute (IACS), Aragon Health Research Institute (IIS Arag\u00f3n), Miguel Servet University Hospital, 50009 Zaragoza, Spain"},{"name":"Research Network on Chronicity, Primary Care, and Health Promotion (RICAPPS), Institute of Health Carlos III (ISCIII), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5440-1710","authenticated-orcid":false,"given":"Antonio","family":"Gimeno-Miguel","sequence":"additional","affiliation":[{"name":"EpiChron Research Group, Aragon Health Sciences Institute (IACS), Aragon Health Research Institute (IIS Arag\u00f3n), Miguel Servet University Hospital, 50009 Zaragoza, Spain"},{"name":"Research Network on Chronicity, Primary Care, and Health Promotion (RICAPPS), Institute of Health Carlos III (ISCIII), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8034-3617","authenticated-orcid":false,"given":"Yolanda","family":"Gilaberte","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Miguel Servet University Hospital, IIS Aragon, Paseo Isabel la Cat\u00f3lica 1-3, 50009 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.ad.2013.12.008","article-title":"Prevalencia de la psoriasis en Espa\u00f1a en la era de los agentes biol\u00f3gicos","volume":"105","author":"Carrascosa","year":"2014","journal-title":"Actas Dermosifiliogr."},{"key":"ref_2","first-page":"159","article-title":"La gen\u00e9tica de la psoriasis","volume":"44","author":"Herraiz","year":"2016","journal-title":"Med. 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