{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:11:08Z","timestamp":1777594268429,"version":"3.51.4"},"reference-count":72,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T00:00:00Z","timestamp":1705449600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFE0203100"],"award-info":[{"award-number":["2023YFE0203100"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["81700799"],"award-info":[{"award-number":["81700799"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["82070926"],"award-info":[{"award-number":["82070926"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["81974151"],"award-info":[{"award-number":["81974151"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Natural Science Foundation of China","award":["2023YFE0203100"],"award-info":[{"award-number":["2023YFE0203100"]}]},{"name":"National Natural Science Foundation of China","award":["81700799"],"award-info":[{"award-number":["81700799"]}]},{"name":"National Natural Science Foundation of China","award":["82070926"],"award-info":[{"award-number":["82070926"]}]},{"name":"National Natural Science Foundation of China","award":["81974151"],"award-info":[{"award-number":["81974151"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>With increased awareness of dry eye disease (DED), a multitude of therapeutic options have become available. Nevertheless, the treatment of severe DED remains difficult. In a patient whose DED is related to the loss of lacrimal function without severe destruction of the salivary glands, autologous transplantation of the latter as functioning exocrine tissue to rebuild a stable tear film is an attractive idea. All three major and minor salivary glands have been used for such transplantation. Due to the complications associated with and unfavorable prognosis of parotid duct and sublingual gland transplantation, surgeons now prefer to use the submandibular gland (SMG) for such procedures. The transplantation of the SMG not only has a high survival rate, but also improves dry eye symptoms and signs for more than 20 years post-surgery. The regulation of the secretion of the transplanted SMG is critical because the denervated SMG changes its mechanism of secretion. Innovative procedures have been developed to stimulate secretion in order to prevent the obstruction of the Wharton\u2019s duct and to decrease secretion when postoperative \u201cepiphora\u201d occurs. Among the minor salivary glands, the transplantation of the labial salivary glands is the most successful in the long-term. The measurement of the flow rates of minor salivary glands and donor-site selection are critical steps before surgery.<\/jats:p>","DOI":"10.3390\/jcm13020521","type":"journal-article","created":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T04:16:56Z","timestamp":1705465016000},"page":"521","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Salivary Gland Transplantation as a Promising Approach for Tear Film Restoration in Severe Dry Eye Disease"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4681-4897","authenticated-orcid":false,"given":"Jiayi","family":"Chen","sequence":"first","affiliation":[{"name":"Beijing Key Laboratory of Damaged Ocular Nerve, Department of Ophthalmology, Peking University Third Hospital, Beijing 100191, China"},{"name":"National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing 100081, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianyi","family":"Bai","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Damaged Ocular Nerve, Department of Ophthalmology, Peking University Third Hospital, Beijing 100191, China"},{"name":"National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing 100081, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiazeng","family":"Su","sequence":"additional","affiliation":[{"name":"National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing 100081, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Cong","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Cardiovascular Sciences, Beijing Key Laboratory of Cardiovascular Receptors Research, Department of Physiology and Pathophysiology, Peking University School of Basic Medical Sciences, Ministry of Education, Beijing 100191, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Beijing Tong Ren Hospital, Capital University of Medical Science, Beijing 100730, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis","family":"Tong","sequence":"additional","affiliation":[{"name":"Cornea and External Eye Disease Service, Singapore National Eye Center, Singapore 168751, Singapore"},{"name":"Ocular Surface Research Group, Singapore Eye Research Institute, Singapore 169856, Singapore"},{"name":"Eye-Academic Clinical Program, Duke-National University of Singapore, Singapore 169857, Singapore"},{"name":"Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haozhe","family":"Yu","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Damaged Ocular Nerve, Department of Ophthalmology, Peking University Third Hospital, Beijing 100191, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9453-3259","authenticated-orcid":false,"given":"Yun","family":"Feng","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Damaged Ocular Nerve, Department of Ophthalmology, Peking University Third Hospital, Beijing 100191, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangyan","family":"Yu","sequence":"additional","affiliation":[{"name":"National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing 100081, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.jtos.2017.05.008","article-title":"TFOS DEWS II Definition and Classification Report","volume":"15","author":"Craig","year":"2017","journal-title":"Ocul. Surf."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.jtos.2017.05.006","article-title":"TFOS DEWS II Management and Therapy Report","volume":"15","author":"Jones","year":"2017","journal-title":"Ocul. Surf."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1136\/bjophthalmol-2020-316611","article-title":"Minor salivary gland transplantation for severe dry eye disease due to cicatrising conjunctivitis: Multicentre long-term outcomes of a modified technique","volume":"105","author":"Vazirani","year":"2020","journal-title":"Br. J. Ophthalmol."},{"key":"ref_4","first-page":"131","article-title":"Surgical treatment of parenchymatous ophthalmoxerosis","volume":"3","author":"Filatov","year":"1951","journal-title":"J. Ophthalmol."},{"key":"ref_5","first-page":"91","article-title":"Treating xerophthalmia with parotid duct transposition through intraoral incision","volume":"2","author":"Zhang","year":"1997","journal-title":"West China J. Stomatol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s12070-018-1559-1","article-title":"Feasibility of Parotid Duct Transposition for the Treatment of Dry Eye: A Cadaveric Study","volume":"71","author":"Agarwal","year":"2019","journal-title":"Indian J. Otolaryngol. Head Neck Surg."},{"key":"ref_7","first-page":"63","article-title":"Management of length deficiency of parotid duct during transposition","volume":"8","author":"Zhang","year":"1954","journal-title":"People\u2019s Mil. Surg."},{"key":"ref_8","first-page":"264","article-title":"Transplantation of salivary gland to the lacrimal basin","volume":"61","year":"1986","journal-title":"Scand. J. Rheumatol. Suppl."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1076\/orbi.22.3.203.15614","article-title":"Surgical treatment of dry eye","volume":"22","author":"Murube","year":"2003","journal-title":"Orbit"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.jtos.2019.04.007","article-title":"Quality of life and patient satisfaction after submandibular gland transplantation in patients with severe dry eye disease","volume":"17","author":"Su","year":"2019","journal-title":"Ocul. Surf."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/j.1442-9071.1992.tb00719.x","article-title":"Submandibular gland transfer in the correction of dry eye","volume":"20","author":"MacLeod","year":"1992","journal-title":"Aust. N. Z. J. Ophthalmol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/978-1-4615-2417-5_96","article-title":"Amylase in mare lacrimale in patients with submandibular salivary gland transplantation to the lacrimal basin","volume":"350","author":"Murube","year":"1994","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S0161-6420(98)93406-6","article-title":"Transplantation of the autologous submandibular gland for most severe cases of keratoconjunctivitis sicca","volume":"105","author":"Geerling","year":"1998","journal-title":"Ophthalmology"},{"key":"ref_14","first-page":"388","article-title":"Reconstructive lacrimal gland with free submandibular gland transfer for management of xerophthalmia","volume":"34","author":"Jia","year":"1998","journal-title":"Zhonghua Yan Ke Za Zhi"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1006\/ijom.2002.0438","article-title":"Microvascular autologous submandibular gland transfer in severe cases of keratoconjunctivitis sicca","volume":"33","author":"Yu","year":"2004","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1097\/01.mlg.0000246953.44163.81","article-title":"Submandibular gland transfer for severe xerophthalmia","volume":"117","author":"Paniello","year":"2007","journal-title":"Laryngoscope"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/j.ajo.2010.05.010","article-title":"Long-term follow-up after submandibular gland transplantation in severe dry eyes secondary to cicatrizing conjunctivitis","volume":"150","author":"Borrelli","year":"2010","journal-title":"Am. J. Ophthalmol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.ijom.2018.07.006","article-title":"Factors influencing the long-term results of autologous microvascular submandibular gland transplantation for severe dry eye disease","volume":"48","author":"Zhang","year":"2019","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1007\/s00784-021-04120-2","article-title":"The association between oral dryness and use of dry-mouth interventions in Sjogren\u2019s syndrome patients","volume":"26","author":"Assy","year":"2022","journal-title":"Clin. Oral Investig."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1136\/annrheumdis-2016-210571","article-title":"2016 American College of Rheumatology\/European League Against Rheumatism classification criteria for primary Sjogren\u2019s syndrome: A consensus and data-driven methodology involving three international patient cohorts","volume":"76","author":"Shiboski","year":"2017","journal-title":"Ann. Rheum. Dis."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"McGurk, M., and Combes, J. (2013). Controversies in the Management of Salivary Gland Disease, Oxford University Press. [2nd ed.].","DOI":"10.1093\/med\/9780199578207.001.0001"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1002\/lary.20183","article-title":"Ophthalmic experience with submandibular gland transplantation for severe dry eyes","volume":"119","author":"Geerling","year":"2009","journal-title":"Laryngoscope"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s40135-013-0009-1","article-title":"Dry Eye Disease: Impact on Quality of Life and Vision","volume":"1","author":"Uchino","year":"2013","journal-title":"Curr. Ophthalmol. Rep."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1186\/s12955-017-0718-5","article-title":"Development and validation of the Chinese version of dry eye related quality of life scale","volume":"15","author":"Zheng","year":"2017","journal-title":"Health Qual. Life Outcomes"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"(2007). Management and therapy of dry eye disease: Report of the Management and Therapy Subcommittee of the International Dry Eye WorkShop (2007). Ocul. Surf., 5, 163\u2013178.","DOI":"10.1016\/S1542-0124(12)70085-X"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.jtos.2017.05.001","article-title":"TFOS DEWS II Diagnostic Methodology report","volume":"15","author":"Wolffsohn","year":"2017","journal-title":"Ocul. Surf."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s40902-015-0006-4","article-title":"Microvascular autologous submandibular gland transplantation in severe cases of keratoconjunctivitis sicca","volume":"37","author":"Su","year":"2015","journal-title":"Maxillofac. Plast. Reconstr. Surg."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.jcms.2007.08.010","article-title":"Long-term results of autologous submandibular gland transfer for the surgical treatment of severe keratoconjunctivitis sicca","volume":"36","author":"Jacobsen","year":"2008","journal-title":"J. Craniomaxillofac. Surg."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1159\/000131094","article-title":"Transplantation of the major salivary glands","volume":"41","author":"Geerling","year":"2008","journal-title":"Dev. Ophthalmol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1016\/j.joms.2018.05.008","article-title":"Microvascular Submandibular Gland Transplantation for Severe Keratoconjunctivitis Sicca: A Single-Institution Experience of 61 Grafts","volume":"76","author":"Wang","year":"2018","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1016\/j.jcms.2017.07.019","article-title":"Effect of computed tomographic venography on donor selection in submandibular gland transplantation in patients with severe dry eye","volume":"45","author":"Su","year":"2017","journal-title":"J. Craniomaxillofac. Surg."},{"key":"ref_32","first-page":"1079","article-title":"Long-term follow-up after autologous submandibular gland transplantation in scarring keratoconjunctivitis with absolute dry eyes","volume":"100","author":"Schroder","year":"2003","journal-title":"Ophthalmologe"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jss.2019.07.084","article-title":"Large-to-Small End-to-Side Venous Anastomosis in Free Flap Transfer","volume":"245","author":"Miyamoto","year":"2020","journal-title":"J. Surg. Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1097\/00029330-200707010-00013","article-title":"Anatomy of arteries and veins of submandibular glands","volume":"120","author":"Li","year":"2007","journal-title":"Chin. Med. J. (Engl.)"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1136\/bjo.2010.199901","article-title":"Minor salivary glands and labial mucous membrane graft in the treatment of severe symblepharon and dry eye in patients with Stevens-Johnson syndrome","volume":"96","author":"Hazarbassanov","year":"2012","journal-title":"Br. J. Ophthalmol."},{"key":"ref_36","first-page":"22","article-title":"Transplantation of autologous labial salivary glands for severe dry eye","volume":"49","author":"Luo","year":"2013","journal-title":"Zhonghua Yan Ke Za Zhi"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1097\/ICO.0b013e31825aba2c","article-title":"Schirmer test in transplanted submandibular gland: Influencing factors and a modified measurement method","volume":"32","author":"Su","year":"2013","journal-title":"Cornea"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.joms.2010.03.006","article-title":"Microanatomic study of the vascular and duct system of the submandibular gland","volume":"69","author":"Xu","year":"2011","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.bjoms.2011.10.004","article-title":"An experimental study of the management of severe keratoconjunctivitis sicca with autologous reduced-sized submandibular gland transplantation","volume":"50","author":"Ge","year":"2012","journal-title":"Br. J. Oral Maxillofac. Surg."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1097\/01.tp.0000296060.39823.a4","article-title":"Innervation and secretory function of transplanted human submandibular salivary glands","volume":"85","author":"Geerling","year":"2008","journal-title":"Transplantation"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1136\/bjophthalmol-2013-303280","article-title":"Microvascular autologous transplantation of partial submandibular gland for severe keratoconjunctivitis sicca","volume":"97","author":"Qin","year":"2013","journal-title":"Br. J. Ophthalmol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1136\/bjophthalmol-2014-305117","article-title":"Obstructive sialadenitis of a transplanted submandibular gland: Chronic inflammation secondary to ductal obstruction","volume":"98","author":"Su","year":"2014","journal-title":"Br. J. Ophthalmol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1111\/j.1601-0825.2009.01633.x","article-title":"Carbachol improves secretion in the early phase after rabbit submandibular gland transplantation","volume":"16","author":"Shi","year":"2010","journal-title":"Oral Dis."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s10735-016-9709-9","article-title":"Muscarinic acetylcholine receptor-mediated tight junction opening is involved in epiphora in late phase of submandibular gland transplantation","volume":"48","author":"Yang","year":"2017","journal-title":"J. Mol. Histol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1177\/0022034513519107","article-title":"Hypersensitive mAChRs are involved in the epiphora of transplanted glands","volume":"93","author":"Ding","year":"2014","journal-title":"J. Dent. Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.ijom.2018.07.003","article-title":"Botulinum toxin A treatment of epiphora secondary to autologous submandibular gland transplantation","volume":"48","author":"Shan","year":"2019","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1242\/jcs.165878","article-title":"Claudin-4 is required for modulation of paracellular permeability by muscarinic acetylcholine receptor in epithelial cells","volume":"128","author":"Cong","year":"2015","journal-title":"J. Cell Sci."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s10735-017-9716-5","article-title":"Decreased interaction between ZO-1 and occludin is involved in alteration of tight junctions in transplanted epiphora submandibular glands","volume":"48","author":"Ding","year":"2017","journal-title":"J. Mol. Histol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.bbrc.2006.04.106","article-title":"Expression and characteristics of vanilloid receptor 1 in the rabbit submandibular gland","volume":"345","author":"Zhang","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"G54","DOI":"10.1152\/ajpgi.00528.2009","article-title":"Activation of transient receptor potential vanilloid subtype 1 increases secretion of the hypofunctional, transplanted submandibular gland","volume":"299","author":"Zhang","year":"2010","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1242\/jcs.111781","article-title":"Occludin is required for TRPV1-modulated paracellular permeability in the submandibular gland","volume":"126","author":"Cong","year":"2013","journal-title":"J. Cell Sci."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1038\/labinvest.2012.12","article-title":"Activation of transient receptor potential vanilloid subtype 1 increases expression and permeability of tight junction in normal and hyposecretory submandibular gland","volume":"92","author":"Cong","year":"2012","journal-title":"Lab. Investig."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1097\/ICO.0000000000000752","article-title":"Effects of Capsaicin and Carbachol on Secretion From Transplanted Submandibular Glands and Prevention of Duct Obstruction","volume":"35","author":"Su","year":"2016","journal-title":"Cornea"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s004170050008","article-title":"Quality of salivary tears following autologous submandibular gland transplantation for severe dry eye","volume":"238","author":"Geerling","year":"2000","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.jtos.2014.04.001","article-title":"A new treatment for epiphora secondary to submandibular gland transplantation: Transcutaneous atropine gel","volume":"12","author":"Cai","year":"2014","journal-title":"Ocul. Surf."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.2967\/jnumed.106.037705","article-title":"Application of 99mTc-pertechnetate scintigraphy to microvascular autologous transplantation of the submandibular gland in patients with severe keratoconjunctivitis sicca","volume":"48","author":"Zhang","year":"2007","journal-title":"J. Nucl. Med."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.jcms.2018.03.006","article-title":"Management of duct obstruction in transplanted submandibular glands","volume":"46","author":"Su","year":"2018","journal-title":"J. Craniomaxillofac. Surg."},{"key":"ref_58","first-page":"948","article-title":"Toxicity of natural tear substitutes in a fully defined culture model of human corneal epithelial cells","volume":"42","author":"Geerling","year":"2001","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1097\/00029330-200603020-00009","article-title":"Establishment of submandibular gland allotransplantation model in miniature swine","volume":"119","author":"Ge","year":"2006","journal-title":"Chin. Med. J. (Engl.)"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1097\/TP.0000000000002612","article-title":"Mesenchymal Stem Cell Therapy in Submandibular Salivary Gland Allotransplantation: Experimental Study","volume":"103","author":"Almansoori","year":"2019","journal-title":"Transplantation"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"197","DOI":"10.5125\/jkaoms.2020.46.3.197","article-title":"FK506 immunosuppression for submandibular salivary gland allotransplantation in rabbit","volume":"46","author":"Almansoori","year":"2020","journal-title":"J. Korean Assoc. Oral Maxillofac. Surg."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.jcms.2013.01.015","article-title":"Allogenic submandibular gland transplantation following hematopoietic stem cell transplantation","volume":"41","author":"Jacobsen","year":"2013","journal-title":"J. Craniomaxillofac. Surg."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.3109\/02713683.2016.1148741","article-title":"Development of Causative Treatment Strategies for Lacrimal Gland Insufficiency by Tissue Engineering and Cell Therapy. Part 1: Regeneration of Lacrimal Gland Tissue: Can We Stimulate Lacrimal Gland Renewal In Vivo?","volume":"41","author":"Dietrich","year":"2016","journal-title":"Curr. Eye Res."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/978-1-4939-6949-4_11","article-title":"Generation of a Bioengineered Lacrimal Gland by Using the Organ Germ Method","volume":"1597","author":"Hirayama","year":"2017","journal-title":"Methods Mol. Biol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1038\/ncomms3497","article-title":"Functional lacrimal gland regeneration by transplantation of a bioengineered organ germ","volume":"4","author":"Hirayama","year":"2013","journal-title":"Nat. Commun."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1089\/ten.tea.2015.0286","article-title":"Three-Dimensional Culture of Functional Adult Rabbit Lacrimal Gland Epithelial Cells on Decellularized Scaffold","volume":"22","author":"Lin","year":"2016","journal-title":"Tissue Eng. Part A"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jtos.2015.11.005","article-title":"Challenges and Strategies for Regenerating the Lacrimal Gland","volume":"14","author":"Hirayama","year":"2016","journal-title":"Ocul. Surf."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"DES174","DOI":"10.1167\/iovs.17-23528","article-title":"Advances in Functional Restoration of the Lacrimal Glands","volume":"59","author":"Hirayama","year":"2018","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"e2001","DOI":"10.1002\/term.2631","article-title":"Development of lacrimal gland spheroids for lacrimal gland tissue regeneration","volume":"12","author":"Massie","year":"2018","journal-title":"J. Tissue Eng. Regen. Med."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"4350","DOI":"10.1167\/iovs.15-16475","article-title":"Isolation and Investigation of Presumptive Murine Lacrimal Gland Stem Cells","volume":"56","author":"Ackermann","year":"2015","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1631\/jzus.B1500113","article-title":"Potential candidate cells for constructing tissue-engineered lacrimal duct epithelium: A histological and cytological study in rabbits","volume":"16","author":"Xie","year":"2015","journal-title":"J. Zhejiang Univ. Sci. B"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"5564","DOI":"10.1167\/iovs.16-20759","article-title":"Evaluation of Decellularized Porcine Jejunum as a Matrix for Lacrimal Gland Reconstruction In Vitro for Treatment of Dry Eye Syndrome","volume":"58","author":"Massie","year":"2017","journal-title":"Investig. Ophthalmol. Vis. Sci."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/2\/521\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T13:48:37Z","timestamp":1760104117000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/2\/521"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,17]]},"references-count":72,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,1]]}},"alternative-id":["jcm13020521"],"URL":"https:\/\/doi.org\/10.3390\/jcm13020521","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,17]]}}}