{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T17:43:20Z","timestamp":1790012600346,"version":"4.0.1"},"reference-count":22,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T00:00:00Z","timestamp":1705622400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Prediabetes is a risk factor for ischemic stroke in atrial fibrillation (AF) patients, yet, its impact on recurrent stroke in AF patients remains understudied. Using the 2018 National Inpatient Sample, we investigated the link between Prediabetes and recurrent stroke in AF patients with prior stroke or transient ischemic attack (TIA). Among 18,905 non-diabetic AF patients, 480 (2.5%) had prediabetes. The prediabetic group, with a median age of 78, exhibited a two-fold higher risk of recurrent stroke compared to the non-prediabetic cohort (median age 82), as evidenced by both unadjusted (OR 2.14, 95% CI 1.72\u20132.66) and adjusted (adjusted for socio-demographics\/comorbidities, OR 2.09, 95% CI 1.65\u20132.64, p &lt; 0.001). The prediabetes cohort, comprising more male and Black patients, demonstrated associations with higher Medicaid enrollment, admissions from certain regions, and higher rates of hyperlipidemia, smoking, peripheral vascular disease, obesity, and chronic obstructive pulmonary disease (all p &lt; 0.05). Despite higher rates of home health care and increased hospital costs in the prediabetes group, the adjusted odds of all-cause mortality were not statistically significant (OR 0.55, 95% CI 0.19\u20131.56, p = 0.260). The findings of this study suggest that clinicians should be vigilant in managing prediabetes in AF patients, and strategies to prevent recurrent stroke in this high-risk population should be considered.<\/jats:p>","DOI":"10.3390\/jcm13020573","type":"journal-article","created":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T03:33:41Z","timestamp":1705635221000},"page":"573","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Association of Prediabetes and Recurrent Stroke in Atrial Fibrillation Patients: A Population-Based Analysis of Hospitalizations and Outcomes"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5315-6426","authenticated-orcid":false,"given":"Rupak","family":"Desai","sequence":"first","affiliation":[{"name":"Independent Researcher, Atlanta, GA 30033, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7756-6606","authenticated-orcid":false,"given":"Advait","family":"Vasavada","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, University of Nebraska Medicine, Omaha, NE 68198, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhavin A.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Graduate Medical Education, Trinity Health Oakland Hospital, Pontiac, MI 48341, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3016-0078","authenticated-orcid":false,"given":"Maharshi","family":"Raval","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Landmark Medical Center, Woonsocket, RI 02895, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avilash","family":"Mondal","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Nazareth Hospital, Philadelphia, PA 19152, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kshitij","family":"Mahajan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Graduate Medical Education, Trinity Health Oakland Hospital, Pontiac, MI 48341, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1721-1453","authenticated-orcid":false,"given":"Nishanth","family":"Katukuri","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yash","family":"Varma","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Graduate Medical Education, Trinity Health Oakland Hospital, Wayne State University, Detroit, MI 48202, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7298-4246","authenticated-orcid":false,"given":"Akhil","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5371-2253","authenticated-orcid":false,"given":"Geetha","family":"Krishnamoorthy","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Graduate Medical Education, Trinity Health Oakland Hospital, Pontiac, MI 48341, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.2337\/dc23-S002","article-title":"Classification and Diagnosis of Diabetes: Standards of Care in Diabetes","volume":"46","author":"ElSayed","year":"2022","journal-title":"Diabetes Care"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"A230","DOI":"10.1161\/circoutcomes.15.suppl_1.230","article-title":"Abstract 230: Prediabetes In Young Adults and Its Association with Type 1 Myocardial Infarction-related Admissions and Outcomes: A Population-based Analysis In The United States","volume":"15","author":"Desai","year":"2022","journal-title":"Circ. 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