{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:03:22Z","timestamp":1787789002902,"version":"build-2784847793"},"reference-count":76,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T00:00:00Z","timestamp":1705622400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Despite significant advances in medical imaging, thrombolytic therapy, and mechanical thrombectomy, acute ischemic strokes (AIS) remain a major cause of mortality and morbidity globally. Targeted temperature management (TTM) has emerged as a potential therapeutic intervention, aiming to mitigate neuronal damage and improve outcomes. This literature review examines the efficacy and challenges of TTM in the context of an AIS. A comprehensive literature search was conducted using databases such as PubMed, Cochrane, Web of Science, and Google Scholar. Studies were selected based on relevance and quality. We identified key factors influencing the effectiveness of TTM such as its timing, depth and duration, and method of application. The review also highlighted challenges associated with TTM, including increased pneumonia rates. The target temperature range was typically between 32 and 36 \u00b0C, with the duration of cooling from 24 to 72 h. Early initiation of TTM was associated with better outcomes, with optimal results observed when TTM was started within the first 6 h post-stroke. Emerging evidence indicates that TTM shows considerable potential as an adjunctive treatment for AIS when implemented promptly and with precision, thereby potentially mitigating neuronal damage and enhancing overall patient outcomes. However, its application is complex and requires the careful consideration of various factors.<\/jats:p>","DOI":"10.3390\/jcm13020586","type":"journal-article","created":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T07:00:32Z","timestamp":1705647632000},"page":"586","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Targeted Temperature Management for Patients with Acute Ischemic Stroke: A Literature Review"],"prefix":"10.3390","volume":"13","author":[{"given":"Dhanesh D.","family":"Binda","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1191-4134","authenticated-orcid":false,"given":"Maxwell B.","family":"Baker","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shama","family":"Varghese","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6760-9855","authenticated-orcid":false,"given":"Jennifer","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7017-0150","authenticated-orcid":false,"given":"Rafael","family":"Badenes","sequence":"additional","affiliation":[{"name":"Department Anesthesiology, Surgical-Trauma Intensive Care and Pain Clinic, Hospital Cl\u00ednic Universitari, University of Valencia, 46010 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2496-6646","authenticated-orcid":false,"given":"Federico","family":"Bilotta","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Critical Care and Pain Medicine, Policlinico Umberto I Teaching Hospital, Sapienza University of Rome, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5755-6347","authenticated-orcid":false,"given":"Ala","family":"Nozari","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,19]]},"reference":[{"key":"ref_1","unstructured":"(2023, November 24). Snapshot, Available online: https:\/\/www.cdc.gov\/nchs\/fastats\/leading-causes-of-death.htm."},{"key":"ref_2","unstructured":"(2023, November 24). AIS-Professional-Education-Presentation-ucm_485538.pdf. Available online: https:\/\/www.stroke.org\/-\/media\/Stroke-Files\/Ischemic-Stroke-Professional-Materials\/AIS-Toolkit\/AIS-Professional-Education-Presentation-ucm_485538."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1056\/NEJMoa1716405","article-title":"Tenecteplase versus alteplase before thrombectomy for ischemic stroke","volume":"378","author":"Campbell","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1136\/practneurol-2020-002557","article-title":"Diagnosis and management of acute ischaemic stroke","volume":"20","author":"Hurford","year":"2020","journal-title":"Pract. Neurol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1001\/jama.2016.13647","article-title":"Time to Treatment With Endovascular Thrombectomy and Outcomes From Ischemic Stroke: A Meta-analysis","volume":"316","author":"Saver","year":"2016","journal-title":"JAMA"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s13049-015-0121-3","article-title":"Therapeutic hypothermia for acute brain injuries","volume":"23","author":"Andresen","year":"2015","journal-title":"Scand. J. Trauma Resusc. Emerg. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1186\/cc8220","article-title":"Bench-to-bedside review: Hypothermia in traumatic brain injury","volume":"14","author":"Sinclair","year":"2010","journal-title":"Crit. Care"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1385\/NCC:1:2:131","article-title":"Technical refinements and drawbacks of a surface cooling technique for the treatment of severe acute ischemic stroke","volume":"1","author":"DeGeorgia","year":"2004","journal-title":"Neurocrit. Care"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1177\/2396987319844690","article-title":"Therapeutic hypothermia for acute ischaemic stroke. Results of a European multicentre, randomised, phase III clinical trial","volume":"4","author":"Macleod","year":"2019","journal-title":"Eur. Stroke J."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.clineuro.2011.08.010","article-title":"Local mild hypothermia with thrombolysis for acute ischemic stroke within a 6-h window","volume":"113","author":"Bi","year":"2011","journal-title":"Clin. Neurol. Neurosurg."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1161\/STROKEAHA.110.592295","article-title":"Intravenous Thrombolysis Plus Hypothermia for Acute Treatment of Ischemic Stroke (ICTuS-L)","volume":"41","author":"Hemmen","year":"2010","journal-title":"Stroke"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1001\/jamaneurol.2018.4822","article-title":"Outcomes of Hypothermia in Addition to Decompressive Hemicraniectomy in Treatment of Malignant Middle Cerebral Artery Stroke","volume":"76","author":"Neugebauer","year":"2019","journal-title":"JAMA Neurol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1212\/01.WNL.0000129840.66938.75","article-title":"Cooling for Acute Ischemic Brain Damage (COOL AID): A feasibility trial of endovascular cooling","volume":"63","author":"Krieger","year":"2004","journal-title":"Neurology"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1161\/STROKEAHA.113.003180","article-title":"Mild hypothermia after intravenous thrombolysis in patients with acute stroke: A randomized controlled trial","volume":"45","author":"Piironen","year":"2014","journal-title":"Stroke"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1111\/ane.12059","article-title":"Feasibility of endovascular and surface cooling strategies in acute stroke","volume":"127","author":"Ovesen","year":"2013","journal-title":"Acta Neurol. Scand."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1159\/000090007","article-title":"Safety and Therapeutical Benefit of Hemicraniectomy Combined with Mild Hypothermia in Comparison with Hemicraniectomy Alone in Patients with Malignant Ischemic Stroke","volume":"21","author":"Els","year":"2006","journal-title":"Cerebrovasc. Dis."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2888","DOI":"10.1161\/STROKEAHA.116.014200","article-title":"Results of the Intravascular Cooling in the Treatment of Acute Stroke 2 Trial (ICTuS-2)","volume":"47","author":"Lyden","year":"2016","journal-title":"Stroke"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1186\/s40064-016-3654-7","article-title":"Protective roles of intra-arterial mild hypothermia and arterial thrombolysis in acute cerebral infarction","volume":"5","author":"Peng","year":"2016","journal-title":"Springer Plus"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1039816","DOI":"10.3389\/fneur.2023.1039816","article-title":"Selective intraarterial hypothermia combined with mechanical thrombectomy for acute cerebral infarction based on microcatheter technology: A single-center, randomized, single-blind controlled study","volume":"14","author":"Wan","year":"2023","journal-title":"Front. Neurol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1161\/STROKEAHA.116.014757","article-title":"COOLIST (Cooling for Ischemic Stroke Trial): A Multicenter, Open, Randomized, Phase II, Clinical Trial","volume":"48","author":"Geurts","year":"2017","journal-title":"Stroke"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1161\/hs0901.095394","article-title":"Feasibility and Safety of Moderate Hypothermia After Massive Hemispheric Infarction","volume":"32","author":"Schwab","year":"2001","journal-title":"Stroke"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.jstrokecerebrovasdis.2008.09.015","article-title":"Combined Neuroprotective Modalities Coupled with Thrombolysis in Acute Ischemic Stroke: A Pilot Study of Caffeinol and Mild Hypothermia","volume":"18","author":"Hallevi","year":"2009","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1161\/01.STR.29.12.2461","article-title":"Moderate hypothermia in the treatment of patients with severe middle cerebral artery infarction","volume":"29","author":"Schwab","year":"1998","journal-title":"Stroke"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Bardutzky, J., Kollmar, R., Al-Rawi, F., Lambeck, J., Fazel, M., Taschner, C., and Niesen, W.D. (2023). COmbination of Targeted temperature management and Thrombectomy after acute Ischemic Stroke (COTTIS): A pilot study. Stroke Vasc. Neurol.","DOI":"10.1136\/svn-2023-002420"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1161\/01.STR.0000016970.51004.D9","article-title":"Hemicraniectomy and moderate hypothermia in patients with severe ischemic stroke","volume":"33","author":"Georgiadis","year":"2002","journal-title":"Stroke"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jstrokecerebrovasdis.2005.01.001","article-title":"Intravascular Cooling in the Treatment of Stroke (ICTuS): Early clinical experience","volume":"14","author":"Lyden","year":"2005","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1197\/j.aem.2006.03.559","article-title":"A Trial of Therapeutic Hypothermia via Endovascular Approach in Awake Patients with Acute Ischemic Stroke: Methodology","volume":"13","author":"Guluma","year":"2006","journal-title":"Acad. Emerg. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/s12028-007-9009-z","article-title":"Effect of Endovascular Hypothermia on Acute Ischemic Edema: Morphometric Analysis of the ICTuS Trial","volume":"8","author":"Guluma","year":"2008","journal-title":"Neurocrit. Care"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1161\/STROKEAHA.108.530410","article-title":"Ice-Cold Saline for the Induction of Mild Hypothermia in Patients with Acute Ischemic Stroke: A Pilot Study","volume":"40","author":"Kollmar","year":"2009","journal-title":"Stroke"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1161\/STROKEAHA.116.012727","article-title":"Endovascular hypothermia in acute ischemic stroke: A pilot study of selective intra-arterial cold saline infusion","volume":"47","author":"Chen","year":"2016","journal-title":"Stroke J. Cereb. Circ."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1177\/0271678X18790139","article-title":"Safety, feasibility, and potential efficacy of intraarterial selective cooling infusion for stroke patients treated with mechanical thrombectomy","volume":"38","author":"Wu","year":"2018","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2550","DOI":"10.1161\/hs1101.097382","article-title":"Endovascular cooling for moderate hypothermia in patients with acute stroke: First results of a novel approach","volume":"32","author":"Georgiadis","year":"2001","journal-title":"Stroke"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1161\/01.STR.31.9.2251","article-title":"Feasibility and safety of inducing modest hypothermia in awake patients with acute stroke through surface cooling: A case-control study: The Copenhagen Stroke Study","volume":"31","author":"Kammersgaard","year":"2000","journal-title":"Stroke"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1161\/01.STR.32.8.1847","article-title":"Cooling for Acute Ischemic Brain Damage (COOL AID)","volume":"32","author":"Krieger","year":"2001","journal-title":"Stroke"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1161\/STROKEAHA.113.003143","article-title":"Therapeutic Hypothermia After Recanalization in Patients With Acute Ischemic Stroke","volume":"45","author":"Hong","year":"2014","journal-title":"Stroke"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1161\/hs0102.100878","article-title":"Effects of Hypothermia on Excitatory Amino Acids and Metabolism in Stroke Patients: A Microdialysis Study","volume":"33","author":"Berger","year":"2002","journal-title":"Stroke"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1161\/STROKEAHA.111.644963","article-title":"Times from symptom onset to hospital arrival in the Get with the Guidelines\u2014Stroke Program 2002 to 2009: Temporal trends and implications","volume":"43","author":"Tong","year":"2012","journal-title":"Stroke"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.neuropharm.2017.08.025","article-title":"Therapeutic hypothermia for ischemic stroke; pathophysiology and future promise","volume":"134","author":"Kurisu","year":"2018","journal-title":"Neuropharmacology"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1227\/NEU.0000000000001088","article-title":"Transarterial Regional Brain Hypothermia Inhibits Acute Aquaporin-4 Surge and Sequential Microvascular Events in Ischemia\/Reperfusion Injury","volume":"79","author":"Kurisu","year":"2016","journal-title":"Neurosurgery"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1161\/01.STR.0000126118.44249.5c","article-title":"Therapeutic Hypothermia for Acute Ischemic Stroke","volume":"35","author":"Krieger","year":"2004","journal-title":"Stroke"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1038\/sj.jcbfm.9600150","article-title":"Influence of Therapeutic Hypothermia on Matrix Metalloproteinase Activity after Traumatic Brain Injury in Rats","volume":"25","author":"Truettner","year":"2005","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.brainres.2010.05.029","article-title":"Effects of hypothermia and cerebral ischemia on cold-inducible RNA-binding protein mRNA expression in rat brain","volume":"1347","author":"Liu","year":"2010","journal-title":"Brain Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/nrn3174","article-title":"Neuroprotective mechanisms of hypothermia in brain ischaemia","volume":"13","author":"Yenari","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/1742-2094-7-74","article-title":"The dual role of the neuroinflammatory response after ischemic stroke: Modulatory effects of hypothermia","volume":"7","author":"ACeulemans","year":"2010","journal-title":"J. Neuroinflammation"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jneuroim.2006.11.014","article-title":"The inflammatory response in stroke","volume":"184","author":"Wang","year":"2007","journal-title":"J. Neuroimmunol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.neuint.2011.01.026","article-title":"Post-ischemic hypothermia promotes generation of neural cells and reduces apoptosis by Bcl-2 in the striatum of neonatal rat brain","volume":"58","author":"Xiong","year":"2011","journal-title":"Neurochem. Int."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1213\/ANE.0b013e3181bab451","article-title":"Mild hypothermia has no long-term impact on postischemic neurogenesis in rats","volume":"109","author":"Lasarzik","year":"2009","journal-title":"Anesth. Analg."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1177\/2048872614557241","article-title":"Impact of time to cooling initiation and time to target temperature in patients treated with hypothermia after cardiac arrest","volume":"4","author":"Uribarri","year":"2015","journal-title":"Eur. Heart J. Acute Cardiovasc. Care"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.bja.2023.04.030","article-title":"Targeted temperature management in patients with intracerebral haemorrhage, subarachnoid haemorrhage, or acute ischaemic stroke: Updated consensus guideline recommendations by the Neuroprotective Therapy Consensus Review (NTCR) group","volume":"131","author":"Lavinio","year":"2023","journal-title":"Br. J. Anaesth."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Dippel, D.W., Van Breda, E.J., van der Worp, H.B., van Gemert, H.M.A., Meijer, R.J., Kappelle, L.J., and Koudstaal, P.J. (2003). and PISA-investigators. Effect of paracetamol (acetaminophen) and ibuprofen on body temperature in acute ischemic stroke PISA, a phase II double-blind, randomized, placebo-controlled trial [ISRCTN98608690]. BMC Cardiovasc. Disord., 3.","DOI":"10.1186\/1471-2261-3-2"},{"key":"ref_51","first-page":"CD001247","article-title":"Cooling therapy for acute stroke","volume":"2009","author":"Tseng","year":"2009","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s12028-014-0001-0","article-title":"Risk of Thromboembolic Events with Endovascular Cooling Catheters in Patients with Subarachnoid Hemorrhage","volume":"21","author":"Lorenz","year":"2014","journal-title":"Neurocrit. Care"},{"key":"ref_53","unstructured":"(2023, December 15). Guidelines for the Early Management of Patients with Acute Ischemic Stroke: 2019 Update to the 2018 Guidelines for the Early Management of Acute Ischemic Stroke: A Guideline for Healthcare Professionals from the American Heart Association\/American Stroke Association|Stroke. Available online: https:\/\/www.ahajournals.org\/doi\/10.1161\/STR.0000000000000211."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1517\/13543784.17.8.1161","article-title":"Induced hypothermia in acute ischemic stroke","volume":"17","author":"Lazzaro","year":"2008","journal-title":"Exp. Opin. Investig. Drugs"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1159\/000324621","article-title":"Temperature management in stroke\u2014An unsolved, but important topic","volume":"31","author":"Kollmar","year":"2011","journal-title":"Cerebrovasc. Dis."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1136\/svn-2017-000123","article-title":"Stroke-induced immunosuppression and poststroke infection","volume":"3","author":"Shi","year":"2018","journal-title":"Stroke Vasc. Neurol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1056\/NEJMoa1310519","article-title":"Targeted Temperature Management at 33 \u00b0C versus 36 \u00b0C after Cardiac Arrest","volume":"369","author":"Nielsen","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1111\/ijs.12086","article-title":"DEcompressive surgery Plus hypoTHermia for Space-Occupying Stroke (DEPTH-SOS): A protocol of a multicenter randomized controlled clinical trial and a literature review","volume":"8","author":"Neugebauer","year":"2013","journal-title":"Int. J. Stroke"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Fan, L., Su, Y., Zhang, Y., Ye, H., Chen, W., and Liu, G. (2021). Decompressive craniectomy combined with mild hypothermia in patients with large hemispheric infarction: A randomized controlled trial. BMC Neurol., 21.","DOI":"10.1186\/s12883-021-02142-7"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1586\/14737175.7.2.155","article-title":"Therapeutic hypothermia in acute ischemic stroke","volume":"7","author":"Dippel","year":"2007","journal-title":"Exp. Rev. Neurother."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"195","DOI":"10.4103\/bc.bc_25_19","article-title":"Evidence and opportunities of hypothermia in acute ischemic stroke: Clinical trials of systemic versus selective hypothermia","volume":"5","author":"Huber","year":"2019","journal-title":"Brain Circ."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1177\/0271678X18800589","article-title":"The importance of comorbidities in ischemic stroke: Impact of hypertension on the cerebral circulation","volume":"38","author":"Cipolla","year":"2018","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1111\/jdi.12932","article-title":"Prevalence of diabetes and its effects on stroke outcomes: A meta-analysis and literature review","volume":"10","author":"Lau","year":"2019","journal-title":"J. Diabetes Investig."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Shigematsu, K., Watanabe, Y., and Nakano, H. (2015). Influences of hyperlipidemia history on stroke outcome; a retrospective cohort study based on the Kyoto Stroke Registry. BMC Neurol., 15.","DOI":"10.1186\/s12883-015-0297-1"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"23","DOI":"10.5339\/qmj.2023.23","article-title":"Cigarette smoking as a risk factor for ischaemic stroke in young South Asian male migrants to Qatar: The BRAINS study","volume":"2023","author":"Khan","year":"2023","journal-title":"Qatar Med. J."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1055\/s-0041-1726332","article-title":"Atrial Fibrillation and Ischemic Stroke: A Clinical Review","volume":"41","author":"Migdady","year":"2021","journal-title":"Semin. Neurol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1007\/s00134-003-2151-y","article-title":"Application of therapeutic hypothermia in the intensive care unit. Opportunities and pitfalls of a promising treatment modality\u2014Part 2: Practical aspects and side effects","volume":"30","author":"Polderman","year":"2004","journal-title":"Intensive Care Med."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.4187\/respcare.02590","article-title":"Airway clearance therapy: Finding the evidence","volume":"58","author":"Volsko","year":"2013","journal-title":"Respir. Care"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1164\/ajrccm.154.6.8970383","article-title":"Mucociliary clearance in the airways","volume":"154","author":"Wanner","year":"1996","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1016\/S0140-6736(14)62456-9","article-title":"The Preventive Antibiotics in Stroke Study (PASS): A pragmatic randomised open-label masked endpoint clinical trial","volume":"385","author":"Westendorp","year":"2015","journal-title":"Lancet Lond. Engl."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1177\/0271678X18773702","article-title":"Therapeutic hypothermia promotes cerebral blood flow recovery and brain homeostasis after resuscitation from cardiac arrest in a rat model","volume":"39","author":"Wang","year":"2019","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"A20","DOI":"10.1186\/cc11278","article-title":"Hypothermia and coagulation","volume":"16","author":"Polderman","year":"2012","journal-title":"Crit. Care"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1212\/WNL.0000000000003966","article-title":"Practice guideline summary: Reducing brain injury following cardiopulmonary resuscitation: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology","volume":"88","author":"Geocadin","year":"2017","journal-title":"Neurology"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1161\/CIRCULATIONAHA.117.029656","article-title":"Confusion Around Therapeutic Temperature Management Hypothermia After In-Hospital Cardiac Arrest?","volume":"137","author":"Polderman","year":"2018","journal-title":"Circulation"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1227\/01.NEU.0000367618.42794.AA","article-title":"Impact of induced normothermia on outcome after subarachnoid hemorrhage: A case-control study","volume":"66","author":"Badjatia","year":"2010","journal-title":"Neurosurgery"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1097\/01.CCM.0000147441.39670.37","article-title":"Clinical trial of a novel surface cooling system for fever control in neurocritical care patients","volume":"32","author":"Mayer","year":"2004","journal-title":"Crit. 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