{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:29:55Z","timestamp":1792189795711,"version":"4.4.0"},"reference-count":99,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,1,21]],"date-time":"2024-01-21T00:00:00Z","timestamp":1705795200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Liver transplantation is currently the only curative therapy for patients with liver cirrhosis. Not all patients in the natural course of the disease will undergo transplantation, but the majority of them will experience portal hypertension and its complications. In addition to medical and endoscopic therapy, a key role in managing these complications is played by the placement of a transjugular intrahepatic portosystemic shunt (TIPS). Some indications for TIPS placement are well-established, and they are expanding and broadening over time. This review aims to describe the role of TIPS in managing patients with liver cirrhosis, in light of liver transplantation. As far as it is known, TIPS placement seems not to affect the surgical aspects of liver transplantation, in terms of intraoperative bleeding rates, postoperative complications, or length of stay in the Intensive Care Unit. However, the placement of a TIPS \u201ctowards transplant\u201d can offer advantages in terms of ameliorating a patient\u2019s clinical condition at the time of transplantation and improving patient survival. Additionally, the TIPS procedure can help preserve the technical feasibility of the transplant itself. In this context, indications for TIPS placement at an earlier stage are drawing particular attention. However, TIPS insertion in decompensated patients can also lead to serious adverse events. For these reasons, further studies are needed to make reliable recommendations for TIPS in the pre-transplant setting.<\/jats:p>","DOI":"10.3390\/jcm13020600","type":"journal-article","created":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T11:36:41Z","timestamp":1705923401000},"page":"600","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Role of Transjugular Intrahepatic Portosystemic Shunt in the Liver Transplant Setting"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6414-4404","authenticated-orcid":false,"given":"Simone","family":"Di Cola","sequence":"first","affiliation":[{"name":"Department of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6761-4969","authenticated-orcid":false,"given":"Lucia","family":"Lapenna","sequence":"additional","affiliation":[{"name":"Department of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakub","family":"Gazda","sequence":"additional","affiliation":[{"name":"2nd Department of Internal Medicine, PJ Safarik University and L. Pasteur University Hospital in Kosice, 040 11 Kosice, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Fonte","sequence":"additional","affiliation":[{"name":"Department of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Cusi","sequence":"additional","affiliation":[{"name":"Department of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuele","family":"Esposito","sequence":"additional","affiliation":[{"name":"Department of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2081-3386","authenticated-orcid":false,"given":"Marco","family":"Mattana","sequence":"additional","affiliation":[{"name":"Department of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3173-9767","authenticated-orcid":false,"given":"Manuela","family":"Merli","sequence":"additional","affiliation":[{"name":"Department of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,21]]},"reference":[{"key":"ref_1","unstructured":"(2023, December 01). Available online: https:\/\/www.who.int\/data\/gho\/data\/themes\/mortality-and-global-health-estimates\/ghe-leading-causes-of-death."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.jhep.2005.10.013","article-title":"Natural history and prognostic indicators of survival in cirrhosis: A systematic review of 118 studies","volume":"44","author":"Pagliaro","year":"2006","journal-title":"J. Hepatol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.jhep.2017.10.020","article-title":"Clinical states of cirrhosis and competing risks","volume":"68","author":"Morabito","year":"2018","journal-title":"J. Hepatol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1111\/liv.14361","article-title":"Optimal management of ascites","volume":"40","author":"Rudler","year":"2020","journal-title":"Liver Int."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.cld.2020.04.011","article-title":"Evaluation and Management of Esophageal and Gastric Varices in Patients with Cirrhosis","volume":"24","author":"Jakab","year":"2020","journal-title":"Clin. Liver Dis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1053\/j.tvir.2016.01.004","article-title":"Evolving Indications for Tips","volume":"19","author":"Smith","year":"2016","journal-title":"Tech. Vasc. Interv. Radiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.jhep.2023.04.028","article-title":"TIPS prevents further decompensation and improves survival in patients with cirrhosis and portal hypertension in an individual patient data meta-analysis","volume":"79","author":"Larrue","year":"2023","journal-title":"J. Hepatol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1002\/lt.25320","article-title":"Liver Transplantation Today: Where We Are Now and Where We Are Going","volume":"24","author":"Bodzin","year":"2018","journal-title":"Liver Transplant."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.jhep.2021.12.022","article-title":"Baveno VII\u2014Renewing consensus in portal hypertension","volume":"76","author":"Bosch","year":"2022","journal-title":"J. Hepatol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1136\/gutjnl-2019-320221","article-title":"Transjugular intrahepatic portosystemic stent-shunt in the management of portal hypertension","volume":"69","author":"Tripathi","year":"2020","journal-title":"Gut"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1016\/j.jhep.2022.05.021","article-title":"Carvedilol reduces the risk of decompensation and mortality in patients with compensated cirrhosis in a competing-risk meta-analysis","volume":"77","author":"Villanueva","year":"2022","journal-title":"J. Hepatol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1002\/ueg2.12226","article-title":"Morbid obesity increases death and dropout from the liver transplantation waiting list: A prospective cohort study","volume":"10","author":"Favre","year":"2022","journal-title":"United Eur. Gastroenterol. J."},{"key":"ref_13","first-page":"166","article-title":"Clinical Impact and Risk Factors of Portal Vein Thrombosis for Patients on Wait List for Liver Transplant","volume":"16","author":"Montenovo","year":"2018","journal-title":"Exp. Clin. Transplant."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.trre.2014.01.003","article-title":"Portal vein thrombosis and liver transplantation: Implications for waiting list period, surgical approach, early and late follow-up","volume":"28","author":"Ponziani","year":"2014","journal-title":"Transplant. Rev."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2774","DOI":"10.4254\/wjh.v7.i27.2774","article-title":"Portal vein thrombosis, mortality and hepatic decompensation in patients with cirrhosis: A meta-analysis","volume":"7","author":"Stine","year":"2015","journal-title":"World J. Hepatol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1097\/TP.0000000000000785","article-title":"Portal Vein Thrombosis Is a Risk Factor for Poor Early Outcomes after Liver Transplantation: Analysis of Risk Factors and Outcomes for Portal Vein Thrombosis in Waitlisted Patients","volume":"100","author":"Ghabril","year":"2016","journal-title":"Transplantation"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1002\/lt.21941","article-title":"Portal vein thrombosis and survival in patients with cirrhosis","volume":"16","author":"Englesbe","year":"2010","journal-title":"Liver Transpl."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1053\/j.tvir.2016.01.006","article-title":"Portal Vein Recanalization and Transjugular Intrahepatic Portosystemic Shunt Creation for Chronic Portal Vein Thrombosis: Technical Considerations","volume":"19","author":"Thornburg","year":"2016","journal-title":"Tech. Vasc. Interv. Radiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1097\/TP.0000000000000729","article-title":"Pretransplant Portal Vein Recanalization-Transjugular Intrahepatic Portosystemic Shunt in Patients with Complete Obliterative Portal Vein Thrombosis","volume":"99","author":"Salem","year":"2015","journal-title":"Transplantation"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.1136\/gutjnl-2017-314634","article-title":"Covered TIPS versus endoscopic band ligation plus propranolol for the prevention of variceal rebleeding in cirrhotic patients with portal vein thrombosis: A randomised controlled trial","volume":"67","author":"Lv","year":"2018","journal-title":"Gut"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1076029619888026","DOI":"10.1177\/1076029619888026","article-title":"Anticoagulation and Transjugular Intrahepatic Portosystemic Shunting for Treatment of Portal Vein Thrombosis in Cirrhosis: A Systematic Review and Meta-Analysis","volume":"25","author":"Davis","year":"2019","journal-title":"Clin. Appl. Thromb.\/Hemost."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.14309\/ajg.0000000000001194","article-title":"Anticoagulation and Transjugular Intrahepatic Portosystemic Shunt for the Management of Portal Vein Thrombosis in Cirrhosis: A Prospective Observational Study","volume":"116","author":"Lv","year":"2022","journal-title":"Am. J. Gastroenterol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/apt.15044","article-title":"Systematic review with meta-analysis: Portal vein recanalisation and transjugular intrahepatic portosystemic shunt for portal vein thrombosis","volume":"49","author":"Rodrigues","year":"2019","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1097\/HEP.0000000000000530","article-title":"AASLD Practice Guidance on the use of TIPS, variceal embolization, and retrograde transvenous obliteration in the management of variceal hemorrhage","volume":"79","author":"Lee","year":"2024","journal-title":"Hepatology"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1007\/s11894-012-0308-y","article-title":"Natural history of cirrhosis","volume":"15","author":"Asrani","year":"2013","journal-title":"Curr. Gastroenterol. Rep."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1002\/hep.20386","article-title":"Influence of portal hypertension and its early decompression by TIPS placement on the outcome of variceal bleeding","volume":"40","author":"Monescillo","year":"2004","journal-title":"Hepatology"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.1056\/NEJMoa0910102","article-title":"Early use of TIPS in patients with cirrhosis and variceal bleeding","volume":"362","author":"Caca","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2040622321995771","DOI":"10.1177\/2040622321995771","article-title":"The role of pre-emptive Transjugular Intrahepatic Portosystemic Shunt in acute variceal bleeding: A literature review","volume":"12","author":"Manning","year":"2021","journal-title":"Ther. Adv. Chronic Dis."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/jgh.15714","article-title":"Does preemptive transjugular intrahepatic portosystemic shunt improve survival after acute variceal bleeding? Systematic review, meta-analysis, and trial sequential analysis of randomized trials","volume":"37","author":"Hussain","year":"2022","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1053\/j.gastro.2020.09.026","article-title":"Effects of Early Placement of Transjugular Portosystemic Shunts in Patients with High-Risk Acute Variceal Bleeding: A Meta-analysis of Individual Patient Data","volume":"160","author":"Han","year":"2021","journal-title":"Gastroenterology"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"S69","DOI":"10.1016\/S0168-8278(03)00007-2","article-title":"Ascites and hepatorenal syndrome in cirrhosis: Pathophysiological basis of therapy and current management","volume":"38","author":"Arroyo","year":"2003","journal-title":"J. Hepatol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1053\/gast.2002.37073","article-title":"Transjugular intrahepatic portosystemic shunting versus paracentesis plus albumin for refractory ascites in cirrhosis","volume":"123","author":"Uriz","year":"2002","journal-title":"Gastroenterology"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1007\/s00535-010-0282-9","article-title":"Transjugular intrahepatic portosystemic shunt versus paracentesis plus albumin in patients with refractory ascites who have good hepatic and renal function: A prospective randomized trial","volume":"46","author":"Narahara","year":"2011","journal-title":"J. Gastroenterol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1053\/j.gastro.2005.07.031","article-title":"Uncovered transjugular intrahepatic portosystemic shunt for refractory ascites: A meta-analysis","volume":"129","author":"Luca","year":"2005","journal-title":"Gastroenterology"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1053\/j.gastro.2007.06.020","article-title":"Transjugular intrahepatic portosystemic shunt for refractory ascites: A meta-analysis of individual patient data","volume":"133","author":"Salerno","year":"2007","journal-title":"Gastroenterology"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2704","DOI":"10.3748\/wjg.v20.i10.2704","article-title":"TIPS improves liver transplantation-free survival in cirrhotic patients with refractory ascites: An updated meta-analysis","volume":"20","author":"Bai","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1053\/gast.2003.50088","article-title":"The North American Study for the Treatment of Refractory Ascites","volume":"124","author":"Sanyal","year":"2003","journal-title":"Gastroenterology"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1016\/j.hep.2003.09.030","article-title":"Humoral and cardiac effects of TIPS in cirrhotic patients with different \u201ceffective\u201d blood volume","volume":"38","author":"Salerno","year":"2003","journal-title":"Hepatology"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"e51","DOI":"10.1016\/j.crad.2015.02.002","article-title":"Survival benefit of TIPS versus serial paracentesis in patients with refractory ascites: A single institution case-control propensity score analysis","volume":"70","author":"Gaba","year":"2015","journal-title":"Clin. Radiol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1007\/s00270-018-02155-9","article-title":"No Increased Mortality After TIPS Compared with Serial Large Volume Paracenteses in Patients with Higher Model for End-Stage Liver Disease Score and Refractory Ascites","volume":"42","author":"Ronald","year":"2019","journal-title":"Cardiovasc. Interv. Radiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"3533","DOI":"10.1016\/j.clnu.2020.09.001","article-title":"ESPEN practical guideline: Clinical nutrition in liver disease","volume":"39","author":"Bischoff","year":"2020","journal-title":"Clin. Nutr."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"European Association for the Study of the Liver (2019). EASL Clinical Practice Guidelines on nutrition in chronic liver disease. J. Hepatol., 70, 172\u2013193.","DOI":"10.1016\/j.jhep.2018.06.024"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1002\/hep.26370","article-title":"The nutritional management of hepatic encephalopathy in patients with cirrhosis: International Society for Hepatic Encephalopathy and Nitrogen Metabolism Consensus","volume":"58","author":"Amodio","year":"2013","journal-title":"Hepatology"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1111\/liv.12128","article-title":"MuRF-1 and p-GSK3\u03b2 expression in muscle atrophy of cirrhosis","volume":"33","author":"Merli","year":"2013","journal-title":"Liver Int."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Kim, G., Kang, S.H., Kim, M.Y., and Baik, S.K. (2017). Prognostic value of sarcopenia in patients with liver cirrhosis: A systematic review and meta-analysis. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0186990"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1016\/j.dld.2019.09.004","article-title":"The additive value of sarcopenia, myosteatosis and hepatic encephalopathy in the predictivity of model for end-stage liver disease","volume":"51","author":"Lattanzi","year":"2019","journal-title":"Dig. Liver Dis."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/S0973-6883(11)60237-5","article-title":"Nutritional status and liver transplantation","volume":"1","author":"Merli","year":"2011","journal-title":"J. Clin. Exp. Hepatol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"100758","DOI":"10.1016\/j.jhepr.2023.100758","article-title":"Body composition and short-term mortality in patients critically ill with acute-on-chronic liver failure","volume":"5","author":"Sacleux","year":"2023","journal-title":"JHEP Rep."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.cgh.2016.10.028","article-title":"Sarcopenia Is Risk Factor for Development of Hepatic Encephalopathy After Transjugular Intrahepatic Portosystemic Shunt Placement","volume":"15","author":"Nardelli","year":"2017","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"e00025","DOI":"10.14309\/ctg.0000000000000025","article-title":"Sarcopenia Is Associated with Development of Acute-on-Chronic Liver Failure in Decompensated Liver Cirrhosis Receiving Transjugular Intrahepatic Portosystemic Shunt","volume":"10","author":"Praktiknjo","year":"2019","journal-title":"Clin. Transl. Gastroenterol."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Gazda, J., Di Cola, S., Lapenna, L., Khan, S., and Merli, M. (2023). The Impact of Transjugular Intrahepatic Portosystemic Shunt on Nutrition in Liver Cirrhosis Patients: A Systematic Review. Nutrients, 15.","DOI":"10.20944\/preprints202302.0361.v1"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"348","DOI":"10.3748\/wjg.v16.i3.348","article-title":"Body composition changes after transjugular intrahepatic portosystemic shunt in patients with cirrhosis","volume":"16","author":"Montomoli","year":"2010","journal-title":"World J. Gastroenterol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"3006","DOI":"10.1007\/s12325-023-02517-x","article-title":"An Economic Analysis of Transjugular Intrahepatic Portosystemic Covered Stent Shunt for Variceal Bleeding and Refractory Ascites in a Spanish Setting","volume":"40","author":"Albillos","year":"2023","journal-title":"Adv. Ther."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.2214\/AJR.13.12232","article-title":"Characterization of liver function parameter alterations after transjugular intrahepatic portosystemic shunt creation and association with early mortality","volume":"203","author":"Casadaban","year":"2014","journal-title":"AJR Am. J. Roentgenol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1136\/gut.2008.172486","article-title":"Liver failure complicating segmental hepatic ischaemia induced by a PTFE-coated TIPS stent","volume":"58","author":"Vizzutti","year":"2009","journal-title":"Gut"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1136\/gut.2006.102467","article-title":"Diastolic dysfunction is associated with poor survival in patients with cirrhosis with transjugular intrahepatic portosystemic shunt","volume":"56","author":"Cazzaniga","year":"2007","journal-title":"Gut"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1002\/hep.30934","article-title":"A prospective study identifying predictive factors of cardiac decompensation after TIPS: The Toulouse algorithm","volume":"70","author":"Billey","year":"2019","journal-title":"Hepatology"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"2738","DOI":"10.1111\/j.1572-0241.2008.02102.x","article-title":"Incidence, natural history, and risk factors of hepatic encephalopathy after transjugular intrahepatic portosystemic shunt with polytetrafluoroethylene-covered stent grafts","volume":"103","author":"Riggio","year":"2008","journal-title":"Am. J. Gastroenterol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.cld.2011.12.008","article-title":"Hepatic encephalopathy after transjugular intrahepatic portosystemic shunt","volume":"16","author":"Riggio","year":"2012","journal-title":"Clin. Liver Dis."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"633","DOI":"10.7326\/M20-0202","article-title":"The Use of Rifaximin in the Prevention of Overt Hepatic Encephalopathy After Transjugular Intrahepatic Portosystemic Shunt: A Randomized Controlled Trial","volume":"174","author":"Bureau","year":"2021","journal-title":"Ann. Intern. Med."},{"key":"ref_61","unstructured":"Nardelli, S. (2023, January 21\u201324). Hepatic encephalopathy after transjugular intrahepatic portosystemic shunt does not increase mortality in patients with cirrhosis. Proceedings of the EASL Congress 2023, Vienna, Austria."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1177\/2050640617704807","article-title":"The role of TIPS in the management of liver transplant candidates","volume":"5","author":"Unger","year":"2017","journal-title":"United Eur. Gastroenterol. J."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1097\/00007890-199408000-00007","article-title":"Is the transjugular intrahepatic portocaval shunt procedure beneficial for liver transplant recipients?","volume":"58","author":"Freeman","year":"1994","journal-title":"Transplantation"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1007\/BF00299089","article-title":"Impact of transjugular intrahepatic portosystemic shunt on orthotopic liver transplantation","volume":"18","author":"Menegaux","year":"1994","journal-title":"World J. Surg."},{"key":"ref_65","first-page":"719","article-title":"Transjugular intrahepatic portosystemic shunt in the management of variceal bleeding: Indications and clinical results","volume":"114","author":"Martin","year":"1993","journal-title":"Surgery"},{"key":"ref_66","first-page":"344","article-title":"Intrahepatic portosystemic vascular stents: A bridge to hepatic transplantation","volume":"113","author":"Woodle","year":"1993","journal-title":"Surgery"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1016\/S0041-1345(03)00685-7","article-title":"Liver transplantation and transjugular intrahepatic portosystemic shunt","volume":"35","author":"Moreno","year":"2003","journal-title":"Transplant. Proc."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.surg.2005.02.004","article-title":"Impact of prior portosystemic shunt procedures on outcome of liver transplantation","volume":"137","author":"Grande","year":"2005","journal-title":"Surgery"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/j.1600-6143.2008.02472.x","article-title":"Impact of tips preliver transplantation for the outcome posttransplantation","volume":"9","author":"Guerrini","year":"2009","journal-title":"Am. J. Transplant."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.clinre.2013.09.003","article-title":"Impact of transjugular intrahepatic portosystemic shunting on liver transplantation: 12-year single-center experience","volume":"38","author":"Barbier","year":"2014","journal-title":"Clin. Res. Hepatol. Gastroenterol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.dld.2016.10.011","article-title":"Consensus conference on TIPS management: Techniques, indications, contraindications","volume":"49","author":"Fagiuoli","year":"2017","journal-title":"Dig. Liver Dis."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jvir.2015.09.018","article-title":"Quality Improvement Guidelines for Transjugular Intrahepatic Portosystemic Shunts","volume":"27","author":"Dariushnia","year":"2016","journal-title":"J. Vasc. Interv. Radiol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.trre.2018.10.004","article-title":"Transjugular intrahepatic portosystemic shunt as a bridge to liver transplant: Current state and future directions","volume":"33","author":"Sellers","year":"2019","journal-title":"Transplant. Rev."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Balducci, D., Montori, M., De Blasio, F., Di Bucchianico, A., Argenziano, M.E., Baroni, G.S., and Scarpellini, E. (2023). The Role of Transjugular Intrahepatic Portosystemic Shunt (TIPS) in Treating Portal Hypertension in Patients with Hepatocellular Carcinoma. Medicina, 59.","DOI":"10.3390\/medicina59061150"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.crad.2022.09.126","article-title":"Safety and effectiveness of transjugular intrahepatic portosystemic shunt in hepatocellular carcinoma patients with portal hypertension: A systematic review and meta-analysis","volume":"78","author":"Chen","year":"2023","journal-title":"Clin. Radiol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3109\/00365528509089633","article-title":"Does a portal-systemic shunt increase the risk of primary hepatic carcinoma in cirrhosis of the liver?","volume":"20","author":"Andersen","year":"1985","journal-title":"Scand J. Gastroenterol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1002\/hep.20576","article-title":"Patients with cirrhosis and bare-stent TIPS may have increased risk of hepatocellular carcinoma","volume":"41","author":"Escudero","year":"2005","journal-title":"Hepatology"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"232","DOI":"10.14218\/JCTH.2019.00007","article-title":"TIPS Is Not Associated with a Higher Risk of Developing HCC in Cirrhotic Patients: A Systematic Review and Meta-analysis","volume":"7","author":"Chen","year":"2019","journal-title":"J. Clin. Transl. Hepatol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1258\/ar.2012.110476","article-title":"Transarterial chemoembolization for hepatocellular carcinoma after transjugular intrahepatic portosystemic shunt","volume":"53","author":"Kang","year":"2012","journal-title":"Acta Radiol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1007\/s00270-005-0063-7","article-title":"Percutaneous treatment of hepatocellular carcinoma in patients with transjugular intrahepatic portosystemic shunts","volume":"29","author":"Tesdal","year":"2006","journal-title":"Cardiovasc. Interv. Radiol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"487","DOI":"10.5152\/dir.2014.13493","article-title":"Repeated transcatheter arterial chemoembolization is safe for hepatocellular carcinoma in cirrhotic patients with transjugular intrahepatic portosystemic shunt","volume":"20","author":"Wang","year":"2014","journal-title":"Diagn. Interv. Radiol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.jvir.2012.09.030","article-title":"Yttrium-90 radioembolization for the treatment of unresectable hepatocellular carcinoma in patients with transjugular intrahepatic portosystemic shunts","volume":"24","author":"Donahue","year":"2013","journal-title":"J. Vasc. Interv. Radiol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1007\/s00270-015-1050-2","article-title":"Radiofrequency Ablation for the Treatment of Hepatocellular Carcinoma in Patients with Transjugular Intrahepatic Portosystemic Shunts","volume":"38","author":"Park","year":"2015","journal-title":"Cardiovasc. Interv. Radiol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.jvir.2012.08.032","article-title":"Hepatotoxicity after transarterial chemoembolization and transjugular intrahepatic portosystemic shunt: Do two rights make a wrong?","volume":"24","author":"Kohi","year":"2013","journal-title":"J. Vasc. Interv. Radiol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1007\/s00270-013-0698-8","article-title":"Efficacy of TACE in TIPS patients: Comparison of treatment response to chemoembolization for hepatocellular carcinoma in patients with and without a transjugular intrahepatic portosystemic shunt","volume":"36","author":"Kuo","year":"2013","journal-title":"Cardiovasc. Interv. Radiol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1053\/j.gastro.2013.02.042","article-title":"Acute-on-chronic liver failure is a distinct syndrome that develops in patients with acute decompensation of cirrhosis","volume":"144","author":"Moreau","year":"2013","journal-title":"Gastroenterology"},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"European Association for the Study of the Liver (2018). EASL Clinical Practice Guidelines for the management of patients with decompensated cirrhosis. J. Hepatol., 69, 406\u2013460. Erratum in J. Hepatol. 2018, 69, 1207.","DOI":"10.1016\/j.jhep.2018.08.009"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1055\/a-2107-0576","article-title":"To TIPS or Not to TIPS in High Risk of Variceal Rebleeding and Acute-on-Chronic Liver Failure","volume":"43","author":"Gu","year":"2023","journal-title":"Semin. Liver Dis."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/hep.20262","article-title":"Midodrine, octreotide, albumin, and TIPS in selected patients with cirrhosis and type 1 hepatorenal syndrome","volume":"40","author":"Wong","year":"2004","journal-title":"Hepatology"},{"key":"ref_90","first-page":"203","article-title":"Severe acute alcoholic hepatitis and hepatorenal syndrome: Role of transjugular intrahepatic portosystemic stent shunt","volume":"5","author":"Testino","year":"2012","journal-title":"J. Med. Life"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1136\/gut.47.2.288","article-title":"Long term outcome after transjugular intrahepatic portosystemic stent-shunt in non-transplant cirrhotics with hepatorenal syndrome: A phase II study","volume":"47","author":"Brensing","year":"2000","journal-title":"Gut"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.dld.2018.01.123","article-title":"Transjugular intrahepatic portosystemic shunt for hepatorenal syndrome: A systematic review and meta-analysis","volume":"50","author":"Song","year":"2018","journal-title":"Dig. Liver Dis."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1186\/s13063-023-07261-9","article-title":"Liver-HERO: Hepatorenal syndrome-acute kidney injury (HRS-AKI) treatment with transjugular intrahepatic portosystemic shunt in patients with cirrhosis-a randomized controlled trial","volume":"24","author":"Ripoll","year":"2023","journal-title":"Trials"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.jceh.2018.08.008","article-title":"Left Ventricular Diastolic Dysfunction is Associated with Renal Dysfunction, Poor Survival and Low Health Related Quality of Life in Cirrhosis","volume":"9","author":"Premkumar","year":"2019","journal-title":"J. Clin. Exp. Hepatol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/j.1572-0241.2002.05438.x","article-title":"Modifications of cardiac function in cirrhotic patients treated with transjugular intrahepatic portosystemic shunt (TIPS)","volume":"97","author":"Merli","year":"2002","journal-title":"Am. J. Gastroenterol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"12719","DOI":"10.1038\/s41598-021-92064-8","article-title":"Cardiovascular magnetic resonance demonstrates structural cardiac changes following transjugular intrahepatic portosystemic shunt","volume":"11","author":"Radunski","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/j.dld.2015.08.014","article-title":"Circulatory response to volume expansion and transjugular intrahepatic portosystemic shunt in refractory ascites: Relationship with diastolic dysfunction","volume":"47","author":"Falletta","year":"2015","journal-title":"Dig. Liver Dis."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"3163","DOI":"10.1002\/hep4.2062","article-title":"Left atrial dysfunction is an independent predictor of mortality in patients with cirrhosis treated by transjugular intrahepatic portosystemic shunt","volume":"6","author":"Meucci","year":"2022","journal-title":"Hepatol. Commun."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"2458","DOI":"10.1038\/ajg.2009.321","article-title":"The use of E\/A ratio as a predictor of outcome in cirrhotic patients treated with transjugular intrahepatic portosystemic shunt","volume":"104","author":"Rabie","year":"2009","journal-title":"Am. J. Gastroenterol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/2\/600\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T13:46:34Z","timestamp":1760103994000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/2\/600"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,21]]},"references-count":99,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,1]]}},"alternative-id":["jcm13020600"],"URL":"https:\/\/doi.org\/10.3390\/jcm13020600","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,21]]}}}