{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T07:03:52Z","timestamp":1782630232630,"version":"3.54.5"},"reference-count":14,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2024,1,26]],"date-time":"2024-01-26T00:00:00Z","timestamp":1706227200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>(1) Background: Conventional open surgery is still the gold standard for aortic arch disease, and despite recent developments in optimizing strategies for neuroprotection, distal organ perfusion, and myocardial protection, aortic arch replacement is still associated with high morbidity and mortality rates. (2) Methods: We present our case series of 12 patients undergoing surgical management of multiple cardiac diseases involving the aortic arch. In this single-center study, we report our initial experience over a five-year period (from December 2018 to October 2023) with the use of a \u201cdebranching first\u201d technique for the supra-aortic vessels of a beating heart, followed by the cardiac step addressing proximal diseases, and a final distal step treating the aortic arch. This strategy aims to minimize cardiac, cerebral, and peripheral ischemia. (3) Results: Six patients underwent aortic root replacement with either Bentall (n = 4) or valve-sparing aortic root (David procedure) (n = 2). The mean nasopharyngeal temperature was 34 \u00b0C and the mean cardiocirculatory arrest was 14.3 min. The early mortality was 8.3% (1 patient); no patient experienced a permanent neurologic event. (4) Conclusions: In patients with complex aortic disease and concomitant cardiac disease, this approach reduces the need for hypothermia and decreases cardiopulmonary bypass time and myocardial arrest time and therefore could represent a valid surgical option, even in high-risk patients.<\/jats:p>","DOI":"10.3390\/jcm13030732","type":"journal-article","created":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T07:49:47Z","timestamp":1706600987000},"page":"732","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Multiple Cardiac Diseases Involving the Aortic Arch: Beating Heart Debranching, and Normothermic Arch Replacement: A Case Series"],"prefix":"10.3390","volume":"13","author":[{"given":"Alessandro","family":"Motta","sequence":"first","affiliation":[{"name":"UO Cardiochirurgia, APSS\u2014Ospedale Santa Chiara, Largo Medaglie d\u2019Oro, 38100 Trento, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian","family":"Scarpari","sequence":"additional","affiliation":[{"name":"UO Cardiochirurgia, APSS\u2014Ospedale Santa Chiara, Largo Medaglie d\u2019Oro, 38100 Trento, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ermelinda","family":"Borrelli","sequence":"additional","affiliation":[{"name":"UO Cardiochirurgia, APSS\u2014Ospedale Santa Chiara, Largo Medaglie d\u2019Oro, 38100 Trento, Italy"},{"name":"UO Cardiochirurgia, Salus Hospital, 42123 Reggio Emilia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3989-6134","authenticated-orcid":false,"given":"Francesco","family":"Formica","sequence":"additional","affiliation":[{"name":"UO Cardiochirurgia, APSS\u2014Ospedale Santa Chiara, Largo Medaglie d\u2019Oro, 38100 Trento, Italy"},{"name":"Department of Medicine and Surgery, University of Parma, 43126 Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1016\/S0003-4975(02)03763-3","article-title":"Arch-first technique for aortic arch aneurysm repair through median sternotomy","volume":"74","author":"Nishimura","year":"2002","journal-title":"Ann. 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