{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:25:05Z","timestamp":1792513505272,"version":"4.5.0"},"reference-count":37,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2024,1,28]],"date-time":"2024-01-28T00:00:00Z","timestamp":1706400000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>(1) Background: Pathological humeral shaft fracture (PHSF) is a frequently observed clinical manifestation in the later stages of tumor metastasis. Surgical interventions are typically recommended to alleviate pain and restore functionality. Intramedullary nail fixation (INF) or plate fixation (PF) is currently recommended for the treatment of PHSF. However, there is still no standard for optimal surgical treatment. Thus, we conducted a meta-analysis comparing the clinical outcomes of INF with PF for PHSF treatment. (2) Methods: We conducted searches in databases, such as Scopus, EMBASE, and PubMed, for studies published prior to May 2023. In total, nine studies with 485 patients were reviewed. (3) Results: There were no significant differences noted in the incidence of fixation failure, local recurrence, wound complication or overall complication. However, the INF group demonstrated a significantly lower incidence of postoperative radial nerve palsy than the PF group (OR, 5.246; 95% CI, 1.548\u201317.774; p = 0.008). A subgroup analysis indicated that there were no statistically significant differences in fixation failure or local recurrence among subgroups categorized by the design of intramedullary nail. (4) Conclusions: Considering the short life expectancy of end-stage patients, the choice of surgical method depends on the patient\u2019s individual condition, fracture and lesion patterns, the surgeon\u2019s experience, and comprehensive discussion between the surgeon and patient.<\/jats:p>","DOI":"10.3390\/jcm13030755","type":"journal-article","created":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T11:35:34Z","timestamp":1706614534000},"page":"755","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Intramedullary Nail vs. Plate Fixation for Pathological Humeral Shaft Fracture: An Updated Narrative Review and Meta-Analysis of Surgery-Related Factors"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7014-2245","authenticated-orcid":false,"given":"Bing-Kuan","family":"Chen","sequence":"first","affiliation":[{"name":"School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan"},{"name":"Division of General Medicine, Department of Medical Education, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting-Han","family":"Tai","sequence":"additional","affiliation":[{"name":"School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan"},{"name":"Department of Orthopedics, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Hsuan","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan"},{"name":"Department of Orthopedics, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuan-Hao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan"},{"name":"Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei 11031, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Min","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5508-7647","authenticated-orcid":false,"given":"Chih-Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan"},{"name":"Department of Orthopedics, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan"},{"name":"International Ph.D. Program in Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei 11031, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/S0748-7983(96)92450-6","article-title":"Treatment of Pathological Fractures of the Humeral Shaft due to Bone Metastases: A Comparison of Intramedullary Locking Nail and Plate Osteosynthesis with Adjunctive Bone Cement","volume":"22","author":"Dijkstra","year":"1996","journal-title":"Eur. J. Surg. Oncol."},{"key":"ref_2","first-page":"276","article-title":"Time of Survival and Quality of Life of the Patients Operatively Treated due to Pathological Fractures due to Bone Metastases","volume":"5","author":"Dutka","year":"2003","journal-title":"Ortop. Traumatol. Rehabil."},{"key":"ref_3","first-page":"789","article-title":"Surgical Treatment of Pathological Fractures of the Shaft of the Humerus","volume":"66","author":"Sarahrudi","year":"2009","journal-title":"J. Trauma"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"282","DOI":"10.5435\/00124635-200307000-00008","article-title":"Metastatic Bone Disease of the Humerus","volume":"11","author":"Frassica","year":"2003","journal-title":"J. Am. Acad. Orthop. Surg."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1016\/j.injury.2010.08.015","article-title":"Surgical Treatment of Pathologic Fractures of Humerus","volume":"41","author":"Piccioli","year":"2010","journal-title":"Injury"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1302\/2058-5241.1.000008","article-title":"Treatment of Pathological Fractures of the Long Bones","volume":"1","author":"Willeumier","year":"2016","journal-title":"EFORT Open Rev."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1302\/0301-620X.93B8.26194","article-title":"Fixation of Pathological Humeral Fractures by the Cemented Plate Technique","volume":"93","author":"Weiss","year":"2011","journal-title":"J. Bone Jt. Surg. Br."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Zheng, K., Yu, X.C., Hu, Y.C., Shao, Z.W., Xu, M., Wang, B.C., and Wang, F. (2019). Outcome of Segmental Prosthesis Reconstruction for Diaphyseal Bone Tumors: A Multi-Center Retrospective Study. BMC Cancer, 19.","DOI":"10.1186\/s12885-019-5865-0"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/s12957-021-02250-1","article-title":"Intercalary Prosthetic Replacement Is a Reliable Solution for Metastatic Humeral Shaft Fractures: Retrospective, Observational Study of a Single Center Series","volume":"19","author":"Zhao","year":"2021","journal-title":"World J. Surg. Oncol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1097\/01.blo.0000165857.12676.00","article-title":"Function after Resection of Humeral Metastases: Analysis of 59 Consecutive Patients","volume":"437","author":"Bickels","year":"2005","journal-title":"Clin. Orthop. Relat. Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"S212","DOI":"10.1097\/01.blo.0000093052.96273.a7","article-title":"Evaluation and Treatment of Metastases to the Humerus","volume":"415","author":"Frassica","year":"2003","journal-title":"Clin. Orthop. Relat. Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.jse.2015.08.009","article-title":"Complications after Surgery for Metastatic Humeral Lesions","volume":"25","author":"Janssen","year":"2016","journal-title":"J. Shoulder Elb. Surg."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/j.jse.2011.06.019","article-title":"Complications and Survival after Surgical Treatment of 214 Metastatic Lesions of the Humerus","volume":"21","author":"Wedin","year":"2012","journal-title":"J. Shoulder Elb. Surg."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.otsr.2018.03.009","article-title":"Humeral Metastasis of Renal Cancer: Surgical Options and Review of Literature","volume":"104","author":"Casadei","year":"2018","journal-title":"Orthop. Traumatol. Surg. Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1097\/COC.0000000000000937","article-title":"Intramedullary Nailing versus Compound Plate Osteosynthesis in Pathologic Diaphyseal Humerus Fractures: A Retrospective Cohort Study","volume":"45","author":"Koob","year":"2022","journal-title":"Am. J. Clin. Oncol."},{"key":"ref_16","first-page":"e13788","article-title":"Intramedullary Nailing versus Plate Osteosynthesis for Humeral Shaft Metastatic Lesions","volume":"13","author":"Ricard","year":"2021","journal-title":"Cureus"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"365","DOI":"10.55095\/achot2014\/050","article-title":"Surgical Management and Outcome of Skeletal Metastatic Disease of the Humerus","volume":"81","author":"Schwabe","year":"2014","journal-title":"Acta Chir. Orthop. Traumatol. Cech."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1053\/j.seminoncol.2007.03.002","article-title":"Surgical Therapy of Bone Metastases","volume":"34","author":"Aboulafia","year":"2007","journal-title":"Semin. Oncol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"518","DOI":"10.3389\/fendo.2018.00518","article-title":"Multimodal Treatment of Bone Metastasis\u2013A Surgical Perspective","volume":"9","author":"Soeharno","year":"2018","journal-title":"Front. Endocrinol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1007\/s00264-009-0833-y","article-title":"Treatment of Pathological Humeral Shaft Fractures with Intramedullary Nailing. A Retrospective Study","volume":"34","author":"Pretell","year":"2010","journal-title":"Int. Orthop."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s00068-017-0775-9","article-title":"Radial Nerve Palsy in Humeral Shaft Fractures with Internal Fixation: Analysis of Management and Outcome","volume":"44","author":"Schwab","year":"2018","journal-title":"Eur. J. Trauma Emerg. Surg."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"73","DOI":"10.29271\/jcpsp.2020.01.73","article-title":"Outcome of Humeral Shaft Fracture Treated with Intramedullary Nail and Plate Fixation","volume":"30","author":"Wang","year":"2020","journal-title":"J. Coll. Physicians Surg. Pak."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e116","DOI":"10.5435\/JAAOS-D-20-00819","article-title":"Management of Metastatic Disease of the Upper Extremity","volume":"29","author":"Voskuil","year":"2021","journal-title":"J. Am. Acad. Orthop. Surg."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1177\/230949901202000304","article-title":"Antegrade Interlocking Nailing versus Dynamic Compression Plating for Humeral Shaft Fractures","volume":"20","author":"Kulkarni","year":"2012","journal-title":"J. Orthop. Surg."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1477-7800-3-5","article-title":"Outcome of Surgical Management of Bony Metastases to the Humerus and Shoulder Girdle: A Retrospective Analysis of 93 Patients","volume":"3","author":"Thai","year":"2006","journal-title":"Int. Semin. Surg. Oncol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.radonc.2016.07.009","article-title":"Lack of Clinical Evidence for Postoperative Radiotherapy after Surgical Fixation of Impending or Actual Pathologic Fractures in the Long Bones in Patients with Cancer; a Systematic Review","volume":"121","author":"Willeumier","year":"2016","journal-title":"Radiother. Oncol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e531","DOI":"10.1016\/j.prro.2015.02.006","article-title":"Postoperative Radiation Therapy for Osseous Metastasis: Outcomes and Predictors of Local Failure","volume":"5","author":"Sullivan","year":"2015","journal-title":"Pract. Radiat. Oncol."},{"key":"ref_28","first-page":"535","article-title":"Impending and Actual Pathological Fractures in Patients with Bone Metastases of the Long Bones. A Retrospective Study of 233 Surgically Treated Fractures","volume":"160","author":"Dijkstra","year":"1994","journal-title":"Eur. J. Surg. Acta Chir."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1007\/s00264-008-0540-0","article-title":"Minimally Invasive Treatment of Pathological Fractures of the Humeral Shaft","volume":"33","author":"Ofluoglu","year":"2009","journal-title":"Int. Orthop."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s11751-014-0204-0","article-title":"Internal Fixation of Shaft Humerus Fractures by Dynamic Compression Plate or Interlocking Intramedullary Nail: A Prospective, Randomised Study","volume":"9","author":"Wali","year":"2014","journal-title":"Strateg. Trauma Limb Reconstr."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1016\/j.injury.2013.10.044","article-title":"Complications after Interlocking Intramedullary Nailing of Humeral Shaft Fractures","volume":"45","author":"Baltov","year":"2014","journal-title":"Injury"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"S85","DOI":"10.1055\/s-2001-17022","article-title":"Pr\u00e4operative Sonographische Untersuchung der Rotatorenmanschette vor Anterograder Nagelung von Humerusschaftfrakturen","volume":"9","author":"Heinsen","year":"2001","journal-title":"Osteosynth. Int."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"103286","DOI":"10.1016\/j.otsr.2022.103286","article-title":"Humeral Shaft Fracture: Outcomes of Percutaneous Antegrade Intramedullary Nailing Using the Long Telegraph\u00ae Nail with Dynamic Distal Locking","volume":"108","author":"Haddaoui","year":"2022","journal-title":"Orthop. Traumatol. Surg. Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/hpb.12349","article-title":"Assessment of Health Care Cost for Complex Surgical Patients: Review of Cost, Re-Imbursement and Revenue Involved in Pancreatic Surgery at a High-Volume Academic Medical Centre","volume":"17","author":"Kachare","year":"2015","journal-title":"HPB"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.jseint.2021.04.005","article-title":"Comparison of Direct Surgical Cost for Humeral Shaft Fracture Fixation: Open Reduction Internal Fixation versus Intramedullary Nailing","volume":"5","author":"Stephens","year":"2021","journal-title":"JSES Int."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s10195-023-00721-7","article-title":"Intramedullary Nailing versus Cemented Plate for Treating Metastatic Pathological Fracture of the Proximal Humerus: A Comparison Study and Literature Review","volume":"24","author":"Wu","year":"2023","journal-title":"J. Orthop. Traumatol."},{"key":"ref_37","first-page":"1548","article-title":"Modified Hackethal\u2019s Technique with Bone Grafting and Plate Fixation: A Case Report of Treatment for Pathological Humeral Shaft Fracture","volume":"7","author":"Lin","year":"2023","journal-title":"Clin. Case Rep. Int."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/3\/755\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T13:50:43Z","timestamp":1760104243000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/3\/755"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,28]]},"references-count":37,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,2]]}},"alternative-id":["jcm13030755"],"URL":"https:\/\/doi.org\/10.3390\/jcm13030755","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,28]]}}}