{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T05:06:50Z","timestamp":1776229610612,"version":"3.50.1"},"reference-count":134,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2024,1,28]],"date-time":"2024-01-28T00:00:00Z","timestamp":1706400000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Health and Medical Research Council (NHMRC)","award":["GNT2025379"],"award-info":[{"award-number":["GNT2025379"]}]},{"name":"National Health and Medical Research Council (NHMRC)","award":["GNT1170958"],"award-info":[{"award-number":["GNT1170958"]}]},{"name":"National Health and Medical Research Council (NHMRC)","award":["GNT1138555"],"award-info":[{"award-number":["GNT1138555"]}]},{"name":"National Health and Medical Research Council (NHMRC)","award":["APP2005981"],"award-info":[{"award-number":["APP2005981"]}]},{"name":"NHMRC","award":["GNT2025379"],"award-info":[{"award-number":["GNT2025379"]}]},{"name":"NHMRC","award":["GNT1170958"],"award-info":[{"award-number":["GNT1170958"]}]},{"name":"NHMRC","award":["GNT1138555"],"award-info":[{"award-number":["GNT1138555"]}]},{"name":"NHMRC","award":["APP2005981"],"award-info":[{"award-number":["APP2005981"]}]},{"name":"NHMRC","award":["GNT2025379"],"award-info":[{"award-number":["GNT2025379"]}]},{"name":"NHMRC","award":["GNT1170958"],"award-info":[{"award-number":["GNT1170958"]}]},{"name":"NHMRC","award":["GNT1138555"],"award-info":[{"award-number":["GNT1138555"]}]},{"name":"NHMRC","award":["APP2005981"],"award-info":[{"award-number":["APP2005981"]}]},{"name":"Charles Darwin International PhD Scholars (CDIPS) Scholarship","award":["GNT2025379"],"award-info":[{"award-number":["GNT2025379"]}]},{"name":"Charles Darwin International PhD Scholars (CDIPS) Scholarship","award":["GNT1170958"],"award-info":[{"award-number":["GNT1170958"]}]},{"name":"Charles Darwin International PhD Scholars (CDIPS) Scholarship","award":["GNT1138555"],"award-info":[{"award-number":["GNT1138555"]}]},{"name":"Charles Darwin International PhD Scholars (CDIPS) Scholarship","award":["APP2005981"],"award-info":[{"award-number":["APP2005981"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Chronic cough is a common symptom of many childhood lung conditions. Given the phenotypic heterogeneity of chronic cough, better characterization through endotyping is required to provide diagnostic certainty, precision therapies and to identify pathobiological mechanisms. This review summarizes recent endotype discoveries in airway diseases, particularly in relation to children, and describes the multi-omic approaches that are required to define endotypes. Potential biospecimens that may contribute to endotype and biomarker discoveries are also discussed. Identifying endotypes of chronic cough can likely provide personalized medicine and contribute to improved clinical outcomes for children.<\/jats:p>","DOI":"10.3390\/jcm13030756","type":"journal-article","created":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T11:35:34Z","timestamp":1706614534000},"page":"756","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Endotypes of Paediatric Cough\u2014Do They Exist and Finding New Techniques to Improve Clinical Outcomes"],"prefix":"10.3390","volume":"13","author":[{"given":"Hannah","family":"O\u2019Farrell","sequence":"first","affiliation":[{"name":"NHMRC Centre for Research Excellence in Paediatric Bronchiectasis (AusBREATHE), Child and Maternal Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, NT 0810, Australia"},{"name":"Australian Centre for Health Services Innovation, Queensland University of Technology, Brisbane, QLD 4000, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hing","family":"Kok","sequence":"additional","affiliation":[{"name":"NHMRC Centre for Research Excellence in Paediatric Bronchiectasis (AusBREATHE), Child and Maternal Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, NT 0810, Australia"},{"name":"Department of Paediatrics, Sabah Women and Children\u2019s Hospital, Kota Kinabalu 88996, Sabah, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suhani","family":"Goel","sequence":"additional","affiliation":[{"name":"Australian Centre for Health Services Innovation, Queensland University of Technology, Brisbane, QLD 4000, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1331-3706","authenticated-orcid":false,"given":"Anne","family":"Chang","sequence":"additional","affiliation":[{"name":"NHMRC Centre for Research Excellence in Paediatric Bronchiectasis (AusBREATHE), Child and Maternal Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, NT 0810, Australia"},{"name":"Australian Centre for Health Services Innovation, Queensland University of Technology, Brisbane, QLD 4000, Australia"},{"name":"Department of Respiratory and Sleep Medicine, Queensland Children\u2019s Hospital, Brisbane, QLD 4101, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4163-4782","authenticated-orcid":false,"given":"Stephanie","family":"Yerkovich","sequence":"additional","affiliation":[{"name":"NHMRC Centre for Research Excellence in Paediatric Bronchiectasis (AusBREATHE), Child and Maternal Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, NT 0810, Australia"},{"name":"Australian Centre for Health Services Innovation, Queensland University of Technology, Brisbane, QLD 4000, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Chang, A.B., Boyd, J., Bell, L., Goyal, V., Masters, I.B., Powell, Z., Wilson, C., Zacharasiewicz, A., Alexopoulou, E., and Bush, A. 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