{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T17:41:28Z","timestamp":1770831688521,"version":"3.50.1"},"reference-count":31,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T00:00:00Z","timestamp":1706486400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Burn wound dressing and debridement are excruciatingly painful procedures that call for appropriate analgesia\u2014typically multimodal. Better post-procedural pain management, less opioid use, and consequently fewer side effects, which could prolong recovery and increase morbidity, are all benefits of this type of analgesia. Intravenously administered ketamine can be effective as monotherapy or in combination with opioids, especially with procedural sedation such as in burn wound dressing. Methods: This observational study investigated the effect of ketamine administered in subanesthetic doses combined with opioids during burn wound dressing. The study was conducted from October 2018 to October 2021. A total of 165 patients met the inclusion criteria. A total of 82 patients were in the ketamine group, while 83 patients were dressed without ketamine. The main outcome was the effect of ketamine on intraprocedural opioid consumption. The secondary outcome included the effect of ketamine on postprocedural pain control. Results: Patients dressed with ketamine were significantly older (p = 0.001), while the mean doses of intraoperatively administered propofol and fentanyl were significantly lower than in patients dressed without ketamine (150 vs. 220 mg, p &lt; 0.001; and 0.075 vs. 0.150 mg, p &lt; 0.001; respectively). Conclusions: Ketamine was an independent predictor of lower intraoperative fentanyl consumption, according to the multivariate regression analysis (p = 0.015). Contrarily, both groups of patients required postoperative tramadol treatment, while intraoperative ketamine administration had no beneficial effects on postoperative pain management.<\/jats:p>","DOI":"10.3390\/jcm13030764","type":"journal-article","created":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T11:35:34Z","timestamp":1706614534000},"page":"764","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Role of Ketamine as a Component of Multimodal Analgesia in Burns: A Retrospective Observational Study"],"prefix":"10.3390","volume":"13","author":[{"given":"Marina","family":"Stojanovi\u0107","sequence":"first","affiliation":[{"name":"Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia"},{"name":"Center for Anesthesiology and Resuscitation, University Clinical Center of Serbia, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7885-467X","authenticated-orcid":false,"given":"Milana","family":"Marinkovi\u0107","sequence":"additional","affiliation":[{"name":"Clinic for Burns, Plastic and Reconstructive Surgery, University Clinical Center of Serbia, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8091-2461","authenticated-orcid":false,"given":"Biljana","family":"Mili\u010di\u0107","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics and Informatics, School of Dental Medicine, University of Belgrade, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4545-4335","authenticated-orcid":false,"given":"Milan","family":"Stoji\u010di\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia"},{"name":"Clinic for Burns, Plastic and Reconstructive Surgery, University Clinical Center of Serbia, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marko","family":"Jovi\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia"},{"name":"Clinic for Burns, Plastic and Reconstructive Surgery, University Clinical Center of Serbia, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milan","family":"Jovanovi\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia"},{"name":"Clinic for Burns, Plastic and Reconstructive Surgery, University Clinical Center of Serbia, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jelena","family":"Isakovi\u0107 Suboti\u0107","sequence":"additional","affiliation":[{"name":"Clinic for Burns, Plastic and Reconstructive Surgery, University Clinical Center of Serbia, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3209-5214","authenticated-orcid":false,"given":"Milana","family":"Juri\u0161i\u0107","sequence":"additional","affiliation":[{"name":"Clinic for Burns, Plastic and Reconstructive Surgery, University Clinical Center of Serbia, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miodrag","family":"Karamarkovi\u0107","sequence":"additional","affiliation":[{"name":"Clinic for Burns, Plastic and Reconstructive Surgery, University Clinical Center of Serbia, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra","family":"\u0110eki\u0107","sequence":"additional","affiliation":[{"name":"Clinic for Burns, Plastic and Reconstructive Surgery, University Clinical Center of Serbia, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9884-3257","authenticated-orcid":false,"given":"Kristina","family":"Radenovi\u0107","sequence":"additional","affiliation":[{"name":"Clinic for Burns, Plastic and Reconstructive Surgery, University Clinical Center of Serbia, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0842-1478","authenticated-orcid":false,"given":"Jovan","family":"Mihaljevi\u0107","sequence":"additional","affiliation":[{"name":"Clinic for Burns, Plastic and Reconstructive Surgery, University Clinical Center of Serbia, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4189-5368","authenticated-orcid":false,"given":"Ivan","family":"Radosavljevi\u0107","sequence":"additional","affiliation":[{"name":"Clinic for Burns, Plastic and Reconstructive Surgery, University Clinical Center of Serbia, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5898-5912","authenticated-orcid":false,"given":"Branko","family":"Su\u0111ecki","sequence":"additional","affiliation":[{"name":"Clinic for Burns, Plastic and Reconstructive Surgery, University Clinical Center of Serbia, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0425-0731","authenticated-orcid":false,"given":"Milan","family":"Savi\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia"},{"name":"Clinic for Thoracic Surgery, University Clinical Center of Serbia, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marko","family":"Kosti\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia"},{"name":"Clinic for Thoracic Surgery, University Clinical Center of Serbia, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u017deljko","family":"Garabinovi\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia"},{"name":"Clinic for Thoracic Surgery, University Clinical Center of Serbia, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jelena","family":"Jeremi\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia"},{"name":"Clinic for Burns, Plastic and Reconstructive Surgery, University Clinical Center of Serbia, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,29]]},"reference":[{"key":"ref_1","first-page":"1","article-title":"Consensus Guidelines on the Use of Intravenous Ketamine Infusions for Acute Pain Management from the American Society of Regional Anesthesia and Pain Medicine, the American Academy of Pain Medicine, and the American Society of Anesthesiologists","volume":"43","author":"Schwenk","year":"2018","journal-title":"Reg. Anesth. Pain Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1089\/wound.2019.0963","article-title":"A Critical Update of the Assessment and Acute Management of Patients with Severe Burns","volume":"8","author":"Lang","year":"2019","journal-title":"Adv. Wound Care"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e115","DOI":"10.1016\/j.anclin.2017.01.018","article-title":"Essential Elements of Multimodal Analgesia in Enhanced Recovery after Surgery (ERAS) Guidelines","volume":"35","author":"Beverly","year":"2017","journal-title":"Anesthesiol. Clin."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1111\/1440-1681.13742","article-title":"Oral Pregabalin Is Effective as Preemptive Analgesia in Abdominal Hysterectomy-A Randomized Controlled Trial","volume":"50","author":"Silva","year":"2023","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1097\/j.pain.0000000000001243","article-title":"Postoperative Pain, Analgesia, and Recovery-Bedfellows That Cannot Be Ignored","volume":"159","author":"Kehlet","year":"2018","journal-title":"Pain"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Bili\u0161kov, A., Ivan\u010dev, B., and Pogoreli\u0107, Z. (2021). Effects on Recovery of Pediatric Patients Undergoing Total Intravenous Anesthesia with Propofol versus Ketofol for Short\u2014Lasting Laparoscopic Procedures. Children, 8.","DOI":"10.3390\/children8070610"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1097\/AJP.0b013e31816cdb20","article-title":"Ketamine and Midazolam Delivered by Patient-Controlled Analgesia in Relieving Pain Associated with Burns Dressings","volume":"24","author":"MacPherson","year":"2008","journal-title":"Clin. J. Pain"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1111\/j.1526-4637.2011.01220.x","article-title":"A Systematic Review of Ketamine as an Analgesic Agent in Adult Burn Injuries","volume":"12","author":"McGuinness","year":"2011","journal-title":"Pain Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1124\/pr.117.015198","article-title":"Ketamine and Ketamine Metabolite Pharmacology: Insights into Therapeutic Mechanisms","volume":"70","author":"Zanos","year":"2018","journal-title":"Pharmacol. Rev."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/S0893-133X(01)00346-3","article-title":"Attenuation of Ketamine Effects by Nimodipine Pretreatment in Recovering Ethanol Dependent Men Psychopharmacologic Implications of the Interaction of NMDA and L-Type Calcium Channel Antagonists","volume":"25","author":"Krupitsky","year":"2001","journal-title":"Neuropsychopharmacology"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Fabbri, A., Voza, A., Riccardi, A., Serra, S., and Iaco, F. (2023). The Pain Management of Trauma Patients in the Emergency Department. J. Clin. Med., 12.","DOI":"10.3390\/jcm12093289"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.annemergmed.2014.06.018","article-title":"The Effect of Ketamine on Intracranial and Cerebral Perfusion Pressure and Health Outcomes: A Systematic Review","volume":"65","author":"Cohen","year":"2015","journal-title":"Ann. Emerg. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.annemergmed.2010.11.030","article-title":"Clinical Practice Guideline for Emergency Department Ketamine Dissociative Sedation: 2011 Update","volume":"57","author":"Green","year":"2011","journal-title":"Ann. Emerg. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1097\/00000542-198210000-00005","article-title":"Comparative Evaluation of Intravenous Agents for Rapid Sequence Induction\u2014Thiopental, Ketamine, and Midazolam","volume":"57","author":"White","year":"1982","journal-title":"Anesthesiology"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1038\/s41598-020-58489-3","article-title":"Author Correction: Association of Ketamine Use with Lower Risks of Post-Intubation Hypotension in Hemodynamically-Unstable Patients in the Emergency Department","volume":"10","author":"Ishimaru","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"103783","DOI":"10.1016\/j.amsu.2022.103783","article-title":"Ketamine as a Component of Multimodal Analgesia for Pain Management in Bariatric Surgery: A Systematic Review and Meta-Analysis of Randomized Controlled Trials","volume":"78","author":"Chaouch","year":"2022","journal-title":"Ann. Med. Surg."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s41572-020-0145-5","article-title":"Burn Injury","volume":"6","author":"Jeschke","year":"2020","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.ccc.2016.06.001","article-title":"The Physiologic Basis of Burn Shock and the Need for Aggressive Fluid Resuscitation","volume":"32","author":"Rae","year":"2016","journal-title":"Crit. Care Clin."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Guillory, A., Clayton, R., Herndon, D., and Finnerty, C. (2016). Cardiovascular Dysfunction Following Burn Injury: What We Have Learned from Rat and Mouse Models. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17010053"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1093\/jbcr\/iraa065","article-title":"Perioperative Multimodal Analgesia Reduces Opioid Use Following Skin Grafting in Nonintubated Burn Patients","volume":"41","author":"Lennertz","year":"2020","journal-title":"J. Burn. Care Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1093\/jbcr\/iry044","article-title":"Intravenous Ketamine as an Adjunct to Procedural Sedation during Burn Wound Care and Dressing Changes","volume":"40","author":"Phg","year":"2019","journal-title":"J. Burn Care Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"220","DOI":"10.4103\/0970-9185.81823","article-title":"Comparison of Effects of Ketamine, Ketamine-Dexmedetomidine and Ketamine-Midazolam on Dressing Changes of Burn Patients","volume":"27","author":"Sakalli","year":"2011","journal-title":"J. Anaesthesiol. Clin. Pharmacol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.burns.2009.08.007","article-title":"Pain Relief during Dressing Changes of Major Adult Burns: Ideal Analgesic Combination with Ketamine","volume":"36","author":"Zora","year":"2010","journal-title":"Burns"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1016\/j.burns.2013.02.012","article-title":"Oral Ketamine and Dexmedetomidine in Adults\u2019 Burns Wound Dressing-A Randomized Double Blind Cross over Study","volume":"39","author":"Kundra","year":"2013","journal-title":"Burns"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1177\/0897190019876497","article-title":"Oral Administration of Injectable Ketamine during Burn Wound Dressing Changes","volume":"34","author":"Lintner","year":"2021","journal-title":"J. Pharm. Pract."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.burns.2018.12.012","article-title":"Rectal Ketamine during Paediatric Burn Wound Dressing Procedures: A Randomised Dose-Finding Study","volume":"45","author":"Grossmann","year":"2019","journal-title":"Burns"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1213\/01.ANE.0000118109.12855.07","article-title":"Ketamine as Adjuvant Analgesic to Opioids: A Quantitative and Qualitative Systematic Review","volume":"99","author":"Subramaniam","year":"2004","journal-title":"Anesth. Analg."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1213\/01.ANE.0000048088.17761.B4","article-title":"A Single Small Dose of Postoperative Ketamine Provides Rapid and Sustained Improvement in Morphine Analgesia in the Presence of Morphine-Resistant Pain","volume":"96","author":"Weinbroum","year":"2003","journal-title":"Anesth. Analg."},{"key":"ref_29","first-page":"CD012033","article-title":"Perioperative Intravenous Ketamine for Acute Postoperative Pain in Adults","volume":"12","author":"Brinck","year":"2018","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1007\/s12630-011-9560-0","article-title":"A Systematic Review of Intravenous Ketamine for Postoperative Analgesia","volume":"58","author":"Laskowski","year":"2011","journal-title":"Can. J. Anaesth."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"110071","DOI":"10.1016\/j.jclinane.2020.110071","article-title":"Perioperative Intravenous S-Ketamine for Acute Postoperative Pain in Adults: A Systematic Review and Meta-Analysis","volume":"68","author":"Wang","year":"2021","journal-title":"J. Clin. Anesth."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/3\/764\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T13:50:49Z","timestamp":1760104249000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/3\/764"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,29]]},"references-count":31,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,2]]}},"alternative-id":["jcm13030764"],"URL":"https:\/\/doi.org\/10.3390\/jcm13030764","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,29]]}}}