{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T20:45:15Z","timestamp":1784925915760,"version":"3.55.0"},"reference-count":34,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T00:00:00Z","timestamp":1706486400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca de la FIESCYL (IBSAL-FIESCYL)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Previous studies have compared levobupivacaine versus ropivacaine in various peripheral nerve blocks in terms of block duration, quality of analgesia, and onset time, but this has not occurred in the PENG block. Here, a single-center, randomized, and controlled clinical trial is presented. One hundred and twenty patients older than 65 years suffering from hip fractures and surgically treated at our institution under spinal anesthesia were eligible for participation; of them, one hundred and eight were analyzed. Patients were randomized to receive ultrasound-guided PENG blocks using 20 mL of either 0.25% levobupivacaine or 0.375% ropivacaine (both of which are equipotent concentrations). The primary endpoint was to compare the analgesic duration (time to first rescue) and analgesic quality (pain scores using the VAS, PAINAD, and AlgoPlus scales) between the groups. Secondary endpoints included comparing the onset time, describing the need for and type of rescue analgesics, and possible associated adverse effects. There were no statistically significant differences in analgesic duration between levobupivacaine (median 861.0, IQR 960) and ropivacaine (median 1205.0, IQR 1379; p = 0.069). Likewise, the quality of analgesia and onset time were comparable among the groups. A small number of patients required opioids as rescue analgesics (4.6%). The possible associated adverse effects included postoperative infection (11.1%) and delirium (2.8%).<\/jats:p>","DOI":"10.3390\/jcm13030770","type":"journal-article","created":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T11:35:34Z","timestamp":1706614534000},"page":"770","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Comparison of the Analgesic Efficacy between Levobupivacaine 0.25% and Ropivacaine 0.375% for PENG (Pericapsular Nerve Group) Block in the Context of Hip Fracture Surgery of Elderly Patients: A Single-Center, Randomized, and Controlled Clinical Trial"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5602-0960","authenticated-orcid":false,"given":"Daniel","family":"Salgado-Garc\u00eda","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Critical Care, Salamanca University Hospital, Gerencia Regional de Salud de Castilla y Le\u00f3n (SACYL), Paseo de la Transici\u00f3n Espa\u00f1ola, 37007 Salamanca, Castilla y Le\u00f3n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6229-8311","authenticated-orcid":false,"given":"Agust\u00edn","family":"D\u00edaz-\u00c1lvarez","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care, Salamanca University Hospital, Gerencia Regional de Salud de Castilla y Le\u00f3n (SACYL), Paseo de la Transici\u00f3n Espa\u00f1ola, 37007 Salamanca, Castilla y Le\u00f3n, Spain"},{"name":"Department of Surgery, Faculty of Medicine, Salamanca University, Calle Alfonso X el Sabio, 37007 Salamanca, Castilla y Le\u00f3n, Spain"},{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca de la FIESCYL (IBSAL-FIESCYL), Paseo de San Vicente 182, 37007 Salamanca, Castilla y Le\u00f3n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8059-1805","authenticated-orcid":false,"given":"Jos\u00e9 Luis","family":"Gonz\u00e1lez-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care, Salamanca University Hospital, Gerencia Regional de Salud de Castilla y Le\u00f3n (SACYL), Paseo de la Transici\u00f3n Espa\u00f1ola, 37007 Salamanca, Castilla y Le\u00f3n, Spain"},{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca de la FIESCYL (IBSAL-FIESCYL), Paseo de San Vicente 182, 37007 Salamanca, Castilla y Le\u00f3n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Roc\u00edo","family":"L\u00f3pez-Iglesias","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care, Salamanca University Hospital, Gerencia Regional de Salud de Castilla y Le\u00f3n (SACYL), Paseo de la Transici\u00f3n Espa\u00f1ola, 37007 Salamanca, Castilla y Le\u00f3n, Spain"},{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca de la FIESCYL (IBSAL-FIESCYL), Paseo de San Vicente 182, 37007 Salamanca, Castilla y Le\u00f3n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"S\u00e1nchez-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care, Salamanca University Hospital, Gerencia Regional de Salud de Castilla y Le\u00f3n (SACYL), Paseo de la Transici\u00f3n Espa\u00f1ola, 37007 Salamanca, Castilla y Le\u00f3n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4727-2404","authenticated-orcid":false,"given":"Manuel Jes\u00fas","family":"S\u00e1nchez-Ledesma","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care, Salamanca University Hospital, Gerencia Regional de Salud de Castilla y Le\u00f3n (SACYL), Paseo de la Transici\u00f3n Espa\u00f1ola, 37007 Salamanca, Castilla y Le\u00f3n, Spain"},{"name":"Department of Surgery, Faculty of Medicine, Salamanca University, Calle Alfonso X el Sabio, 37007 Salamanca, Castilla y Le\u00f3n, Spain"},{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de Salamanca de la FIESCYL (IBSAL-FIESCYL), Paseo de San Vicente 182, 37007 Salamanca, Castilla y Le\u00f3n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Isabel","family":"Mart\u00ednez-Trufero","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care, Salamanca University Hospital, Gerencia Regional de Salud de Castilla y Le\u00f3n (SACYL), Paseo de la Transici\u00f3n Espa\u00f1ola, 37007 Salamanca, Castilla y Le\u00f3n, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1007\/s00198-019-04939-2","article-title":"Spanish National Hip Fracture Registry (RNFC): Analysis of its first annual report and international comparison with other established registries","volume":"30","author":"Currie","year":"2019","journal-title":"Osteoporos. 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