{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T17:42:04Z","timestamp":1787679724868,"version":"build-2784847793"},"reference-count":32,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T00:00:00Z","timestamp":1707091200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100016224","name":"University Medical Centre Maribor","doi-asserted-by":"publisher","award":["IRP-2018\/01-16"],"award-info":[{"award-number":["IRP-2018\/01-16"]}],"id":[{"id":"10.13039\/501100016224","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>(1) Background: The purpose of our prospective, single-blinded, randomized, sham-controlled study was to investigate the effect of the additional extracorporeal magnetic stimulation (ExMI) to pharmacological treatment in overactive bladder syndrome (OAB) in women. (2) Methods: We recruited 56 women with OAB, who were allocated into two study groups: the active group received mirabegron 50 mg daily and a total of 16 sessions of ExMI in 8 weeks, whereas the sham group received mirabegron 50 mg daily and sham stimulation following the same treatment protocol. Treatment success was evaluated after 4 and 8 weeks. (3) Results: Both groups experienced significant reduction in daytime urinary frequency, nocturia, and number of weekly incontinence episodes after 8 weeks. There were no statistically significant differences in end-point daytime urinary frequency and nocturia between groups. However, the overall average reduction rate in weekly number of incontinence episodes was 43.7% in treatment group and 24.2% in the control group. The number of urinary incontinence episodes in the treatment and control group was reduced for 3.8 \u00b1 11.8 vs. 2.5 \u00b1 4.3 episodes at week 4 and additional 3.3 \u00b1 6 vs. 0.4 \u00b1 3.2 episodes at week 8, respectively (p = 0.013). Moreover, IIQ-7 score showed a significantly greater score reduction and patients\u2019 evaluated improvement of symptoms was higher in the active group. (4) Conclusions: The addition of ExMI to mirabegron in OAB treatment further improves the weekly incontinence episode reduction rate and also leads to grater improvement in symptoms.<\/jats:p>","DOI":"10.3390\/jcm13030916","type":"journal-article","created":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T12:38:24Z","timestamp":1707223104000},"page":"916","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Impact of Extracorporeal Magnetic Stimulation as Addition to Mirabegron in Overactive Bladder Treatment in Women: A Single-Centre Randomized Sham-Controlled Study"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8029-1586","authenticated-orcid":false,"given":"Uros","family":"Bele","sequence":"first","affiliation":[{"name":"Medical Faculty, University of Maribor, 2000 Maribor, Slovenia"},{"name":"Department of Urology, Medical University of Graz, 8036 Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Serdin\u0161ek","sequence":"additional","affiliation":[{"name":"Medical Faculty, University of Maribor, 2000 Maribor, Slovenia"},{"name":"Department of General Gynaecology and Gynaecologic Urology, Clinic for Gynecology and Perinatology, University Medical Centre Maribor, 2000 Maribor, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evgenija","family":"Hom\u0161ak","sequence":"additional","affiliation":[{"name":"Medical Faculty, University of Maribor, 2000 Maribor, Slovenia"},{"name":"Department of Laboratory Diagnostics, University Medical Centre Maribor, 2000 Maribor, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"But","sequence":"additional","affiliation":[{"name":"Medical Faculty, University of Maribor, 2000 Maribor, Slovenia"},{"name":"Department of General Gynaecology and Gynaecologic Urology, Clinic for Gynecology and Perinatology, University Medical Centre Maribor, 2000 Maribor, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s00192-015-2932-1","article-title":"An International Urogynecological Association (IUGA)\/International Continence Society (ICS) Joint Report on the Terminology for Female Pelvic Organ Prolapse (POP)","volume":"27","author":"Haylen","year":"2016","journal-title":"Int. Urogynecol. J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1016\/j.eururo.2006.09.019","article-title":"Population-Based Survey of Urinary Incontinence, Overactive Bladder, and Other Lower Urinary Tract Symptoms in Five Countries: Results of the EPIC Study","volume":"50","author":"Irwin","year":"2006","journal-title":"Eur. Urol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/j.1464-410X.2009.08371.x","article-title":"The Burden of Lower Urinary Tract Symptoms: Evaluating the Effect of LUTS on Health-Related Quality of Life, Anxiety and Depression: EpiLUTS","volume":"103","author":"Coyne","year":"2009","journal-title":"BJU Int."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.urology.2009.06.096","article-title":"Economic Costs of Overactive Bladder in the United States","volume":"75","author":"Ganz","year":"2010","journal-title":"Urology"},{"key":"ref_5","first-page":"130","article-title":"Economic Burden of Urgency Urinary Incontinence in the United States: A Systematic Review","volume":"20","author":"Coyne","year":"2014","journal-title":"J. Manag. Care Pharm."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1002\/nau.23477","article-title":"The Economic Burden of Overactive Bladder in the United States: A Systematic Literature Review","volume":"37","author":"Powell","year":"2018","journal-title":"Neurourol. Urodyn."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1002\/nau.23513","article-title":"The Economic Burden of Overactive Bladder (OAB) and Its Effects on the Costs Associated with Other Chronic, Age-Related Comorbidities in the United States","volume":"37","author":"Durden","year":"2018","journal-title":"Neurourol. Urodyn."},{"key":"ref_8","unstructured":"Shamliyan, T., Wyman, J., and Kane, R.L. (2012). Nonsurgical Treatments for Urinary Incontinence in Adult Women: Diagnosis and Comparative Effectiveness."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.juro.2013.10.046","article-title":"Long-Term Adherence to Antimuscarinic Therapy in Everyday Practice: A Systematic Review","volume":"191","author":"Veenboer","year":"2014","journal-title":"J. Urol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/j.juro.2009.11.026","article-title":"Overactive Bladder Medication Adherence When Medication Is Free to Patients","volume":"183","author":"Sears","year":"2010","journal-title":"J. Urol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1177\/2042098616659412","article-title":"Mirabegron in Overactive Bladder Patients: Efficacy Review and Update on Drug Safety","volume":"7","author":"Warren","year":"2016","journal-title":"Ther. Adv. Drug Saf."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.eururo.2012.10.048","article-title":"Randomized Double-Blind, Active-Controlled Phase 3 Study to Assess 12-Month Safety and Efficacy of Mirabegron, a \u03b2(3)-Adrenoceptor Agonist, in Overactive Bladder","volume":"63","author":"Chapple","year":"2013","journal-title":"Eur. Urol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.eururo.2022.01.045","article-title":"European Association of Urology Guidelines on the Diagnosis and Management of Female Non-Neurogenic Lower Urinary Tract Symptoms. Part 1: Diagnostics, Overactive Bladder, Stress Urinary Incontinence, and Mixed Urinary Incontinence","volume":"82","author":"Nambiar","year":"2022","journal-title":"Eur. Urol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s00404-009-1243-5","article-title":"Long-Term Effects of Extracorporeal Magnetic Innervations in the Treatment of Women with Urinary Incontinence: Results of 3-Year Follow-Up","volume":"282","author":"Kilic","year":"2010","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1016\/S0090-4295(99)00037-0","article-title":"Extracorporeal Magnetic Innervation Therapy for Stress Urinary Incontinence","volume":"53","author":"Galloway","year":"1999","journal-title":"Urology"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Strojek, K., Str\u0105czy\u0144ska, A., Radzimi\u0144ska, A., and Weber-Rajek, M. (2023). The Effects of Extracorporeal Magnetic Innervation in the Treatment of Women with Urinary Incontinence: A Systematic Review. J. Clin. Med., 12.","DOI":"10.3390\/jcm12175455"},{"key":"ref_17","first-page":"395","article-title":"SMN-X Study Group Multicenter, Randomized, Sham-Controlled Study on the Efficacy of Magnetic Stimulation for Women with Urgency Urinary Incontinence","volume":"21","author":"Yamanishi","year":"2014","journal-title":"Int. J. Urol. Off. J. Jpn. Urol. Assoc."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/S0022-5347(05)64569-7","article-title":"Magnetic Stimulation of the Sacral Roots for the Treatment of Urinary Frequency and Urge Incontinence: An Investigational Study and Placebo Controlled Trial","volume":"168","author":"Fujishiro","year":"2002","journal-title":"J. Urol."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Schulz, K.F., Altman, D.G., and Moher, D. (2010). The CONSORT Group CONSORT 2010 Statement: Updated Guidelines for Reporting Parallel Group Randomised Trials. BMC Med., 8.","DOI":"10.1186\/1741-7015-8-18"},{"key":"ref_20","unstructured":"Oh-Oka, H. (2024, January 04). Neuromodulation in Management of Overactive Bladder. V: Carrillo-Ruiz JD (Ur.). Topics in Neuromodulation Treatment. Available online: https:\/\/www.intechopen.com\/chapters\/33468."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"3491","DOI":"10.1016\/j.jmmm.2012.02.073","article-title":"Effect of Pulse Magnetic Field Stimulation on Calcium Channel Current","volume":"324","author":"Fan","year":"2012","journal-title":"J. Magn. Magn. Mater."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1097\/01.ju.0000157336.87781.32","article-title":"Functional Magnetic Stimulation for Mixed Urinary Incontinence","volume":"173","author":"But","year":"2005","journal-title":"J. Urol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1002\/nau.22672","article-title":"Efficacy of Electromagnetic Therapy for Urinary Incontinence: A Systematic Review","volume":"34","author":"Lim","year":"2015","journal-title":"Neurourol. Urodyn."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/S0090-4295(02)02249-5","article-title":"Conservative Treatment of Female Urinary Incontinence with Functional Magnetic Stimulation","volume":"61","author":"But","year":"2003","journal-title":"Urology"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/j.eururo.2007.02.026","article-title":"Extracorporeal Magnetic Stimulation Is of Limited Clinical Benefit to Women with Idiopathic Detrusor Overactivity: A Randomized Sham Controlled Trial","volume":"52","author":"Morris","year":"2007","journal-title":"Eur. Urol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1046\/j.1464-410X.2003.04235.x","article-title":"The Acute Effect of Magnetic Stimulation of the Pelvic Floor on Involuntary Detrusor Activity during Natural Filling and Overactive Bladder Symptoms","volume":"91","author":"Bradshaw","year":"2003","journal-title":"BJU Int."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1007\/s00192-006-0261-0","article-title":"Symptom Change in Women with Overactive Bladder after Extracorporeal Magnetic Stimulation: A Prospective Trial","volume":"18","author":"Choe","year":"2007","journal-title":"Int. Urogynecol. J."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1111\/jog.12090","article-title":"Effect of Extracorporeal Magnetic Energy Stimulation on Bothersome Lower Urinary Tract Symptoms and Quality of Life in Female Patients with Stress Urinary Incontinence and Overactive Bladder","volume":"39","author":"Lo","year":"2013","journal-title":"J. Obstet. Gynaecol. Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1007\/s00192-023-05492-7","article-title":"Magnetic Stimulation in the Treatment of Female Urgency Urinary Incontinence: A Systematic Review","volume":"34","year":"2023","journal-title":"Int. Urogynecol. J."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"9077","DOI":"10.1038\/s41598-019-45330-9","article-title":"An Effective Meta-Analysis of Magnetic Stimulation Therapy for Urinary Incontinence","volume":"9","author":"He","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/j.eururo.2014.01.019","article-title":"What Is the Most Bothersome Lower Urinary Tract Symptom? Individual- and Population-Level Perspectives for Both Men and Women","volume":"65","author":"Agarwal","year":"2014","journal-title":"Eur. Urol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.bpobgyn.2006.12.002","article-title":"Psychological Morbidity and Female Urinary Incontinence","volume":"21","author":"Yip","year":"2007","journal-title":"Best Pract. Res. Clin. Obstet. Gynaecol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/3\/916\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T13:55:21Z","timestamp":1760104521000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/13\/3\/916"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,5]]},"references-count":32,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,2]]}},"alternative-id":["jcm13030916"],"URL":"https:\/\/doi.org\/10.3390\/jcm13030916","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,5]]}}}