{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T09:50:26Z","timestamp":1770976226885,"version":"3.50.1"},"reference-count":33,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T00:00:00Z","timestamp":1707091200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>This study explored short- and mid-term functional outcomes in patients undergoing decompressive hemicraniectomy (DHC) due to space-occupying cerebral infarction and asked whether there is a potentially harmful effect of a priorly performed endovascular treatment (EVT). Medical records were screened for patients requiring DHC due to space-occupying cerebral infarction between January 2016 and July 2021. Functional outcomes at hospital discharge and at 3 months were assessed by the modified Rankin Scale (mRS). Out of 65 patients with DHC, 39 underwent EVT before DHC. Both groups, i.e., EVT + DHC and DHC alone, had similar volumes (280 \u00b1 90 mL vs. 269 \u00b1 73 mL, t-test, p = 0.633) and proportions of edema and infarction (22.1 \u00b1 6.5% vs. 22.1 \u00b1 6.1%, t-test, p = 0.989) before the surgical intervention. Patients undergoing EVT + DHC tended to have a better functional outcome at hospital discharge compared to DHC alone (mRS 4.8 \u00b1 0.8 vs. 5.2 \u00b1 0.7, Mann\u2013Whitney-U, p = 0.061), while the functional outcome after 3 months was similar (mRS 4.6 \u00b1 1.1 vs. 4.8 \u00b1 0.9, Mann\u2013Whitney-U, p = 0.352). In patients initially presenting with a relevant infarct demarcation (Alberta Stroke Program Early CT Score \u2264 5), the outcome was similar at hospital discharge and after 3 months between patients with EVT + DHC and DHC alone. This study provided no evidence for a harmful effect of EVT before DHC in patients with space-occupying brain infarction.<\/jats:p>","DOI":"10.3390\/jcm13030918","type":"journal-article","created":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T12:38:24Z","timestamp":1707223104000},"page":"918","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["No Harmful Effect of Endovascular Treatment before Decompressive Surgery\u2014Implications for Handling Patients with Space-Occupying Brain Infarction"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4391-2280","authenticated-orcid":false,"given":"Johann Otto","family":"Pelz","sequence":"first","affiliation":[{"name":"Department of Neurology, University Hospital Leipzig, 04103 Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone","family":"Engelmann","sequence":"additional","affiliation":[{"name":"Institute of Neuroradiology, University Hospital Leipzig, 04103 Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cordula","family":"Scherlach","sequence":"additional","affiliation":[{"name":"Institute of Neuroradiology, University Hospital Leipzig, 04103 Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peggy","family":"Bungert-Kahl","sequence":"additional","affiliation":[{"name":"Neurological Rehabilitation Center Leipzig, 04828 Bennewitz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alhuda","family":"Dabbagh","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital Leipzig, 04103 Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk","family":"Lindner","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University Hospital Leipzig, 04103 Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominik","family":"Michalski","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital Leipzig, 04103 Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1001\/archneur.1996.00550040037012","article-title":"\u2018Malignant\u2019 middle cerebral artery territory infarction: Clinical course and prognostic signs","volume":"53","author":"Hacke","year":"1996","journal-title":"Arch. 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