{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T02:24:59Z","timestamp":1790735099547,"version":"4.1.0"},"reference-count":78,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T00:00:00Z","timestamp":1707177600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Left atrial appendage occlusion (LAAO) is an increasingly used alternative to oral anticoagulation in patients with atrial fibrillation, especially in patients with absolute\/relative contraindications to these therapies. This review will cover three main aspects of the procedure. In the fist part of the manuscript, we focus on patient selection. We describe three main categories of patients with primary indication to LAAO, namely patients with previous or at a high risk of intracerebral bleeding, patients with a history of major gastrointestinal bleeding and patients with end-stage renal disease and absolute contraindication to novel oral anticoagulants. Some other potential indications are also described. In the second part of the manuscript, we review available devices, trying to highlight different aspects and potential specific advantages. The last section overviews different ways for pre-, intra- and postprocedural imaging, in order to improve procedural safety and efficacy and ameliorate patient outcome. The characteristics of available contemporary devices and the role of imaging in procedural planning, intraprocedural guidance and follow-up are described.<\/jats:p>","DOI":"10.3390\/jcm13040939","type":"journal-article","created":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T12:38:24Z","timestamp":1707223104000},"page":"939","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["State-of-the-Art of Transcatheter Left Atrial Appendage Occlusion"],"prefix":"10.3390","volume":"13","author":[{"given":"Luigi Emilio","family":"Pastormerlo","sequence":"first","affiliation":[{"name":"UOC Diagnostica Interventistica Fondazione Toscana Gabriele Monasterio Massa, 54100 Massa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto Ranieri","family":"De Caterina","sequence":"additional","affiliation":[{"name":"UOC Diagnostica Interventistica Fondazione Toscana Gabriele Monasterio Massa, 54100 Massa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augusto","family":"Esposito","sequence":"additional","affiliation":[{"name":"UOC Diagnostica Interventistica Fondazione Toscana Gabriele Monasterio Massa, 54100 Massa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasper","family":"Korsholm","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Aarhus University Hospital, C319, 8200 Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5244-0556","authenticated-orcid":false,"given":"Sergio","family":"Berti","sequence":"additional","affiliation":[{"name":"UOC Diagnostica Interventistica Fondazione Toscana Gabriele Monasterio Massa, 54100 Massa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.1001\/jama.285.18.2370","article-title":"Prevalence of diagnosed atrial fibrillation in adults: National implications for rhythm management and stroke prevention: The anticoagulation and risk factors in atrial fibrillation (ATRIA) Study","volume":"285","author":"Go","year":"2001","journal-title":"JAMA"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/S0140-6736(87)90174-7","article-title":"Risk of stroke in non-rheumatic atrial fibrillation","volume":"1","author":"Flegel","year":"1987","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"857","DOI":"10.7326\/0003-4819-146-12-200706190-00007","article-title":"Meta-analysis: Antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation","volume":"146","author":"Hart","year":"2007","journal-title":"Ann. Intern. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.ahj.2013.12.014","article-title":"Physician practices regarding contraindications to oral anticoagulation in atrial fibrillation: Findings from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) registry","volume":"167","author":"Holmes","year":"2014","journal-title":"Am. Heart J."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/1755-5922.12129","article-title":"Contraindications to anticoagulation therapy and eligibility for novel anticoagulants in older patients with atrial fibrillation","volume":"33","author":"Steinberg","year":"2015","journal-title":"Cardiovasc. Ther."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1056\/NEJMoa0905561","article-title":"Dabigatran versus warfarin in patients with atrial fibrillation","volume":"361","author":"Connolly","year":"2009","journal-title":"NEJM"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1056\/NEJMoa1009638","article-title":"Rivaroxaban versus warfarin in nonvalvular atrial fibrillation","volume":"365","author":"Patel","year":"2011","journal-title":"NEJM"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1056\/NEJMoa1107039","article-title":"Apixaban versus warfarin in patients with atrial fibrillation","volume":"365","author":"Granger","year":"2011","journal-title":"NEJM"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"20193","DOI":"10.1056\/NEJMoa1310907","article-title":"Edoxaban versus warfarin in patients with atrial fibrillation","volume":"369","author":"Giugliano","year":"2013","journal-title":"NEJM"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/S0140-6736(13)62343-0","article-title":"Comparison of the efficacy and safety of new oral anticoagulants with warfarin in patients with atrial fibrillation: A meta-analysis of randomised trials","volume":"383","author":"Ruff","year":"2014","journal-title":"Lancet"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Kakkar, A.K., Mueller, I., Bassand, J.P., Fitzmaurice, D.A., Goldhaber, S.Z., Goto, S., Haas, S., Hacke, W., Lip, G.Y., and Mantovani, L.G. (2013). Risk profiles and antithrombotic treatment of patients newly diagnosed with atrial fibrillation at risk of stroke: Perspectives from the international, observational, prospective GARFIELD registry. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0063479"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/S0140-6736(09)61343-X","article-title":"PROTECT AF Investigators. Percutaneous closure of the left atrial appendage versus warfarin therapy for prevention of stroke in patients with atrial fibrillation: A randomised non-inferiority trial","volume":"374","author":"Holmes","year":"2009","journal-title":"Lancet"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jacc.2014.04.029","article-title":"Prospective randomized evaluation of the Watchman Left Atrial Appendage Closure device in patients with atrial fibrillation versus long-term warfarin therapy: The PREVAIL trial","volume":"64","author":"Holmes","year":"2014","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_14","first-page":"e199","article-title":"2014 AHA\/ACC\/HRS guideline for the management of patients with atrial fibrillation: A report of the American College of Cardiology\/American Heart Association Task Force on practice guidelines and the Heart Rhythm Society","volume":"130","author":"January","year":"2014","journal-title":"Circulation"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1093\/eurheartj\/ehw210","article-title":"2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS","volume":"37","author":"Kirchhof","year":"2016","journal-title":"Eur. Heart J."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1161\/CIR.0000000000001193","article-title":"2023 ACC\/AHA\/ACCP\/HRS Guideline for the Diagnosis and Management of Atrial Fibrillation: A Report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"149","author":"Joglar","year":"2024","journal-title":"Circulation"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"3122","DOI":"10.1016\/j.jacc.2020.04.067","article-title":"Left Atrial Appendage Closure Versus Direct Oral Anticoagulants in High-Risk Patients With Atrial Fibrillation","volume":"75","author":"Osmancik","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e006841","DOI":"10.1161\/CIRCEP.118.006841","article-title":"Evaluating real-world clinical outcomes in atrial fibrillation patients receiving the WATCHMAN left atrial appendage closure technology","volume":"12","author":"Boersma","year":"2019","journal-title":"Circ. Arrhythm. Electrophysiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.4244\/EIJY15M01_06","article-title":"Left atrial appendage occlusion for stroke prevention in atrial fibrillation: Multicentre experience with the AMPLATZER cardiac plug","volume":"11","author":"Tzikas","year":"2016","journal-title":"EuroIntervention"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.ijcard.2022.06.065","article-title":"Clinical outcomes of left atrial appendage occlusion versus direct oral anticoagulation in patients with atrial fibrillation and prior ischemic stroke: A propensity-score matched study","volume":"363","author":"Korsholm","year":"2022","journal-title":"Int. J. Cardiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jcin.2020.09.051","article-title":"Clinical Outcomes Associated With Left AtrialAppendageOcclusion Versus Direct OralAnticoagulation in AtrialFibrillation","volume":"14","author":"Korsholm","year":"2021","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.jcin.2022.02.009","article-title":"Clinical Outcomesat 1 Year Following Transcatheter Left AtrialAppendageOcclusion in the United States","volume":"15","author":"Price","year":"2022","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1016\/j.jcin.2022.02.029","article-title":"Patient-Level Analysis of Watchman Left AtrialAppendageOcclusion in Practice Versus Clinical Trials","volume":"15","author":"Friedman","year":"2022","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"3782","DOI":"10.1093\/eurheartj\/ehz155","article-title":"Oralanticoagulationamongatrialfibrillationpatients with anaemia: An observationalcohort study","volume":"40","author":"Bonde","year":"2019","journal-title":"Eur. Heart J."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"i3189","DOI":"10.1136\/bmj.i3189","article-title":"Comparative effectiveness and safety of non-vitamin K antagonistoralanticoagulants and warfarin in patients with atrial fibrillation: Propensity weighted nationwide cohort study","volume":"353","author":"Larsen","year":"2016","journal-title":"BMJ"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1002\/pds.5317","article-title":"Major bleeding in users of direct oral anticoagulants in atrial fibrillation: A pooled analysis of results from multiple population-based cohort studies","volume":"30","author":"Souverein","year":"2021","journal-title":"Pharmacoepidemiol. Drug Saf."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.amjcard.2022.02.036","article-title":"Comparison of the Safety of Left Atrial Appendage Occlusion in Patients Aged <75 Versus Those Aged \u226575 Years (from a Nationwide Cohort Sample)","volume":"172","author":"Shatla","year":"2022","journal-title":"Am. J. Cardiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"371","DOI":"10.4244\/EIJ-D-17-00201","article-title":"Left atrial appendage occlusion versus standard medical care in patients with atrial fibrillation and intracerebral haemorrhage: A propensity score-matched follow-up study","volume":"13","author":"Johnsen","year":"2017","journal-title":"EuroIntervention"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s12975-020-00838-5","article-title":"Left Atrial Appendage Closure for Patients with Cerebral Amyloid Angiopathy and Atrial Fibrillation: The LAA-CAA Cohort","volume":"12","author":"Schrag","year":"2021","journal-title":"Transl. Stroke Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1111\/j.1750-3639.2002.tb00449.x","article-title":"Sporadic and familial cerebral amyloid angiopathies","volume":"12","author":"Revesz","year":"2002","journal-title":"Brain Pathol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1055\/a-1496-8969","article-title":"Diagnosis and management of acute lowergastrointestinalbleeding: European Society of GastrointestinalEndoscopy (ESGE) Guideline","volume":"53","author":"Triantafyllou","year":"2021","journal-title":"Endoscopy"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.amjcard.2017.04.046","article-title":"Left atrial appendage occlusion in patients with atrial fibrillation and previous major gastrointestinal gleeding (from the Amplatzer Cardiac Plug Multicenter Registry)","volume":"120","author":"Lempereur","year":"2017","journal-title":"Am. J. Cardiol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1681\/ASN.2019060579","article-title":"Multicenter Randomized Controlled Trial of Vitamin K Antagonist Replacement by Rivaroxaban with or without Vitamin K2 in Hemodialysis Patients with Atrial Fibrillation: The Valkyrie Study","volume":"31","author":"Pyfferoen","year":"2020","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1161\/CIRCULATIONAHA.121.054990","article-title":"Apixaban for Patients With Atrial Fibrillation on Hemodialysis: A Multicenter Randomized Controlled Trial","volume":"146","author":"Pokorney","year":"2022","journal-title":"Circulation"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1161\/CIRCULATIONAHA.122.062779","article-title":"A Randomized Controlled Trial Comparing Apixaban With the Vitamin K Antagonist Phenprocoumon in Patients on Chronic Hemodialysis: The AXADIA-AFNET 8 Study","volume":"147","author":"Reinecke","year":"2023","journal-title":"Circulation"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1093\/eurheartj\/ehaa612","article-title":"2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS): The Task Force for the diagnosis and management of atrial fibrillation of the European Society of Cardiology (ESC) Developed with the special contribution of the European Heart Rhythm Association (EHRA) of the ESC","volume":"42","author":"Hindricks","year":"2021","journal-title":"Eur. Heart J."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Luani, B., Genz, C., Herold, J., Mitrasch, A., Mitusch, J., Wiemer, M., Schmei\u00dfer, A., Braun-Dullaeus, R.C., and Rauwolf, T. (2019). Cerebrovascular events, bleeding complications and device related thrombi in atrial fibrillation patients with chronic kidney disease and left atrial appendage closure with the WATCHMAN\u2122 device. BMC Cardiovasc. Disord., 19.","DOI":"10.1186\/s12872-019-1097-0"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s10840-021-01090-z","article-title":"Left atrialappendageocclusion in haemophilia patients with atrial fibrillation","volume":"64","author":"Kramer","year":"2022","journal-title":"J. Interv. Card. Electrophysiol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1002\/ana.25700","article-title":"RAF, RAF-DOAC, CROMIS-2, SAMURAI, NOACISP, Erlangen, and Verona registrycollaborators. Ischemic Stroke despiteOralAnticoagulant Therapy in Patients with AtrialFibrillation","volume":"87","author":"Seiffge","year":"2020","journal-title":"Ann. Neurol."},{"key":"ref_40","first-page":"212","article-title":"Left Atrial Appendage Occlusion as Adjunctive Therapy to Anticoagulation for Stroke Recurrence","volume":"31","author":"Freixa","year":"2019","journal-title":"J. Invasive Cardiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.4244\/EIJY19M08_01","article-title":"EHRA\/EAPCI expert consensus statement on catheter-based left atrial appendage occlusion\u2014An update","volume":"15","author":"Glikson","year":"2020","journal-title":"EuroIntervention"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.1016\/j.jacc.2017.03.540","article-title":"Influence of direct oral anticoagulants on rates of oral anticoagulation for atrial fibrillation","volume":"69","author":"Marzec","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1016\/j.hrthm.2017.05.038","article-title":"Efficacy and safety of left atrial appendage closure with WATCHMAN in patients with or without contraindication to oral anticoagulation: 1-Year follow-up outcome data of the EWOLUTION trial","volume":"14","author":"Boersma","year":"2017","journal-title":"Heart Rhythm"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1001\/jama.2014.15192","article-title":"Percutaneous left atrial appendage closure vs warfarin for atrial fibrillation: A randomized clinical trial","volume":"312","author":"Reddy","year":"2014","journal-title":"JAMA"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1016\/j.jcin.2022.09.002","article-title":"Comparative Safety of Transcatheter LAAO With the First-Generation Watchman and Next-Generation Watchman FLX Devices","volume":"15","author":"Price","year":"2022","journal-title":"J. Am. Coll. Cardiovasc. Interv."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1161\/CIRCULATIONAHA.120.050117","article-title":"PrimaryOutcome Evaluation of a Next-Generation Left AtrialAppendageClosure Device: Results From the PINNACLE FLX Trial","volume":"143","author":"Kar","year":"2021","journal-title":"Circulation"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1016\/j.jacep.2023.04.013","article-title":"Enhanced Thromboresistance and Endothelialization of a Novel Fluoropolymer-Coated Left Atrial Appendage Closure Device","volume":"9","author":"Saliba","year":"2023","journal-title":"JACC Clin. Electrophysiol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1016\/j.jacc.2019.12.040","article-title":"The NCDR Left AtrialAppendageOcclusionRegistry","volume":"75","author":"Freeman","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"e005359","DOI":"10.1161\/CIRCINTERVENTIONS.117.005359","article-title":"Percutaneous left atrial appendage closure: Current devices and clinical outcomes","volume":"10","author":"Asmarats","year":"2017","journal-title":"Circ. Cardiovasc. Interv."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1161\/CIRCULATIONAHA.121.057063","article-title":"Amplatzer amulet left atrial appendage occluder versus Watchman device for stroke prophylaxis (Amulet IDE): A randomized, controlled trial","volume":"144","author":"Lakkireddy","year":"2021","journal-title":"Circulation"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1161\/CIRCULATIONAHA.121.057859","article-title":"Amulet or Watchman device for percutaneous left atrial appendage closure: Primary results of the SWISS-APERO randomized clinical trial","volume":"145","author":"Galea","year":"2022","journal-title":"Circulation"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1002\/ccd.30336","article-title":"Left atrial appendage closure with the II generation Ultraseal device: An international registry. The LIGATE study","volume":"100","author":"Pivato","year":"2022","journal-title":"Catheter. Cardiovasc. Interv."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"e376","DOI":"10.4244\/EIJ-D-20-00552","article-title":"First-in-human results of the Omega leftatrialappendage occluder for patients with non-valvularatrialfibrillation","volume":"17","author":"Wilkins","year":"2021","journal-title":"EuroIntervention"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.tcm.2018.08.008","article-title":"An overview of current and emerging devices for percutaneous left atrial appendage closure","volume":"29","author":"Chow","year":"2019","journal-title":"Trends Cardiovasc. Med."},{"key":"ref_55","first-page":"E1011","article-title":"State-of-the-art preclinical testing of the OMEGATM leftatrialappendage occluder","volume":"97","author":"Hafiz","year":"2021","journal-title":"Catheter. Cardiovasc. Interv."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.1016\/j.jcin.2017.06.072","article-title":"Percutaneous left atrial appendage closure with the LAmbre device for stroke prevention in atrial fibrillation: A prospective, multicenter clinical study","volume":"10","author":"Huang","year":"2017","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Sommer, R.J., Lamport, R., Melanson, D., Devellian, C., Levine, A., Cain, C.M., Kaplan, A.V., and Gray, W.A. (2021). Preclinical assessment of a novel conformable foam-based left atrial appendage closure device. Biomed. Res. Int., 2021.","DOI":"10.1155\/2021\/4556400"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"2368","DOI":"10.1016\/j.jcin.2021.08.060","article-title":"Conformal Left Atrial Appendage Seal Device for Left Atrial Appendage Closure","volume":"14","author":"Sommer","year":"2021","journal-title":"J. Am. Coll. CardiolIntv."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/j.jcin.2023.04.028","article-title":"Transcatheter Left Atrial Appendage Exclusion: Preclinical and Early Clinical Results With the Laminar Device","volume":"16","author":"Wong","year":"2023","journal-title":"J. Am. Coll. Cardiol. Interv."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"e05","DOI":"10.15420\/usc.2022.37","article-title":"Transcatheter Left Atrial Appendage Closure: Devices Available, Pitfalls, Advantages, and Future Directions","volume":"17","author":"Bavishi","year":"2023","journal-title":"US Cardiol. Rev."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"e1435","DOI":"10.4244\/EIJ-D-21-00555","article-title":"Computed tomography-based selection of transseptal puncture site for percutaneous left atrial appendage closure","volume":"17","author":"Fukutomi","year":"2022","journal-title":"EuroIntervention"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1016\/j.jcin.2016.07.038","article-title":"Application of 3-Dimensional Computed Tomographic Image Guidance to WATCHMAN Implantation and Impact on Early Operator Learning Curve: Single-Center Experience","volume":"9","author":"Wang","year":"2016","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1016\/j.jcin.2021.05.042","article-title":"Impact of Echocardiographic Guidance on Safety and Efficacy of Left Atrial Appendage Closure: An Observational Study","volume":"14","author":"Galea","year":"2021","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1053\/j.jvca.2005.01.020","article-title":"Transesophageal echocardiographyrelated gastrointestinal complications in cardiac surgical patients","volume":"19","author":"Lennon","year":"2005","journal-title":"J. Cardiothorac. Vasc. Anesth."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/j.jcin.2018.05.008","article-title":"Intracardiac Versus Transesophageal Echocardiographic Guidance for Left Atrial Appendage Occlusion: The LAAO Italian Multicenter Registry","volume":"11","author":"Berti","year":"2018","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/j.jcin.2019.04.035","article-title":"Use of Intracardiac Compared With Transesophageal Echocardiography for Left Atrial Appendage Occlusion in the Amulet Observational Study","volume":"12","author":"Berti","year":"2019","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.jacep.2019.11.014","article-title":"Outcomes of Routine Intracardiac Echocardiography to Guide Left Atrial Appendage Occlusion","volume":"6","author":"Alkhouli","year":"2020","journal-title":"JACC Clin. Electrophysiol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1111\/echo.14415","article-title":"Comparison of intracardiac and transoesophageal echocardiography for guidance of percutaneous left atrial appendage occlusion: A meta-analysis","volume":"36","author":"Ribeiro","year":"2019","journal-title":"Echocardiography"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.jcin.2022.10.024","article-title":"Intracardiac Echocardiography to Guide Watchman FLX Implantation: The ICE LAA Study","volume":"16","author":"Berti","year":"2023","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1016\/j.jcmg.2021.09.015","article-title":"First Experience With a Novel Live 3D ICE Catheter to Guide Transcatheter Structural Heart Interventions","volume":"15","author":"Alkhouli","year":"2022","journal-title":"JACC Cardiovasc. Imaging."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1161\/CIRCULATIONAHA.118.035090","article-title":"Device-related thrombus after left atrial appendage closure","volume":"138","author":"Dukkipati","year":"2018","journal-title":"Circulation"},{"key":"ref_72","first-page":"1629","article-title":"Incidence and clinical impact of device-related thrombus following percutaneous left atrial appendage occlusion: A meta-analysis","volume":"4","author":"Alkhouli","year":"2018","journal-title":"J. Am. Coll. Cardiol. EP"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"e008112","DOI":"10.1161\/CIRCINTERVENTIONS.119.008112","article-title":"Detection of Device-Related Thrombosis Following Left Atrial Appendage Occlusion: A Comparison Between Cardiac Computed Tomography and Transesophageal Echocardiography","volume":"12","author":"Korsholm","year":"2019","journal-title":"Circ. Cardiovasc. Interv."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.jacc.2021.04.098","article-title":"Predictors of Device-Related Thrombus Following Percutaneous Left Atrial Appendage Occlusion","volume":"78","author":"Simard","year":"2021","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1093\/eurheartj\/ehad828","article-title":"Residual leaks following percutaneous left atrial appendage occlusion and outcomes: A meta-analysis","volume":"45","author":"Samaras","year":"2024","journal-title":"Eur. Heart J."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1093\/ehjci\/jev097","article-title":"Multimodality imaging in preoperative assessment of left atrial appendage transcatheter occlusion with the Amplatzer Cardiac Plug","volume":"16","author":"Clemente","year":"2015","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.jcin.2020.10.034","article-title":"Peridevice Leak Following Amplatzer Left Atrial Appendage Occlusion: Cardiac Computed Tomography Classification and Clinical Outcomes","volume":"14","author":"Korsholm","year":"2021","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.jacep.2022.03.001","article-title":"Clinical Impact of Residual Leaks Following Left Atrial Appendage Occlusion: Insights From the NCDR-LAAO Registry","volume":"8","author":"Alkhouli","year":"2022","journal-title":"JACC Clin. 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