{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:48:06Z","timestamp":1760143686502,"version":"build-2065373602"},"reference-count":63,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T00:00:00Z","timestamp":1707436800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Spanish Research Net REI-RICORS","award":["RD21\/0002\/0032"],"award-info":[{"award-number":["RD21\/0002\/0032"]}]},{"name":"Institute of Health Carlos III, Madrid, Spain","award":["RD21\/0002\/0032"],"award-info":[{"award-number":["RD21\/0002\/0032"]}]},{"name":"NextGenerationEU FIS\/FEDER","award":["RD21\/0002\/0032"],"award-info":[{"award-number":["RD21\/0002\/0032"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: The goal was to evaluate the diagnostic capability of different parameters obtained with the posterior pole (PP) software in Spectralis SD-OCT with the 8 \u00d7 8 grid tilted at 7\u00b0 and horizontalized in glaucomatous eyes. Methods: A total of 299 eyes were included, comprising 136 healthy eyes and 163 with primary open-angle glaucoma (POAG). The following segmentations were evaluated: complete retina, retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), GCL and inner plexiform layer (GCLIPL), ganglion cell complex (GCC), outer plexiform layer and outer nuclear layer (OPLONL), inner retinal layer (IRL), and outer retinal layer (ORL). Different patterns of macular damage were represented using heatmaps for each studied layer, where the areas under the curve (AUROC) values and a retinal thickness cutoff point were defined to discriminate POAG patients. Results: There was not any difference in the diagnostic capability for detecting glaucoma between the grid tilted at 7\u00b0 and horizontalized. The macular segmentations that offer the highest diagnostic ability in glaucoma discrimination were, in the following order, RNFL (AUROC = 0.796), GCC (AUROC = 0.785), GCL (AUROC = 0.784), GCLIPL (AUROC = 0.770), IRL (AUROC = 0.755), and the complete retina (AUROC = 0.752). In contrast, ORL and OPLONL do not appear to be helpful for discriminating POAG. Conclusions: Some results of PP software may be useful for discriminating POAG.<\/jats:p>","DOI":"10.3390\/jcm13041016","type":"journal-article","created":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T11:42:05Z","timestamp":1707478925000},"page":"1016","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of the Diagnostic Capability of Spectralis SD-OCT 8 \u00d7 8 Posterior Pole Software with the Grid Tilted at 7 Degrees and Horizontalized in Glaucoma"],"prefix":"10.3390","volume":"13","author":[{"given":"Aurora","family":"Alvarez-Sarrion","sequence":"first","affiliation":[{"name":"Department of Ophthalmology and Optometry, University of Murcia, 30120 Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6245-7271","authenticated-orcid":false,"given":"Jose Javier","family":"Garcia-Medina","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Optometry, University of Murcia, 30120 Murcia, Spain"},{"name":"Department of Ophthalmology, General University Hospital Morales Meseguer, 30008 Murcia, Spain"},{"name":"Ophthalmic Research Unit \u201cSantiago Grisolia\u201d, 28029 Valencia, Spain"},{"name":"Spanish Net of Inflammatory Diseases RICORS, Institute of Health Carlos III, 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Palazon-Cabanes","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hospital Virgen del Castillo, Yecla, 30510 Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0118-7837","authenticated-orcid":false,"given":"Maria Dolores","family":"Pinazo-Duran","sequence":"additional","affiliation":[{"name":"Ophthalmic Research Unit \u201cSantiago Grisolia\u201d, 28029 Valencia, Spain"},{"name":"Spanish Net of Inflammatory Diseases RICORS, Institute of Health Carlos III, 28029 Madrid, Spain"},{"name":"Cellular and Molecular Ophthalmo-Biology Group, Department of Surgery, University of Valencia, 46010 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Del-Rio-Vellosillo","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, General University Hospital Morales Meseguer, 30008 Murcia, Spain"},{"name":"Department of Surgery, Obstetrics and Gynecology and Pediatrics, University of Murcia, 30120 Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,9]]},"reference":[{"key":"ref_1","unstructured":"Pastor-Jimeno, J.C., and Maldonado-L\u00f3pez, M.J. 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