{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T01:31:57Z","timestamp":1777426317427,"version":"3.51.4"},"reference-count":18,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T00:00:00Z","timestamp":1707696000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005298","name":"Office of International Affairs and External Cooperation, University of Costa Rica","doi-asserted-by":"publisher","award":["OAICE-143-2020"],"award-info":[{"award-number":["OAICE-143-2020"]}],"id":[{"id":"10.13039\/501100005298","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fundaci\u00f3n para la Investigaci\u00f3n Biosantitaria de Andaluc\u00eda Oriental-Alejandro Otero","award":["OAICE-143-2020"],"award-info":[{"award-number":["OAICE-143-2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Negative outcomes associated with medications (NOM) and drug-related problems (DRP) significantly impact individuals with kidney replacement therapy (KRT) given the complexities of managing kidney disease and associated comorbidities. The present study aims to assess the frequency of NOMs\/DRPs among KRT patients and identify contributing factors. Methods: A cross-sectional study was conducted at Virgen de las Nieves University Hospital (Granada, Spain), involving 117 outpatient adults with KRT. Data were collected from February 2021 to July 2023 using electronic records, semi-structured interviews (D\u00e1der Method), and discussions with nephrology specialists. NOMs\/DRPs were identified following treatment guidelines. Binary logistic regression was used to determine associated factors (p-value &lt; 0.05). Results: Across 117 patients, 2436 NOMs and 3303 DRPs were identified, averaging 20.82 NOMs and 28.23 DRPs per patient. Prevalent NOMs included untreated conditions (58.95%), quantitative ineffectiveness (35.43%), and non-quantitative safety problems (5.13%). Dominant DRPs were undertreated conditions (37.63%), wrong dose\/posology\/length (33.00%), risk of adverse drug reactions (ADR) (16.14%), and non-adherence (6.87%). Patients with ADR, undertreated conditions, and anemia were associated with quantitative ineffectiveness. Risk of ADR and vitamin D deficiency\/insufficiency correlated with non-quantitative safety problems. Conclusions: KRT patients exhibited a substantial prevalence of NOMs\/DRPs. Further research is needed to deepen our understanding of these complexities for improved patient care.<\/jats:p>","DOI":"10.3390\/jcm13041048","type":"journal-article","created":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T04:47:45Z","timestamp":1707713265000},"page":"1048","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Factors Contributing to Negative Outcomes Associated with Medications and Drug-Related Problems in Kidney Replacement Therapy\u2014A Hospital-Based Prospective Observational Study"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1539-3305","authenticated-orcid":false,"given":"Alfonso","family":"Pereira-C\u00e9spedes","sequence":"first","affiliation":[{"name":"Pharmaceutical Care Research Group, Pharmacy Faculty, University of Granada, 18071 Granada, Spain"},{"name":"Pharmacy Department, Hospital Universitario Virgen de las Nieves, 18014 Granada, Spain"},{"name":"Centro Nacional de Informaci\u00f3n de Medicamentos, Instituto de Investigaciones Farmac\u00e9uticas, Pharmacy Faculty, University of Costa Rica, San Jos\u00e9 11501-2060, Costa Rica"},{"name":"Nephrology Department, Hospital Universitario Virgen de las Nieves, 18014 Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Jim\u00e9nez-Morales","sequence":"additional","affiliation":[{"name":"Pharmaceutical Care Research Group, Pharmacy Faculty, University of Granada, 18071 Granada, Spain"},{"name":"Pharmacy Department, Hospital Universitario Virgen de las Nieves, 18014 Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aurora","family":"Polo-Moyano","sequence":"additional","affiliation":[{"name":"Nephrology Department, Hospital Universitario Virgen de las Nieves, 18014 Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Palomares-Bayo","sequence":"additional","affiliation":[{"name":"Nephrology Department, Hospital Universitario Virgen de las Nieves, 18014 Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Mart\u00ednez-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Pharmaceutical Care Research Group, Pharmacy Faculty, University of Granada, 18071 Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel \u00c1ngel","family":"Calleja-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Pharmaceutical Care Research Group, Pharmacy Faculty, University of Granada, 18071 Granada, Spain"},{"name":"Pharmacy Department, Hospital Universitario Virgen Macarena, 41009 Seville, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Pereira-C\u00e9spedes, A., Jim\u00e9nez-Morales, A., Palomares-Bayo, M., Mart\u00ednez-Mart\u00ednez, F., and Calleja-Hern\u00e1ndez, M. 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