{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:45:41Z","timestamp":1760143541630,"version":"build-2065373602"},"reference-count":24,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T00:00:00Z","timestamp":1707782400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>This study investigated the changes in the ganglion cell complex (GCC) of patients with acute central serous chorioretinopathy (CSC) following focal laser photocoagulation (FLP) and sought to determine its correlation with visual acuity (VA). Our retrospective study was conducted on 30 patients diagnosed with acute CSC between January 2015 and April 2022, who underwent FLP within 3 months of symptom onset. The study assessed GCC changes by measuring the thickness of its inner retinal layers\u2014retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), and inner plexiform layer (IPL) using optical coherence tomography (OCT). GCC thickness was compared between the affected and unaffected eyes and a healthy control group. VA was also assessed at baseline and at 1, 3, and 6 months post-treatment. VA showed significant improvement from 0.20 \u00b1 0.14 at baseline to 0.10 \u00b1 0.12 logMAR at 6 months post-treatment (p = 0.003). There was no significant change in GCC thickness over the 6-month period. No significant differences in GCC thickness were observed when comparing CSC eyes with fellow eyes or with normal controls at any time point. Final VA was significantly related only to baseline VA, with no correlation found with other factors, including RNFL, GCL, and IPL thickness. In summary, for patients with acute CSC undergoing FLP, our findings indicate that there is no significant change in GCC thickness detectable by OCT before and after the resolution of subretinal fluid (SRF), despite improvements in VA post-laser treatment. This suggests that any potential impact of FLP on GCC thickness may be minimal and not discernible with the current measurement methods, such as OCT, emphasizing that VA improvements may be primarily associated with alterations in the outer retina rather than the inner retina. Further studies with extended follow-up durations are warranted to evaluate any potential long-term changes in GCC.<\/jats:p>","DOI":"10.3390\/jcm13041064","type":"journal-article","created":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T04:18:22Z","timestamp":1707884302000},"page":"1064","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Focal Laser Photocoagulation on the Ganglion Cell Complex Thickness in Acute Central Serous Chorioretinopathy"],"prefix":"10.3390","volume":"13","author":[{"given":"A Young","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Hangil Eye Hospital, Incheon 21388, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinyoung","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hangil Eye Hospital, Incheon 21388, Republic of Korea"},{"name":"Department of Ophthalmology, Catholic Kwandong University College of Medicine, Incheon 22711, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Un","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hangil Eye Hospital, Incheon 21388, Republic of Korea"},{"name":"Department of Ophthalmology, Catholic Kwandong University College of Medicine, Incheon 22711, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chul Woo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hangil Eye Hospital, Incheon 21388, Republic of Korea"},{"name":"Department of Ophthalmology, Catholic Kwandong University College of Medicine, Incheon 22711, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1808-3169","authenticated-orcid":false,"given":"Daniel Duck-Jin","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hangil Eye Hospital, Incheon 21388, Republic of Korea"},{"name":"Department of Ophthalmology, Catholic Kwandong University College of Medicine, Incheon 22711, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1016\/S0161-6420(84)34117-3","article-title":"Peripheral retinal detachments and retinal pigment epithelial atrophic tracts secondary to central serous pigment epitheliopathy","volume":"91","author":"Yannuzzi","year":"1984","journal-title":"Ophthalmology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.preteyeres.2015.05.003","article-title":"Central serous chorioretinopathy: Recent findings and new physiopathology hypothesis","volume":"48","author":"Daruich","year":"2015","journal-title":"Prog. 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