{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T23:17:25Z","timestamp":1776381445755,"version":"3.51.2"},"reference-count":50,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T00:00:00Z","timestamp":1707955200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Union\u2019s Horizon 2020 research and innovation program","award":["965221"],"award-info":[{"award-number":["965221"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>This comprehensive study delves into the intricate landscape surrounding the role of human papillomavirus (HPV) in extragenital keratinocyte skin tumors, specifically exploring Bowen\u2019s disease (BD) and in situ squamous-cell carcinoma (iSCC). Through a multifaceted examination, this research study elucidates the nuanced interplay of HPV, gender dynamics, anatomical site variations, and potential implications for the etiopathogenesis of these malignancies.<\/jats:p>","DOI":"10.3390\/jcm13041091","type":"journal-article","created":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T03:57:29Z","timestamp":1707969449000},"page":"1091","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Unraveling the Complex Nexus of Human Papillomavirus (HPV) in Extragenital Keratinocyte Skin Tumors: A Comprehensive Analysis of Bowen\u2019s Disease and In Situ Squamous-Cell Carcinoma"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5126-8873","authenticated-orcid":false,"given":"Claudio","family":"Conforti","sequence":"first","affiliation":[{"name":"IDI-IRCCS, Dermatological Research Hospital, 00167 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Retrosi","sequence":"additional","affiliation":[{"name":"IDI-IRCCS, Dermatological Research Hospital, 00167 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Agozzino","sequence":"additional","affiliation":[{"name":"Dermatology Clinic, Maggiore Hospital, Piazza Ospitale 1, 34125 Trieste, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caterina","family":"Dianzani","sequence":"additional","affiliation":[{"name":"Department of Plastic, Reconstructive and Cosmetic Surgery, Dermatology Section, Campus Bio-Medico University Hospital, 00128 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ermanno","family":"Nardon","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences (DSM), University of Trieste, 34149 Trieste, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anselmo","family":"Oliveri","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences (DSM), University of Trieste, 34149 Trieste, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5193-268X","authenticated-orcid":false,"given":"Eros","family":"Azzalini","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences (DSM), University of Trieste, 34149 Trieste, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Guida","sequence":"additional","affiliation":[{"name":"Dermatology Clinic, IRCCS San Raffaele Hospital, Vita-Salute University, 20132 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Pellacani","sequence":"additional","affiliation":[{"name":"Dermatology Clinic, Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, 00196 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Di Lella","sequence":"additional","affiliation":[{"name":"IDI-IRCCS, Dermatological Research Hospital, 00167 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2227-581X","authenticated-orcid":false,"given":"Franco","family":"Rongioletti","sequence":"additional","affiliation":[{"name":"Dermatology Clinic, IRCCS San Raffaele Hospital, Vita-Salute University, 20132 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iris","family":"Zalaudek","sequence":"additional","affiliation":[{"name":"Dermatology Clinic, Maggiore Hospital, Piazza Ospitale 1, 34125 Trieste, Italy"},{"name":"Department of Medical Sciences (DSM), University of Trieste, 34149 Trieste, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7349-0296","authenticated-orcid":false,"given":"Serena","family":"Bonin","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences (DSM), University of Trieste, 34149 Trieste, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/jdv.18548","article-title":"The role of HPV in keratinocyte skin cancer development: A systematic review","volume":"37","author":"Neagu","year":"2023","journal-title":"J. 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