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In recent decades, it has experienced an exponential increase in life expectancy, leading to a rise in age-related diseases, including Alzheimer\u2019s disease (AD). Specific health plans for the comprehensive care of the DS community are an unmet need, which is crucial for the early and accurate diagnosis of main medical comorbidities. We present the protocol of a newly created clinical and research cohort and its feasibility in real life. Methods: The Down Syndrome\u2014Basque Alzheimer Initiative (DS-BAI) is a population-based, inclusive, multidisciplinary initiative for the clinical-assistance and clinical-biological research approach to aging in DS led by the CITA-Alzheimer Foundation (Donostia, Basque Country). It aims to achieve the following: (1) provide comprehensive care for adults with DS, (2) optimize access to rigorous and quality training for socio-family and healthcare references, and (3) create a valuable multimodal clinical-biological research platform. Results: During the first year, 114 adults with DS joined the initiative, with 36% of them showing symptoms indicative of AD. Furthermore, adherence to training programs for healthcare professionals and families has been high, and the willingness to collaborate in basic and translational research has been encouraging. Conclusion: Specific health plans for DS and conducting clinical and translational research on the challenges of aging, including AD, are necessary and feasible.<\/jats:p>","DOI":"10.3390\/jcm13041139","type":"journal-article","created":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T03:18:38Z","timestamp":1708312718000},"page":"1139","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Down Syndrome\u2014Basque Alzheimer Initiative (DS-BAI): Clinic-Biological Cohort"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9709-5314","authenticated-orcid":false,"given":"Miren","family":"Altuna","sequence":"first","affiliation":[{"name":"Fundaci\u00f3n CITA-Alzheimer Fundazioa, 20009 Donostia, Spain"},{"name":"Debabarrena Integrated Health Organization, Osakidetza Basque Health Service, 20690 Gipuzkoa, Spain"},{"name":"Department of Medicine, Faculty of Health Sciences, University of Deusto, 48007 Bilbo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ainara","family":"Estanga","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n CITA-Alzheimer Fundazioa, 20009 Donostia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adolfo","family":"Garrido","sequence":"additional","affiliation":[{"name":"Donostialdea Integrated Health Organisation, Clinical Biochemistry Department, Osakidetza Basque Health Service, 20014 Donostia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jon","family":"Saldias","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n CITA-Alzheimer Fundazioa, 20009 Donostia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Ca\u00f1ada","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n CITA-Alzheimer Fundazioa, 20009 Donostia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maitane","family":"Echeverria","sequence":"additional","affiliation":[{"name":"Donostialdea Integrated Health Organisation, Clinical Biochemistry Department, Osakidetza Basque Health Service, 20014 Donostia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 \u00c1ngel","family":"Larrea","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Health Sciences, University of Deusto, 48007 Bilbo, Spain"},{"name":"Donostialdea Integrated Health Organisation, Radiology Department, Osakidetza Basque Health Service, 20014 Donostia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Ayo","sequence":"additional","affiliation":[{"name":"Atzegi, 20004 Donostia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ainhoa","family":"Fiz","sequence":"additional","affiliation":[{"name":"Atzegi, 20004 Donostia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0162-8495","authenticated-orcid":false,"given":"Mar\u00eda","family":"Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Goyeneche de San Sebasti\u00e1n, 20018 Donostia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Santa-In\u00e9s","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Goyeneche de San Sebasti\u00e1n, 20018 Donostia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria","family":"Garc\u00eda-Landarte","sequence":"additional","affiliation":[{"name":"FEVAS Plena Inclusi\u00f3n Euskadi, 48009 Bilbo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3480-6056","authenticated-orcid":false,"given":"Maite","family":"Garc\u00eda-Sebasti\u00e1n","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n CITA-Alzheimer Fundazioa, 20009 Donostia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41572-019-0143-7","article-title":"Down Syndrome","volume":"6","author":"Antonarakis","year":"2020","journal-title":"Nat. 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