{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T02:35:33Z","timestamp":1790303733499,"version":"4.1.0"},"reference-count":66,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T00:00:00Z","timestamp":1708473600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Texas Rio Grande Valley, Office of Faculty Success and Diversity"},{"name":"School of Podiatric Medicine, UTRGV"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Diabetic foot ulcers (DFUs) pose a significant threat to individuals with diabetes mellitus (DM), such as lower limb amputation and severe morbidity. Bioengineered skin substitutes (BSS) are alternatives to traditional interventions for treating DFUs, but their efficacy compared to standard wound care (SWC) or other treatment types, such as allografts, remains unknown. A scoping review of human studies was conducted to identify current approaches in the treatment of DFUs using BSS as compared with other treatment options. Systematic searches in PubMed, Cochrane Library, and Web of Science were conducted to identify comparative studies that enrolled 10 or more patients and evaluated wound healing outcomes (closure, time-to-healing, and area reduction). Database searches isolated articles published from 1 December 2012 to 1 December 2022 and were conducted in accordance with PRISMA-ScR guidelines. The literature search yielded 1312 articles, 24 of which were included for the qualitative analysis. Findings in these studies demonstrated that BSS outperformed SWC in all measured outcomes, suggesting that BSS may be a superior treatment for DFUs. Of the 24 articles, 8 articles compared human amniotic membrane allografts (hAMA) to BSS. Conflicting evidence was observed when comparing BSS and hAMA treatments, highlighting the need for future research.<\/jats:p>","DOI":"10.3390\/jcm13051221","type":"journal-article","created":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T06:50:22Z","timestamp":1708498222000},"page":"1221","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Bioengineered Skin for Diabetic Foot Ulcers: A Scoping Review"],"prefix":"10.3390","volume":"13","author":[{"given":"Nathaniel R.","family":"Primous","sequence":"first","affiliation":[{"name":"Department of Podiatric Medicine, Surgery and Biomechanics, School of Podiatric Medicine, University of Texas Rio Grande Valley, Harlingen, TX 78550, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter T.","family":"Elvin","sequence":"additional","affiliation":[{"name":"Department of Podiatric Medicine, Surgery and Biomechanics, School of Podiatric Medicine, University of Texas Rio Grande Valley, Harlingen, TX 78550, USA"},{"name":"Department of Biomedical Engineering, University of Texas at Dallas, Dallas, TX 75080, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8955-4912","authenticated-orcid":false,"given":"Kathleen V.","family":"Carter","sequence":"additional","affiliation":[{"name":"Library, School of Medicine, University of Texas Rio Grande Valley, Harlingen, TX 78550, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hagner L.","family":"Andrade","sequence":"additional","affiliation":[{"name":"Department of Podiatric Medicine, Surgery and Biomechanics, School of Podiatric Medicine, University of Texas Rio Grande Valley, Harlingen, TX 78550, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"La Fontaine","sequence":"additional","affiliation":[{"name":"Department of Podiatric Medicine, Surgery and Biomechanics, School of Podiatric Medicine, University of Texas Rio Grande Valley, Harlingen, TX 78550, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naohiro","family":"Shibuya","sequence":"additional","affiliation":[{"name":"Department of Podiatric Medicine, Surgery and Biomechanics, School of Podiatric Medicine, University of Texas Rio Grande Valley, Harlingen, TX 78550, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4503-3108","authenticated-orcid":false,"given":"Claudia C.","family":"Biguetti","sequence":"additional","affiliation":[{"name":"Department of Podiatric Medicine, Surgery and Biomechanics, School of Podiatric Medicine, University of Texas Rio Grande Valley, Harlingen, TX 78550, USA"},{"name":"Department of Biomedical Engineering, University of Texas at Dallas, Dallas, TX 75080, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"107843","DOI":"10.1016\/j.diabres.2019.107843","article-title":"Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9th edition","volume":"157","author":"Saeedi","year":"2019","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1111\/iwj.12404","article-title":"The impact of foot ulceration and amputation on mortality in diabetic patients. I: From ulceration to death, a systematic review","volume":"13","author":"Jupiter","year":"2016","journal-title":"Int. Wound J."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.2337\/dc05-2425","article-title":"Risk Factors for Foot Infections in Individuals With Diabetes","volume":"29","author":"Lavery","year":"2006","journal-title":"Diabetes Care"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/S0140-6736(03)13169-8","article-title":"Diabetic foot ulcers","volume":"361","author":"Jeffcoate","year":"2003","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"21847","DOI":"10.3402\/dfa.v4i0.21847","article-title":"The system of care for the diabetic foot: Objectives, outcomes, and opportunities","volume":"4","author":"Barshes","year":"2013","journal-title":"Diabet. Foot Ankle"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"37","DOI":"10.4239\/wjd.v6.i1.37","article-title":"Literature review on the management of diabetic foot ulcer","volume":"6","author":"Yazdanpanah","year":"2015","journal-title":"World J. Diabetes"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/j.ijbiomac.2019.08.007","article-title":"Biopolymer-based biomaterials for accelerated diabetic wound healing: A critical review","volume":"139","author":"Shah","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s40204-018-0083-4","article-title":"Synthetic polymeric biomaterials for wound healing: A review","volume":"7","author":"Mir","year":"2018","journal-title":"Prog. Biomater."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Bardill, J.R., Laughter, M.R., Stager, M., Liechty, K.W., Krebs, M.D., and Zgheib, C. (2022). Topical gel-based biomaterials for the treatment of diabetic foot ulcers. Acta Biomater., 138.","DOI":"10.1016\/j.actbio.2021.10.045"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Gao, D., Zhang, Y., Bowers, D.T., Liu, W., and Ma, M. (2021). Functional hydrogels for diabetic wound management. APL Bioeng., 5.","DOI":"10.1063\/5.0046682"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1007\/s12325-014-0140-x","article-title":"Pathogenesis and Treatment of Impaired Wound Healing in Diabetes Mellitus: New Insights","volume":"31","author":"Baltzis","year":"2014","journal-title":"Adv. Ther."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.trsl.2021.05.006","article-title":"Macrophage polarization and diabetic wound healing","volume":"236","author":"Louiselle","year":"2021","journal-title":"Transl. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1080\/21691401.2017.1304407","article-title":"Diabetic ulcer regeneration: Stem cells, biomaterials, growth factors","volume":"46","author":"Zarei","year":"2018","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1160\/TH03-11-0720","article-title":"Neutrophil function in the healing wound: Adding insult to injury?","volume":"92","author":"Dovi","year":"2004","journal-title":"Thromb. Haemost."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/nyas.13569","article-title":"Update on management of diabetic foot ulcers","volume":"1411","author":"Everett","year":"2018","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.cpm.2019.02.003","article-title":"Conservative Offloading","volume":"36","author":"Crisologo","year":"2019","journal-title":"Clin. Podiatr. Med. Surg."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"102876","DOI":"10.1016\/j.amsu.2021.102876","article-title":"The role of debridement in wound bed preparation in chronic wound: A narrative review","volume":"71","author":"Thomas","year":"2021","journal-title":"Ann. Med. Surg."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1001\/jamadermatol.2013.4960","article-title":"Frequency of Debridements and Time to Heal","volume":"149","author":"Wilcox","year":"2013","journal-title":"JAMA Dermatol."},{"key":"ref_19","unstructured":"(2024, January 03). Debridement Procedures for Managing Diabetic Foot Ulcers: A Review of Clinical Effectiveness, Cost-Effectiveness, and Guidelines, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK253769\/."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1089\/wound.2021.0016","article-title":"Debridement of Diabetic Foot Ulcers","volume":"11","author":"Dayya","year":"2022","journal-title":"Adv. Wound Care"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.12968\/bjon.2014.23.sup12.S10","article-title":"Understanding methods of wound debridement","volume":"23","author":"Atkin","year":"2014","journal-title":"Br J Nurs."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/iwj.12045","article-title":"New techniques for wound debridement","volume":"10","author":"Madhok","year":"2013","journal-title":"Int. Wound J."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e3283","DOI":"10.1002\/dmrr.3283","article-title":"Guidelines on use of interventions to enhance healing of chronic foot ulcers in diabetes (IWGDF 2019 update)","volume":"36","author":"Rayman","year":"2020","journal-title":"Diabetes Metab. Res. Rev."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"82S","DOI":"10.1097\/PRS.0000000000002651","article-title":"Current Concepts in Debridement","volume":"138","author":"Anghel","year":"2016","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1111\/wrr.12961","article-title":"A molecular approach to maggot debridement therapy with Lucilia sericata and its excretions\/secretions in wound healing","volume":"29","author":"Tombulturk","year":"2021","journal-title":"Wound Repair Regen."},{"key":"ref_26","first-page":"CD006214","article-title":"Debridement for surgical wounds","volume":"2013","author":"Smith","year":"2013","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_27","first-page":"CD011255","article-title":"Skin grafting and tissue replacement for treating foot ulcers in people with diabetes","volume":"2016","author":"Santema","year":"2016","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Kohlhauser, M., Luze, H., Nischwitz, S.P., and Kamolz, L.P. (2021). Historical Evolution of Skin Grafting\u2014A Journey through Time. Medicina, 57.","DOI":"10.3390\/medicina57040348"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.cpm.2012.04.011","article-title":"An Overview of Autologous Skin Grafts and Advanced Biologics for the Diabetic Foot","volume":"29","author":"Ramanujam","year":"2012","journal-title":"Clin. Podiatr. Med. Surg."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/iwj.12575","article-title":"Skin grafting for the treatment of chronic leg ulcers\u2014A systematic review in evidence-based medicine","volume":"14","author":"Serra","year":"2017","journal-title":"Int. Wound J."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"e443","DOI":"10.1097\/BCR.0000000000000314","article-title":"Back Grafting the Split-Thickness Skin Graft Donor Site","volume":"38","author":"Goverman","year":"2017","journal-title":"J. Burn. Care Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"132","DOI":"10.4103\/JCAS.JCAS_83_18","article-title":"Human skin allograft: Is it a viable option in management of burn patients?","volume":"12","author":"Gupta","year":"2019","journal-title":"J. Cutan. Aesthetic Surg."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.clindermatol.2004.07.018","article-title":"Guidelines on processing and clinical use of skin allografts","volume":"23","author":"Kearney","year":"2005","journal-title":"Clin. Dermatol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1002\/term.3086","article-title":"Intermediate layer contribution in placental membrane allografts","volume":"14","author":"Roy","year":"2020","journal-title":"J. Tissue Eng. Regen. Med."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Dixit, S., Baganizi, D.R., Sahu, R., Dosunmu, E., Chaudhari, A., Vig, K., Pillai, S.R., Singh, S.R., and Dennis, V.A. (2017). Immunological challenges associated with artificial skin grafts: Available solutions and stem cells in future design of synthetic skin. J. Biol. Eng., 11.","DOI":"10.1186\/s13036-017-0089-9"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1016\/j.burns.2018.02.029","article-title":"Skin xenotransplantation: Historical review and clinical potential","volume":"44","author":"Yamamoto","year":"2018","journal-title":"Burns"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/xen.12219","article-title":"The pathobiology of pig-to-primate xenotransplantation: A historical review","volume":"23","author":"Cooper","year":"2016","journal-title":"Xenotransplantation"},{"key":"ref_38","unstructured":"Rijal, N.P., and Narmoneva, D.A. (2020). Wound Healing, Tissue Repair, and Regeneration in Diabetes, Elsevier."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Oualla-Bachiri, W., Fern\u00e1ndez-Gonz\u00e1lez, A., Qui\u00f1ones-Vico, M.I., and Arias-Santiago, S. (2020). From Grafts to Human Bioengineered Vascularized Skin Substitutes. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21218197"},{"key":"ref_40","first-page":"4","article-title":"Skin Substitutes: A Brief Review of Types and Clinical Applications","volume":"24","author":"Alrubaiy","year":"2009","journal-title":"Oman Med. J."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1002\/term.2884","article-title":"Cellular versus acellular matrix devices in the treatment of diabetic foot ulcers: Interim results of a comparative efficacy randomized controlled trial","volume":"13","author":"Dahle","year":"2019","journal-title":"J. Tissue Eng. Regen. Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"467","DOI":"10.7326\/M18-0850","article-title":"PRISMA Extension for Scoping Reviews (PRISMA-ScR): Checklist and Explanation","volume":"169","author":"Tricco","year":"2018","journal-title":"Ann. Intern. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"797","DOI":"10.2217\/cer-2018-0031","article-title":"Comparative effectiveness of a bilayered living cellular construct and an acellular fetal bovine collagen dressing in the treatment of venous leg ulcers","volume":"7","author":"Sabolinski","year":"2018","journal-title":"J. Comp. Eff. Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1002\/term.3003","article-title":"Engineered skin graft with stromal vascular fraction cells encapsulated in fibrin\u2013collagen hydrogel: A clinical study for diabetic wound healing","volume":"14","author":"Nilforoushzadeh","year":"2020","journal-title":"J. Tissue Eng. Regen. Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1111\/iwj.13715","article-title":"Use of a purified reconstituted bilayer matrix in the management of chronic diabetic foot ulcers improves patient outcomes vs standard of care: Results of a prospective randomised controlled multi-centre clinical trial","volume":"19","author":"Armstrong","year":"2022","journal-title":"Int. Wound J."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.12968\/jowc.2021.30.Sup7.S5","article-title":"Observed impact of skin substitutes in lower extremity diabetic ulcers: Lessons from the Medicare Database (2015\u20132018)","volume":"30","author":"Armstrong","year":"2021","journal-title":"J. Wound Care"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s13304-017-0461-9","article-title":"To evaluate the efficacy of an acellular Flowable matrix in comparison with a wet dressing for the treatment of patients with diabetic foot ulcers: A randomized clinical trial","volume":"69","author":"Campitiello","year":"2017","journal-title":"Updates Surg."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.12968\/jowc.2020.29.Sup3.S13","article-title":"Application of a collagen matrix dressing on a neuropathic diabetic foot ulcer: A randomised control trial","volume":"29","author":"Djavid","year":"2020","journal-title":"J. Wound Care"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1089\/wound.2015.0645","article-title":"The Management of Diabetic Foot Ulcers with Porcine Small Intestine Submucosa Tri-Layer Matrix: A Randomized Controlled Trial","volume":"4","author":"Cazzell","year":"2015","journal-title":"Adv. Wound Care"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1111\/wrr.12357","article-title":"A clinical trial of Integra Template for diabetic foot ulcer treatment","volume":"23","author":"Driver","year":"2015","journal-title":"Wound Repair Regen."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"S18","DOI":"10.12968\/jowc.2016.25.Sup7.S18","article-title":"Evaluation of tissue engineering products for the management of neuropathic diabetic foot ulcers: An interim analysis","volume":"25","author":"Frykberg","year":"2016","journal-title":"J. Wound Care"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1007\/s10439-019-02220-5","article-title":"Regeneration of Diabetic Foot Ulcers Based on Therapy with Red LED Light and a Natural Latex Biomembrane","volume":"47","author":"Rosa","year":"2019","journal-title":"Ann. Biomed. Eng."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"521","DOI":"10.12968\/jowc.2014.23.11.521","article-title":"Randomised controlled clinical trial for autologous fibroblast-hyaluronic acid complex in treating diabetic foot ulcers","volume":"23","author":"You","year":"2014","journal-title":"J. Wound Care"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1111\/iwj.12242","article-title":"A prospective, randomised comparative study of weekly versus biweekly application of dehydrated human amnion\/chorion membrane allograft in the management of diabetic foot ulcers","volume":"11","author":"Zelen","year":"2014","journal-title":"Int. Wound J."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1111\/iwj.12395","article-title":"A prospective, randomised, controlled, multi-centre comparative effectiveness study of healing using dehydrated human amnion\/chorion membrane allograft, bioengineered skin substitute or standard of care for treatment of chronic lower extremity diabetic ulcers","volume":"12","author":"Zelen","year":"2015","journal-title":"Int. Wound J."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1111\/iwj.12566","article-title":"Treatment of chronic diabetic lower extremity ulcers with advanced therapies: A prospective, randomised, controlled, multi-centre comparative study examining clinical efficacy and cost","volume":"13","author":"Zelen","year":"2016","journal-title":"Int. Wound J."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/iwj.12600","article-title":"A prospective, randomised, controlled, multicentre clinical trial examining healing rates, safety and cost to closure of an acellular reticular allogenic human dermis versus standard of care in the treatment of chronic diabetic foot ulcers","volume":"14","author":"Zelen","year":"2017","journal-title":"Int. Wound J."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/wrr.12551","article-title":"A randomized clinical trial of a human acellular dermal matrix demonstrated superior healing rates for chronic diabetic foot ulcers over conventional care and an active acellular dermal matrix comparator","volume":"25","author":"Cazzell","year":"2017","journal-title":"Wound Repair Regen."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1097\/GOX.0000000000002371","article-title":"Placental Membrane Provides Improved Healing Efficacy and Lower Cost Versus a Tissue-Engineered Human Skin in the Treatment of Diabetic Foot Ulcerations","volume":"7","author":"Glat","year":"2019","journal-title":"Plast. Reconstr. Surg. Glob. Open"},{"key":"ref_60","first-page":"26","article-title":"Prospective, multicenter, randomized, controlled clinical trial comparing a bioengineered skin substitute to a human skin allograft","volume":"60","author":"Sanders","year":"2014","journal-title":"Ostomy\/Wound Manag."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1111\/wrr.12332","article-title":"Comparative effectiveness of a bioengineered living cellular construct vs. a dehydrated human amniotic membrane allograft for the treatment of diabetic foot ulcers in a real-world setting","volume":"23","author":"Kirsner","year":"2015","journal-title":"Wound Repair Regen."},{"key":"ref_62","first-page":"125","article-title":"The Comparative Effectiveness of a Human Fibroblast Dermal Substitute versus a Dehydrated Human Amnion\/Chorion Membrane Allograft for the Treatment of Diabetic Foot Ulcers in a Real-world Setting","volume":"29","author":"Kraus","year":"2017","journal-title":"Wounds A Compend. Clin. Res. Pract."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"26","DOI":"10.25270\/wmp.2019.9.2634","article-title":"Evaluation of Wound Closure Rates Using a Human Fibroblast-derived Dermal Substitute Versus a Fetal Bovine Collagen Dressing: A Retrospective Study","volume":"65","author":"Fitzgerald","year":"2019","journal-title":"Wound Manag. Prev."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"149","DOI":"10.12968\/jowc.2015.24.3.149","article-title":"Wound closure in patients with DFU: A cost-effectiveness analysis of two cellular\/tissue-derived products","volume":"24","author":"Gilligan","year":"2015","journal-title":"J. Wound Care"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1111\/wrr.12645","article-title":"A multicenter, randomized, single-blind trial comparing the efficacy of viable cryopreserved placental membrane to human fibroblast-derived dermal substitute for the treatment of chronic diabetic foot ulcers","volume":"26","author":"Ananian","year":"2018","journal-title":"Wound Repair Regen."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1","DOI":"10.19080\/ARR.2020.06.555678","article-title":"A Comparative Analysis of the Cost Effectiveness of Five Advanced Skin Substitutes in the Treatment of Foot Ulcers in Patients with Diabetes","volume":"6","author":"Snyder","year":"2020","journal-title":"Ann. Rev. 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