{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T18:32:49Z","timestamp":1784140369102,"version":"3.55.0"},"reference-count":64,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T00:00:00Z","timestamp":1708560000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>This review navigates the intricate relationship between gender, hormonal influences, and the progression of autosomal dominant polycystic kidney disease (ADPKD), highlighting the limited literature on this crucial topic. The study explores the impact of female sex hormones on liver and renal manifestations, uncovering gender-specific differences in disease progression. Actually, hormonal therapy in women with ADPKD remains a challenging issue and is a source of concern regarding its potential impact on disease outcomes, particularly at the hepatic level. Notably, women with ADPKD exhibit a slower renal disease progression compared to men, attributed to hormonal dynamics. This review sheds light on the role of estrogen in regulating pathways of the renin\u2013angiotensin\u2013aldosterone system, revealing its complex interplay and implications for cardiovascular and renal health. Therapeutic considerations for fertile women with ADPKD, including contraception options, are discussed, emphasizing the necessity for personalized approaches. In the postmenopausal phase, the review evaluates the role of hormonal replacement therapy, considering its potential benefits and risks in the context of ADPKD. The review concludes by underscoring the imperative need for tailored treatment approaches for ADPKD patients, considering individual risks and benefits. The scarcity of literature underlines the call for further research to enhance our understanding of optimal hormonal therapies in the context of ADPKD, ultimately paving the way for innovative and personalized therapeutic interventions.<\/jats:p>","DOI":"10.3390\/jcm13051257","type":"journal-article","created":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T11:28:47Z","timestamp":1708601327000},"page":"1257","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Role of Female Sex Hormones in ADPKD Progression and a Personalized Approach to Contraception and Hormonal Therapy"],"prefix":"10.3390","volume":"13","author":[{"given":"Micaela","family":"Petrone","sequence":"first","affiliation":[{"name":"O.U. Obstetric and Gynecology, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7475-9066","authenticated-orcid":false,"given":"Martina","family":"Catania","sequence":"additional","affiliation":[{"name":"O.U. Nephrology and Dialysis, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy"},{"name":"Vita Salute San Raffaele University, 20132 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliana Italia","family":"De Rosa","sequence":"additional","affiliation":[{"name":"O.U. Nephrology and Dialysis, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy"},{"name":"Vita Salute San Raffaele University, 20132 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca S.","family":"Degliuomini","sequence":"additional","affiliation":[{"name":"O.U. Obstetric and Gynecology, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy"},{"name":"Vita Salute San Raffaele University, 20132 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristiana","family":"Kola","sequence":"additional","affiliation":[{"name":"O.U. Nephrology and Dialysis, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy"},{"name":"Vita Salute San Raffaele University, 20132 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Lupi","sequence":"additional","affiliation":[{"name":"O.U. Obstetric and Gynecology, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy"},{"name":"Vita Salute San Raffaele University, 20132 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Brambilla Pisoni","sequence":"additional","affiliation":[{"name":"O.U. 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Med., 9.","DOI":"10.3390\/jcm9010146"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1681\/ASN.2015010016","article-title":"The PROPKD Score: A New Algorithm to Predict Renal Survival in Autosomal Dominant Polycystic Kidney Disease","volume":"27","author":"Gall","year":"2016","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_3","unstructured":"Finnigan, N.A., and Leslie, S.W. (2023). Polycystic Kidney Disease in Adults, StatPearls Publishing."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1681\/ASN.V112319","article-title":"Effect of gender on the progression of nondiabetic renal disease: A meta-analysis","volume":"11","author":"Neugarten","year":"2000","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_5","unstructured":"Peter, C.H. (2022). Gene Reviews\u2014NCBI Bookshelf, National Institutes of Health."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Liu, J., Fujikura, K., Dev, H., Riyahi, S., Blumenfeld, J., Kim, J., Rennert, H., and Prince, M.R. (2022). Pericardial Effusion on MRI in Autosomal Dominant Polycystic Kidney Disease. J. Clin. Med., 11.","DOI":"10.3390\/jcm11041127"},{"key":"ref_7","first-page":"157","article-title":"Polycystic Kidney Disease and Polycystic Liver Disease Associated to Advanced Gastric Cancer: An External Complication of Potter III Disease","volume":"18","author":"Coco","year":"2023","journal-title":"Maedica"},{"key":"ref_8","first-page":"1282","article-title":"Postmenopausal estrogen therapy selectively stimulates hepatic enlargement in women with autosomal dominant polycystic kidney disease","volume":"26","author":"Sherstha","year":"1997","journal-title":"Hepatology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1681\/ASN.V551178","article-title":"Pregnancy outcome and its relationship to progression of renal failure in autosomal dominant polycystic kidney disease","volume":"5","author":"Chapman","year":"1994","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S0039-128X(00)00113-6","article-title":"Progesterone action and responses in the alphaERKO mouse","volume":"65","author":"Hewitt","year":"2000","journal-title":"Steroids"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Kolatorova, L., Vitku, J., Suchopar, J., Hill, M., and Parizek, A. (2022). Progesterone: A Steroid with wide Range of Effects in Physiology as Well as Human Medicine. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23147989"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1056\/NEJMra050776","article-title":"Estrogen carcinogenesis in breast cancer","volume":"354","author":"Yager","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1590\/S0100-879X2011007500101","article-title":"Gender-dependent effects of aging on the kidney","volume":"44","author":"Gava","year":"2011","journal-title":"Braz. J. Med. Biol. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"R459","DOI":"10.1152\/ajpregu.00222.2013","article-title":"Sex differences in angiotensin II- and aldosterone-induced hypertension: The central protective effects of estrogen","volume":"305","author":"Xue","year":"2013","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1111\/j.1472-8206.2010.00854.x","article-title":"Gender and the renin-angiotensin-aldosterone system","volume":"24","author":"Komukai","year":"2010","journal-title":"Fundam. Clin. Pharmacol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e060223213459","DOI":"10.2174\/1573403X19666230206130205","article-title":"Cardio-Metabolic Health and HRT in Menopause: Novel Insights in Mitochondrial Biogenesis and RAAS","volume":"19","author":"Renke","year":"2023","journal-title":"Curr. Cardiol. Rev."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1097\/MNH.0b013e328011d7f6","article-title":"Gonadal steroids, salt-sensitivity and renal function","volume":"16","author":"Burnier","year":"2007","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1681\/ASN.V132446","article-title":"Variation in the renin angiotensin system throughout the normal menstrual cycle","volume":"13","author":"Chidambaram","year":"2002","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"3130","DOI":"10.1016\/j.mayocp.2021.08.009","article-title":"The Renin-Angiotensin-Aldosterone System in Postmenopausal Women: The Promise of Hormone Therapy","volume":"96","author":"Gersh","year":"2021","journal-title":"Mayo Clin. Proc."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"R498","DOI":"10.1152\/ajpregu.00182.2014","article-title":"Estrogen status and the renin angiotensin aldosterone system","volume":"307","author":"Floras","year":"2014","journal-title":"Am. J. Physiol. Integr. Comp. Physiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1016\/S0022-5347(05)64264-4","article-title":"Etiological role of estrogen status in renal stone formation","volume":"168","author":"Heller","year":"2002","journal-title":"J. Urol."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Conte, C., Antonelli, G., Melica, M.E., Tarocchi, M., Romagnani, P., and Peired, A.J. (2023). Role of Sex Hormones in Prevalent Kidney Diseases. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24098244"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Talbi, K., Cabrita, I., Schreiber, R., and Kunzelmann, K. (2021). Gender-Dependent Phenotype in Polycystic Kidney Disease Is Determined by Differential Intracellular Ca2+ Signals. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22116019"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.steroids.2013.11.023","article-title":"Estrogen and the cystic fibrosis gender gap","volume":"81","author":"Harvey","year":"2014","journal-title":"Steroids"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Howard, S.A., and Benhabbour, S.R. (2023). Non-Hormonal Contraception. J. Clin. Med., 12.","DOI":"10.3390\/jcm12144791"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.bpobgyn.2019.12.002","article-title":"Long-acting reversible contraceptive (LARCs) methods","volume":"66","author":"Bahamondes","year":"2020","journal-title":"Best Pract. Res. Clin. Obstet. Gynaecol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.contraception.2008.11.012","article-title":"Side effects from the copper IUD: Do they decrease over time?","volume":"79","author":"Hubacher","year":"2009","journal-title":"Contraception"},{"key":"ref_28","unstructured":"Horvath, S., Schreiber, C.A., and Sonalkar, S. (2000). Contraception, MDText.com, Inc."},{"key":"ref_29","first-page":"445","article-title":"Intrauterine devices: An update","volume":"89","author":"Hardeman","year":"2014","journal-title":"Am. Fam. Physician"},{"key":"ref_30","unstructured":"(2015). Medical Eligibility Criteria for Contraceptive Use, World Health Organization. [5th ed.]."},{"key":"ref_31","unstructured":"(2016). Management of Endometrial Hyperplasia, StatPearls Publishing."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"ACOG (2011). Practice Bulletin No. 121: Long-acting reversible contraception: Implants and intrauterine devices. Obstet. Gynecol., 118, 184\u2013196.","DOI":"10.1097\/AOG.0b013e318227f05e"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"143","DOI":"10.2174\/157488710792007301","article-title":"Mirena intra-uterine system: Does it improve long term symptoms in women with chronic pelvic pain and\/or endometriosis after laparoscopy? A multicentre randomized controlled trial","volume":"5","author":"Alhamdan","year":"2010","journal-title":"Rev. Recent Clin. Trials."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.ejogrb.2022.06.029","article-title":"Uterine volume, menstrual patterns, and contraceptive outcomes in users of the levonorgestrel-releasing intrauterine system: A cohort study with a five-year follow-up","volume":"276","author":"Magalhaes","year":"2022","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"S134","DOI":"10.1016\/j.contraception.2006.12.008","article-title":"Use of the levonorgestrel-releasing intrauterine system in women with endometriosis, chronic pelvic pain and dysmenorrhea","volume":"75","author":"Bahamondes","year":"2007","journal-title":"Contraception"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"hoac009","DOI":"10.1093\/hropen\/hoac009","article-title":"ESHRE guideline: Endometriosis","volume":"2022","author":"Becker","year":"2022","journal-title":"Hum. Reprod. Open"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.fertnstert.2005.06.040","article-title":"Comparison of uterine concentrations of ethinyl estradiol and etonogestrel after use of a contraceptive vaginal ring and an oral contraceptive","volume":"85","author":"Roumen","year":"2006","journal-title":"Fertil. Steril."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.3332\/ecancer.2022.1416","article-title":"Review of the literature on combined oral contraceptives and cancer","volume":"16","author":"Kamani","year":"2022","journal-title":"Ecancermedicalscience"},{"key":"ref_39","unstructured":"Grimes, D.A. (2009). Cochrane Database of Systematic Reviews, John Wiley & Sons, Ltd."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1210\/jc.2017-02052","article-title":"Treatment Options for Hirsutism: A Systematic Review and Network Meta-Analysis","volume":"103","author":"Barrionuevo","year":"2018","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"580.e1","DOI":"10.1016\/j.ajog.2017.02.002","article-title":"Lifetime cancer risk and combined oral contraceptives: The Royal College of General Practitioners\u2019 Oral Contraception Study","volume":"216","author":"Iversen","year":"2017","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1055\/s-2001-18637","article-title":"Noncontraceptive Benefits and Therapeutic Uses of the Oral Contraceptive Pill","volume":"19","author":"Dayal","year":"2001","journal-title":"Semin. Reprod. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1080\/13625180701536771","article-title":"The effects of an oestrogen-free, desogestrel-containing oral contraceptive in women with cyclical symptoms: Results from two studies on oestrogen-related symptoms and dysmenorrhoea","volume":"12","author":"Ahrendt","year":"2007","journal-title":"Eur. J. Contracept. Reprod. Health Care"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1055\/s-2001-18646","article-title":"Contraceptive vaginal rings","volume":"19","author":"Harwood","year":"2001","journal-title":"Semin. Reprod. Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1097\/GRF.0b013e318159c07e","article-title":"Contraceptive vaginal ring","volume":"50","author":"Madden","year":"2007","journal-title":"Clin. Obstet. Gynecol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"839","DOI":"10.2174\/138920010794479646","article-title":"Is the vagina an adequate route for the administration of hormonal contraceptives?","volume":"11","author":"Lete","year":"2010","journal-title":"Curr. Drug Metab."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1783\/147118908786000451","article-title":"Ovulation incidence with oral contraceptives: A literature review","volume":"34","author":"Milsom","year":"2008","journal-title":"J. Fam. Plann. Reprod. Health Care"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"World Health Organization Collaborative Study of Cardiovascular Disease and Steroid Hormone Contraception (1998). Cardiovascular disease and use of oral and injectable progestogen-only contraceptives and combined injectable contraceptives. Results of an international, multicenter, case-control study. Contraception, 57, 315\u2013324.","DOI":"10.1016\/S0010-7824(98)00041-9"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.fertnstert.2017.01.008","article-title":"Introduction: A focus on the medical management of endometriosis","volume":"107","author":"Casper","year":"2017","journal-title":"Fertil. Steril."},{"key":"ref_50","first-page":"195","article-title":"Novel strategies in the management of polycystic ovary syndrome","volume":"40","author":"Spritzer","year":"2015","journal-title":"Minerva Endocrinol."},{"key":"ref_51","first-page":"8971900231167925","article-title":"The Art of Hormone Replacement Therapy (HRT) in Menopause Management","volume":"2023","author":"Cameron","year":"2023","journal-title":"J. Pharm. Pract."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3109\/13697137.2011.647840","article-title":"Vaginal Health: Insights, Views & Attitudes (VIVA)\u2014Results from an international survey","volume":"15","author":"Nappi","year":"2012","journal-title":"Climacteric"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1097\/GME.0000000000001831","article-title":"Management of osteoporosis in postmenopausal women: The 2021 position statement of The North American Menopause Society","volume":"28","author":"Blake","year":"2021","journal-title":"Menopause"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.semnephrol.2017.05.013","article-title":"Menopause and Chronic Kidney Disease","volume":"37","author":"Ahmed","year":"2017","journal-title":"Semin. Nephrol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1053\/ajkd.2003.50126","article-title":"Permanent cessation of menses and postmenopausal hormone use in dialysis-dependent women: The HELP study","volume":"41","author":"Kramer","year":"2003","journal-title":"Am. J. Kidney Dis."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"e017416","DOI":"10.1161\/JAHA.120.017416","article-title":"Menopausal Vasomotor Symptoms and Risk of Incident Cardiovascular Disease Events in SWAN","volume":"10","author":"Thurston","year":"2021","journal-title":"J. Am. Heart Assoc."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1080\/13697137.2017.1315089","article-title":"Vasomotor symptoms in menopause: A biomarker of cardiovascular disease risk and other chronic diseases?","volume":"20","author":"Biglia","year":"2017","journal-title":"Climacteric"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1080\/13697137.2016.1196047","article-title":"Revised Global Consensus Statement on Menopausal Hormone Therapy","volume":"19","author":"Hall","year":"2016","journal-title":"Climacteric"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1080\/13697137.2017.1280251","article-title":"The evidence base for HRT: What can we believe?","volume":"20","author":"Langer","year":"2017","journal-title":"Climacteric"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1080\/13697137.2020.1851183","article-title":"Hormone replacement therapy\u2014Where are we now?","volume":"24","author":"Langer","year":"2021","journal-title":"Climacteric"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Nilsson, S., Henriksson, M., Berin, E., Engblom, D., Holm, A.C.S., and Hammar, M. (2022). Resistance training reduced luteinising hormone levels in postmenopausal women in a substudy of a randomised controlled clinical trial: A clue to how resistance training reduced vasomotor symptoms. PLoS ONE, 17.","DOI":"10.1371\/journal.pone.0267613"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2554","DOI":"10.1001\/jama.2016.8012","article-title":"Use of Plant-Based Therapies and Menopausal Symptoms: A Systematic Review and Meta-analysis","volume":"315","author":"Franco","year":"2016","journal-title":"JAMA"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"107846","DOI":"10.1016\/j.maturitas.2023.107846","article-title":"Sequential management of postmenopausal health and osteoporosis: An update","volume":"177","author":"Cano","year":"2023","journal-title":"Maturitas"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1210\/clinem\/dgad058","article-title":"Efficacy and Safety of Fezolinetant in Moderate to Severe Vasomotor Symptoms Associated with Menopause: A Phase 3 RCT","volume":"108","author":"Johnson","year":"2023","journal-title":"J. Clin. Endocrinol. 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